Cited by 791Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroinflammation and Neurodegeneration Mechanisms

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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

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Bond, Allison M., Ming, Guo-li, Song, Hongjun·2015·Cell Stem Cell

DOI 10.1016/j.stem.2015.09.003PMC PMC4683085

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Abstract

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.

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Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · cited 2×
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Method
Neurogenesis in the adult human hippocampus
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Background
Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
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“…will also become possible to directly image the behavior of individual adult NSCs in vivo to explore how experience impacts NSC activation and division directly, as was achieved in adult fish (Barbosa et al., 2015) and for other adult somatic stem cells (Ritsma et al., 2014; Rompolas et al., 2012).”
Background
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Background
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“Significant progress in the investigation of this phenomenon has since led to remarkable knowledge about adult NSCs and neurogenesis (Ming and Song, 2011).”
BackgroundInfluentialSelf-citation
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Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · cited 1×
“In onemodel, NSCs are gradually specified during development and become restricted in the lineage potential in adult (Kriegstein and Alvarez-Buylla, 2009).”
Background
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BackgroundInfluential
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Background
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“The completion of adult neurogenesis includes the proliferation, differentiation, and integration of newborn cells into existing neural networks at appropriate locations within the brain (Bond et al., 2015 )— which are processes that can be regulated by external stimuli.”
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“Aging and PD are characterized by a reduction in the number of adult nerves, which is associated with the block of NSC activation to produce new neurons (Apple et al., 2017; Bond et al., 2015; Chandel 10.3389/fnagi.2024.1451655 Frontiers in Aging Neuroscience 04 frontiersin.org et al., 2016).”
BackgroundInfluential
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Background
An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach
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“These hNPCs not only play critical roles during fetal brain development, but also persist in the adult brain throughout life [34], suggesting that the ZIKV-mediated growth retardation potentially contributes to long-term neurodevelopmental defects through exposure to the virus.”
Background
NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer’s Disease
Blanco-Luquin, I., Acha, B., Urdánoz-Casado, A., Gómez-Orte, E., Roldan, M., Pérez-Rodríguez, D., Cabello, J., & Mendioroz, M. (2022) · Cells · doi:10.3390/cells11071069 · Cited by 6
“Research in this field requires non-invasive monitoring to understand the lifelong impact [59].”
Background
SETD4 cells contribute to brain development and maintain adult stem cell reservoir for neurogenesis
Cai, S.-L., Yang, Y.-S., Ding, Y.-F., Yang, S., Jia, X.-Z., Gu, Y.-W., Wood, C., Huang, X.-T., Yang, J., & Yang, W. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.07.017 · Cited by 7
“Adult neural stem cells (NSCs) residing within the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus are known for their ability to generate new neurons that contribute to complex sensory and cognitive functions throughout the lifetime of mammals (Bond et al., 2015;…”
Background
Intranasal delivery of stem cells labeled by nanoparticles in neurodegenerative disorders: Challenges and opportunities
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“New neurons in the adult mammalian brain are known to originate from mainly two regions, the subventricular zone, in the walls of the lateral ventricles, and the subgranular zone (SGZ), in the dentate gyrus (DG) of the hippocampus (Bond et al., 2015).”
Background
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain
Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M., & Nakashima, K. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.05.007 · Cited by 7
Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system
Beyer, F., Jadasz, J. J., Agrelo, I. S., Schira‐Heinen, J., Groh, J., Manousi, A., Bütermann, C., Estrada, V., Reiche, L., Cantone, M., et al. (2019) · Glia · doi:10.1002/glia.23724 · Cited by 7
