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Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
Open accessAbstract
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome towards meaningful therapeutic outcomes is challenging due to limited control on cytokine production following transplantation. This review outlines current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights and perspectives for future development of the MSC secretome as a therapeutic tool.
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Metadata
- Authors
- Ranganath, S. H., Levy, O., Inamdar, M. S., & Karp, J. M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 10
- Issue
- 3
- Pages
- 244-258
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2123771262
- Cited by
- 809
- References
- 7
- FWCI
- 30.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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