Green improved processes to extract bioactive phenolic compounds from brown macroalgae using Sargassum muticum as model
Abstract
A comparative study between "alternative" extraction processes such as centrifugal partition extraction (CPE), supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE) and classical solid/liquid used in the laboratory are currently focusing on the efficiency (selectivity and productivity) to obtain bioactive phenolic compounds from the phaeophyte Sargassum muticum model. The choice of the best process was based on several measurements: (i) the total phenolic content measured by the colorimetric Folin-Ciocalteu assay, (ii) radical scavenger and antioxidant activities assessed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, and the β-carotene bleaching method and finally (iii) the method productivity. Irrespective of the solvent used in the processes, alternative methods are always sharply more effective than classical ones. With the exception of SFE which does not allow extracting the totality of the active phenolic compounds, two of the other extraction methods were particularly promising. First, CPE afforded the most important yields in concentrated phenolic compounds (PC) (22.90±0.65% DW) also displaying the best activities (0.52±0.02 and 0.58±0.19 mg/mL for IC50 and AAC700, respectively). Secondly, PLE using an EtOH:water mixture 75:25 (v/v) allowed a good PC extraction (10.18±0.25% DW) with huge efficiency. Despite a lesser activity of the extracts (0.77±0.01 and 1.59±0.15 mg/mL for IC50 and AAC700, respectively) PLE is a green process and potentially complies European norms requirements for the prospective valorization of phenolic compounds from S. muticum in Brittany.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Macroalgae species and season of collecting affect phenolics extraction; it is important to collect macroalgae during summer because then they produce maximum phenolic compounds.
“Besides, macroalgae species as well as the season of their collecting affects phenolics extraction. It is important to collect macroalgae during the summer [36] because then they produce the maximum of phenolic compounds.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [36]
According to published studies, SWE is the most promising technique for extraction of bioactive compounds.
“According to published studies [14,31,36], this is the most promising technique for the extraction of bioactive compounds.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [36]
Cites
Green Chemistry: Theory and Practice
Anastas, P. T., & Warner, J. C. (1998) · Medical Entomology and Zoology · Cited by 8,599 · see citing works
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162 · see citing works
Screening of Plant Extracts for Antioxidant Activity: a Comparative Study on Three Testing Methods
Koleva, I. I., van Beek, T. A., Linssen, J. P. H., de Groot, C. P. G. M., & Evstatieva, L. N. (2002) · Phytochemical Analysis · doi:10.1002/pca.611 · Cited by 1,785 · see citing works
Anti-oxidant activity and total phenolic content of some Asian vegetables
Kaur, C., & Kapoor, H. C. (2002) · International Journal of Food Science & Technology · doi:10.1046/j.1365-2621.2002.00552.x · Cited by 1,158 · see citing works
Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds
Wang, T., Jónsdóttir, R., & Ólafsdóttir, G. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.02.041 · Cited by 699 · see citing works
Screening for bioactive compounds from algae
Plaza, M., Santoyo, S., Jaime, L., Reina, G. G.-B., Herrero, M., Señoráns, F. J., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.016 · Cited by 493 · see citing works
In vitro antioxidant activities of three selected brown seaweeds of India
Chandini, S., Ganesan, P., & Bhaskar, N. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.08.081 · Cited by 423 · see citing works
Antioxidant activity of fresh and processed edible seaweeds
Jiménez‐Escrig, A., Jiménez‐Jiménez, I., Pulido, R., & Saura-Calixto, F. D. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.842 · Cited by 417 · see citing works
Subcritical Water Extraction of Antioxidant Compounds from Rosemary Plants
Ibáñez, E., Kubátová, A., Señoráns, F. J., Cavero, S., Reglero, G., & Hawthorne, S. B. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025878j · Cited by 417 · see citing works
Koivikko, R., Loponen, J. M., Honkanen, T., & Jormalainen, V. (2005) · Journal of Chemical Ecology · doi:10.1007/s10886-005-0984-2 · Cited by 368 · see citing works
Ecological Roles of Marine Natural Products
(2020) · Cornell University Press eBooks · doi:10.7591/9781501737435 · Cited by 347 · see citing works
Polyphenol Profiles of French Cider Apple Varieties ( Malus domestica sp.)
