Cited by 1,008Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNF-κB Signaling Pathways

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TNF and ROS Crosstalk in Inflammation

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Blaser, Heiko, Dostert, Catherine, Mak, Tak W., Brenner, Dirk·2016·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.12.002

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Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

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Activation of apoptosis signalling pathways by reactive oxygen species
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“While, some of the reactive species produced from PGs metabolism may exacerbate inflammation and induce tissue damage (Blaser et al., 2016).”
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Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,068
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
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Authors: Blaser, H., Dostert, C., Mak, T. W., & Brenner, D.
Affiliations: University Health Network (CA)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Brenner, Dirk
ORCID: Mak, Tak W.
Brenner, Dirk
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2016-04
Volume: 26
Issue: 4
Pages: 249-261
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.12.002
OpenAlex: W2236270374
Cited by: 1,008
References: 131
Citations by year: 2026: 75 · 2025: 89 · 2024: 114 · 2023: 134 · 2022: 147 · 2021: 143 · 2020: 110 · 2019: 73 · 2018: 53 · 2017: 51 · 2016: 19
FWCI: 6.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Fonds National de la Recherche Luxembourg (C15/BM/10355103)
Canadian Institutes of Health Research (S2B141816)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: TNF-α, reactive oxygen species, reactive nitrogen species, inflammation, innate immunity, NF-κB signaling, JNK signaling, apoptosis, necroptosis, cell survival, innate immune cells
MeSH terms: Animals, Cell Survival, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Inflammation, Lymphocytes, Necrosis, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species, MAP Kinase Kinase 4

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