Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

Miller, Justine D., Ganat, Yosif M., Kishinevsky, Sarah, Bowman, Robert L., Liu, Becky, Tu, Edmund Y., Mandal, Pankaj K., Vera, Elsa, Shim, Jae-won, Kriks, Sonja, Taldone, Tony, Fusaki, Noemi, Tomishima, Mark J., Krainc, Dimitri, Milner, Teresa A., Rossi, Derrick J., Studer, Lorenz·2013·Cell stem cell
DOI 10.1016/j.stem.2013.11.006

Cites (291)

Items 201–290 of 290

  1. Human embryonic stem cells: research, ethics and policy
    Guido M W R de Wert · 2003 · Human Reproduction
  2. Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
    Fredrik H. Sterky, Seungmin Lee, Rolf Wibom, Lars Olson, Nils‐Göran Larsson · 2011 · Proceedings of the National Academy of Sciences
  3. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
    Julia I. Toth, Shao Hua Yang, Xin Qiao, Anne P. Beigneux, Michael H. Gelb, Casey L. Moulson, Jeffrey H. Miner, Stephen G. Young, Loren G. Fong · 2005 · Proceedings of the National Academy of Sciences
  4. Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
    Papapetrou, Eirini P., Tomishima, Mark J., Chambers, Stuart M., Mica, Yvonne, Reed, Evan, Menon, Jayanthi, Tabar, Viviane, Mo, Qianxing, Studer, Lorenz, Sadelain, Michel · 2009 · Proceedings of the National Academy of Sciences
  5. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
    Larson, Kimberly, Yan, Shian-Jang, Tsurumi, Amy, Liu, Jacqueline, Zhou, Jun, Gaur, Kriti, Guo, Dongdong, Eickbush, Thomas H., Li, Willis X. · 2012 · PLoS Genetics
  6. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
    Cao, Kan, Blair, Cecilia D., Faddah, Dina A., Kieckhaefer, Julia E., Olive, Michelle, Erdos, Michael R., Nabel, Elizabeth G., Collins, Francis S. · 2011 · Journal of Clinical Investigation
  7. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
    Mark W. Dodson, Ming Guo · 2007 · Current Opinion in Neurobiology
  8. Nuclear Reprogramming in Nuclear Transplant Rabbit Embryos
    Steven L. Stice, James M. Robl · 1988 · Biology of Reproduction
  9. Is Parkinson's disease a prion disorder?
    C. Warren Olanow, Stanley B. Prusiner · 2009 · Proceedings of the National Academy of Sciences
  10. MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
    Medvedik, Oliver, Lamming, Dudley W, Kim, Keyman D, Sinclair, David A · 2007 · PLoS Biology
  11. Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
    Angot, Elodie, Steiner, Jennifer A., Lema Tomé, Carla M., Ekström, Peter, Mattsson, Bengt, Björklund, Anders, Brundin, Patrik · 2012 · PLoS ONE
  12. An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
    Manabu Funayama, Kazuko Hasegawa, Etsuro Ohta, Noriko Kawashima, Masaru Komiyama, Hisayuki Kowa, Shoji Tsuji, Fumiya Obata · 2005 · Annals of Neurology
  13. Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa
    Yoland Smith, Thomas Wichmann, Stewart Alan Factor, Mahlon R. DeLong · 2011 · Neuropsychopharmacology
  14. A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
    Kan Cao, Brian C. Capell, Michael R. Erdos, Karima Djabali, Francis S. Collins · 2007 · Proceedings of the National Academy of Sciences
  15. Incomplete processing of mutant lamin A in Hutchinson–Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
    Michael W. Glynn, Thomas W. Glover · 2005 · Human Molecular Genetics
  16. Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
