The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
X-Ray Scattering Used to Map the Preferred Collagen Orientation in the Human Cornea and Limbus
Open accessAbstract
Many properties of connective tissues are governed by the organization of the constituent collagen. For example, the organization of collagen in the cornea and the limbus, where the cornea and sclera meet, is an important determinant of corneal curvature and hence of the eye's focusing power. We have used synchrotron X-ray scattering to map the orientation of the collagen fibrils throughout the human cornea, limbus, and adjacent sclera. We demonstrate a preferred orientation of collagen in the vertical and horizontal directions that is maintained to within about 1 mm from the limbus, where a circular or tangential disposition of fibrils occurs. The data are also used to map the relative distribution of both the total and the preferentially aligned collagen in different parts of the tissue, revealing considerable anisotropy. The detailed structural information provided is an important step toward understanding the shape and the mechanical properties of the tissue.
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In the citing paper
“Maurice and colleagues initially employed X‐rays to investigate structural features pertaining to the arrangement of collagen fibers in corneal tissues, enabling the quantification of the orientation and content of collagen fibers across the cornea and limbus, with changes in fiber arrangement being readily detected via X‐ray scattering patterns.[ 94 , 105 , 111 ]”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [111]
In the citing paper
“although water distribution from central cornea to limbus is not known for human corneas, it seems likely that alterations in tissue thickness are due to an increase in the amount of collagen in the peripheral stroma (Aghamohammadzadeh et al., 2004, Boote et al., 2011, Henriksson et al., 2012).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“Collagen lamellae in the deeper stroma (Fig. 1a) have preferred directions, which appear to be close to the inferior-superior and nasal-temporal directions (Meek et al., 1987, Aghamohammadzadeh et al., 2004, Abahussin et al., 2009, Kamma-Lorger et al., 2010).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“X-ray scattering has also suggested the presence of a network of collagen lamellae that enter the cornea close to the inferior, superior, nasal and temporal positions, and which probably originate in the adjacent sclera (Aghamohammadzadeh et al., 2004).”
From Corneal structure and transparency (2015) · cites this paper as Aghamohammadzadeh et al., 2004
In the citing paper
“X-ray scattering has shown that the lamellae have preferred orientations in the human cornea: inferior-superior and nasal-temporal in the central cornea and circumferential at the limbus.”
From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [13]
In the citing paper
“Throughout the optical zone, there is a preference for lamellae to run in the inferior-superior and temporal-nasal directions.”
From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [13]
Citations
Cites
Principles and Practice of Ophthalmology
(1981) · American Journal of Ophthalmology · doi:10.1016/0002-9394(81)90081-7 · Cited by 1,073
Maurice, D. M. (1962) · Elsevier eBooks · doi:10.1016/b978-1-4832-3090-0.50013-7 · Cited by 436
Principles and Practice of Ophthalmology,
Tessler, H. H. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00166-1 · Cited by 409
(1997) · PubMed · Cited by 326
The organization of collagen in the corneal stroma
Meek, K. M., & Boote, C. (2003) · Experimental Eye Research · doi:10.1016/j.exer.2003.07.003 · Cited by 297
Self-citationRegional elastic performance of the human cornea
Hjortdal, J. (1996) · Journal of Biomechanics · doi:10.1016/0021-9290(95)00152-2 · Cited by 233
Meek, K. M., Blamires, T., Elliott, G. F., Gyi, T. J., & Nave, C. (1987) · Current Eye Research · doi:10.3109/02713688709034853 · Cited by 161
Self-citationInterlacing and cross-angle distribution of collagen lamellae in the human cornea
Radner, W., Zehetmayer, M., Aufreiter, R., & Mallinger, R. (1998) · Cornea · doi:10.1097/00003226-199809000-00012 · Cited by 153
The use of X-ray scattering techniques to determine corneal ultrastructure
Meek, K. M., & Quantock, A. J. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00016-1 · Cited by 139
Self-citation(1998) · PubMed · Cited by 111
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853
Self-citationChanges in Collagen Orientation and Distribution in Keratoconus Corneas
Meek, K. M., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R., & Bron, A. J. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1253 · Cited by 511
Self-citationReinstein, D. Z., Archer, T. J., Gobbé, M., Silverman, R. H., & Coleman, D. J. (2009) · Journal of Refractive Surgery · doi:10.3928/1081597x-20090813-04 · Cited by 299
Meek, K. M., & Boote, C. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.005 · Cited by 248
Self-citationPandolfi, A. M., & Holzapfel, G. A. (2008) · Journal of Biomechanical Engineering · doi:10.1115/1.2982251 · Cited by 245
Metadata
- Authors
- Aghamohammadzadeh, H., Newton, R. H., & Meek, K. M.
- Affiliations
- Cardiff University (GB)
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 12
- Issue
- 2
- Pages
- 249-256
- ISSN
- 0969-2126 (ISSN-L)
- OpenAlex
- W2081339779
- Cited by
- 233
- References
- 19
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 18 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 5
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Structure (publishedVersion)
- PubMed (publishedVersion)
- ePubs (Science and Technology Facilities Council, Research Councils UK) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Physics and Astronomy › Radiation › Advanced X-ray Imaging Techniques
- Keywords
- collagen fibril orientation, cornea, limbus, sclera, collagen anisotropy, corneal curvature, synchrotron X-ray scattering, tissue mechanical properties
- MeSH terms
- Animals, Corneal Stroma, Humans, Sclera, X-Ray Diffraction, Limbus Corneae, Fibrillar Collagens
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