The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
Open accessAbstract
Summary The transcription factor Sox2 maintains the pluripotency of early embryonic cells and regulates the formation of several epithelia during fetal development. Whether Sox2 continues to play a role in adult tissues remains largely unknown. We here show that Sox2 marks adult cells in several epithelial tissues where its expression has not previously been characterized, including the stomach, cervix, anus, testes, lens and multiple glands. Genetic lineage tracing and transplantation experiments demonstrate that Sox2-expressing cells continuously give rise to mature cell types within these tissues, documenting their self-renewal and differentiation potentials. Consistent with these findings, ablation of Sox2+ cells in mice results in a disruption of epithelial tissue homeostasis and lethality. Developmental fate mapping reveals that Sox2+ adult stem cells originate from fetal Sox2+ tissue progenitors. Thus, our results identify Sox2 expression in numerous adult ectodermal and endodermal stem cell compartments, which are critical for normal tissue regeneration and survival.
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., & Lovell-Badge, R. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,369
Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dötsch, V., Andrews, N. C., Caput, D., & McKeon, F. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80275-0 · Cited by 2,085
Spermatogenesis following male germ-cell transplantation.
Brinster, R. L., & Zimmermann, J. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11298 · Cited by 1,570
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.013 · Cited by 1,547
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,341
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1589 · Cited by 1,252
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,204
Bmi1 is expressed in vivo in intestinal stem cells
Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,194
Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains
Feil, R., Wagner, J., Metzger, D., & Chambon, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7124 · Cited by 991
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Bass, A. J., Watanabe, H., Mermel, C. H., Yu, S., Perner, S., Verhaak, R. G., Kim, S. Y., Wardwell, L., Tamayo, P., Gat-Viks, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.465 · Cited by 942
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.722 · Cited by 834
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
Suh, H., Consiglio, A., Ray, J., Sawai, T., D'Amour, K. A., & Gage, F. H. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.09.002 · Cited by 818
Ellis, P., Fagan, B. M., Magness, S. T., Hutton, S., Taranova, O., Hayashi, S., McMahon, A., Rao, M., & Pevny, L. (2004) · Developmental Neuroscience · doi:10.1159/000082134 · Cited by 742
SOX2 is a dose-dependent regulator of retinal neural progenitor competence
Taranova, O. V., Magness, S. T., Fagan, B. M., Wu, Y., Surzenko, N., Hutton, S. R., & Pevny, L. H. (2006) · Genes & Development · doi:10.1101/gad.1407906 · Cited by 557
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
Montgomery, R. K., Carlone, D. L., Richmond, C. A., Farilla, L., Kranendonk, M. E. G., Henderson, D. E., Baffour-Awuah, N. Y., Ambruzs, D. M., Fogli, L. K., Algra, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013004108 · Cited by 540
Sox2 is required for sensory organ development in the mammalian inner ear
Kiernan, A. E., Pelling, A. L., Leung, K. K. H., Tang, A. S. P., Bell, D. M., Tease, C., Lovell-Badge, R., Steel, K. P., & Cheah, K. S. E. (2005) · Nature · doi:10.1038/nature03487 · Cited by 539
Que, J., Okubo, T., Goldenring, J. R., Nam, K.-T., Kurotani, R., Morrisey, E. E., Taranova, O., Pevny, L. H., & Hogan, B. L. M. (2007) · Development · doi:10.1242/dev.003855 · Cited by 518
Lefebvre, V., Dumitriu, B., Penzo-Méndez, A., Han, Y., & Pallavi, B. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.05.019 · Cited by 467
Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal
Lengner, C. J., Camargo, F. D., Hochedlinger, K., Welstead, G. G., Zaidi, S., Gokhale, S., Scholer, H. R., Tomilin, A., & Jaenisch, R. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.020 · Cited by 411
Self-citationFauquier, T., Rizzoti, K., Dattani, M., Lovell-Badge, R., & Robinson, I. C. A. F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707886105 · Cited by 381
