Cited by 1,008Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNF-κB Signaling Pathways

The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.

TNF and ROS Crosstalk in Inflammation

Open access

Blaser, Heiko, Dostert, Catherine, Mak, Tak W., Brenner, Dirk·2016·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.12.002

Open this paper in CoChat — free account Open PDF

Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tcb.2015.12.002

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

GRIM-19 Mediated Translocation of STAT3 to Mitochondria is Necessary for TNF Induced Necroptosis.
Shulga, N., & Pastorino, J. G. (2012) · Journal of Cell Science · doi:10.1242/jcs.103093 · Cited by 101
Retracted
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
Self-citation
Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505
Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

Show all 131 references

Sorted by citations

Items 301–400 of 998

Polymer/Aptamer-Integrated Gold Nanoconstruct Suppresses the Inflammatory Process by Scavenging ROS and Capturing Pro-inflammatory Cytokine TNF-α
Kim, J., Park, H., Saravanakumar, G., & Kim, W. J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c15727 · Cited by 34
Multiple Roles of Black Raspberry Anthocyanins Protecting against Alcoholic Liver Disease
Xiao, T., Luo, Z., Guo, Z., Wang, X., Ding, M., Wang, W., Shen, X., & Zhao, Y. (2021) · Molecules · doi:10.3390/molecules26082313 · Cited by 33
Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
Cárdenas‐Rodríguez, N., Bandala, C., Vanoye–Carlo, A., Ignacio‐Mejía, I., Gómez‐Manzo, S., Cruz, E. Y. H., Pedraza‐Chaverrí, J., Carmona‐Aparicio, L., & Hernández‐Ochoa, B. (2021) · Antioxidants · doi:10.3390/antiox10060971 · Cited by 34
“Interestingly, NOX can also be activated by the release of TNF-α during the pro-inflammatory cytokine storm, contributing to local oxidative stress and endothelial dysfunction [188,189].”
Background
Sources, chemical components, and toxicological responses of size segregated urban air PM samples in high air pollution season in Guangzhou, China
Yang, M., Zeng, H.-X., Wang, X., Hakkarainen, H., Leskinen, A., Komppula, M., Roponen, M., Wu, Q.-Z., Xu, S.-L., Lin, L., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.161092 · Cited by 33
Knockdown of deleterious miRNA in progenitor cell–derived small extracellular vesicles enhances tissue repair in myocardial infarction
Park, H., Hoffman, J. R., Brown, M. E., Bheri, S., Brazhkina, O., Son, Y. H., & Davis, M. E. (2023) · Science Advances · doi:10.1126/sciadv.abo4616 · Cited by 33
“Under the inflammatory condition, TNF-α triggers necrotic cell death by accelerating ROS generation ( 35 ).”
Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
Chumphukam, O., Pintha, K., Khanaree, C., Chewonarin, T., Chaiwangyen, W., Tantipaiboonwong, P., Suttajit, M., & Khantamat, O. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12556 · Cited by 33
Effect of Perillaldehyde on Prophylaxis and Treatment of Vaginal Candidiasis in a Murine Model
Qu, S., Chen, L., Tian, H., Wang, Z., Wang, F., Wang, L., Li, J., Ji, H., Xi, L., Feng, Z., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01466 · Cited by 33
Shaoyao-Gancao Decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy/mitophagy
Wu, Y., Li, W., Zhang, J., Lin, J., You, L., Su, J., Zheng, C., Gao, Y., Kong, X., & Sun, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156053 · Cited by 33
FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation
Huang, X., Chen, H., Xie, Y., Cao, Z., Lin, X., & Wang, Y. (2019) · Stem Cells International · doi:10.1155/2019/2120453 · Cited by 32
“TNF-α directly or indirectly causes cellular damage and tissue destruction by inducing oxidative stress, leading to lipid peroxidation, DNA damage, and protein fragmentation [30].”
Background
Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes
Li, M., Zhao, H., Wu, J., Wang, L., Wang, J., Lv, K., Liu, S., Wang, M., Guan, W., Liu, J., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01722 · Cited by 32
Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods
Noh, S., Kim, J., Kim, G., Park, C., Jang, H., Lee, M., & Lee, T. (2021) · Sensors · doi:10.3390/s21093024 · Cited by 36
TNF promotes M1 polarization through mitochondrial metabolism in injured spinal cord
Lin, S., Zhou, Z., Zhao, H., Xu, C., Guo, Y., Gao, S., Mei, X., & Tian, H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.014 · Cited by 32
