The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
X-Ray Scattering Used to Map the Preferred Collagen Orientation in the Human Cornea and Limbus
Open accessAbstract
Many properties of connective tissues are governed by the organization of the constituent collagen. For example, the organization of collagen in the cornea and the limbus, where the cornea and sclera meet, is an important determinant of corneal curvature and hence of the eye's focusing power. We have used synchrotron X-ray scattering to map the orientation of the collagen fibrils throughout the human cornea, limbus, and adjacent sclera. We demonstrate a preferred orientation of collagen in the vertical and horizontal directions that is maintained to within about 1 mm from the limbus, where a circular or tangential disposition of fibrils occurs. The data are also used to map the relative distribution of both the total and the preferentially aligned collagen in different parts of the tissue, revealing considerable anisotropy. The detailed structural information provided is an important step toward understanding the shape and the mechanical properties of the tissue.
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In the citing paper
“Maurice and colleagues initially employed X‐rays to investigate structural features pertaining to the arrangement of collagen fibers in corneal tissues, enabling the quantification of the orientation and content of collagen fibers across the cornea and limbus, with changes in fiber arrangement being readily detected via X‐ray scattering patterns.[ 94 , 105 , 111 ]”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [111]
In the citing paper
“although water distribution from central cornea to limbus is not known for human corneas, it seems likely that alterations in tissue thickness are due to an increase in the amount of collagen in the peripheral stroma (Aghamohammadzadeh et al., 2004, Boote et al., 2011, Henriksson et al., 2012).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“Collagen lamellae in the deeper stroma (Fig. 1a) have preferred directions, which appear to be close to the inferior-superior and nasal-temporal directions (Meek et al., 1987, Aghamohammadzadeh et al., 2004, Abahussin et al., 2009, Kamma-Lorger et al., 2010).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“X-ray scattering has also suggested the presence of a network of collagen lamellae that enter the cornea close to the inferior, superior, nasal and temporal positions, and which probably originate in the adjacent sclera (Aghamohammadzadeh et al., 2004).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“X-ray scattering has shown that the lamellae have preferred orientations in the human cornea: inferior-superior and nasal-temporal in the central cornea and circumferential at the limbus.”
From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [13]
In the citing paper
“Throughout the optical zone, there is a preference for lamellae to run in the inferior-superior and temporal-nasal directions.”
From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [13]
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Opto-Mechanical Model of Arcuates for Astigmatism Correction. Low and High Order Aberrations
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Metadata
- Authors
- Aghamohammadzadeh, H., Newton, R. H., & Meek, K. M.
- Affiliations
- Cardiff University (GB)
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 12
- Issue
- 2
- Pages
- 249-256
- ISSN
- 0969-2126 (ISSN-L)
- OpenAlex
- W2081339779
- Cited by
- 233
- References
- 19
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 18 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 5
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Structure (publishedVersion)
- PubMed (publishedVersion)
- ePubs (Science and Technology Facilities Council, Research Councils UK) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Physics and Astronomy › Radiation › Advanced X-ray Imaging Techniques
- Keywords
- collagen fibril orientation, cornea, limbus, sclera, collagen anisotropy, corneal curvature, synchrotron X-ray scattering, tissue mechanical properties
- MeSH terms
- Animals, Corneal Stroma, Humans, Sclera, X-Ray Diffraction, Limbus Corneae, Fibrillar Collagens
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