The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Epigenetic flexibility in metabolic regulation: disease cause and prevention
Abstract
Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone modifications are thought to play an important role in the development of and predisposition to metabolic diseases. This review highlights the key functions of DNA methylation and histone modifications and elucidates the underlying mechanisms of in utero programming and epigenetic inheritance, which could account for the global increase in obesity and T2DM. The impact of exercise and nutrition on the tissue-specific epigenetic profile is discussed, because these lifestyle factors may modify epigenetic programming and predisposition to obesity and T2DM.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Short-term, high-intensity exercise decreases muscle promoter methylation of genes involved in mitochondrial function such as PGC1α, TFAM, MEF2A, and PDK4, whereas in patients with T2DM, these regions usually have higher methylation levels (137).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [137]
Citations
Cites
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
He, Y., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,776
Flagged first, then by citations
1 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787
The nexus of chromatin regulation and intermediary metabolism
Gut, P., & Verdin, E. M. (2013) · Nature · doi:10.1038/nature12752 · Cited by 431
Drug-induced liver injury: Interactions between drug properties and host factors
Chen, M., Suzuki, A., Borlak, J. T., Andrade, R. J., & Lucena, M. I. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.016 · Cited by 410
“Host factors influencing mitochondrial functions are listed in Table 1 [26,69,70].”
BackgroundObesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
Kim, A. Y., Park, Y. J., Pan, X., Shin, K. C., Kwak, S., Bassas, A. F., Sallam, R. M., Park, K. S., Alfadda, A. A., Xu, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8585 · Cited by 241
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Barrès, R., & Zierath, J. R. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.87 · Cited by 198
Tan, X. W., Chapman, C. D., Cedernaes, J., & Benedict, C. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.11.001 · Cited by 202
vel Szic, K. S., Declerck, K., Vidaković, M., & Vanden Berghe, W. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0068-2 · Cited by 192
“dehydrogenase kinase; AKT/PKB, protein kinase B; PGC1, peroxisome proliferat metabolism, cellular signaling, and the epigenetic control of transcription programs [108-116] (Figure 3).”
BackgroundKirchner, H., Sinha, I., Gao, H., Ruby, M. A., Schönke, M., Lindvall, J. M., Barrès, R., Krook, A., Näslund, E. B., Dahlman‐Wright, K., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.004 · Cited by 141
“Since DNA methylation can lead to stable alterations in the transcriptional potential, epigenetic mechanisms may partly explain the rapidly increasing prevalence of type 2 diabetes [23].”
BackgroundNanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health
Smolková, B., Yamani, N. E., Collins, A. R., Gutleb, A. C., & Dušinská, M. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.12.015 · Cited by 138
“Aberrant DNA methylation was also associated with osteoarthritis (Fernández-Tajes et al., 2014) and cardiovascular disease (Kim et al., 2013), pre-eclampsia (Anderson et al., 2013), rheumatoid arthritis (Liu et al., 2013) and metabolic disorders (Bruce and Cagampang, 2011; Kirchner et al., 2013).”
BackgroundBromodomains and Their Pharmacological Inhibitors
Gallenkamp, D., Gelato, K. A., Haendler, B., & Weinmann, H. (2014) · ChemMedChem · doi:10.1002/cmdc.201300434 · Cited by 129
Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney
Marumo, T., Yagi, S., Kawarazaki, W., Nishimoto, M., Ayuzawa, N., Watanabe, A., Ueda, K., Hirahashi, J., Hishikawa, K., Sakurai, H., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014070665 · Cited by 118
Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond
Cheng, Z., Zheng, L., & Almeida, F. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.004 · Cited by 117
“The recognition of epigenetic reprogramming in metabolic diseases has stimulated the interest in identifying epigenetic markers for diagnosis and intervention assessment [24,39,115,127,128].”
Backgrounddos Santos, J. M., Moreli, M. L., Tewari, S., & Benite‐Ribeiro, S. A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.09.013 · Cited by 108
Stephens, N. A., & Sparks, L. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2545 · Cited by 102
“A recent review by Kirchner et al (106) about epigenetic flexibility in metabolic regulation emphasizes the need for a better understanding of lifestyle factors—such as exercise training or lack thereof—that may modify epigenetic programming and a predisposition to conditions such as exercise resistance (Figure 1).”
