Cited by 1,008Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNF-κB Signaling Pathways

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TNF and ROS Crosstalk in Inflammation

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Blaser, Heiko, Dostert, Catherine, Mak, Tak W., Brenner, Dirk·2016·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.12.002

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Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

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1 retracted

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“Indeed, ROS interact with the NF-κB signaling pathway in many ways [1–3] and the transcription of NF-κB-dependent genes has been shown to influence the levels of ROS in the cell and, in turn, the levels of NF-κB activity are also influenced by the levels of ROS [1,42,66,67].”
Background
Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against Staphylococcus aureus
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Framework nucleic acids as promising reactive oxygen species scavengers for anti-inflammatory therapy
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Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α immunotherapy
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“Following this, mitochondrial damage, and excessive production of reactive oxygen species (ROS) were observed [44].”
Background
Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays
Capone, F., Guerriero, E., Sorice, A., Colonna, G., Ciliberto, G., & Costantini, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/3064643 · Cited by 38
The New Frontier of Host-Directed Therapies for Mycobacterium avium Complex
Crilly, N. P., Ayeh, S. K., & Karakousis, P. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.623119 · Cited by 39
“TNF-a also promotes killing of intracellular mycobacteria by macrophages, as the TNF blockers adalimumab and infliximab suppressed phagosome maturation in primary human PBMCs in the presence or absence of IFN-g (66) Moreover, TNF-a serves macrophage antimicrobial functions by activating reactive oxygen and nitrogen sp…”
Background
Application of photodynamic therapy in cancer: challenges and advancements
Wang, Z., Peng, H., Shi, W., Gan, L., Zhong, L., HE, J., Xie, L., Wu, P., Zhao, Y., Deng, Z., et al. (2021) · Biocell · doi:10.32604/biocell.2021.014439 · Cited by 38
“As a multi-potent cytokine, tumor necrosis factor-alpha (TNF-α) not only induces cell differentiation, survival, and apoptosis but also changes the intracellular redox state in the cell and increases ROS content (Blaser et al., 2016; Pinegin et al., 2018).”
Background
Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis
Redondo, J., Sarkar, P., Kemp, K., Heesom, K. J., Wilkins, A., Scolding, N. J., & Rice, C. M. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0045 · Cited by 37
Flavonoids and cellular stress: a complex interplay affecting human health
Vissenaekens, H., Criel, H., Grootaert, C., Raes, K., Smagghe, G. J., & Camp, J. V. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1929822 · Cited by 40
“Blaser et al. (2016) reviewed how TNF-a signaling induces ROS production through activation of NADPH oxidase 1 (NOX1) or NADPH oxidase 2 (NOX2) (Blaser et al. 2016).”
BackgroundInfluential
Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss
Paciello, F., Pisani, A., Rinaudo, M., Cocco, S., Paludetti, G., Fetoni, A. R., & Grassi, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106024 · Cited by 37
MAPK inhibitors, particularly the JNK inhibitor, increase cell death effects in H2O2-treated lung cancer cells via increased superoxide anion and glutathione depletion
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Time‐course study of macrophage infiltration and inflammation in cast immobilization–induced atrophied muscle of mice
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A secret that underlies Parkinson's disease: The damaging cycle
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Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism
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TLR2 Signaling Pathway Combats Streptococcus uberis Infection by Inducing Mitochondrial Reactive Oxygen Species Production
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“In most tissues, mROS from the respiratory chain is essential [14] because in innate immunity, mitochondria primarily fight bacterial infections through mROS, and this is evidenced by the fact that mROS modulates multiple signaling pathways including NF-B, C-Jun N-terminal kinase, and the caspase-1 inflammasomes [15].”
Background
Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice
Wu, Y., Xue-ya, L., Tan, F., Zhou, X., Mu, J., & Zhao, X. (2021) · Journal of Inflammation · doi:10.1186/s12950-021-00272-w · Cited by 40
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
Kim, Y.-M., Krantz, S., Jambusaria, A., Tóth, P. T., Moon, H., Gunarathna, I., Park, G. Y., & Rehman, J. (2021) · Nature Communications · doi:10.1038/s41467-021-23047-6 · Cited by 42
Application of Disulfiram and its Metabolites in Treatment of Inflammatory Disorders
Guo, W., Chen, S., Li, C., Xu, J., & Wang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.795078 · Cited by 38
