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Endocytosis: the DUB version

Clague, Michael J., Urbé, Sylvie·2006·Trends in Cell Biology
DOI 10.1016/j.tcb.2006.09.002
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Abstract

Dynamic modification of endosomal cargo proteins, such as the epidermal growth factor receptor, by ubiquitin can regulate their sorting into the lumen of multivesicular bodies through interactions with a complex protein network incorporating the endosomal sorting complexes required for transport (ESCRTs). Two deubiquitinating enzymes, AMSH and UBPY, interact with ESCRT protein components but exert opposite effects upon the rate of epidermal growth factor receptor downregulation. This might reflect their distinct specificities for different types of polyubiquitin chain linkage. We propose that AMSH might rescue ubiquitinated cargo from lysosomal degradation through disassembly of K63-linked polyubiquitin chains. UBPY function is essential for effective downregulation but is likely to be multifaceted, encompassing activity against both K63-linked and K48-linked polyubiquitin chains and including regulation of the stability of ESCRT-associated proteins such as STAM, by reversing their ubiquitination.

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Research works printed but not linked: 70

  1. Pickart, 2004, Ubiquitin: structures, functions, mechanisms, Biochim. Biophys. Acta, 1695, 55, 10.1016/j.bbamcr.2004.09.019 · DOI
  2. Kirkpatrick, 2006, Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology, Nat Cell Biol, 8, 700, 10.1038/ncb1436 · DOI
  3. Hurley, 2006, THE ESCRT complexes: structure and mechanism of a membrane-trafficking network, Annu. Rev. Biophys. Biomol. Struct., 35, 277, 10.1146/annurev.biophys.35.040405.102126 · DOI · Paper page
  4. Futter, 1996, Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes, J. Cell Biol., 132, 1011, 10.1083/jcb.132.6.1011 · DOI
  5. Reggiori, 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting, EMBO J., 20, 5176, 10.1093/emboj/20.18.5176 · DOI · Paper page
  6. Galan, 1997, Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein, EMBO J., 16, 5847, 10.1093/emboj/16.19.5847 · DOI
  7. Haglund, 2003, Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation, Nat. Cell Biol., 5, 461, 10.1038/ncb983 · DOI · Paper page
  8. Mosesson, 2003, Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation, J. Biol. Chem., 278, 21323, 10.1074/jbc.C300096200 · DOI · Paper page
  9. Carter, 2004, The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity, J. Biol. Chem., 279, 52835, 10.1074/jbc.M407769200 · DOI
  10. Huang, 2006, Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain, Mol. Cell, 21, 737, 10.1016/j.molcel.2006.02.018 · DOI · Paper page
  11. Geetha, 2005, Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling, Mol. Cell, 20, 301, 10.1016/j.molcel.2005.09.014 · DOI
  12. Duncan, 2006, Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules, EMBO J., 25, 1635, 10.1038/sj.emboj.7601056 · DOI
  13. Thien, 2001, Cbl: many adaptations to regulate protein tyrosine kinases, Nat Rev. Mol. Cell. Biol., 2, 294, 10.1038/35067100 · DOI
  14. Nijman, 2005, A genomic and functional inventory of deubiquitinating enzymes, Cell, 123, 773, 10.1016/j.cell.2005.11.007 · DOI · Paper page
  15. Yao, 2002, A cryptic protease couples deubiquitination and degradation by the proteasome, Nature, 419, 403, 10.1038/nature01071 · DOI
  16. Verma, 2002, Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome, Science, 298, 611, 10.1126/science.1075898 · DOI
  17. Papa, 1999, Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome, Mol. Biol. Cell, 10, 741, 10.1091/mbc.10.3.741 · DOI
  18. Bowers, 2004, Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae, Traffic, 5, 194, 10.1111/j.1600-0854.2004.00169.x · DOI