Sanoner, P., Guyot, S., Marnet, N., Mollé, D., & Drilleau, J.-F. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990563y · Cited by 324 · see citing works
Ecological roles of marine natural products
(1993) · Choice Reviews Online · doi:10.5860/choice.30-2662 · Cited by 310 · see citing works
Developments in the application of counter-current chromatography to plant analysis
Marston, A., & Hostettmann, K. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.10.018 · Cited by 272 · see citing works
Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts
Zubia, M., Fabre, M. S., Kerjean, V., Lann, K. L., Stiger‐Pouvreau, V., Fauchon, M., & Deslandes, É. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.03.025 · Cited by 252 · see citing works
Onofrejová, L., Vašíčková, J., Klejdus, B., Stratil, P., Mišurcová, L., Kráčmar, S., Kopecký, J., & Vacek, J. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.027 · Cited by 229 · see citing works
Rodríguez‐Meizoso, I., Jaime, L., Santoyo, S., Señoráns, F. J., Cifuentes, A., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.014 · Cited by 223 · see citing works
López, A., Rico, M., Rivero, A., & de Tangil, M. S. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.101 · Cited by 221 · see citing works
Ong, E. S., Cheong, J. S. H., & Goh, D. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.12.052 · Cited by 219 · see citing works
Countercurrent Separation of Natural Products
Pauli, G. F., Pro, S. M., & Friesen, J. B. (2008) · Journal of Natural Products · doi:10.1021/np800144q · Cited by 204 · see citing works
(2011) · Wiley eBooks · doi:10.1002/9781119977087 · Cited by 180 · see citing works
Natural dyes extraction from cochineal (Dactylopius coccus). New extraction methods
Borges, M. E., Tejera, R. L., Díaz, L., Esparza, P., & Ibáñez, E. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.018 · Cited by 174 · see citing works
Taamalli, A., Arraéz-Román, D., Barrajón‐Catalán, E., Ruiz-Torres, V., Pérez-Sánchez, A., Herrero, M., Ibáñez, E., Micol, V., Zarrouk, M., Segura‐Carretero, A., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.090 · Cited by 160 · see citing works
Intra-thallus phlorotannin content and antioxidant activity in Phaeophyceae of temperate waters
Connan, S., Delisle, F., Deslandes, É., & Gall, E. A. (2006) · Botanica Marina · doi:10.1515/bot.2006.005 · Cited by 157 · see citing works
Klejdus, B., Kopecký, J., Benešová, L., & Vacek, J. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.11.096 · Cited by 143 · see citing works
Santoyo, S., Rodríguez-Meizoso, I., Cifuentes, A., Jaime, L., García-Blairsy Reina, G., Señorans, F. J., & Ibáñez, E. (2009) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2009.01.012 · Cited by 133 · see citing works
Plouguerné, E., Lann, K. L., Connan, S., Jechoux, G., Deslandes, É., & Stiger‐Pouvreau, V. (2006) · Aquatic Botany · doi:10.1016/j.aquabot.2006.06.011 · Cited by 127 · see citing works
Borrás‐Linares, I., Arraéz-Román, D., Herrero, M., Ibáñez, E., Segura‐Carretero, A., & Fernández‐Gutiérrez, A. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.07.021 · Cited by 122 · see citing works
L�der, U. H., & Clayton, M. N. (2004) · Planta · doi:10.1007/s00425-003-1176-3 · Cited by 115 · see citing works
Tena, M. T., Valcárcel, M., Hidalgo, P. J., & Ubera, J. L. (1997) · Analytical Chemistry · doi:10.1021/ac960506t · Cited by 114 · see citing works
Phlorotannins as Radical Scavengers from the Extract of Sargassum ringgoldianum
Nakai, M., Kageyama, N., Nakahara, K., & Miki, W. (2006) · Marine Biotechnology · doi:10.1007/s10126-005-6168-9 · Cited by 114 · see citing works
Stiger‐Pouvreau, V., Deslandes, É., & Payri, C. E. (2004) · Botanica Marina · doi:10.1515/bot.2004.058 · Cited by 110 · see citing works
Lann, K. L., Jégou, C., & Stiger‐Pouvreau, V. (2008) · Phycological Research · doi:10.1111/j.1440-1835.2008.00505.x · Cited by 108 · see citing works
Kuda, T., Kunii, T., Goto, H., Suzuki, T., & Yano, T. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.09.042 · Cited by 107 · see citing works