Simplified α2-macroglobulin as a TNF-α inhibitor for inflammation alleviation in osteoarthritis and myocardial infarction therapy
Zheng, W., Zhou, T., Zhang, Y., Ding, J., Xie, J., Wang, S., Wang, Z., Wang, K., Shen, L., Zhu, Y., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122247 · Cited by 36
Glutaredoxin 3 promotes migration and invasion via the Notch signalling pathway in oral squamous cell carcinoma
Li, B., Chen, M., Lu, M., Jiang, X.-X., Pan, M., & Mao, J.-W. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1435871 · Cited by 36
dCK negatively regulates the NRF 2/ ARE axis and ROS production in pancreatic cancer
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Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial
Gouzi, F., Maury, J., Héraud, N., Molinari, N., Bertet, H., Ayoub, B., Blaquière, M., Bughin, F., De Rigal, P., Poulain, M., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5496346 · Cited by 38
“Antioxidants alsophysiologicallypreventmuscledysfunction and atrophy by buffering ROS [7], lowering systemic inflammation [9], and modulating cell functions [10].”
Background
Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols
Fetoni, A. R., Paciello, F., & Troiani, D. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0183 · Cited by 37
Network Pharmacology-Based and Molecular Docking Analysis of Resveratrol’s Pharmacological Effects on Type I Endometrial Cancer
Zheng, Y., Zhong, Z., & Guo, X. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666211015140455 · Cited by 36
“It is essential for the immunity and cellular homeostasis of human beings, playing a key role in angiogenesis by inducing VEGF production synergistically with interleukin-1 beta (IL1B) and IL6 [53, 54].”
BackgroundInfluential
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling
Liu, X., Li, Y., Zhao, J., Hu, Z., Fang, W., Ke, J., Li, W., & Long, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110781 · Cited by 39
The SP/NK1R system promotes the proliferation of breast cancer cells through NF-κB-mediated inflammatory responses
Jafarinezhad, S., Darban, R. A., Javid, H., & Hashemy, S. I. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01171-y · Cited by 35
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Background
Mechanism of Reactive Oxygen Species-Guided Immune Responses in Gouty Arthritis and Potential Therapeutic Targets
Zhang, S., Li, D., Fan, M., Yuan, J., Xie, C., Yuan, H., Xie, H., & Gao, H. (2024) · Biomolecules · doi:10.3390/biom14080978 · Cited by 39
“…NF-κ B to cause the transcription of target genes and as a common second signaling molecule in the body, specifically activating the NLRP3 inflammatory vesicles, in which NIMA-related kinase 7 (NEK7) serves as a specific sensor for the ROS activation of NLRP3 inflammatory vesicles [77,78].”
Background
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells
Sundarraj, K., Raghunath, A., Panneerselvam, L., & Perumal, E. (2019) · BioFactors · doi:10.1002/biof.1577 · Cited by 36
Dietary Supplementation of Apple Phlorizin Attenuates the Redox State Related to Gut Microbiota Homeostasis in C57BL/6J Mice Fed with a High-Fat Diet
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Adverse Effects of Oxidative Stress on Bone and Vasculature in Corticosteroid-Associated Osteonecrosis: Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 in Cytoprotection
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Pharmacogenomics of Anti-TNF Treatment Response Marks a New Era of Tailored Rheumatoid Arthritis Therapy
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“activation, ROS contribute to TNF‐induced NF‐kB activation, decreased NO bioavailabil‐ ity and progression of atherosclerosis [40].”
Background
Advances in Delivering Oxidative Modulators for Disease Therapy
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Background
Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.
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Background
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer
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Authors: Blaser, H., Dostert, C., Mak, T. W., & Brenner, D.
Affiliations: University Health Network (CA)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Brenner, Dirk
ORCID: Mak, Tak W.
Brenner, Dirk
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2016-04
Volume: 26
Issue: 4
Pages: 249-261
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.12.002
OpenAlex: W2236270374
Cited by: 1,008
References: 131
Citations by year: 2026: 75 · 2025: 89 · 2024: 114 · 2023: 134 · 2022: 147 · 2021: 143 · 2020: 110 · 2019: 73 · 2018: 53 · 2017: 51 · 2016: 19
FWCI: 6.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Fonds National de la Recherche Luxembourg (C15/BM/10355103)
Canadian Institutes of Health Research (S2B141816)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: TNF-α, reactive oxygen species, reactive nitrogen species, inflammation, innate immunity, NF-κB signaling, JNK signaling, apoptosis, necroptosis, cell survival, innate immune cells
MeSH terms: Animals, Cell Survival, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Inflammation, Lymphocytes, Necrosis, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species, MAP Kinase Kinase 4

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