The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Open accessAbstract
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · cited 2×
“Instead of snapshot analyses of discrete time points, future studies will be greatly facilitated by novel bioinformatic tools, such as Monocle (Trapnell et al., 2014), SCUBA (Marco et al., 2014), and Waterfall (Shin et al., 2015), and novel sequencing technologies, such as FISSEQ (Lee et al.,…”
MethodNeurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · cited 2×
“Previous studies of postmortem tissues pulsed with BrdU have demonstrated the presence of adult neurogenesis in humans (Eriksson et al., 1998), and an innovative approach using 14C from nuclear bomb testing has started to reveal quantitatively the extent of human neurogenesis over a lifetime.”
BackgroundReynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482 · cited 1×
“…will also become possible to directly image the behavior of individual adult NSCs in vivo to explore how experience impacts NSC activation and division directly, as was achieved in adult fish (Barbosa et al., 2015) and for other adult somatic stem cells (Ritsma et al., 2014; Rompolas et al., 2012).”
BackgroundSubventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · cited 1×
“Under homeostatic conditions, microglia phagocytose IPCs that have undergone apoptosis (Sierra et al., 2010), while activated microglia reduce neurogenesis (Ekdahl et al., 2003).”
BackgroundAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · cited 1×
“Another important transcription factor, achaete-scute homolog 1 (Ascl1), is expressed in a small subset of adult NSCs at a given time and activates NSCs by targeting cell-cycle regulators (Andersen et al., 2014).”
BackgroundAdult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · cited 3×
“Significant progress in the investigation of this phenomenon has since led to remarkable knowledge about adult NSCs and neurogenesis (Ming and Song, 2011).”
BackgroundInfluentialSelf-citationThe Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · cited 1×
“In onemodel, NSCs are gradually specified during development and become restricted in the lineage potential in adult (Kriegstein and Alvarez-Buylla, 2009).”
BackgroundNew neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · cited 10×
“Adult SVZ NSCs and their immediate progeny secrete diazepam binding inhibitor, which antagonizes GABA signaling and promotes proliferation of neuroblasts (Alfonso et al., 2012).”
BackgroundInfluentialDynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · cited 1×
“For example, viral-mediated expression of exogenous Sox2 in resident astrocytes in the adult mouse reprograms them into proliferating neuroblasts in striatum and spinal cord, regions outside canonical neurogenic niches (Niu et al., 2013; Su et al., 2014).”
BackgroundThe ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Flagged first, then by citations
Cited by
Sorted by citations
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.016 · Cited by 1,292
“Our study also raises the question of whether ZIKV infects neural stem cells in adult humans (Bond et al., 2015).”
Self-citationNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
“B1 cell-intrinsic factors and their role in V-SVZ neurogenesis have been reviewed elsewhere (e.g. Lim and Alvarez-Buylla, 2016; Jones and Connor, 2012; Bond et al., 2015; Murao et al., 2016) and are not discussed here.”
BackgroundAdvances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications
Liu, G., David, B. T., Trawczynski, M., & Fessler, R. G. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09935-x · Cited by 557
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521
Mitochondria as central regulators of neural stem cell fate and cognitive function
Khacho, M., Harris, R., & Slack, R. S. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0091-3 · Cited by 409
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
Self-citationThe m6A epitranscriptome: transcriptome plasticity in brain development and function
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease
Babcock, K. R., Page, J. S., Fallon, J. R., & Webb, A. E. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.01.019 · Cited by 330
“During the precursor phase, astrocyte-like quiescent NSCs activate and either divide symmetrically to generate new NSCs or asymmetrically to generate a progenitor and an NSC (Bond et al., 2015).”
BackgroundNeuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 354
“The prolonged capacity of NSCs in the SGZ to self-renew, retain cellular identity, and react to specific signals is fundamental for mammals to ensure life-long neurogenesis in the DG [50].”
BackgroundBeckervordersandforth, R., Ebert, B., Schäffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.017 · Cited by 303
“Neurogenesis from a quiescent radial glia-like NSC is achieved through a stereotypic developmental sequence controlled by the interplay of neurogenic niche-derived signals with intracellular pathways (Bond et al., 2015).”
BackgroundSelf-citationCenteno, E. G. Z., Cimarosti, H., & Bithell, A. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0258-4 · Cited by 268
“niches, NSCs give rise to a range of differentiated neurons and glia via specific intermediates [49, 37, 49, 50].”