    Tollervey, James R., Wang, Zhen, Hortobágyi, Tibor, Witten, Joshua T., Zarnack, Kathi, Kayikci, Melis, Clark, Tyson A., Schweitzer, Anthony C., Rot, Gregor, Curk, Tomaž et al. · 2011 · Genome Research
  17. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia et al. · 2013 · Nature Cell Biology
  18. Programmed Cell Death in Parkinson's Disease
    Kateřina Venderová, David S. Park · 2012 · Cold Spring Harbor Perspectives in Medicine
  19. Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases
    John T. Finn, Miguel Weil, Fabienne Archer, Robert Siman, Anu N. Srinivasan, MARTIN C. RAFF · 2000 · Journal of Neuroscience
  20. Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity
    Mesquita, Ana, Weinberger, Martin, Silva, Alexandra, Sampaio-Marques, Belém, Almeida, Bruno, Leão, Cecília, Costa, Vítor, Rodrigues, Fernando, Burhans, William C., Ludovico, Paula · 2010 · Proceedings of the National Academy of Sciences
  21. The heterochromatin loss model of aging
    Villeponteau, Bryant · 1997 · Experimental Gerontology
  22. Mitochondrial Rejuvenation After Induced Pluripotency
    Steven T. Suhr, Eun Ah Chang, Jonathan Tjong, Nathan J. Alcasid, Guy A Perkins, Marcelo Demarchi Goissis, Mark H. Ellisman, Gloria I. Perez, Jose Bernardo Cibelli · 2010 · PLoS ONE
  23. Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
    Gabsang Lee, Christina N. Ramirez, Hyesoo Kim, Nadja Zeltner, Becky Liu, Constantin Radu, Bhavneet Bhinder, Yong Jun Kim, In Young Choi, Bipasha Mukherjee-Clavin et al. · 2012 · Nature Biotechnology
  24. Lab-Specific Gene Expression Signatures in Pluripotent Stem Cells
    Aaron M. Newman, James B. Cooper · 2010 · Cell stem cell
  25. RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation
    Malagelada, Cristina, Jin, Zong Hao, Greene, Lloyd A. · 2008 · The Journal of Neuroscience
  26. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
    Kruegel, Undine, Robison, Brett, Dange, Thomas, Kahlert, Günther, Delaney, Joe R., Kotireddy, Soumya, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Murakami, Christopher J., Schleit, Jennifer et al. · 2011 · PLoS Genetics
  27. Reprogramming human fibroblasts to pluripotency using modified mRNA
    P. Mandal, Derrick J. Rossi · 2013 · Nature Protocols
  28. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
    Hea-Jin Jung, Catherine Coffinier, Youngshik Choe, Anne P. Beigneux, Brandon S.J. Davies, Shao Hua Yang, Richard H. Barnes, Janet Hong, Tao Sun, Samuel J. Pleasure et al. · 2012 · Proceedings of the National Academy of Sciences
  29. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
    Miguel Mitne‐Neto, Marcela Câmara Machado Costa, Maria Carolina Marchetto, Mário Henrique Bengtson, Claudio A.P. Joazeiro, Hiroshi Tsuda, Hugo Jozef Bellen, Helga Cristina Almeida da Silva, Acary Souza Bullé Oliveira, Monize Lazar et al. · 2011 · Human Molecular Genetics
  30. Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
    Siebold, Alex P., Banerjee, Rakhee, Tie, Feng, Kiss, Daniel L., Moskowitz, Jacob, Harte, Peter J. · 2010 · Proceedings of the National Academy of Sciences
  31. LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM
    David M. A. Mann, Peter O. Yates · 1974 · Brain
  32. Increased risk of Parkinson's disease in parents and siblings of patients
    Haydeh Payami, Kimberly Larsen, Steven Bernard, John Nutt · 1994 · Annals of Neurology
  33. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