BackgroundGillberg, L., Perfilyev, A., Brøns, C., THOMASEN, M. L., Grunnet, L. G., Volkov, P., Rosqvist, F., Iggman, D., Dahlman, I. A., Risérus, U., et al. (2016) · Diabetologia · doi:10.1007/s00125-015-3852-9 · Cited by 99
Zhao, H., Ding, T., Ren, Y., Li, T., Li, R., Fan, Y., Yan, J., Zhao, Y., Li, M., Yu, Y., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dev345 · Cited by 79
Vähämiko, S., Laiho, A., Lund, R., Isolauri, E., Salminen, S., & Laitinen, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1601-1 · Cited by 77
“In particular, when occurring in utero or during the early neonatal stages, these changes in DNA methylation have been postulated to induce long-term changes in gene expression and further to act as causative agents for lifelong effects on health [10, 11].”
BackgroundJacobsen, S. C., Gillberg, L., Bork‐Jensen, J., Ribel‐Madsen, R., Lara, E., Calvanese, V., Ling, C., Fernández, A. F., Fraga, M. F., Poulsen, P., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3198-8 · Cited by 72
“The involvement of tissue-specific DNA methylation in the pathogenesis of type 2 diabetes is supported by several studies [2–4].”
BackgroundResultAltered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner, H., Nylén, C., Laber, S., Barrès, R., Yan, J., Krook, A., Zierath, J. R., & Näslund, E. B. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.12.019 · Cited by 72
“Epigenetic gene regulation plays a role in the pathogenesis of metabolic diseases, such as obesity and type 2 diabetes [1].”
BackgroundGuéant, J., Akoum, R. E., Ziegler, O., Coelho, D., Feigerlová, E., Daval, J., & Guéant‐Rodriguez, R. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1339-4 · Cited by 69
“Consistently, sedentary lifestyle and lack of physical activity may modify epigenetic programming and predisposition to obesity and T2DM, as recently reviewed [94].”
BackgroundOrtega, J. G., Echeverri, I., Plata, C. A., & Castillo, A. (2014) · Nutrition Reviews · doi:10.1093/nutrit/nuu001 · Cited by 63
Grilo, L. F., Tocantins, C., Diniz, M. S., Gomes, R. M., Oliveira, P. J., Matafome, P. N., & Pereira, S. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13625 · Cited by 67
Gu, T., Gu, H. F., Hilding, A., Sjöholm, L. K., Östenson, C.-G., Ekström, T. J., & Brismar, K. (2013) · Clinical Epigenetics · doi:10.1186/1868-7083-5-21 · Cited by 58
“Therefore, epigenetic studies may provide further information to give a better understanding of the pathogenesis of type 2 diabetes [4-6].”
BackgroundSeman, N. A., Mohamud, W. N. W., Östenson, C., Brismar, K., & Gu, H. F. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0049-5 · Cited by 53
“Epigenetic factors mainly including DNA methylation changes have been considered to be involved in the pathogenesis of T2D [13-15].”
BackgroundRecent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances
Ning, C., Jiao, Y., Wang, J., Li, W., Zhou, J., Lee, Y., Ma, D., Leung, C., Zhu, R., & Wang, H. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.04.004 · Cited by 58
Naidoo, V., Naidoo, M., & Ghai, M. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12723 · Cited by 51
“A genome‐wide association studies (GWASs) identified genes which accounted for just 10% of the heritable risk for T2DM, whilst the remaining “missing” heritability could be contributed by rare variants, gene‐environment interactions, gene‐gene interactions and epigenetic factors.(8) Altered DNAm as well as decreased e…”
BackgroundUnderstanding type 2 diabetes: from genetics to epigenetics
Raciti, G. A., Longo, M., Parrillo, L., Ciccarelli, M., Mirra, P., Ungaro, P., Formisano, P., Miele, C., & Bèguinot, F. (2015) · Acta Diabetologica · doi:10.1007/s00592-015-0741-0 · Cited by 52
“modifications of the DNA [1].”
Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
Liu, J., Lang, G.-P., & Shi, J. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s291932 · Cited by 49
Personalized Medicine and Type 2 Diabetes: Lesson from Epigenetics
Raciti, G. A., Nigro, C., Longo, M., Parrillo, L., Miele, C., Formisano, P., & Bèguinot, F. (2014) · Epigenomics · doi:10.2217/epi.14.10 · Cited by 49
Post‐translational modifications of the cardiac proteome in diabetes and heart failure
Wende, A. R. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500052 · Cited by 50
“Although epigenetics can be transgenerational [57], the associated modifications can be dynamically regulated by lifestyle [58].”
BackgroundBourlier, V., Saint-Laurent, C., Louche, K., Badin, P.-M., Thalamas, C., de Glisezinski, I., Langin, D., Sengenès, C., & Moro, C. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-1727 · Cited by 51
“Lifestyle factors such as exercise and nutrition could influence epigenetic metabolic programming of muscle cells and predisposition to obesity and T2DM, as recently discussed (29).”
BackgroundEpigenetic inheritance of metabolic state
Palu, R. A. S., & Thummel, C. S. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.008 · Cited by 44
“Because these chromatin marks tend to be more dynamic than DNA methylation, their levels have not been examined as closely [25].”
BackgroundSen, S., Sanyal, S., Srivastava, D. K., Dasgupta, D., Roy, S., & Das, C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.786863 · Cited by 37
“Further, alteration in H3K4Me2/3 status in the adipocyte cells has been reported in T2D patients (11).”
BackgroundInfluentialMaternal diabetes, programming of beta-cell disorders and intergenerational risk of type 2 diabetes
Chavey, A., Kioon, M. D. A., Bailbé, D., Movassat, J., & Portha, B. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.02.003 · Cited by 43
“However, recent research has provided vidence that epigenetic mechanisms are flexible, allowing rapid daptation to a changing environment such as altered nutrition, nd may contribute to the development and transgenerational nheritance of obesity and T2D [69].”
BackgroundMałodobra-Mazur, M., Dziewulska, A., Koziński, K., Dobrzyń, P., Kolczyńska, K., Janikiewicz, J., & Dobrzyń, A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.08.005 · Cited by 37
Elevated CpG island methylation of GCK gene predicts the risk of type 2 diabetes in Chinese males
Tang, L., Ye, H., Hong, Q., Wang, L., Wang, Q., Wang, H., Xu, L., Bu, S., Zhang, L., Cheng, J. R., et al. (2014) · Gene · doi:10.1016/j.gene.2014.06.062 · Cited by 36
Kijimoto, T., Snell‐Rood, E. C., Pespeni, M. H., Rocha, G., Kafadar, K., & Moczek, A. P. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2084 · Cited by 36
“Moreover, dysfunctional nutrition-dependent gene expression is thought to underlie many human diseases such as diabetes, obesity, Crohn’s disease and possibly even cancer [4–8].”
BackgroundOlioso, D., Dauriz, M., Bacchi, E., Negri, C., Santi, L., Bonora, E., & Moghetti, P. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01820 · Cited by 39
“The effect of environmental factors on metabolic regulation has recently gained molecular rationale by insights brought by epigenetics (6, 7).”
Epigenetics and Helicobacter pylori
Capparelli, R., & Iannelli, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031759 · Cited by 35
“In addition to cancer, epigenetics also influences infectious diseases (see below) and metabolic diseases (type 2 diabetes, obesity, cardiovascular diseases) [24,25].”
BackgroundEnquobahrie, D. A., Moore, A. L., Muhie, S. Y., Tadesse, M. G., Lin, S., & Williams, M. A. (2015) · Reproductive Sciences · doi:10.1177/1933719115570903 · Cited by 33
“Variations in DNA methylation have been associated with the pathogenesis of metabolic diseases, including type 2 diabetes (T2D).(2,3) Gestational diabetes mellitus (GDM), abnormal glucose metabolism first diagnosed during pregnancy, is a complex disorder that shares risk factors and pathophysiological characteristics…”
BackgroundThe metabolic-epigenetic nexus in type 2 diabetes mellitus
Davison, G. W., Irwin, R. E., & Walsh, C. P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.025 · Cited by 35
Association of Interleukin-10 Methylation Levels With Gestational Diabetes in a Taiwanese Population
Kang, J., Lee, C., Li, H., Hsu, K.-H., Wang, S., & Lin, S. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00222 · Cited by 30
Mudry, J. M., Lassiter, D. G., Nylén, C., García-Calzón, S., Näslund, E. B., Krook, A., & Zierath, J. R. (2016) · Diabetes · doi:10.2337/db16-0882 · Cited by 32
“Skeletal muscle insulin resistance may arise in part from a dysfunctional metabolic program, either of an epigenetic or genetic origin (6).”
