Cited by 1,015Neurogenesis and neuroplasticity mechanismsCerebrospinal fluid and hydrocephalusDevelopmental Biology and Gene Regulation

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Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

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Mirzadeh, Zaman, Merkle, Florian T., Soriano-Navarro, Mario, Garcia-Verdugo, Jose Manuel, Alvarez-Buylla, Arturo·2008·Cell stem cell

DOI 10.1016/j.stem.2008.07.004PMC PMC2613692

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Abstract

Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but, unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular zone (SVZ) by ependymal cells. Apical and basal compartments, which in embryonic NSCs play essential roles in self-renewal and differentiation, are not evident in adult NSCs. Here we show that SVZ B1 cells in adult mice extend a minute apical ending to directly contact the ventricle and a long basal process ending on blood vessels. A closer look at the ventricular surface reveals a striking pinwheel organization specific to regions of adult neurogenesis. The pinwheel's core contains the apical endings of B1 cells and in its periphery two types of ependymal cells: multiciliated (E1) and a type (E2) characterized by only two cilia and extraordinarily complex basal bodies. These results reveal that adult NSCs retain fundamental epithelial properties, including apical and basal compartmentalization, significantly reshaping our understanding of this adult neurogenic niche.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
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Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
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Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
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Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H., & Weissman, I. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14720 · Cited by 1,829
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Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N. E., Vincent, P. A., Pumiglia, K. M., & Temple, S. (2004) · Science · doi:10.1126/science.1095505 · Cited by 1,574
Vertebrate Smoothened functions at the primary cilium
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Rafii, S., Butler, J. M., & Ding, B. (2016) · Nature · doi:10.1038/nature17040 · Cited by 963
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The brain tumor microenvironment
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Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche
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Guirao, B., Meunier, A., Mortaud, S., Aguilar, A., Corsi, J.-M., Strehl, L., Hirota, Y., Desoeuvre, A., Boutin, C., Han, Y.-G., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2040 · Cited by 418
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Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 200
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Başak, O., Giachino, C., Fiorini, E., MacDonald, H. R., & Taylor, V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0455-12.2012 · Cited by 175
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Keryer, G., Pineda, J. R., Liot, G., Kim, J., Dietrich, P., Benstaali, C., Smith, K., Cordelières, F. P., Spassky, N., Ferrante, R. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57552 · Cited by 168

Authors: Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A.
Affiliations: University of California, San Francisco (US)
ORCID: Mirzadeh, Zaman
Merkle, Florian T.
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2008-09
Volume: 3
Issue: 3
Pages: 265-278
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2008.07.004
PMC: PMC2613692
OpenAlex: W2026598324
Cited by: 1,015
References: 72
Citations by year: 2026: 20 · 2025: 36 · 2024: 28 · 2023: 45 · 2022: 41 · 2021: 53 · 2020: 62 · 2019: 51 · 2018: 54 · 2017: 70 · 2016: 56 · 2015: 71 · 2014: 69 · 2013: 82 · 2012: 87
FWCI: 19.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Apollo (University of Cambridge) (submittedVersion)
Funders: University of California, San Francisco
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: neural stem cells, subventricular zone, lateral ventricle, adult neurogenesis, ependymal cells, basal bodies, blood vessels, neurogenic niche, stem cell self-renewal
MeSH terms: Animals, Brain, Humans, Mice, Inbred Strains, Mitosis, Neuroglia, Lateral Ventricles, Mice, Embryonic Stem Cells, Adult Stem Cells

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Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

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