    Peter Sazani, Ryszard Kole · 2003 · Journal of Clinical Investigation
  34. Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease
    Pierluigi Caboni, Todd Sherer, Nanjing Zhang, Georgia Taylor, Hye Mee Na, J. Timothy Greenamyre, John E. Casida · 2004 · Chemical Research in Toxicology
  35. The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny
    Shannon McKinney‐Freeman, Patrick Cahan, Hu Li, Scott Allen Lacadie, Hsuan-Ting Huang, Matthew S. Curran, Sabine Loewer, Olaia Naveiras, Katie L. Kathrein, Martina Konantz et al. · 2012 · Cell stem cell
  36. Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    Viviane S. Tabar, Georgia Panagiotakos, Edward D. Greenberg, Bill K Chan, Michel Sadelain, Philip H. Gutin, Lorenz Studer · 2005 · Nature Biotechnology
  37. Revealing Global Regulatory Perturbations across Human Cancers
    Hani Goodarzi, Olivier Elemento, Saeed Tavazoie · 2009 · Molecular Cell
  38. Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
    Erica K. Benson, Sam W. Lee, Stuart A. Aaronson · 2010 · Journal of Cell Science
  39. Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice
    Edgar, Daniel, Shabalina, Irina, Camara, Yolanda, Wredenberg, Anna, Calvaruso, Maria Antonietta, Nijtmans, Leo, Nedergaard, Jan, Cannon, Barbara, Larsson, Nils-Göran, Trifunovic, Aleksandra · 2009 · Cell Metabolism
  40. Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    David Sulzer, Eugene V. Mosharov, Zsolt Tallóczy, Fabio Andrea Zucca, John D. Simon, Luigi Zecca · 2008 · Journal of Neurochemistry
  41. Akt signal transduction dysfunction in Parkinson's disease
    Suzanne Timmons, Meghan F. Coakley, Aileen M. Moloney, Cora O’ Neill · 2009 · Neuroscience Letters
  42. Functional Properties of Human Embryonic Stem Cell–Derived Cardiomyocytes: Intracellular Ca2+ Handling and the Role of Sarcoplasmic Reticulum in the Contraction
    Katya Dolnikov, Mark Shilkrut, Naama Zeevi‐Levin, Sharon Gerecht, Michal Amit, Asaf Danon, Joseph Itskovitz‐Eldor, Ofer Binah · 2005 · Stem Cells
  43. Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA
    Xavier Nissan, Sophie Blondel, Claire Laure Navarro, Yves Maury, Cécile Denis, Mathilde Girard, Cécile Martinat, Annachiara De Sandre‐Giovannoli, Nicolas Lévy, Marc Peschanski · 2012 · Cell Reports
  44. Aging of Hutchinson–Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis
    Joanna M. Bridger, Ian R. Kill · 2004 · Experimental Gerontology
  45. Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors
    Antonio E. Rusiñol, Michael S. Sinensky · 2006 · Journal of Cell Science
  46. Aging and reprogramming: a two-way street
    Mahmoudi, Salah, Brunet, Anne · 2012 · Current Opinion in Cell Biology
  47. An epigenetic hypothesis of aging-related cognitive dysfunction
    Penner · 2010 · Frontiers in Aging Neuroscience
  48. Levodopa-Induced Dyskinesia Is Strongly Associated with Resonant Cortical Oscillations
    Pär Halje, Martin Tamté, Ulrike Richter, Mohsin Mohammed, Maria Angela Cenci, Per Petersson · 2012 · Journal of Neuroscience
  49. Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment
    Yosif M. Ganat, Elizabeth L. Calder, Sonja Kriks, Jenny Nelander, Edmund Y. Tu, Fan Jia, Daniela Battista, Neil L. Harrison, Malin Parmar, Mark J. Tomishima et al. · 2012 · Journal of Clinical Investigation
  50. Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons.