BackgroundNilsson, E., Ernst, B., Voisin, S. A. C., Almén, M. S., Benedict, C., Mwinyi, J., Fredriksson, R., Schultes, B., & Schiöth, H. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115186 · Cited by 30
“These findings may form the basis for further investigations to unravel the molecular effects of gastric bypass surgery, as epigenetic modifications are proposed to play an important role in the development of metabolic diseases, including type 2 diabetes and obesity [15].”
BackgroundKasch, J., Kanzleiter, I., Saussenthaler, S., Schürmann, A., Keijer, J., van Schothorst, E. M., Klaus, S., & Schumann, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.015 · Cited by 30
Ciccarelli, M., Vastolo, V., Albano, L., Lecce, M., Cabaro, S., Liotti, A., Longo, M., Oriente, F., Russo, G. L., Macchia, P. E., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3774-6 · Cited by 30
“understanding of the molecular events involved in the remarkable impact of the environment on type 2 diabetes risk [12, 13]”
BackgroundHernández‐Aguilera, A., Fernández‐Arroyo, S., Cuyàs, E., Luciano‐Mateo, F., Cabré, N., Camps, J., López‐Miranda, J., Menéndez, J. A., & Joven, J. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.08.006 · Cited by 30
“Therefore, available data provide evidence that diet-induced metabolic changes might influence preconceptional behavior (Kirchner et al., 2013; Patti, M AN US CR IP T AC CE PT ED 28 2013), but mechanistic insights are not sufficient to explain the overall picture.”
BackgroundBengtsen, M., Winje, I. M., Eftestøl, E., Landskron, J., Sun, C., Nygård, K., Domańska, D., Millay, D. P., Meza‐Zepeda, L. A., & Gundersen, K. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009907 · Cited by 26
“Epigenetic mechanisms like histone modifications and chromatin structure have been suggested to play an important role in the development of and predisposition for metabolic syndrome [12], but data supporting this is currently scarce.”
BackgroundEpigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predisposition
Sterns, J. D., Smith, C. B., Steele, J. R., Stevenson, K. L., & Gallicano, G. I. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00015 · Cited by 27
“…interplays with the enormous epigenetic variation induced postnatally by various environmental stimuli and aging, pharmaceutical intervention, and lifestyle choices such as exercise (Fraga et al., 2005; Kaminsky et al., 2009; Pinney et al., 2011; Nitert et al., 2012; Kirchner et al., 2013).”
BackgroundResultA decrease in hepatic microRNA-9 expression impairs gluconeogenesis by targeting FOXO1 in obese mice
Yan, C., Chen, J., Li, M., Xuan, W., Su, D., You, H., Huang, Y., Chen, N., & Liang, X. (2016) · Diabetologia · doi:10.1007/s00125-016-3932-5 · Cited by 28
“Recent research has shown that epigenetic DNA modifications contribute to the development of type 2 diabetes [22, 23].”
BackgroundAberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Oba, S., Ayuzawa, N., Nishimoto, M., Kawarazaki, W., Ueda, K., Hirohama, D., Kawakami-Mori, F., Shimosawa, T., Marumo, T., & Fujita, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-34612-3 · Cited by 29
Woelfel, J. R., Dudley‐Javoroski, S., & Shields, R. K. (2018) · Physical Therapy · doi:10.1093/ptj/pzy092 · Cited by 25
Inflammation, Advancing Age and Nutrition
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-08000-6 · Cited by 25
“intercellular/extracellular energetic status, nutrientresponsive metabolites, such as ATP, acetyl-CoA, UDP-N-acetylglucosamine (UDP-GlcNAc), and SAM, mediate crosstalk between metabolism, cellular signaling, and epigenetic control of transcriptional programs [40–48].”