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246
The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging
Vecchio, L. M., Meng, Y., Xhima, K., Lipsman, N., Hamani, C., & Aubert, I. (2018) · Brain Plasticity · doi:10.3233/bpl-180069 · Cited by 244
“[60], there has been some discrepancy as to whether”
ResultRegenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
Sivandzade, F., & Cucullo, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042153 · Cited by 224
The biosynthesis, signaling, and neurological functions of bile acids
Kiriyama, Y., & Nochi, H. (2019) · Biomolecules · doi:10.3390/biom9060232 · Cited by 204
“In contrast, NSCs in adult rodent SVZ may produce functional neurons in the olfactory bulb [150].”
BackgroundA mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198
“In the adult mammalian brain, stem cells reside in two main germinal regions: the subgranular zone (SGZ) of the dentate gyrus in the hippocampus, and the ventricular–subventricular zone (V-SVZ) adjacent to the lateral ventricles.(6) In this review, we focus primarily on the adult V-SVZ niche, which gives rise to astro…”
BackgroundAstrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions
Chi, S., Cui, Y., Wang, H., Jiang, J., Zhang, T., Sun, S., Zhou, Z., Zhong, Y., & Xiao, B. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.010 · Cited by 203
“For instance, adult hippocampal neurogenesis is restricted in the specialized neurogenic niche of the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), where the maintenance, proliferation, and fate choices of neural stem cells (NSCs) are orchestrated by diverse cell types and local chemical and mechanical…”
BackgroundWalgrave, H., Balusu, S., Snoeck, S., Vanden Eynden, E., Craessaerts, K., Thrupp, N., Wolfs, L., Horré, K., Fourne, Y., Ronisz, A., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.001 · Cited by 175
“give rise to dentate granule neurons (Bond et al., 2015).”
Transforming Professional Development Into Student Results
Reeves, D. B. (2010) · Cited by 190
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186
“In this paradigm, following entry of qNSCs into the cycle only one daughter cell returns to quiescence, while the other differentiates into a TA cell either directly or through a series of terminal divisions (31).”
Bustamante-Barrientos, F. A., Luque‐Campos, N., Araya, M. J., Lara-Barba, E., Solminihac, J. D., Pradenas, C., Molina, L., Herrera-Luna, Y., Utreras‐Mendoza, Y., Elizondo-Vega, R. J., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04493-w · Cited by 204
“Adult NSC are predominantly confined to the dentate gyrus located in the hippocampus and the subventricular zone of the lateral ventricles, representing a self-repairing mechanism that generates functional neurons after brain injury [180].”
BackgroundBuckley, M. T., Sun, E., George, B. M., Liu, L. A., Schaum, N., Xu, L., Reyes, J. M., Goodell, M. A., Weissman, I. L., Wyss‐Coray, T., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00335-4 · Cited by 201
A comparative view of regenerative neurogenesis in vertebrates
Alunni, A., & Bally‐Cuif, L. (2016) · Development · doi:10.1242/dev.122796 · Cited by 189
“D E V E LO P M E N T ‘mammals’ or, likewise, of ‘zebrafish’ to ‘fish’.”
BackgroundMarchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 189
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
Wang, J., Cui, Y., Yu, Z., Wang, W., Cheng, X., Ji, W., Guo, S., Zhou, Q., Wu, N., Chen, Y., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.09.009 · Cited by 172
LEWITT, M. S., & Boyd, G. W. (2019) · Biochemistry Insights · doi:10.1177/1178626419842176 · Cited by 166
Zhong, D., Cao, Y. B., Li, C., Li, M., Rong, Z., Jiang, L., Guo, Z., Lü, H., & Hu, J. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219895491 · Cited by 158
“Neural stem cells (NSCs) have a crucial role in the origination and neural tissue repair of cerebral nerve and can differentiate into neuron and neurogliocytes.(6,7) NSCs are recognized as the most promising natural resource for the treatment of nervous system diseases due to their proliferation, renewal, and passage…”
BackgroundXu, Y., Qiu, Y., Zhang, B., Chen, G., Chen, Q., Wang, M., Mo, F., Xu, J., Wu, J., Zhang, R., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0152-9 · Cited by 156
Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins
Gehring, J., Hwee Park, J., Chen, S., Thomson, M., & Pachter, L. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0372-z · Cited by 122
Li, Y., Luo, Y., Chen, Z.-K., Quintanilla, L., Chérasse, Y., Zhang, L., Lazarus, M., Huang, Z., & Song, J. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01065-x · Cited by 160
Born this way: Hippocampal neurogenesis across the lifespan
Kozareva, D. A., Cryan, J. F., & Nolan, Y. M. (2019) · Aging Cell · doi:10.1111/acel.13007 · Cited by 155
The Hippo pathway in tissue homeostasis and regeneration
Wang, Y., Yu, A., & Yu, F. (2017) · Protein & Cell · doi:10.1007/s13238-017-0371-0 · Cited by 152
“The cell cycle is strictly coordinated in NSCs to ensure precise neurogenesis (Bond et al., 2015).”