  19. Amerik, 2000, The DoA4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways, Mol. Biol. Cell, 11, 3365, 10.1091/mbc.11.10.3365 · DOI
  20. Luhtala, 2004, Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes, J. Cell Biol., 166, 717, 10.1083/jcb.200403139 · DOI
  21. Swaminathan, 1999, The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast, Mol. Biol. Cell, 10, 2583, 10.1091/mbc.10.8.2583 · DOI
  22. Losko, 2001, Uptake of the ATP-binding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 mutant, Mol. Biol. Cell, 12, 1047, 10.1091/mbc.12.4.1047 · DOI
  23. Raiborg, 2002, Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes, Nat. Cell Biol., 4, 394, 10.1038/ncb791 · DOI · Paper page
  24. Urbé, 2003, The UIM domain of Hrs couples receptor sorting to vesicle formation, J. Cell Sci., 116, 4169, 10.1242/jcs.00723 · DOI · Paper page
  25. Bache, 2003, STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes, J. Biol. Chem., 278, 12513, 10.1074/jbc.M210843200 · DOI · Paper page
  26. Mizuno, 2003, STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif, Mol. Biol. Cell, 14, 3675, 10.1091/mbc.E02-12-0823 · DOI
  27. Clague, 2003, Hrs function: viruses provide the clue, Trends Cell Biol., 13, 603, 10.1016/j.tcb.2003.10.002 · DOI
  28. Sachse, 2002, Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes, Mol. Biol. Cell, 13, 1313, 10.1091/mbc.01-10-0525 · DOI · Paper page
  29. Clague, 2002, Membrane transport: a coat for ubiquitin, Curr. Biol., 12, R529, 10.1016/S0960-9822(02)01030-8 · DOI
  30. Kato, 2000, A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP, J. Biol. Chem., 275, 37481, 10.1074/jbc.M007251200 · DOI · Paper page
  31. McCullough, 2006, Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery, Curr. Biol., 16, 160, 10.1016/j.cub.2005.11.073 · DOI
  32. Tanaka, 1999, Possible involvement of a novel STAM-associated molecule ‘AMSH’ in intracellular signal transduction mediated by cytokines, J. Biol. Chem., 274, 19129, 10.1074/jbc.274.27.19129 · DOI
  33. Kaneko, 2003, Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain, J. Biol. Chem., 278, 48162, 10.1074/jbc.M306677200 · DOI · Paper page
  34. Maytal-Kivity, 2002, MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function, BMC Biochem., 3, 28, 10.1186/1471-2091-3-28 · DOI
  35. Scott, 2005, Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A, Proc. Natl. Acad. Sci. U. S. A., 102, 13813, 10.1073/pnas.0502165102 · DOI
  36. Tsang, 2006, A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex, Genomics, 88, 333, 10.1016/j.ygeno.2006.04.003 · DOI
  37. McCullough, 2004, AMSH is an endosome-associated ubiquitin isopeptidase, J. Cell Biol., 166, 487, 10.1083/jcb.200401141 · DOI
  38. Mizuno, 2005, Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes, Mol. Biol. Cell, 16, 5163, 10.1091/mbc.E05-06-0560 · DOI · Paper page
  39. Kee, 2005, The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme, EMBO J., 24, 2414, 10.1038/sj.emboj.7600710 · DOI
  40. Nakamura, 2006, Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes, Genes Cells, 11, 593, 10.1111/j.1365-2443.2006.00963.x · DOI
  41. Agromayor, 2006, Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo, J. Biol. Chem., 281, 23083, 10.1074/jbc.M513803200 · DOI
  42. Raiborg, 2001, Hrs recruits clathrin to early endosomes, EMBO J., 20, 5008, 10.1093/emboj/20.17.5008 · DOI
  43. Kikuchi, 2003, Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif, Biochem. Biophys. Res. Commun., 306, 637, 10.1016/S0006-291X(03)01009-X · DOI
  44. Ibarrola, 2004, Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling, BMC Cell Biol., 5, 2, 10.1186/1471-2121-5-2 · DOI
  45. Kitajima, 2003, A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells, Biochem. Biophys. Res. Commun., 309, 135, 10.1016/S0006-291X(03)01550-X · DOI