    Urban Ungerstedt, Thomas Ljungberg, G. Steg · 1974 · PubMed
  51. Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy
    Hsiao-Chun Cheng, Sang Ryong Kim, Tinmarla Frances Oo, Tatyana Kareva, Olga Yarygina, Margarita Rzhetskaya, Chuansong Wang, Matthew J. During, Zsolt Tallóczy, Keiji Tanaka et al. · 2011 · Journal of Neuroscience
  52. Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells
    Francesco Fornai, Paola Lenzi, Marco Gesi, Paola Soldani, Michela Ferrucci, Gloria Lazzeri, Loredana Capobianco, Giuseppe Battaglia, Antonio De Blasi, Ferdinando Nicoletti et al. · 2003 · Journal of Neurochemistry
  53. THE HISTOCHEMICAL RELATIONSHIP OF NEUROMELANIN AND LIPOFUSCIN
    Herbert Barden · 1969 · Journal of Neuropathology & Experimental Neurology
  54. Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration
    Tomasz Jaworski, Benoit Lechat, David Demedts, Lies Gielis, Herman Devijver, Peter Borghgraef, Hans Duimel, Fons Verheyen, Sebastian Kügler, Fred VAN LEUVEN · 2011 · American Journal Of Pathology
  55. Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation
    Philipp Koch, Irfan Y. Tamboli, Jérôme Mertens, Patrick Wunderlich, Julia Ladewig, Kathrin Stüber, Hermann Esselmann, Jens Wiltfang, Oliver Brüstle, Jochen Walter · 2012 · American Journal Of Pathology
  56. The role of ubiquitin–proteasome system in ageing
    Péter Lőw · 2011 · General and Comparative Endocrinology
  57. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
    Gang Liu, Jason V. Rogers, Coleen T. Murphy, Christopher Rongo · 2011 · The EMBO Journal
  58. Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant
    Motokuni Yonetani, Takashi Nonaka, Masami Masuda, Yuki Inukai, Takayuki Oikawa, Shin‐ichi Hisanaga, Masato Hasegawa · 2009 · Journal of Biological Chemistry
  59. Ultrastructural observations in Parkinsonism
    S. Roy, Lionel Wolman · 1969 · The Journal of Pathology
  60. Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites.
    K. Ikegami, T. Koike · 2003 · Neuroscience
  61. Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome
    Wood, Shona H., Craig, Thomas, Li, Yang, Merry, Brian, de Magalhães, João Pedro · 2013 · AGE
  62. Developmental potential and behavior of tetraploid cells in the mouse embryo
    Guy S. Eakin, Anna‐Katerina Hadjantonakis, Virginia E. Papaioannou, Richard R. Behringer · 2005 · Developmental Biology
  63. Analysis of gene expression changes in a cellular model of Parkinson disease
    Elizabeth J. Ryu, James M. Angelastro, Lloyd A. Greene · 2004 · Neurobiology of Disease
  64. Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration
    Phillips, S. E., Woodruff, E. A., Liang, P., Patten, M., Broadie, K. · 2008 · Journal of Neuroscience
  65. Degenerating Processes Identified by Electron Microscopic Immunocytochemical Methods
    Teresa A. Milner, Elizabeth M. Waters, Danielle C. Robinson, Joseph P. Pierce · 2011 · Methods in molecular biology
  66. Neural transplantation studies reveal the brain's capacity for continuous reconstruction
    Ole Isacson · 1997 · Trends in Neurosciences
  67. Induced pluripotent stem cells for modelling human diseases
    Juli Unternaehrer, George Q. Daley · 2011 · Philosophical Transactions of the Royal Society B Biological Sciences
  68. The Free Radical Theory of Aging: The Effect of Age on Serum Mercaptan Levels
    Denham Harman · 1960 · Journal of Gerontology
  69. Senescence-related changes in gene expression in muscle: similarities and differences between mice and men
    Stephen L. Welle, Andrew I. Brooks, Charles A. Thornton · 2001 · Physiological Genomics
  70. iPSC technology to study human aging and aging-related disorders
    Guang‐Hui Liu, Zhichao Ding, Juan Carlos Izpisúa Belmonte · 2012 · Current Opinion in Cell Biology
  71. The case for induced pluripotent stem cell‐derived cardiomyocytes in pharmacological screening