BackgroundYonamine, C. Y., Alves-Wagner, A. B., Esteves, J. V. D. C., Okamoto, M. M., Corrêa‐Giannella, M. L., Giannella‐Neto, D., & Machado, U. F. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.11.006 · Cited by 23
Geißler, C., Krause, C., Neumann, A., Britsemmer, J. H., Taege, N., Grohs, M., Kaehler, M., Cascorbi, I., Lewis, A. G., Seeley, R. J., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108907 · Cited by 22
Social Environment and Epigenetics
Merrill, S. M., Gladish, N., & Kobor, M. S. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_114 · Cited by 24
The effect of diet on the intestinal epigenome
Johnson, I. T., & Belshaw, N. J. (2014) · Epigenomics · doi:10.2217/epi.14.8 · Cited by 21
BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males
Tang, L., Wang, L., Ye, H., Xu, X., Hong, Q., WANG, H., Xu, L., Bu, S., Zhang, L., Cheng, J. R., et al. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1783 · Cited by 21
“DNA methylation and histone modification have become alternative approaches that have aided the understanding of β -cell dysfunction in the pathogenesis (11) and the high growth rate of T2D (12).”
Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy
Witasp, A., Luttropp, K., Qureshi, A. R., Barany, P. F., Heimbürger, O., Wennberg, L. M., Ekström, T. J., Shiels, P. G., Stenvinkel, P., & Nordfors, L. (2022) · Scientific Reports · doi:10.1038/s41598-021-04321-5 · Cited by 20
Epigenetic Downregulation of FASN in Visceral Adipose Tissue of Insulin Resistant Subjects
Sievert, H., Krause, C., Geißler, C., Grohs, M., Gammal, A. T. E., Wolter, S., Mann, O., Lehnert, H., & Kirchner, H. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1150-7446 · Cited by 20
Yonamine, C. Y., Passarelli, M., Suemoto, C. K., Pasqualucci, C. A., Filho, W. J., Alves, V. A. F., Marie, S. K. N., Corrêa‐Giannella, M. L., Britto, L. R., & Machado, U. F. (2023) · Cells · doi:10.3390/cells12091250 · Cited by 18
“Among PTMs, lysine acetylation of histone 3 and 4 (H3Kac, H4Kac) are the most studied [64], and changes in H3Kac content have already been reported to be triggered by DM in the Slc2a4 promoter, accompanying a reduction in muscle Slc2a4/GLUT4 expression [51,65].”
BackgroundKhatun, M., Lundin, K., Naillat, F., Loog, L., Saarela, U., Tuuri, T., Salumets, A., Piltonen, T., & Tapanainen, J. S. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10627-w · Cited by 20
“Epigenetic alterations and both heritable and non-heritable changes in gene expression not affecting underlying DNA sequences, have also been offered as a possible explanation for missing heritability in this complex metabolic disorder [79, 84, 85].”
BackgroundTranscriptional and epigenetic control of adipocyte remodeling during obesity
Barilla, S., Treuter, E., & Venteclef, N. (2021) · Obesity · doi:10.1002/oby.23248 · Cited by 20
“DNA methylation can potentially be the result of the interaction between genetics and the environment, which can influence metabolic homeostasis and predispose one to metabolic disease (84).”
BackgroundPrenatal inflammation exposure-programmed cardiovascular diseases and potential prevention
Deng, Y., Song, L., Nie, X., Shou, W., & Li, X. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.009 · Cited by 18
Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine
Zhang, W., Liu, S., Han, D., & He, Z. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.034 · Cited by 17
Deligiannidou, G.-E., Athina, S., Berghe, W. V., Christos, K., & Constantinides, T. K. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1573407215666190628150921 · Cited by 17
Huang, C.-C., Chen, M., Lan, C.-W., Wu, C.-E., Huang, M.-C., Kuo, H., & Ho, H. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.05.004 · Cited by 17
Yan, L., Huang, J., Xie, Z., Wang, C., Li, Y., Hua, Y., Liu, C., & Yuan, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1282077 · Cited by 15
Esefeld, K., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Thurm, U., Gehr, B., Brinkmann, C. K., & Halle, M. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1284-6097 · Cited by 17
Embryonic programming of heart disease in response to obesity during pregnancy
Ahmed, A., & Delgado-Olguı́n, P. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.028 · Cited by 15
Lü, X., Hu, S., Liao, Y., Zheng, J., Zeng, T., Zhong, X., Liu, G., Gou, L., & Chen, L. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00090.2020 · Cited by 14