BackgroundCell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction
Llaguno, S. R. A., Sun, D., Pedraza, A. M., Vera, E., Wang, Z., Burns, D. K., & Parada, L. F. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0333-8 · Cited by 152
Argentati, C., Morena, F., Tortorella, I., Bazzucchi, M., Porcellati, S., Emiliani, C., & Martino, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215337 · Cited by 143
Early stem cell aging in the mature brain
Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137
Olfactory training – Thirteen years of research reviewed
Pieniak, M., Oleszkiewicz, A., Avaro, V., Calegari, F., & Hummel, T. R. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104853 · Cited by 135
Knobloch, M., & Jessberger, S. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.006 · Cited by 128
“However, an excess of lipid droplets in the ependymal cells lining the ventricular zone, part of the niche in the mammalian SVZ, have been recently associated with Alzheimer disease pathology [20].”
BackgroundInfluentialWang, H., Ran, H.-F., Yin, Y., Xu, X., Jiang, B.-X., Yu, S.-Q., Chen, Y., Ren, H., Feng, S., Zhang, J., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00803-4 · Cited by 131
“Neurogenesis and angiogenesis was promoted by catalpol in the brain of ischemic stroke rats Generally, the neurogenesis in adult mammalian brain is mainly generated in two areas: subgranular zone of hippocampal dentate gyrus (DG-SGZ) and subventricular zone of lateral ventricle (LVSVZ) [39].”
BackgroundMechanisms of radial glia progenitor cell lineage progression
Beattie, R., & Hippenmeyer, S. (2017) · FEBS Letters · doi:10.1002/1873-3468.12906 · Cited by 136
Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases
Gao, J., Liao, Y., Qiu, M. S., & Shen, W. (2020) · The Neuroscientist · doi:10.1177/1073858420914509 · Cited by 129
Adult Stem Cells for Regenerative Therapy
Gurusamy, N., Alsayari, A., Rajasingh, S., & Rajasingh, J. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.009 · Cited by 133
Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation
Ramosaj, M., Madsen, S., Maillard, V., Scandella, V., Sudria-Lopez, D., Yuizumi, N., Telley, L., & Knobloch, M. (2021) · Nature Communications · doi:10.1038/s41467-021-27365-7 · Cited by 122
Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 135
Zhang, H., Kang, E., Wang, Y., Yang, C., Yu, H., Wang, Q., Chen, Z.-Y., Zhang, C., Christian, K. M., Song, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11773 · Cited by 119
Self-citationTranscriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans
Wang, W., Wang, M., Yang, M., Zeng, B., Qiu, W., Ma, Q., Jing, X., Zhang, Q., Wang, B., Yin, C., et al. (2022) · Cell Research · doi:10.1038/s41422-022-00678-y · Cited by 125
“The DG and CA subregions contain distinct cell types and have different physiological functions.(30,32) In addition to the unique cell types, for example, pyramidal neurons (CA1–3) in the CA regions and GCs, immature neurons (ImmN) and adult NSCs in the DG subregions, other major cell types (Astrocyte, OPC, Oligodendr…”
BackgroundZhang, G., Zhu, Z., Wang, H., Yu, Y., Chen, W., Waqas, A., Wang, Y., & Chen, L. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.05.017 · Cited by 118
Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities
Ming, G., Tang, H., & Song, H. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.014 · Cited by 121
“During development, somatic stem cells give rise tocellular buildingblocks for different tissues; in someorgans, such as the brain, they continue to produce progeny to maintain tissue homeostasis and play important functions throughout life (Bond et al., 2015).”
Self-citationNeural stem cell niche heterogeneity
Andreotti, J. P., da Silva, W. N., Costa, A. C., Picoli, C. C., Bitencourt, F. C. O., Coimbra-Campos, L. M. C., Resende, R. R., Magno, L. A. V., Romano‐Silva, M. A., Mintz, A., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.005 · Cited by 117
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou, Y. F., Bond, A. M., Shade, J. E., Zhu, Y., Davis, C.-H. O., Wang, X., Su, Y., Yoon, K., Phan, A. T., Chen, W. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.005 · Cited by 114
“Both extrinsic environmental signals and intrinsic signaling pathways regulate the sequential process of neurogenesis in adult SGZ and SVZ, ranging from quiescent neural stem cell activation and fate specification to new neuron development and integration (Bond et al., 2015).”