    Jaffar M. Khan, Alexander Richard Lyon, Siân E. Harding · 2012 · British Journal of Pharmacology
  72. Biosignatures for Parkinson’s Disease and Atypical Parkinsonian Disorders Patients
    Judith A. Potashkin, José A. Santiago, Bernard M. Ravina, Arthur Watts, Alexey A. Leontovich · 2012 · PLoS ONE
  73. Expression of Nuclear Lamins in Human Tissues and Cancer Cell Lines and Transcription from the Promoters of the Lamin A/C and B1 Genes
    Feng Lin, Howard J. Worman · 1997 · Experimental Cell Research
  74. Human Pluripotent Stem Cell-Derived Cardiomyocytes: Response to TTX and Lidocain Reveals Strong Cell to Cell Variability
    Xiaowu Sheng, Michael Reppel, Filomain Nguemo, Farooq Ibrahem Mohammad, Alexey Kuzmenkin, Jürgen Hescheler, Kurt Pfannkuche · 2012 · PLoS ONE
  75. Identification and Chromosomal Location of Two Human Genes Encoding Enzymes Potentially Involved in Proteolytic Maturation of Farnesylated Proteins
    José M.P. Freije, Pilar Blay, Alberto M. Pendás, Juan Cadiñanos, Piero Crespo, Carlos López-Otı́n · 1999 · Genomics
  76. Hutchinson–Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature
    J. Mazereeuw‐Hautier, Louise C. Wilson, Shehla N. Mohammed, Dawn T. Smallwood, Sue Shackleton, David J. Atherton, John I Harper · 2007 · British Journal of Dermatology
  77. Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
    Swindell, William R., Masternak, Michal M., Kopchick, John J., Conover, Cheryl A., Bartke, Andrzej, Miller, Richard A. · 2009 · Mechanisms of Ageing and Development
  78. Reprogramming aging and progeria
    Freije, José MP, López-Otín, Carlos · 2012 · Current Opinion in Cell Biology
  79. Mouse models of α-synucleinopathy and Lewy pathology
    Bernd Sommer, Samuel Barbieri, Katja Hofele, Karl‐Heinz Wiederhold, A. Probst, Claudia Mistl, Simone Danner, S Kauffmann, Will P. J. M. Spooren, Markus Tolnay et al. · 2000 · Experimental Gerontology
  80. A quantitative model for age-dependent expression of the p16INK4a tumor suppressor
    Denis Tsygankov, Yan Liu, Hanna Kelly Sanoff, Norman E. Sharpless, Timothy C. Elston · 2009 · Proceedings of the National Academy of Sciences
  81. Fate of tetraploid cells in 4n↔2n chimeric mouse blastocysts
    Gillian E. MacKay, John D. West · 2005 · Mechanisms of Development
  82. Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Aβ in distal axons
    Song, Mee-Sook, Saavedra, Lucila, de Chaves, Elena I. Posse · 2006 · Neurobiology of Aging
  83. Melanin pigmentation of the substantia nigra in primates
    Hans-Joachim Scherer · 1939 · The Journal of Comparative Neurology
  84. Regulatory deficits after unilateral electrolytic or 6-OHDA lesions of the substantia nigra
    HC Fibiger, A. G. Phillips, RA Clouston · 1973 · American Journal of Physiology-Legacy Content
  85. Production of identical twin and triplet mice by nuclear transplantation
    Tomohiro Kono, Y. Tsunoda, Tsutomu Nakahara · 1991 · Journal of Experimental Zoology
  86. The role of the environment in Parkinson's disease.
    Jay M. Gorrell, Donato A. Di Monte, D. G. Graham · 1996 · Environmental Health Perspectives
  87. Distribution of paraquat into the brain after its systemic injection in rats.
    Maria Tiziana Corasaniti, Maria Concetta Strongoli, A Pisanelli, P Bruno, Domenicantonio Rotiroti, Giuseppe Nappi, G Nisticò · 1992 · PubMed
  88. Identification of the human fibroblast surface glycoprotein (FSG) as aminopeptidase M
    J. Verlinden, F. Van Leuven, J.J. Cassiman, Herman VAN DEN BERGHE · 1981 · FEBS Letters
  89. Dedifferentiation rescues senescence of progeria cells but only while pluripotent
    Laura J. Niedernhofer, Joseph C. Glorioso, Paul D. Robbins · 2011 · Stem Cell Research & Therapy
  90. Kinetics and Geometry of the Excitatory Dopaminergic Transmission in the Rat Striatum in Vivo
    F. Gonon, Bertrand Bloch · 1997 · Advances in pharmacology