Terra, M. M., Fontoura, T. S., Nogueira, A. O., Lopes, J. F., Mathias, P. C. D. F., Andreazzi, A. E., Guerra, M. D. O., & Peters, V. M. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000503 · Cited by 13
Guarasci, F., D’Aquila, P., Montesanto, A., Corsonello, A., Bellizzi, D., & Passarino, G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191112095655 · Cited by 14
Davis, R., Murgia, C., Dordevic, A. L., Bonham, M. P., & Huggins, C. E. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.011 · Cited by 13
Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity
Wang, D., Kuang, Y., Zhang, G., Xiao, K., & Liu, Y. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac080 · Cited by 12
Kemmer, F., Halle, M., Stümvoll, M., Thurm, U., & Zimmer, P. (2011) · Diabetologie und Stoffwechsel · doi:10.1055/s-0031-1283771 · Cited by 12
Current epigenetic aspects the clinical kidney researcher should embrace
Witasp, A., Craenenbroeck, A. H. V., Shiels, P. G., Ekström, T. J., Stenvinkel, P., & Nordfors, L. (2017) · Clinical Science · doi:10.1042/cs20160596 · Cited by 13
Varghese, D. S., Alawathugoda, T. T., Sheikh, M. A., Challagandla, A. K., Emerald, B. S., & Ansari, S. A. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05125-9 · Cited by 12
“Identifying epigenetic biomarkers in individuals with a genetic predisposition to obesity could be considered to avoid further exacerbation due to geneenvironment interactions [27].”
BackgroundKernel machine methods for integrative analysis of genome‐wide methylation and genotyping studies
Zhao, N., Zhan, X., Huang, Y., Almli, L. M., Smith, A. K., Epstein, M. P., Conneely, K. N., & Wu, M. C. (2017) · Genetic Epidemiology · doi:10.1002/gepi.22100 · Cited by 11
“The etiology for most common human diseases is believed to be multifactorial, with risk factors including heritable genetic variants as well as environmental, behavioral factors and possible interactions between them (Luzzatto and Pandolfi, 2015; Kirchner et al., 2013).”
BackgroundHigh-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion
Shiratori, H., Feinweber, C., Knothe, C., Lötsch, J., Thomas, D., Geißlinger, G., Parnham, M. J., & Resch, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163184 · Cited by 11
Sen, D., Maniyadath, B., Chowdhury, S., Kaur, A., Khatri, S., Chakraborty, A., Mehendale, N., Nadagouda, S., Sandra, U. S., Kamat, S. S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107128 · Cited by 9
Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine
Baghel, R., Maan, K., Haritwal, T., & Rana, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85652-2.00002-6 · Cited by 10
Metaboloepigenetics: The Emerging Network in Stem Cell Homeostasis Regulation
Avitabile, D., Magenta, A., Lauri, A., Gambini, E., Spaltro, G., & Vinci, M. C. (2016) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x11666151203223839 · Cited by 10
Epigenetic regulation and heart failure
Cao, D. J. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.942285 · Cited by 10
“The offspring of these parents were predisposed to develop obesity and Type 2 diabetes [108].”
BackgroundChildhood obesity: a (re) programming disease?
Paes, S. T., Gonçalves, C. F., Terra, M. M., Fontoura, T. S., Guerra, M. D. O., Peters, V. M., Mathias, P. C. D. F., & Andreazzi, A. E. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415007837 · Cited by 9
“Consequently, this can either enhance or silence the expression of genes affecting body weight control and appetite.(24,29) It is necessary to develop and encourage preventive measures and attenuation of the incidence of obesity in the early periods of life, as the early adoption of positive metabolic stimuli could ev…”
BackgroundInfluentialVascular Smooth Muscle as a Target for Novel Therapeutics
Porter, K. E., & Riches‐Suman, K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0647-9 · Cited by 8
Esefeld, K., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Thurm, U., Gehr, B., Brinkmann, C. K., & Halle, M. (2021) · Diabetologie und Stoffwechsel · doi:10.1055/a-1515-8792 · Cited by 8
Oelkrug, R., Herrmann, B., Geißler, C., Harder, L., Koch, C. E., Lehnert, H., Oster, H., Kirchner, H., & Mittag, J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.016 · Cited by 7
S-Nitrosoglutathione Reverts Dietary Sucrose-Induced Insulin Resistance
Sousa‐Lima, I., Fernandes, A. B., Patarrão, R. S., Kim, Y., & Macedo, M. P. (2020) · Antioxidants · doi:10.3390/antiox9090870 · Cited by 8
“The development of T2D is now agreed to be a consequence of both lifestyle and genetic background [2,3].”
BackgroundInsulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes
Hafez, S. M., Abou‐Youssef, H. S., Awad, M. A. M., Kamel, S. A., Youssef, R. N., Elshiekh, S. M., Raslan, H. M., & Hasan, N. S. (2021) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-021-00153-0 · Cited by 8
“Due to the limited information provided on epigenetic factors associated with T2D until now, further epigenetic studies have been required, to help in better understand T2D pathogenesis [4].”
BackgroundDeriving at candidate genes of metabolic stress from pancreas of WNIN/GR-Ob mutant rats
Singh, H., Nappanveettil, G., Bhonde, R. R., & Venkatesan, V. (2013) · Islets · doi:10.4161/isl.25520 · Cited by 6
Esefeld, K., Heinicke, V., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Brinkmann, C. K., & Halle, M. (2020) · Ernährung & Medizin · doi:10.1055/a-1126-9975 · Cited by 5
Esefeld, K., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Thurm, U., Gehr, B., Halle, M., & Brinkmann, C. K. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1946-3768 · Cited by 7
Lu, X., Lou, Y., Zhou, K., Jiang, S., & Shi, J. (2022) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2022.2057534 · Cited by 5
“In other words, metabolic diseases maybe related with the DNA character.[30] So, the binding interaction of FBST with DNA has great significance for further understanding the pharmacological and toxicological functions of FBST.”
Transcriptome profiling of liver of non-genetic low birth weight and long term health consequences
Bedate, A. M., López‐Cardona, A. P., Laguna‐Barraza, R., Calle, A., López‐Vidriero, I., Pintado, B., & Gutiérrez‐Adán, A. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-327 · Cited by 4
“The mechanisms whereby an event that occurs early in life may have long term effects on the phenotype of an organism many years later are only now starting to emerge [14-17].”
BackgroundSleep disorders interactions with obesity and type 2 diabetes
Brodovskaya, T. O., Grishina, I. F., Babykina, G., Николаенко, О. В., Kovin, E. A., Bazhenova, O. V., Beresneva, V. E., & Buharova, S. Y. (2019) · Obesity and metabolism · doi:10.14341/omet9963 · Cited by 5
Esefeld, K., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Thurm, U., Gehr, B., Brinkmann, C. K., & Halle, M. (2020) · Diabetologie und Stoffwechsel · doi:10.1055/a-1193-3901 · Cited by 4
Hasan, N. S., Dine, H. G. E., Kamel, S. A., Hamed, M., Youssef, R. N., Hassan, E. M., Abdelrahman, A. H., Musa, N. I., Ali, A., & Awadallah, E. A. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110677 · Cited by 3
Esefeld, K., Heinicke, V., Kreß, S., Behrens, M., Zimmer, P., Stümvoll, M., Brinkmann, C. K., & Halle, M. (2020) · Der Diabetologe · doi:10.1007/s11428-020-00610-1 · Cited by 3
Early introduction of exercise prevents insulin resistance in postnatal overfed rats
Fischer, S. V., Appel, M. H., Naliwaiko, K., Pagliosa, D. D., Araújo, D. N., Capote, A. E., Oliveira, B. A. C., & Fernandes, L. C. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e11987 · Cited by 2
Metadata
- Authors
- Kirchner, H., Osler, M. E., Krook, A., & Zierath, J. R.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Zierath, Juleen R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 23
- Issue
- 5
- Pages
- 203-209
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2082220761
- Cited by
- 143
- References
- 69
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 15 · 2015: 19 · 2014: 19 · 2013: 7
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, DNA methylation, histone modifications, metabolic disorders, type 2 diabetes, obesity, in utero programming, epigenetic inheritance, physical activity, nutrition, disease prevention
- MeSH terms
- Diabetes Mellitus, Type 2, Environment, Female, Fetal Growth Retardation, Histones, Humans, Life Style, Obesity, Pregnancy, Exercise, DNA Methylation, Genetic Predisposition to Disease, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