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Clark, L., Yun, S., Acquah, N. K., Kumar, P., Metheny, H., Paixao, R. C. C., Cohen, A., & Eisch, A. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.07.330118 · Cited by 7
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Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders
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“Another aspect of the important function of NSCs in normal brain development is neural cell migration [52].”
Background
Dynamic spatiotemporal activation of a pervasive neurogenic competence in striatal astrocytes supports continuous neurogenesis following injury
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“[5,7,17–24].”
UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death
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“SVZ contains NS/PCs which have the ability to proliferate into neuroblasts [46].”
OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage.
Qiu, J., Gao, S.-Q., Chen, Y.-S., Wang, X., Zhuang, Y.-S., Miao, S., Zheng, X.-B., Zhao, R., Sun, Y., & Zhou, M.-L. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148758 · Cited by 4
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Stankiewicz, A. J., Mortazavi, F., Kharchenko, P. V., McGowan, E., Kharchenko, V. A., & Zhdanova, I. V. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2730-18.2019 · Cited by 6
“Metabolic abnormalities, including those associated with diabetes or obesity, appear to have some of the most powerful effects on the aging process (Thorpe and Ferraro, 2004; Haslam and James, 2005; Barbagallo and Dominguez, 2014; Bonomini et al., 2015).”
Background
Lentiviral vector-mediated transduction of adult neural stem/progenitor cells isolated from the temporal tissues of epileptic patients.
Abdolahi, S., Khodakaram‐Tafti, A., Aligholi, H., Ziaei, S., Ghadiri, M. K., Stummer, W., & Gorji, A. (2020) · PubMed Central · doi:10.22038/ijbms.2019.42285.9983 · Cited by 6
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“In tissues with low turnover, such as brain and skeletal muscle, the activity of stem cells is more restricted to specific stimuli such as establishing new neural circuits during learning [7] or responses to episodes of injury or disease in the skeletal muscle [8–11].”
Background
Computational Strategies for Niche-Dependent Cell Conversion to Assist Stem Cell Therapy
del Sol, A., Okawa, S., & Ravichandran, S. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.01.005 · Cited by 6
“A prospective study of assessment of neurocognitive function in illiterate patients with gliomas treated with chemoradiation”
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PirB functions as an intrinsic suppressor in hippocampal neural stem cells
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Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemiaPreprint
Ardaya, M., Tiveron, M.-C., Cremer, H., Rubio-López, E., Martín, A., Dehay, B., Pérez‐Cerdá, F., Matute, C., Soria, F. N., & Cavaliere, F. (2024) · eLife · doi:10.7554/elife.96076 · Cited by 7
“Cell regeneration in the adult mammalian brain occurs mainly in two neurogenic niches: the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) in the dentate gyrus of the hippocampus ( Bond et al., 2015 ).”
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“83,84 In vitro , NSCs generate neurospheres in epidermal growth factor (EGF)-enriched serum-free media, with subsequent differentiation requiring lineage-specific adherent conditions.”
EID1 plays a crucial role in proliferation of neural stem cell
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Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation
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“This then facilitates the establishment of neurological integrity through plastic changes and the establishment of synaptic connections with other neurons (Lledo et al. 2006; Bond et al. 2015).”
Background
Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation
Chiareli, R. A., Marques, B. L., Carvalho, G. A., Souza, R. T. V., Santana, P. H. G., Santiago, H. C., Pinto, M. C. X., Birbrair, A., Parreira, R. C., Ulrich, H., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10423-y · Cited by 5
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Adult neurogenesis research in China
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“…that adult neurogenesis predominantly takes place in the two neurogenic niches present in the adult mammalian brain (Figure 1a): the SGZ, located within the hippocampal dentate gyrus (DG), and the subventricular zone (SVZ), which lines the lateral ventricle (Bond et al., 2015; Ming & Song, 2011).”
Background
Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice
Janssen, P., Pauw, L. D., Mambretti, M., Lara, O., Walckiers, J., Mackens, L., Rooman, I., Guillaume, B., Ridder, M. D., Ates, G., et al. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2283092 · Cited by 5
