The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Epigenetic flexibility in metabolic regulation: disease cause and prevention
Abstract
Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone modifications are thought to play an important role in the development of and predisposition to metabolic diseases. This review highlights the key functions of DNA methylation and histone modifications and elucidates the underlying mechanisms of in utero programming and epigenetic inheritance, which could account for the global increase in obesity and T2DM. The impact of exercise and nutrition on the tissue-specific epigenetic profile is discussed, because these lifestyle factors may modify epigenetic programming and predisposition to obesity and T2DM.
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“Short-term, high-intensity exercise decreases muscle promoter methylation of genes involved in mitochondrial function such as PGC1α, TFAM, MEF2A, and PDK4, whereas in patients with T2DM, these regions usually have higher methylation levels (137).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [137]
Citations
Cites
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787
The nexus of chromatin regulation and intermediary metabolism
Gut, P., & Verdin, E. M. (2013) · Nature · doi:10.1038/nature12752 · Cited by 431
Drug-induced liver injury: Interactions between drug properties and host factors
Chen, M., Suzuki, A., Borlak, J. T., Andrade, R. J., & Lucena, M. I. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.016 · Cited by 410
“Host factors influencing mitochondrial functions are listed in Table 1 [26,69,70].”
BackgroundObesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
Kim, A. Y., Park, Y. J., Pan, X., Shin, K. C., Kwak, S., Bassas, A. F., Sallam, R. M., Park, K. S., Alfadda, A. A., Xu, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8585 · Cited by 241
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Barrès, R., & Zierath, J. R. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.87 · Cited by 198
Metadata
- Authors
- Kirchner, H., Osler, M. E., Krook, A., & Zierath, J. R.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Zierath, Juleen R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 23
- Issue
- 5
- Pages
- 203-209
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2082220761
- Cited by
- 143
- References
- 69
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 15 · 2015: 19 · 2014: 19 · 2013: 7
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, DNA methylation, histone modifications, metabolic disorders, type 2 diabetes, obesity, in utero programming, epigenetic inheritance, physical activity, nutrition, disease prevention
- MeSH terms
- Diabetes Mellitus, Type 2, Environment, Female, Fetal Growth Retardation, Histones, Humans, Life Style, Obesity, Pregnancy, Exercise, DNA Methylation, Genetic Predisposition to Disease, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development
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