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Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain
Open accessAbstract
Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but, unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular zone (SVZ) by ependymal cells. Apical and basal compartments, which in embryonic NSCs play essential roles in self-renewal and differentiation, are not evident in adult NSCs. Here we show that SVZ B1 cells in adult mice extend a minute apical ending to directly contact the ventricle and a long basal process ending on blood vessels. A closer look at the ventricular surface reveals a striking pinwheel organization specific to regions of adult neurogenesis. The pinwheel's core contains the apical endings of B1 cells and in its periphery two types of ependymal cells: multiciliated (E1) and a type (E2) characterized by only two cilia and extraordinarily complex basal bodies. These results reveal that adult NSCs retain fundamental epithelial properties, including apical and basal compartmentalization, significantly reshaping our understanding of this adult neurogenic niche.
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“They contact the cerebrospinal fluid in the ventricles at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature (Mirzadeh et al., 2008; Shen et al., 2008; Tavazoie et al., 2008).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Mirzadeh et al., 2008
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Metadata
- Authors
- Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 265-278
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC2613692
- OpenAlex
- W2026598324
- Cited by
- 1,015
- References
- 72
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 28 · 2023: 45 · 2022: 41 · 2021: 53 · 2020: 62 · 2019: 51 · 2018: 54 · 2017: 70 · 2016: 56 · 2015: 71 · 2014: 69 · 2013: 82 · 2012: 87
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Funders
- University of California, San Francisco
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neural stem cells, subventricular zone, lateral ventricle, adult neurogenesis, ependymal cells, basal bodies, blood vessels, neurogenic niche, stem cell self-renewal
- MeSH terms
- Animals, Brain, Humans, Mice, Inbred Strains, Mitosis, Neuroglia, Lateral Ventricles, Mice, Embryonic Stem Cells, Adult Stem Cells
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