Self-citationEnhanced lysosomal degradation maintains the quiescent state of neural stem cells
Kobayashi, T., Piao, W., Takamura, T., Kori, H., Miyachi, H., Kitano, S., Iwamoto, Y., Yamada, M., Imayoshi, I., Shioda, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13203-4 · Cited by 111
Neurobiology of cannabinoid receptor signaling
Lutz, B. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/blutz · Cited by 119
Tang, C., Wang, M., Wang, P., Wang, L., Wu, Q., & Guo, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.051 · Cited by 103
Therapeutic Plasticity of Neural Stem Cells
Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 105
“In young adult mice, B1 cells produce around 10,000 young interneurons every day that migrate for 3–8mm along the rostral migratory stream to the olfactory bulb (73).”
BackgroundDifferentiation of Mesenchymal Stem Cells to Neuroglia: in the Context of Cell Signalling
George, S., Hamblin, M. R., & Abrahamse, H. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09917-z · Cited by 97
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy
Ammothumkandy, A., Rāviņa, K., Wolseley, V., Tartt, A. N., Yu, P.-N., Corona, L., Zhang, N., Nune, G. C., Kalayjian, L. A., Mann, J. J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01044-2 · Cited by 95
Blomfield, I. M., Rocamonde, B., Masdeu, M., Mulugeta, E., Vaga, S., van den Berg, D. L. C., Huillard, E., Guillemot, F., & Urbán, N. (2019) · eLife · doi:10.7554/elife.48561 · Cited by 94
“In the adult brain, NSC populations in the ventricular-subventricular zone (V-SVZ) of the lateral ventricles and in the dentate gyrus (DG) of the hippocampus, generate new neurons and glia that integrate into pre-existing neuronal networks (Bond et al., 2015; Lim and Alvarez-Buylla, 2016).”
Brain Structural Plasticity: From Adult Neurogenesis to Immature Neurons
Rosa, C. L., Parolisi, R., & Bonfanti, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00075 · Cited by 107
“Although we have learned a lot about neural stem cell (NSC) biology and the molecular/cellular mechanisms that sustain neurogenesis in rodents (Bond et al., 2015; Kempermann et al., 2015; Lim and Alvarez-Buylla, 2016), direct analysis of human brain has produced many conflicting results (discussed in Arellano et al.”
ResultAl-Naama, N., Mackeh, R., & Kino, T. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00032 · Cited by 92
“NSCs undergo three major stages: (1) proliferation and renewal of the lineage, (2) migration to appropriate brain areas, and (3) differentiation into neurons, astrocytes, or oligodendrocytes; precise transitioning between these stages is critical for normal brain development (7).”
BackgroundExtracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
Xia, X., Wang, Y., & Zheng, J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00330-0 · Cited by 97
Kong, X., Gong, Z., Zhang, L., Sun, X., Ou, Z., Xu, B., Huang, J., Long, D., He, X., Lin, X.-H., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.027 · Cited by 94
Neural stem cell therapy aiming at better functional recovery after spinal cord injury
Zhu, Y., Uezono, N., Yasui, T., & Nakashima, K. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24558 · Cited by 91
“In the adult brain, NSCs reside in the subventricular zone and the subgranular zone of the hippocampal dentate gyrus (Bond et al., 2015).”
BackgroundBrain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis
Ferreira, F. F., Ribeiro, F. F., Rodrigues, R. S., Sebastião, A. M., & Xapelli, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00441 · Cited by 89
Pannexin‐1 in the CNS: Emerging concepts in health and disease
Yeung, A. K., Patil, C. S., & Jackson, M. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15004 · Cited by 90
Kong, X., Lyu, W., Lin, X., Lin, C., Feng, H., Lin, X., Shan, K., Wei, P., & Li, J. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03103-w · Cited by 88
“Neural stem cells form the basis of adult neurogenesis and can differentiate into immature neurons under appropriate stimuli, which can mature further into fully functional neurons [51].”