Schoenwaelder, M. E. A., & Clayton, M. N. (1998) · Journal of Phycology · doi:10.1046/j.1529-8817.1998.340969.x · Cited by 102 · see citing works
High antioxidant activity of extracts obtained from sage by supercritical co2 extraction
Ďjarmati, Z., Jankov, R., Schwirtlich, E., Djulinac, B., & Djordjevic, A. N. (1991) · Journal of the American Oil Chemists Society · doi:10.1007/bf02662161 · Cited by 93 · see citing works
Deal, M. S., Hay, M. E., Wilson, D. M., & Fenical, W. (2003) · Oecologia · doi:10.1007/s00442-003-1242-3 · Cited by 91 · see citing works
Removal of Dissolved Brown Algal Phlorotannins Using Insoluble Polyvinylpolypyrrolidone (PVPP)
Toth, G. B., & Pavia, H. (2001) · Journal of Chemical Ecology · doi:10.1023/a:1010421128190 · Cited by 82 · see citing works
Rapid linear scale-up of a protein separation by centrifugal partition chromatography
Sutherland, I., Audo, G., Bourton, E. C., Couillard, F. D., Fisher, D., Garrard, I. J., Hewitson, P., & Intes, O. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.092 · Cited by 79 · see citing works
Plouguerné, E., Hellio, C., Deslandes, É., Véron, B., & Stiger‐Pouvreau, V. (2008) · Botanica Marina · doi:10.1515/bot.2008.026 · Cited by 71 · see citing works
Lann, K. L., Ferret, C., VanMee, E., Spagnol, C., Lhuillery, M., Payri, C., & Stiger-Pouvreau, V. (2012) · Phycological Research · doi:10.1111/j.1440-1835.2011.00634.x · Cited by 68 · see citing works
Lee, S., Kang, S., Ko, S., Lee, D.-H., & Jeon, Y. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.036 · Cited by 65 · see citing works
Supercritical fluid processing of food and biomaterials
Clifford, A. A. (1994) · Trends in Food Science & Technology · doi:10.1016/0924-2244(94)90173-2 · Cited by 65 · see citing works
Leal, P. F., Kfouri, M. B., Alexandre, F. C., Fagundes, F. H. R., Prado, J. M., Toyama, M. H., & Meireles, M. A. A. (2010) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2010.03.007 · Cited by 62 · see citing works
Yoon, K. D., Chin, Y., Yang, M. H., & Kim, J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.05.005 · Cited by 58 · see citing works
Distribution and radical scavenging activity of phenols in Ascophyllum nodosum (Phaeophyceae)
Breton, F., Cérantola, S., & Gall, E. A. (2011) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2011.01.002 · Cited by 52 · see citing works
Lann, K. L., Connan, S., & Stiger‐Pouvreau, V. (2012) · Marine Environmental Research · doi:10.1016/j.marenvres.2012.05.011 · Cited by 51 · see citing works
Silkina, A., Bazes, A., Mouget, J., & Bourgougnon, N. (2012) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2012.06.028 · Cited by 47 · see citing works
Perez-Rodrigues, E., Aguilera, J. M., mez, I. G. X. F., & Figueroa, F. L. (2001) · Marine Biology · doi:10.1007/s002270100588 · Cited by 45 · see citing works
Intensified extraction of ionized natural products by ion pair centrifugal partition extraction
Hamzaoui, M., Hubert, J., Salem, J. H., Richard, B., Harakat, D., Marchal, L., Foucault, A. P., Lavaud, C., & Renault, J. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.018 · Cited by 26 · see citing works
Margraff, R., Intes, O., Renault, J., & Garret, P. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200063539 · Cited by 20 · see citing works
Toribio, A., Nuzillard, J., Pinel, B., Boudesocque‐Delaye, L., LAFOSSE, M., Poype, F. D. L., & Renault, J. (2009) · Journal of Separation Science · doi:10.1002/jssc.200800651 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Application of Novel Extraction Technologies for Bioactives from Marine Algae
Kadam, S. U., Tiwari, B. K., & O’Donnell, C. P. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400819p · Cited by 547 · see citing works
Herrero, M., Sánchez‐Camargo, A. D. P., Cifuentes, A., & Ibáñez, E. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.01.018 · Cited by 344 · see citing works
Li, Y., Fu, X., Duan, D., Liu, X., Xu, J., & Gao, X. (2017) · Marine Drugs · doi:10.3390/md15020049 · Cited by 272 · see citing works
Alternative and efficient extraction methods for marine-derived compounds
Grosso, C., Valentão, P., Ferreres, F., & Andrade, P. (2015) · Marine Drugs · doi:10.3390/md13053182 · Cited by 248 · see citing works