Karam, S. M., & Leblond, C. P. (1993) · The Anatomical Record · doi:10.1002/ar.1092360202 · Cited by 372
Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs
Barker, N., Bartfeld, S., & Clevers, H. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.016 · Cited by 352
Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction
Kamachi, Y., Uchikawa, M., Collignon, J., Lovell-Badge, R., & Kondoh, H. (1998) · Development · doi:10.1242/dev.125.13.2521 · Cited by 334
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
Multiple roles for Sox2 in the developing and adult mouse trachea
Que, J., Luo, X., Schwartz, R. J., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.034629 · Cited by 321
Graw, J. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)90010-0 · Cited by 273
Induction of Pluripotency in Adult Unipotent Germline Stem Cells
Ko, K., Tapia, N., Wu, G., Kim, J. B., Bravo, M. J. A., Sasse, P., Glaser, T., Ruau, D., Han, D. W., Greber, B., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.025 · Cited by 262
Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells
Galan-Caridad, J. M., Harel, S., Arenzana, T. L., Hou, Z. E., Doetsch, F. K., Mirny, L. A., & Reizis, B. (2007) · Cell · doi:10.1016/j.cell.2007.03.014 · Cited by 244
Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., & Basilico, C. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200409182 · Cited by 234
Cell Lineage Mapping of Taste Bud Cells and Keratinocytes in the Mouse Tongue and Soft Palate
Okubo, T., Clark, C., & Hogan, B. L. M. (2009) · Stem Cells · doi:10.1634/stemcells.2008-0611 · Cited by 210
Sox2 is required for development of taste bud sensory cells
Okubo, T., Pevny, L. H., & Hogan, B. L. M. (2006) · Genes & Development · doi:10.1101/gad.1457106 · Cited by 199
Brazel, C. Y., Limke, T. L., Osborne, J. K., Miura, T., Cai, J., Pevny, L., & Rao, M. S. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00158.x · Cited by 165
Multipotential stem cells in adult mouse gastric epithelium
Bjerknes, M., & Cheng, H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00415.2001 · Cited by 165
Generation of mTert -GFP mice as a model to identify and study tissue progenitor cells
Breault, D. T., Min, I. M., Carlone, D. L., Farilla, L. G., Ambruzs, D. M., Henderson, D. E., Algra, S., Montgomery, R. K., Wagers, A. J., & Hole, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804800105 · Cited by 143
Imamura, M., Miura, K., Iwabuchi, K. A., Ichisaka, T., Nakagawa, M., Lee, J., Kanatsu‐Shinohara, M., Shinohara, T., & Yamanaka, S. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-34 · Cited by 126
Sangiorgi, E., & Capecchi, M. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902508106 · Cited by 111
Epithelial Stem/Progenitor Cells in the Embryonic Mouse Submandibular Gland
Lombaert, I. M. A., & Hoffman, M. P. (2010) · Frontiers of oral physiology/Frontiers of oral biology · doi:10.1159/000313709 · Cited by 55
In Vitro Transdifferentiation of Mature Hepatocytes into Insulin-Producing Cells
Yamada, S., Yamamoto, Y., Nagasawa, M., Hara, A., Kodera, T., & Kojima, I. (2006) · Endocrine Journal · doi:10.1507/endocrj.k06-116 · Cited by 29
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Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., Vries, R., Peters, P. J., & Clevers, H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.09.042 · Cited by 820
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT
Malladi, S., Macalinao, D. G., Jin, X., He, L., Basnet, H., Zou, Y., de Stanchina, E., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.02.025 · Cited by 791
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
Boumahdi, S., Driessens, G., Lapouge, G., Rorive, S., Nassar, D., Le Mercier, M., Delatte, B., Caauwe, A., Lenglez, S., Nkusi, E., et al. (2014) · Nature · doi:10.1038/nature13305 · Cited by 656
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Herriges, M., & Morrisey, E. E. (2014) · Development · doi:10.1242/dev.098186 · Cited by 613
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Metadata
- Authors
- Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N., & Hochedlinger, K.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 9
- Issue
- 4
- Pages
- 317-329
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2018647497
- Cited by
- 768
- References
- 43
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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