“Therefore, we quantified the number of GFAP þ progenitor cells (Figure 7(F)) and DCX þ immature neurons (Figure 7(H)) in the subgranular zone of the hippocampus (Bond et al., 2015).”
Method
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Latchney, S. E., Lopez, B. R. R., Womble, P. D., Blandin, K. J., & Lugo, J. N. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1308066 · Cited by 5
“…and progenitors in the SGZ, their diﬀerentiation into neuroblasts, and subsequent survival into glutamatergic granule cells (Aimone et al., 2014; Bond et al., 2015; Kempermann et al., 2015) – we quantiﬁed multiple neurogenic markers to evaluate the proliferation, diﬀerentiation, and apoptosis…”
Background
The defects of the hippocampal ripples and theta rhythm in depression, and the effects of physical exercise on their amelioration
Koketsu, S., Matsubara, K., Ueki, Y., Shinohara, Y., Inoue, K., Murakami, S., & Ueki, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2023.e23738 · Cited by 5
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Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone
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“Adult neurogenesis is the process of generating functional neurons from adult neural stem cells (NSCs), which can differentiate into both neurons and glia that compose the central nervous system and replicate through cell division [1].”
Background
CREB5 Promotes the Proliferation of Neural Stem/Progenitor Cells in the Rat Subventricular Zone via the Regulation of NFIX Expression
Yu, T., Zhang, H., Zhang, C., Ma, G., Shen, T., Luan, Y., & Zhang, Z. (2025) · Cells · doi:10.3390/cells14161240 · Cited by 5
“These cells reside in two specialized regions: the subventricular zone (SVZ), which lines the lateral ventricle walls, and the subgranular zone (SGZ) in the hippocampal dentate gyrus [1].”
Isolation and comparison of neural stem cells from the adult rat brain and spinal cord canonical neurogenic niches
Schiro, L. E., Bauer, U. S., Sandvig, A., & Sandvig, I. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101426 · Cited by 5
Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells
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“Finally, the post-mitotic neuronal progeny of GC can be functionally integrated into the adult hippocampal circuitry (Bond et al., 2015; Kempermann et al., 2015).”
LocalZProjector and DeProj : A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy imagesPreprint
Herbert, S., Valon, L., Mancini, L., Dray, N., Caldarelli, P., Gros, J., Esposito, E., Shorte, S. L., Bally‐Cuif, L., Levayer, R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.15.426809 · Cited by 5
Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis
Mai, N. T. Q., Jeon, S., & Moon, B.-S. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01510-4 · Cited by 4
“In addition, extrinsic niche stimuli 9 and intrinsic transcription factors 10 have been indicated to be crucial for maintaining NPC reservoirs throughout the formation of functional neural circuits, a process largely coordinated by signaling pathways.”
Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration
Li, Z., Zhang, J., Liu, Z., Yu, L., Yang, C., Zhang, L., Xiang, Z., Hu, F., Brazh, N., Shu, K., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00895-0 · Cited by 6
“Unlike most somatic cells, neurons in the human CNS possess limited regenerative capacity, with neurogenesis primarily confined to the sub-ventricular zone (SVZ) and sub-granular zone (SGZ) [26].”
Potential role of tanycyte-derived neurogenesis in Alzheimer’s disease
Qi, G., Tang, H., Hu, J., Kang, S., & Qin, S. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01865 · Cited by 7
Dynamics of Neurogenic Signals as Biological Switchers of Brain Plasticity
Moreira, J. A. F., & Solá, S. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10788-2 · Cited by 5
“Despite having great replicative potential, one of the hallmarks of NSCs is the ability to remain in a quiescent state for long periods, ren - dering them resistant to metabolic stress and genetically stable [13].”
Background
Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats
Prajit, R., Sritawan, N., Aranarochana, A., Sirichoat, A., Pannangrong, W., Wigmore, P. M., & Welbat, J. U. (2025) · Biogerontology · doi:10.1007/s10522-025-10215-0 · Cited by 4
“Notch1 and Sox2 are required for maintaining the NSCs/IPCs proliferation and disappear when they differentiate into the neuroblasts (Bond et al. 2015).”
Influential
Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms
Li, J., Godoy, M. I., Lu, Y., Zhang, A. J., Diamante, G., Rathbun, E. M., Tian, M., Ahn, I. S., Cebrián‐Silla, A., Álvarez-Buylla, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60895-y · Cited by 4
“In the postnatal and adult brain, newly generated neurons from NSCs migrate to the olfactory bulb via the rostral migratory stream 13,48 .”
Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling
Danciu, D.-P., Klawe, F. Z., Kazarnikov, A., Femmer, L., Kostina, E., Martín-Villalba, A., & Marciniak-Czochra, A. K. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00563-5 · Cited by 4
Localization and Characterization of Major Neurogenic Niches in the Brain of the Lesser-Spotted Dogfish Scyliorhinus canicula
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Treatment with quercetin increases Nrf2 expression and neuronal differentiation of sub ventricular zone derived neural progenitor stem cells in adult rats
Ebrahimi, A., Parivar, K., Roodbari, N., & Eidi, A. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08707-8 · Cited by 4
“There are two major neurogenic niches in the adult mammalian brain where NSCs reside, namely the subventricular zone located in the lateral ventricles and the subgranular zone (SGZ) within the dentate gyrus of the hippocampus [4].”
Background
Single-Cell Transcriptome Analysis of Neural Stem Cells
Li, Y., Anderson, J., Kwan, K. Y., & Cai, L. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0084-3 · Cited by 5
“Both intrinsic and extrinsic pathways have been identified for the adult neurogenesis process [7].”
Background
Population dynamics of neural progenitor cells during aging in the cerebral cortex
Okada, Y., & Ohira, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.050 · Cited by 4
Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders
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Influential
Neurodegenerative Diseases and Cell Reprogramming
Sallam, A., & Mousa, S. A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02039-5 · Cited by 4
Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
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Morphological Diversity of Calretinin Interneurons Generated From Adult Mouse Olfactory Bulb Core Neural Stem Cells
Acosta, F. J. F., Luque-Molina, I., Vecino, R., Díaz‐Guerra, E., Defteralı, Ç., Pignatelli, J., & Vicario‐Abejón, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.932297 · Cited by 5
“New neurons continue to be generated from neural stem cells (NSCs) present in the adult brain (Altman and Das, 1965; Bayer, 1983; Bond et al., 2015).”
Background
Cannabinerol and NSC-34 Transcriptomic Analysis: Is the Dose Who Makes Neuronal Differentiation?
Valeri, A., Chiricosta, L., Gugliandolo, A., Pollastro, F., Salamone, S., Zingale, V. D., Silvestro, S., & Mazzon, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147541 · Cited by 4
“They seem to have the capacity to differentiate either in neurons or in astrocytes, while the generation of oligodendrocytes was evaluated in vitro [11].”
Background
The Multifaceted Effects of Flavonoids on Neuroplasticity
Rivi, V., Batabyal, A., & Lukowiak, K. (2023) · Brain Plasticity · doi:10.3233/bpl-230150 · Cited by 4
Neuron and Brain Maturation 2.0
Bonfanti, L., & Couillard‐Després, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317113 · Cited by 4
“The whole process is designated as neurogenesis [1–3].”
Background
Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling
Zhang, X., Zhang, Q., Zhang, Q., Wang, H., Yin, Y., Li, H., Huang, Q., Guo, C., Zhong, J., Zhou, T., et al. (2024) · eNeuro · doi:10.1523/eneuro.0021-24.2024 · Cited by 4
Inhibition of Microglial Activation Ameliorates Inflammation, Reduced Neurogenesis in the hippocampus, and Impaired Brain Function in a Rat Model of Bilirubin Encephalopathy
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“NSPCs possess the capacity to differentiate into newborn neurons, which can subsequently be integrated into neural circuits to improve learning and memory (Bond et al. 2015; Denoth-Lippuner and Jessberger 2021).”
A possible role for the immune system in adult neurogenesis: new insights from an invertebrate model
Harzsch, S., & Halbach, O. V. B. U. (2015) · Zoology · doi:10.1016/j.zool.2015.11.003 · Cited by 4
Histological Assessment of Cre-loxP Genetic Recombination in the Aging Subventricular Zone of Nestin-CreERT2/Rosa26YFP Mice
Omais, S., Halaby, N. N., Habashy, K. J., Jaafar, C., Bejjani, A. T., & Ghanem, N. (2019) · Methods in molecular biology · doi:10.1007/7651_2019_214 · Cited by 4
Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesisPreprint
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Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitorsPreprint
Özkan, A., Padmanabhan, H. K., Shipman, S. L., Azim, E., Kumar, P., Sadegh, C., Başak, A. N., & Macklis, J. D. (2024) · eLife · doi:10.7554/elife.100340 · Cited by 5
“…enabling desired integration of newly recruited neurons at the single-cell level ( Wuttke et al., 2018 ; Michelsen et al., 2015 ; Espuny-Camacho et al., 2013 ), emulating endogenous adult neurogenesis ( Gage, 2019 ; Bond et al., 2015 ; Kempermann, 2016 ); and avoiding pathological heterotopias.”
The Fate and Dynamics of Neural Stem Cells (NSCs) and Their Neurogenic Decline in Alzheimer’s Disease