Golden Tides: Problem or Golden Opportunity? The Valorisation of Sargassum from Beach Inundations
Milledge, J. J., & Harvey, P. J. (2016) · Journal of Marine Science and Engineering · doi:10.3390/jmse4030060 · Cited by 235 · see citing works
Cikoš, A.-M., Jokić, S., Šubarić, D., & Jerković, I. (2018) · Marine Drugs · doi:10.3390/md16100348 · Cited by 225 · see citing works
Tyśkiewicz, K., Konkol, M., & Rój, E. (2018) · Molecules · doi:10.3390/molecules23102625 · Cited by 208 · see citing works
Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications
Silva, A., Silva, S. A., Carpena, M., Garcia‐Oliveira, P., Gullón, P., Barroso, M. F., Prieto, M. A., & Simal‐Gándara, J. (2020) · Antibiotics · doi:10.3390/antibiotics9100642 · Cited by 207 · see citing works
Milledge, J. J., Nielsen, B. V., & Bailey, D. (2016) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-015-9381-7 · Cited by 193 · see citing works
Hardouin, K., Bedoux, G., Burlot, A.-S., Donnay‐Moreno, C., Bergé, J.-P., Collén, P. N., & Bourgougnon, N. (2016) · Algal Research · doi:10.1016/j.algal.2016.03.013 · Cited by 188 · see citing works
Santos, S. A. O., Félix, R., Pais, A. C. S., Rocha, S. M., & Silvestre, A. J. D. (2019) · Biomolecules · doi:10.3390/biom9120847 · Cited by 160 · see citing works
Sánchez‐Camargo, A. D. P., Montero, L., Stiger‐Pouvreau, V., Tanniou, A., Cifuentes, A., Herrero, M., & Ibáñez, E. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.098 · Cited by 149 · see citing works
Montero, L., Sánchez-Camargo, A. P., García-Cañas, V., Tanniou, A., Stiger-Pouvreau, V., Russo, M., Rastrelli, L., Cifuentes, A., Herrero, M., & Ibáñez, E. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.07.053 · Cited by 145 · see citing works
Self-citationLeyton, A., Pezoa‐Conte, R., Barriga, A., Buschmann, A. H., Mäki‐Arvela, P., Mikkola, J., & Lienqueo, M. E. (2016) · Algal Research · doi:10.1016/j.algal.2016.03.019 · Cited by 141 · see citing works
Sosa‐Hernández, J. E., Escobedo-Avellaneda, Z. J., Iqbal, H. M. N., & Welti‐Chanes, J. (2018) · Molecules · doi:10.3390/molecules23112953 · Cited by 134 · see citing works
Otero, P., Quintana, S. E., Reglero, G., Fornari, T., & García‐Risco, M. R. (2018) · Marine Drugs · doi:10.3390/md16050156 · Cited by 130 · see citing works
Perez-Vazquez, A., Carpena, M., Barciela, P., Cassani, L., Simal-gandara, J., & Prieto, M. (2023) · Antioxidants · doi:10.3390/antiox12030612 · Cited by 98 · see citing works
Dang, T. T., Van Vuong, Q., Schreider, M. J., Bowyer, M. C., Van Altena, I. A., & Scarlett, C. J. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1162-y · Cited by 116 · see citing works
A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins
Zheng, H., Zhao, Y., & Guo, L. (2022) · Marine Drugs · doi:10.3390/md20120742 · Cited by 120 · see citing works
Fraguela-Meissimilly, H., Bastías‐Montes, J. M., Vergara, C., Ortíz, J., Lemus-Mondaca, R. A., Flores, M., Toledo-Merma, P., Alcázar-Alay, S. C., & Gallón-Bedoya, M. (2023) · Molecules · doi:10.3390/molecules28114421 · Cited by 117 · see citing works
Milledge, J. J., Maneein, S., López, E. A., & Bartlett, D. (2020) · Energies · doi:10.3390/en13061523 · Cited by 118 · see citing works
Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges
Getachew, A. T., Jacobsen, C., & Holdt, S. L. (2020) · Marine Drugs · doi:10.3390/md18080389 · Cited by 115 · see citing works
Seaweed-Based Compounds and Products for Sustainable Protection against Plant Pathogens
Shukla, P. S., Borza, T., Critchley, A. T., & Prithiviraj, B. (2021) · Marine Drugs · doi:10.3390/md19020059 · Cited by 113 · see citing works
Tanniou, A., Vandanjon, L., Incera, M., León, E. S., Husa, V., Grand, J. L., Nicolas, J.-L., Poupart, N., Kervarec, N., Engelen, A. H., et al. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0198-x · Cited by 108 · see citing works
Challenges and Opportunities in Relation to Sargassum Events Along the Caribbean Sea
Robledo, D., Vázquez-Delfín, E. F., Freile‐Pelegrín, Y., Vásquez‐Elizondo, R. M., Qui‐Minet, Z. N., & Salazar-Garibay, A. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.699664 · Cited by 104 · see citing works