BackgroundXi, Y., Dhaliwal, J., Ceizar, M., Vaculik, M., Kumar, K. L., & Lagace, D. C. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.406 · Cited by 89
JNK Signaling in Stem Cell Self-Renewal and Differentiation
Semba, T., Sammons, R. M., Wang, X., Xie, X., Dalby, K. N., & Ueno, N. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072613 · Cited by 84
“They can generate multiple neural lineages, including neurons and astrocytes [84].”
BackgroundLong-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition
Zhang, B., Wang, L., Zhan, A., Wang, M., Tian, L., Guo, W., & Pan, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-21468-x · Cited by 86
Neural Stem Cell Niche and Adult Neurogenesis
Li, Y., & Guo, W. (2020) · The Neuroscientist · doi:10.1177/1073858420939034 · Cited by 86
Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair
Li, J., Luo, W., Xiao, C., Zhao, J., Xiang, C., Liu, W., & Gu, R. (2023) · Theranostics · doi:10.7150/thno.84133 · Cited by 89
“Transcriptional control works in conjunction with chromatin remodeling and epigenetic alterations under strict regional and temporal manners to promote eNSPC differentiation and self-renewal [158].”
BackgroundRegulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 89
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H. (2018) · F1000Research · doi:10.12688/f1000research.12684.1 · Cited by 89
Self-citationElectrical Guidance of Human Stem Cells in the Rat Brain
Feng, J.-F., Liu, J., Zhang, L., Jiang, J.-Y., Russell, M., Lyeth, B. G., Nolta, J. A., & Zhao, M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.035 · Cited by 80
“Researchers have demonstrated the rich availability of NSCs both endogenously and through transplantation (Arvidsson et al., 2002; Bond et al., 2015; Gage, 2000).”
BackgroundJang, J.-Y., Hong, Y. J., Lim, J.-S., Choi, J., Choi, E. H., Kang, S., & Rhim, H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.045 · Cited by 84
Liang, J., Wang, H., Zeng, Y., Qu, Y., Liu, Q., Zhao, F., Duan, J., Jiang, Y., Li, S., Ying, J., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0099 · Cited by 87
Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 85
“Specifically, the subgranular zone (SGZ) of the dentate gyrus of the hippocampus has been established as the primary area involved in this process (Bond et al., 2015).”
BackgroundMitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis
Beckervordersandforth, R. (2017) · Brain Plasticity · doi:10.3233/bpl-170044 · Cited by 82
The spinal ependymal zone as a source of endogenous repair cells across vertebrates
Becker, C. G., Becker, T., & Hugnot, J. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.04.002 · Cited by 80
Spampinato, S. F., Bortolotto, V., Canonico, P. L., Sortino, M. A., & Grilli, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01346 · Cited by 81
CTNNB1 in neurodevelopmental disorders
Zhuang, W., Ye, T., Wang, W., Song, W., & Tan, T. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1143328 · Cited by 86
“Further studies also suggest its role in the CNS, especially in cortical development (4), neural stem cell proliferation and neurogenesis (5), neuronal apoptosis (6), cell adhesion (7), and synaptic connection (8).”
BackgroundModeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons
Habela, C. W., Song, H., & Ming, G. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.12.002 · Cited by 80
“…synapses throughout life in the form of synaptic plasticity of early born neurons, and at the cellular level in the form of the birth and integration of adult-born neurons in the hippocampus, a brain region known to be essential for learning andmemory (Bond et al., 2015; Christian et al., 2014).”
Self-citationKyle, J., Wu, M. W., Gourzi, S., & Tsirka, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00097 · Cited by 80
Puma, D. D. L., Piacentini, R., Leone, L., Gironi, K., Marcocci, M. E., Chiara, G. D., Palamara, A. T., & Grassi, C. (2019) · Stem Cells · doi:10.1002/stem.3072 · Cited by 75
Metabolic regulation of neurodifferentiation in the adult brain
Maffezzini, C., Calvo‐Garrido, J., Wredenberg, A., & Freyer, C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03430-9 · Cited by 86
“Structurally, the SVZ in the adult brain lines the lateral ventricles, separated by a layer of ependymal cells [46].”
BackgroundHorgusluoglu, E., Nho, K. T., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M. J., Trojanowski, J. Q., Aisen, P. S. S., Petersen, R. C., Jack, C. R., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.010 · Cited by 81
Meneghini, V., Frati, G., Sala, D., Cicco, S. D., Luciani, M., Cavazzin, C., Paulis, M., Mentzen, W. I., Morena, F., Giannelli, S. G., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0414 · Cited by 77
Lepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 75
“Adult neural stem cells (NSCs) reside in few specific and restricted neurogenic niches of the mammalian brain (Weinandy et al , 2011; Ming & Song, 2012; Bond et al , 2015; Cameron & Glover, 2015) and generate neurons lifelong in the otherwise gliogenic environment (Ninkovic & Gotz, 2013).”
Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation
Yim, E. K. F., Jain, D., Mattiassi, S., & Goh, E. K. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266907 · Cited by 76
Dar, N. J., & Glazner, G. W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03404-x · Cited by 77
Mesenchymal Stem Cell Therapy and Alzheimer’s Disease: Current Status and Future Perspectives
Kim, J., Lee, Y., Lee, S., Kim, K., Song, M., & Lee, J. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200219 · Cited by 73
The Role of Lipid Metabolism for Neural Stem Cell Regulation
Knobloch, M. (2017) · Brain Plasticity · doi:10.3233/bpl-160035 · Cited by 78
“brain development and NSPC regulation and the many transcription factors and signaling pathways involved in this process [3, 4, 7].”
BackgroundZhou, Q., Zhu, L., Qiu, W., Liu, Y., Yang, F., Chen, W., & Xu, R. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.38487 · Cited by 76
“It is well definitely recommended that DCX+ cells migrate from SVZ to OB rostral migratory stream (RMS) means migration of immature neurons [54].”
BackgroundEliwa, H., Brizard, B., Guisquet, A. L., Hen, R., Belzung, C., & Surget, A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105097 · Cited by 77
“Chronic stress substantially downregulates AHN in various mammal species (Bond et al., 2015; Eliwa et al., 2017), affecting both the early phase of neurogenesis (cell proliferation) and later stages like neuronal survival and integration into the DG circuitry.”
BackgroundHerbert, S., Valon, L., Mancini, L., Dray, N., Caldarelli, P., Gros, J., Esposito, E., Shorte, S. L., Bally‐Cuif, L., Aulner, N., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01037-w · Cited by 72
Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma
Parmigiani, E., Taylor, V., & Giachino, C. (2020) · Cells · doi:10.3390/cells9102304 · Cited by 74
“After formation of the central nervous system is completed, NSCs persist within two restricted regions of the mammalian brain, the subgranular zone of the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of the lateral ventricles [61,62].”
BackgroundAdult hippocampal neurogenesis: Is it the alpha and omega of antidepressant action?
Eliwa, H., Belzung, C., & Surget, A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.08.005 · Cited by 73
“BMPs play an important role in maintaining the balance between quiescence and proliferation [27].”
BackgroundLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Knaus, L. S., Basilico, B., Malzl, D., Gerykova Bujalkova, M., Smogavec, M., Schwarz, L. A., Gorkiewicz, S., Amberg, N., Pauler, F. M., Knittl-Frank, C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.037 · Cited by 70
Li, W., Chen, G., Liu, M., Zheng, J., Xu, Y., & He, Q. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265185 · Cited by 72
Stem cell therapies in age-related neurodegenerative diseases and stroke
Wang, Y., Ji, X., Leak, R. K., Chen, F., & Cao, G. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.002 · Cited by 74
Hu, X.-L., Chen, G., Zhang, S., Zheng, J., Wu, J., Bai, Q., Wang, Y., Li, J., Wang, H., Han, F., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.047 · Cited by 70
Matsubara, S., Matsuda, T., & Nakashima, K. (2021) · Cells · doi:10.3390/cells10051145 · Cited by 72
“The subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus and ventricular subventricular zone (V-SVZ) lining the lateral ventricle retain adult neural stem cells (NSCs) that can generate new neurons and glial cells (Figure 1A,B) [1].”
Background
Metadata
- Authors
- Bond, A. M., Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Song, Hongjun
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 17
- Issue
- 4
- Pages
- 385-395
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC4683085
- OpenAlex
- W1828558002
- Cited by
- 791
- References
- 113
- Citations by year
- 2026: 41 · 2025: 61 · 2024: 68 · 2023: 76 · 2022: 74 · 2021: 105 · 2020: 90 · 2019: 93 · 2018: 67 · 2017: 67 · 2016: 43 · 2015: 4
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH105128, R01MH105128)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R21NS093772, R37NS047344, NS093772, NS09538, R56NS047344)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, adult neurogenesis, adult stem cells, tissue regeneration, stem cell plasticity, regenerative medicine, stem cell niche
- MeSH terms
- Adult, Animals, Homeostasis, Humans, Regenerative Medicine, Adult Stem Cells, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