  46. Bowers, 2006, Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII, J. Biol. Chem., 281, 5094, 10.1074/jbc.M508632200 · DOI · Paper page
  47. Schmitz, 2005, The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway, Mol. Biol. Cell, 16, 1319, 10.1091/mbc.E04-05-0425 · DOI
  48. Garrus, 2001, Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding, Cell, 107, 55, 10.1016/S0092-8674(01)00506-2 · DOI · Paper page
  49. Odorizzi, 1998, Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body, Cell, 95, 847, 10.1016/S0092-8674(00)81707-9 · DOI · Paper page
  50. Onishi, 2003, Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe, Biosci. Biotechnol. Biochem., 67, 1772, 10.1271/bbb.67.1772 · DOI
  51. Chen, 2005, Ubiquitin signalling in the NF-κB pathway, Nat. Cell Biol., 7, 758, 10.1038/ncb0805-758 · DOI · Paper page
  52. Clague, 2001, The interface of receptor trafficking and signalling, J. Cell Sci., 114, 3075, 10.1242/jcs.114.17.3075 · DOI
  53. Ishii, 2001, Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice, Mol. Cell. Biol., 21, 8626, 10.1128/MCB.21.24.8626-8637.2001 · DOI
  54. Wagner, 2006, Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes, EMBO J., 25, 752, 10.1038/sj.emboj.7600988 · DOI
  55. Asada, 1999, Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT, J. Exp. Med., 189, 1383, 10.1084/jem.189.9.1383 · DOI
  56. Itoh, 2001, Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads, EMBO J., 20, 4132, 10.1093/emboj/20.15.4132 · DOI
  57. Wicks, 2005, The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling, Oncogene, 24, 8080, 10.1038/sj.onc.1208944 · DOI
  58. Li, 2004, An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein, Oncogene, 23, 1801, 10.1038/sj.onc.1207319 · DOI
  59. Tong, 2002, A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules, Science, 295, 321, 10.1126/science.1064987 · DOI
  60. Naviglio, 1998, UBPY: a growth-regulated human ubiquitin isopeptidase, EMBO J., 17, 3241, 10.1093/emboj/17.12.3241 · DOI · Paper page
  61. Row, 2006, The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation, J. Biol. Chem., 281, 12618, 10.1074/jbc.M512615200 · DOI · Paper page
  62. Kanazawa, 2003, Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation, Biochem. Biophys. Res. Commun., 309, 848, 10.1016/j.bbrc.2003.08.078 · DOI · Paper page
  63. Bilodeau, 2002, The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting, Nat. Cell Biol., 4, 534, 10.1038/ncb815 · DOI
  64. Mizuno, 2006, A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes, Traffic, 7, 1017, 10.1111/j.1600-0854.2006.00452.x · DOI
  65. Di Fiore, 2003, When ubiquitin meets ubiquitin receptors: a signalling connection, Nat. Rev. Mol. Cell Biol., 4, 491, 10.1038/nrm1124 · DOI
  66. Soares, 2004, Two isoforms of otubain 1 regulate T cell anergy via GRAIL, Nat. Immunol., 5, 45, 10.1038/ni1017 · DOI
  67. Wu, 2004, Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8, Mol. Cell. Biol., 24, 7748, 10.1128/MCB.24.17.7748-7757.2004 · DOI · Paper page
  68. Gnesutta, 2001, Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1, J. Biol. Chem., 276, 39448, 10.1074/jbc.M103454200 · DOI
  69. Rape, 2006, The processivity of multiubiquitination by the APC determines the order of substrate degradation, Cell, 124, 89, 10.1016/j.cell.2005.10.032 · DOI
  70. von Schwedler, 2003, The protein network of HIV budding, Cell, 114, 701, 10.1016/S0092-8674(03)00714-1 · DOI

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Metadata

Authors
Clague, M. J., & Urbé, S.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2006-11
Volume
16
Issue
11
Pages
551-559
ISSN
0962-8924
DOI
10.1016/j.tcb.2006.09.002
Cited by
244
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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