Extraction of biomolecules from seaweeds
Kadam, S. U., Álvarez, C., Tiwari, B. K., & O’Donnell, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00009-x · Cited by 98 · see citing works
Michalak, I., Chojnacka, K., & Saeid, A. (2017) · Molecules · doi:10.3390/molecules22010066 · Cited by 98 · see citing works
Michalak, I., Górka, B., Wieczorek, P. P., Rój, E., Lipok, J., Łęska, B., Messyasz, B., Wilk, R., Schroeder, G., Dobrzyńska-Inger, A., et al. (2016) · European Journal of Phycology · doi:10.1080/09670262.2015.1134813 · Cited by 91 · see citing works
Erpel, F., Mateos, R., Pérez‐Jiménez, J., & Pérez‐Correa, J. R. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109589 · Cited by 88 · see citing works
Pintéus, S., Lemos, M. F. L., Alves, C., Neugebauer, A. Z., Silva, J., Thomas, O., Botana, L. M., Gaspar, H., & Pedrosa, R. (2018) · Algal Research · doi:10.1016/j.algal.2018.06.018 · Cited by 88 · see citing works
Puspita, M., Déniel, M., Widowati, I., Radjasa, O. K., Douzenel, P., Marty, C., Vandanjon, L., Bedoux, G., & Bourgougnon, N. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1086-6 · Cited by 83 · see citing works
Microwave hydrodiffusion and gravity processing of Sargassum muticum
Pérez, L., Conde, E., & Domínguez, H. (2014) · Process Biochemistry · doi:10.1016/j.procbio.2014.02.020 · Cited by 81 · see citing works
Supercritical fluid extraction as a tool to valorize underexploited freshwater green algae
Fabrowska, J., Ibañez, E., Łęska, B., & Herrero, M. (2016) · Algal Research · doi:10.1016/j.algal.2016.09.008 · Cited by 76 · see citing works
Cassani, L., Gómez‐Zavaglia, A., Jiménez-López, C., Lourenço‐Lopes, C., Prieto, M. A., & Simal‐Gándara, J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109676 · Cited by 73 · see citing works
Phlorotannins in Sargassaceae Species from Brittany (France)
Stiger‐Pouvreau, V., Jégou, C., Cérantola, S., Guérard, F., & Lann, K. L. (2014) · Advances in botanical research · doi:10.1016/b978-0-12-408062-1.00013-5 · Cited by 67 · see citing works
Marine green macroalgae: A source of natural compounds with mineralogenic and antioxidant activities
Surget, G., Roberto, V. P., Le Lann, K., Mira, S., Guérard, F., Laizé, V., Poupart, N., Cancela, M. L., & Stiger-Pouvreau, V. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0968-3 · Cited by 63 · see citing works
Green Analytical Methodologies for Preparation of Extracts and Analysis of Bioactive Compounds
Duarte, K. R., Justino, C. I. L., Gomes, A., Rocha‐Santos, T., & Duarte, A. C. (2014) · Comprehensive analytical chemistry · doi:10.1016/b978-0-444-63359-0.00004-5 · Cited by 64 · see citing works
Monroy-García, I. N., Torres-Romero, S., Castro-Ochoa, D., Mendoza-Acosta, A., Viveros‐Valdez, E., & Ayala-Zavala, J. F. (2025) · Stresses · doi:10.3390/stresses5010022 · Cited by 61 · see citing works
Supercritical Fluid Extraction
Sánchez‐Camargo, A. D. P., Mendiola, J. A., Ibáñez, E., & Herrero, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.10753-x · Cited by 62 · see citing works
Self-citationJégou, C., Kervarec, N., Cérantola, S., Bihannic, I., & Stiger‐Pouvreau, V. (2014) · Talanta · doi:10.1016/j.talanta.2014.11.059 · Cited by 61 · see citing works
Olivares-Molina, A., & Fernández, K. F. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0665-7 · Cited by 59 · see citing works
Barbosa, M., Lopes, G., Andrade, P. B., & Valentão, P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.037 · Cited by 58 · see citing works
Extraction and Purification of Phlorotannins from Brown Algae
Gall, E. A., Lelchat, F., Hupel, M., Jégou, C., & Stiger‐Pouvreau, V. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2684-8_7 · Cited by 56 · see citing works
Milledge, J. J., Nielsen, B. V., & Harvey, P. J. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1512-4 · Cited by 55 · see citing works
Angelis, A., Hamzaoui, M., Aligiannis, N., Νίκου, Θ., Michailidis, D., Gerolimatos, P., Termentzi, A., Hubert, J., Halabalaki, M., Renault, J., et al. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.02.046 · Cited by 54 · see citing works
