The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Open accessAbstract
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.
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“Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [2]
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Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · cited 2×
“Instead of snapshot analyses of discrete time points, future studies will be greatly facilitated by novel bioinformatic tools, such as Monocle (Trapnell et al., 2014), SCUBA (Marco et al., 2014), and Waterfall (Shin et al., 2015), and novel sequencing technologies, such as FISSEQ (Lee et al.,…”
MethodNeurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · cited 2×
“Previous studies of postmortem tissues pulsed with BrdU have demonstrated the presence of adult neurogenesis in humans (Eriksson et al., 1998), and an innovative approach using 14C from nuclear bomb testing has started to reveal quantitatively the extent of human neurogenesis over a lifetime.”
BackgroundReynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482 · cited 1×
“…will also become possible to directly image the behavior of individual adult NSCs in vivo to explore how experience impacts NSC activation and division directly, as was achieved in adult fish (Barbosa et al., 2015) and for other adult somatic stem cells (Ritsma et al., 2014; Rompolas et al., 2012).”
BackgroundSubventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · cited 1×
“Under homeostatic conditions, microglia phagocytose IPCs that have undergone apoptosis (Sierra et al., 2010), while activated microglia reduce neurogenesis (Ekdahl et al., 2003).”
BackgroundAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · cited 1×
“Another important transcription factor, achaete-scute homolog 1 (Ascl1), is expressed in a small subset of adult NSCs at a given time and activates NSCs by targeting cell-cycle regulators (Andersen et al., 2014).”
BackgroundAdult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · cited 3×
“Significant progress in the investigation of this phenomenon has since led to remarkable knowledge about adult NSCs and neurogenesis (Ming and Song, 2011).”
BackgroundInfluentialSelf-citationThe Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · cited 1×
“In onemodel, NSCs are gradually specified during development and become restricted in the lineage potential in adult (Kriegstein and Alvarez-Buylla, 2009).”
BackgroundNew neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · cited 10×
“Adult SVZ NSCs and their immediate progeny secrete diazepam binding inhibitor, which antagonizes GABA signaling and promotes proliferation of neuroblasts (Alfonso et al., 2012).”
BackgroundInfluentialDynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · cited 1×
“For example, viral-mediated expression of exogenous Sox2 in resident astrocytes in the adult mouse reprograms them into proliferating neuroblasts in striatum and spinal cord, regions outside canonical neurogenic niches (Niu et al., 2013; Su et al., 2014).”
BackgroundThe ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.016 · Cited by 1,292
“Our study also raises the question of whether ZIKV infects neural stem cells in adult humans (Bond et al., 2015).”
Self-citationNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
“B1 cell-intrinsic factors and their role in V-SVZ neurogenesis have been reviewed elsewhere (e.g. Lim and Alvarez-Buylla, 2016; Jones and Connor, 2012; Bond et al., 2015; Murao et al., 2016) and are not discussed here.”
BackgroundAdvances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications
Liu, G., David, B. T., Trawczynski, M., & Fessler, R. G. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09935-x · Cited by 557
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521
Mitochondria as central regulators of neural stem cell fate and cognitive function
Khacho, M., Harris, R., & Slack, R. S. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0091-3 · Cited by 409
Metadata
- Authors
- Bond, A. M., Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Song, Hongjun
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 17
- Issue
- 4
- Pages
- 385-395
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC4683085
- OpenAlex
- W1828558002
- Cited by
- 791
- References
- 113
- Citations by year
- 2026: 41 · 2025: 61 · 2024: 68 · 2023: 76 · 2022: 74 · 2021: 105 · 2020: 90 · 2019: 93 · 2018: 67 · 2017: 67 · 2016: 43 · 2015: 4
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH105128, R01MH105128)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R21NS093772, R37NS047344, NS093772, NS09538, R56NS047344)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, adult neurogenesis, adult stem cells, tissue regeneration, stem cell plasticity, regenerative medicine, stem cell niche
- MeSH terms
- Adult, Animals, Homeostasis, Humans, Regenerative Medicine, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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