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Phylogenetic variation of layer II cortical immature neurons in dog and horse confirms covariance with brain size and neocortical surface
Pattaro, A., Ghibaudi, M., Corrente, C., Telitsyn, N., Graïc, J., Aresu, L., Sherwood, C. C., & Bonfanti, L. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-02981-x · Cited by 4
Effects of thyroid disruption on neural cells stem fate in the mouse brain
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Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions
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“Regions capable of providing a microenvironment that allows the accommodation and differentiation of these cells are known as neurogenic niches [4,5].”
Longitudinal transformation of mitochondrial metabolism during neurogenesis
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“However, several challenges remain prior to clinical application of NSCs, the most important being the elucidation of the differentiation mechanism and precise control over the fate of the stem cells ( 6 , 7 ).”
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Isolation and Culture of Neural Stem/Progenitor Cells from the Hippocampal Dentate Gyrus of Young Adult and Aged Rats
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“The study of NSPCs function and their responses to aging, regeneration purposes, and molecular and cellular mechanisms of neurogenesis in various cell-culture-based models of different neurological disorders, including neurodegenerative and neurovascular diseases, requires isolation and culture of NSPCs from adult neu…”
Background
Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning
Maheshwari, M., Singla, A., Rawat, A., Banerjee, T., Pati, S., Shah, S. A., Maiti, S., & Vaidya, V. A. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.01.002 · Cited by 4
Dual recombinase-mediated intersectional genetics defines the functional heterogeneity of neural stem cells in adult hippocampus
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“Adult neurogenesis is a developmental process of generating functional neurons from radial-glia-like neural stem cells (rNSCs) throughout life in the adult hippocampus [1, 2].”
Inverse and dynamic levels of H3K4me3 and H3K27me3 regulate mouse postnatal dental gyrus development
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Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation
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Sex-specific effects of intermittent fasting on hippocampal neurogenesis via the gut-brain axis
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Sex differences in the influence of adult‐onset hypothyroidism on hippocampal progenitor survival and neuronal differentiation in mice
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Adaptive neurogenesis in the cerebral cortex and contralateral subventricular zone induced by unilateral cortical devascularization: Possible modulation by dopamine neurotransmission
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“Current knowledge supports the role of SVZ, RMS, and SGZ in the turnover of neurons in the OB and granular layer of the hippocampus, respectively (Bond et al., 2015).”
Background
An Engineered Mouse to Identify Proliferating Cells and Their Derivatives
Jang, J.-Y., Engleka, K., Liu, F.-Y., Li, L., Song, G., Epstein, J., & Li, D.-Q. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00388 · Cited by 3
Newborn Neurons in the Aged Hippocampus—Scarce and Slow but Highly Plastic
Beckervordersandforth, R. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.049 · Cited by 3

Authors: Bond, A. M., Ming, G.-L., & Song, H.
Affiliations: Johns Hopkins University (US)
Corresponding author: Song, Hongjun
ORCID: Ming, Guo-li
Song, Hongjun
Venue: Cell Stem Cell
Publisher: Elsevier BV
Published: 2015-10
Volume: 17
Issue: 4
Pages: 385-395
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2015.09.003
PMC: PMC4683085
OpenAlex: W1828558002
Cited by: 791
References: 113
Citations by year: 2026: 41 · 2025: 61 · 2024: 68 · 2023: 76 · 2022: 74 · 2021: 105 · 2020: 90 · 2019: 93 · 2018: 67 · 2017: 67 · 2016: 43 · 2015: 4
FWCI: 7.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH105128, R01MH105128)
National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R21NS093772, R37NS047344, NS093772, NS09538, R56NS047344)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: adult neural stem cells, adult neurogenesis, adult stem cells, tissue regeneration, stem cell plasticity, regenerative medicine, stem cell niche
MeSH terms: Adult, Animals, Homeostasis, Humans, Regenerative Medicine, Adult Stem Cells, Neurogenesis, Neural Stem Cells

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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

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