Vieira, F. A., Guilherme, R. J. R., Neves, M. C., Rego, A. M., Abreu, H., Coutinho, J. A. P., & Ventura, S. P. M. (2017) · Separation and Purification Technology · doi:10.1016/j.seppur.2017.05.006 · Cited by 49 · see citing works
Single-step extraction of carotenoids from brown macroalgae using non-ionic surfactants
Vieira, F. A., Guilherme, R. J. R., Neves, M. C., Abreu, H., Rodrigues, E. R. O., Maraschin, M., Coutinho, J. A. P., & Ventura, S. P. M. (2016) · Separation and Purification Technology · doi:10.1016/j.seppur.2016.07.052 · Cited by 46 · see citing works
Bioactive compounds against neglected diseases isolated from macroalgae: a review
Falkenberg, M. B., Nakano, E., Zambotti‐Villela, L., Zatelli, G. A., Philippus, A. C., Imamura, K. B., Velásquez, Á. M. A., Freitas, R. P., Tallarico, L. D. F., Colepicolo, P., et al. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1572-5 · Cited by 46 · see citing works
Setyawidati, N. A. R., Puspita, M., Kaimuddin, A. H., Widowati, I., Deslandes, É., Bourgougnon, N., & Stiger‐Pouvreau, V. (2018) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2017.11.068 · Cited by 45 · see citing works
A concise review of the highly diverse genus Sargassum C. Agardh with wide industrial potential
Stiger‐Pouvreau, V., Mattio, L., N’Yeurt, A. D. R., Uwai, S., Domı́nguez, H., Flórez-Fernández, N., Connan, S., & Critchley, A. T. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-02959-4 · Cited by 43 · see citing works
McGurrin, A., Maguire, J., Tiwari, B. K., & García‐Vaquero, M. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00946-w · Cited by 43 · see citing works
Klejdus, B., Plaza, M., Šnóblová, M., & Lojková, L. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.12.015 · Cited by 43 · see citing works
Tanniou, A., Vandanjon, L., Gonçalves, O., Kervarec, N., & Stiger‐Pouvreau, V. (2014) · Talanta · doi:10.1016/j.talanta.2014.09.002 · Cited by 42 · see citing works
Stiger‐Pouvreau, V., & Thouzeau, G. (2015) · Open Journal of Ecology · doi:10.4236/oje.2015.55019 · Cited by 41 · see citing works
Bioactive compounds from micro-algae and its application in foods: A review
Siddhnath, Surasani, V. K. R., Singh, A., Singh, S. M., Hauzoukim, Murthy, L. N., & Baraiya, K. G. (2024) · Discover Food · doi:10.1007/s44187-024-00096-6 · Cited by 42 · see citing works
Abdelhamid, A., Lajili, S., Kaibi, M. A. E., Salem, Y. B., Abdelhamid, A., Muller, C. D., Majdoub, H., Kraı̈em, J., & Bouraoui, A. (2019) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2019.1662865 · Cited by 39 · see citing works
Tapia‐Salazar, M., Arévalo-Rivera, I. G., Maldonado-Muñiz, M., García-Amezquita, L. E., Nieto-López, M. G., Ricque-Marie, D., Cruz‐Suárez, L. E., & Welti‐Chanes, J. (2019) · Food and Bioprocess Technology · doi:10.1007/s11947-018-2229-8 · Cited by 36 · see citing works
Puspita, M., Setyawidati, N. A. R., Stiger‐Pouvreau, V., Vandanjon, L., Widowati, I., Radjasa, O. K., Bedoux, G., & Bourgougnon, N. (2020) · Advances in botanical research · doi:10.1016/bs.abr.2019.12.002 · Cited by 35 · see citing works
ElShafei, R. A. E. N., Hegazy, H., & Acharya, B. (2021) · Energies · doi:10.3390/en14113092 · Cited by 36 · see citing works
Kadam, S. U., Álvarez, C., Tiwari, B. K., & O’Donnell, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00004-0 · Cited by 32 · see citing works
Costa, A. R., de Freitas, L. A. P., Mendiola, J. A., & Ibáñez, E. (2015) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2015.02.028 · Cited by 31 · see citing works
Self-citationSeaweed as an Ingredient for Nutritional Improvement of Fish Jerky
Hanjabam, M. D., Zynudheen, A. A., Ninan, G., & Panda, S. K. (2016) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12845 · Cited by 30 · see citing works
Ktari, L., M’dallel, C., Aoun, B., Ajjabi, L. C., & Sadok, S. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.647159 · Cited by 29 · see citing works
Wekre, M. E., Hellesen Brunvoll, S., & Jordheim, M. (2022) · Phytochemical Analysis · doi:10.1002/pca.3162 · Cited by 29 · see citing works
Castillo, A., Celeiro, M., Lores, M., Grgić, K., Banožić, M., Jerković, I., & Jokić, S. (2023) · Marine Drugs · doi:10.3390/md21020097 · Cited by 30 · see citing works
An Overview on Effects of Processing on the Nutritional Content and Bioactive Compounds in Seaweeds
de Quirós, A. R. B., & López-Hernández, J. (2021) · Foods · doi:10.3390/foods10092168 · Cited by 28 · see citing works
Maliki, I. M., Misson, M., Teoh, P. L., Rodrigues, K. F., & Yong, W. T. L. (2022) · Marine Drugs · doi:10.3390/md20020102 · Cited by 27 · see citing works
Keramane, B., Sánchez‐Camargo, A. D. P., Montero, L., Laincer, F., Bedjou, F., & Ibáñez, E. (2023) · Algal Research · doi:10.1016/j.algal.2023.103293 · Cited by 27 · see citing works
Bensemmane, N., Bouzidi, N., Daghbouche, Y., Garrigues, S., de la Guárdia, M., & Hattab, M. E. (2020) · Phytochemical Analysis · doi:10.1002/pca.2974 · Cited by 26 · see citing works
Yılmaz, G. G., Gómez‐Pinchetti, J. L., Cifuentes, A., Herrero, M., & Ibáñez, E. (2019) · Analytical Letters · doi:10.1080/00032719.2019.1597878 · Cited by 26 · see citing works
Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects
Okeke, E. S., Nweze, E. J., Chibuogwu, C. C., Anaduaka, E. G., Chukwudozie, K. I., & Ezeorba, T. P. C. (2021) · Natural Product Communications · doi:10.1177/1934578x211056144 · Cited by 25 · see citing works
Erpel, F., Mariotti‐Celis, M. S., Parada, J., Pedreschi, F., & Pérez‐Correa, J. R. (2021) · Antioxidants · doi:10.3390/antiox10071105 · Cited by 24 · see citing works
Barbosa, M., Fernandes, F., Carlos, M. J., Valentão, P., & Andrade, P. B. (2021) · Algal Research · doi:10.1016/j.algal.2021.102455 · Cited by 24 · see citing works
Green analytical methodologies for the discovery of bioactive compounds from marine sources
Duarte, K., Justino, C. I. L., Pereira, R., Freitas, A. C., Gomes, A. M., Duarte, A. C., & Rocha-Santos, T. A. P. (2014) · Trends in Environmental Analytical Chemistry · doi:10.1016/j.teac.2014.11.001 · Cited by 21 · see citing works
Gager, L., Lalegerie, F., Connan, S., & Stiger‐Pouvreau, V. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch11 · Cited by 21 · see citing works
Sustainable approach in phlorotannin recovery from macroalgae
Chia, S. R., Show, P. L., Phang, S., Ling, T. C., & Ong, H. C. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.02.015 · Cited by 20 · see citing works
Gager, L., Connan, S., Cérantola, S., Petek, S., Couteau, C., Coiffard, L. J. M., & Stiger‐Pouvreau, V. (2024) · Marine Drugs · doi:10.3390/md22030112 · Cited by 19 · see citing works
Advanced and Potential Methods for Extraction of Bioactive Compounds from Avocado Peel—A Review
Muhammad, D. R. A., Ayouaz, S., Rachmawati, A. N., Madani, K., Fibri, D. L. N., Rafi, M., Julianti, E., & Fahmy, K. (2024) · Applied Sciences · doi:10.3390/app14146018 · Cited by 21 · see citing works
Tang, X., Wang, L., Zhang, Y., & Sun, C. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125370 · Cited by 18 · see citing works
Zeb, L., Shafiq, M., & Jordheim, M. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144941 · Cited by 17 · see citing works
Zúñiga, A., Sáez, C. A., Trabal, A., Figueroa, F. L., Pardo, D., Navarrete, C., Rodríguez-Rojas, F., Moenne, F., & Celis‐Plá, P. S. M. (2020) · Water · doi:10.3390/w13010006 · Cited by 15 · see citing works
Messina, C. M., Arena, R., Ficano, G., Randazzo, M., Morghese, M., Barbera, L. L., Sadok, S., & Santulli, A. (2021) · Foods · doi:10.3390/foods10112522 · Cited by 15 · see citing works
Stiger‐Pouvreau, V., & Guérard, F. (2018) · Blue Biotechnology · doi:10.1002/9783527801718.ch22 · Cited by 14 · see citing works
Arena, R., Manuguerra, S., Collins, E., Mahdhi, A., Renda, G., Messina, C. M., & Santulli, A. (2020) · Applied Sciences · doi:10.3390/app10072374 · Cited by 13 · see citing works
Ubiquitous Phlorotannins Prospects and Perspectives
Creis, E., Gall, E. A., & Potin, P. (2018) · Blue Biotechnology · doi:10.1002/9783527801718.ch3 · Cited by 12 · see citing works
Боголицын, К. Г., Дружинина, А. С., Ovchinnikov, D., Александрович, К. П., Shulgina, E. V., & Parshina, A. (2018) · chemistry of plant raw material · doi:10.14258/jcprm.2018031898 · Cited by 12 · see citing works
Seaweed-based fertilizing products
Choulot, M., Guillard, C. L., Bourgougnon, N., & Michalak, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824270-4.00012-2 · Cited by 9 · see citing works
Parida, S., Jena, M., Behera, A. K., Mandal, A. K., Nayak, R., & Patra, S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673273106231208102105 · Cited by 9 · see citing works
Green and Environmentally Friendly Technologies to Develop Macroalgal Biorefineries
Mirzapour‐Kouhdasht, A., Taghizadeh, M. S., Niazi, A., & García‐Vaquero, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-65529-6_2 · Cited by 8 · see citing works
Chanthini, K. M.-P., & Senthil‐Nathan, S. (2024) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2024.102240 · Cited by 8 · see citing works
Biosorption of dye from synthetic wastewater using alga enriched in phenolic compounds
Deniz, F., & Kepekçi, R. A. (2015) · Environmental Progress & Sustainable Energy · doi:10.1002/ep.12286 · Cited by 8 · see citing works
Ivane, N. M. A., Ozoh, C. F., & Michelle, D. T. F. (2025) · Aquaculture International · doi:10.1007/s10499-025-01844-w · Cited by 8 · see citing works
Melchor-Martínez, E. M., Reyes, A. G., Peña‐Rodríguez, A., Delgado-Cortez, I. G., & Flores-Contreras, E. A. (2025) · Journal of Applied Phycology · doi:10.1007/s10811-025-03508-x · Cited by 7 · see citing works
Marine phenolics: Extractions at low pressure
Cotas, J., Pacheco, D., Monteiro, P., Gonçalves, A. M. M., & Pereira, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823589-8.00015-7 · Cited by 8 · see citing works
Bāliņa, K., Ivanovs, K., Romagnoli, F., & Blumberga, D. (2020) · Environmental and Climate Technologies · doi:10.2478/rtuect-2020-0065 · Cited by 7 · see citing works
Vandanjon, L., Déniel, M., Puspita, M., Douzenel, P., Stiger‐Pouvreau, V., Bedoux, G., & Bourgougnon, N. (2017) · Journal of Analytical Bioanalytical and Separation Techniques · doi:10.15436/2476-1869.17.1555 · Cited by 7 · see citing works
Extraction Technologies to Recover Dietary Polyphenols from Macro‐ and Microalgae
Shanmugam, M., Ganesan, A. R., & Rajauria, G. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch7 · Cited by 5 · see citing works
Seaweed-derived green hydrogels: advances, biomedical applications, and future perspectives-a review
Vijayakumar, D. (2026) · Polymer Bulletin · doi:10.1007/s00289-026-06378-6 · Cited by 4 · see citing works
Two-phase solvent extraction of phenolics from Origanum vulgare subsp. glandulosum
Krim, S., Rihani, R., Marchal, L., Foucault, A. P., Bentahar, F., & Legrand, J. (2020) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2020.100273 · Cited by 4 · see citing works
Extraction of marine phenolics using compressed fluids
Montero, L., Socas‐Rodríguez, B., Mendiola, J. A., & Ibáñez, E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823589-8.00007-8 · Cited by 4 · see citing works
Self-citation
- Authors
- Anaëlle, T., Serrano Leon, E., Laurent, V., Elena, I., Mendiola, J. A., Stéphane, C., Nelly, K., Stéphane, L. B., Luc, M., & Valérie, S.-P.
- Affiliations
- Instituto de Investigación en Ciencias de la Alimentación (ES)
- ORCID
- Mendiola, Jose A.
- Venue
- Talanta
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 104
- Pages
- 44-52
- ISSN
- 0039-9140 (ISSN-L)
- OpenAlex
- W2008473817
- Cited by
- 121
- References
- 53
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 8 · 2013: 2
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Talanta (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Ministère de l'Education Nationale, de l'Enseignement Supérieur et de Recherche
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- Sargassum muticum, brown macroalgae, phenolic compounds, extraction methods, supercritical fluid extraction, accelerated solvent extraction, green extraction, antioxidant activity, free radical scavenging, total phenolic content
- MeSH terms
- Antioxidants, Biphenyl Compounds, Magnetic Resonance Spectroscopy, Phenols, Picrates, Plant Extracts, beta Carotene, Sargassum, Green Chemistry Technology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