A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology
Chester, J., Johnston, E., Walker, D., Jones, M., Ionescu, C. M., Wagle, S. R., Kovačević, B., Brown, D. J., Mikov, M., Mooranian, A., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071041 · Cited by 39
“The result of this is proinflammatory cytokine synthesis ultimately increasing TNF-α, creating a positive feedback loop [48].”
Background
Quercetin Improves Mitochondrial Function and Inflammation in H2O2-Induced Oxidative Stress Damage in the Gastric Mucosal Epithelial Cell by Regulating the PI3K/AKT Signaling Pathway
Yao, X., Mei, Y., & Mao, W.-Y. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1386078 · Cited by 32
TNF-α Induces Mitophagy in Rheumatoid Arthritis Synovial Fibroblasts, and Mitophagy Inhibition Alleviates Synovitis in Collagen Antibody-Induced Arthritis
Nam, J.-H., Lee, J., Choi, H., Choi, S.-Y., Noh, K.-E., Jung, N.-C., Song, J. Y., Choi, J., Seo, H. G., Jung, Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105650 · Cited by 32
“TNF-α induce autophagy by increasing the generation of reactive oxygen species (ROS), but RASFs are relatively resistant to TNF-α-induced apoptosis [8,9].”
Background
Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells
Lu, C., Xu, W., & Zheng, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.037 · Cited by 34
The role of oxidative stress in aortic dissection: a potential therapeutic target
Xu, S., Han, X., Wang, X., Yu, Y., Qu, C., Liu, X., & Yang, B. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1410477 · Cited by 36
Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180‐Bearing/Residual Mouse
Zou, P., Yang, X. H., Zhang, Y., Du, P., Yuan, S., Yang, D., & Wang, J. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13538 · Cited by 31
The role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of myocardial ischemia–reperfusion
Hou, H., Wang, Y., Li, Q., Li, Z., Teng, Y., Li, J., Wang, X., Chen, J., & Huang, N. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy108 · Cited by 31
“Necroptosis is a regulated, procedural, necrotic pathway which has the same morphological features as unregulated necrosis [37].”
Mitochondrial dysfunction and oxidative stress in bone marrow stromal cells induced by daunorubicin leads to DNA damage in hematopoietic cells
Li, Y., Xue, Z., Dong, X., Liu, Q., Liu, Z., Li, H., Xing, H., Xu, Y., Tang, K., Tian, Z., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.007 · Cited by 31
Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells
Fan, H., Bhullar, K. S., & Wu, J. (2021) · Antioxidants · doi:10.3390/antiox10020290 · Cited by 31
“Mechanistically, TNFα induces ROS production through its receptors; Ang II activates ROS production through AT1R, whereas elimination of ROS involves MasR that has been characterized to counterbalance harmful effects from the Ang II–AT1R axis [42,43].”
Background
Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases
López-Pedrera, C., Villalba, J. M., Patiño-Trives, A. M., Luque-Tévar, M., Barbarroja, N., Aguirre, M. A., Escudero‐Contreras, A., & Pérez‐Sánchez, C. (2021) · Antioxidants · doi:10.3390/antiox10040600 · Cited by 33
Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction
Kanda, Y., Osaki, M., & Okada, F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040867 · Cited by 32
“NF-κB activation also increases the expression of ROS-producing enzymes (gp91phox, xanthine oxidase) or inducible NO synthase (Figure 3), resulting in the promotion of cell proliferation, the acquisition of apoptosis resistance and induction of genetic instability [214,234,235].”
Background
In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy
Li, S., Zhang, H., Xie, J., Wang, Z., Wang, K., Zhai, Z., Ding, J., Wang, S., Shen, L., Wen, J., et al. (2023) · Materials Horizons · doi:10.1039/d3mh00594a · Cited by 30
CPT2-mediated fatty acid oxidation inhibits tumorigenesis and enhances sorafenib sensitivity via the ROS/PPARγ/NF-κB pathway in clear cell renal cell carcinoma
Zeng, K., Li, Q., Song, G., Chen, B., Luo, M., Miao, J., & Liu, B. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110838 · Cited by 30
Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor–adipocyte interaction indicating an altered immune response
Grosser, B., Heyer, C. M., Austgen, J., Sipos, É., Reitsam, N. G., Hauser, A., VanSchoiack, A., Kroeppler, D., Vlasenko, D., Probst, A., et al. (2023) · Gastric Cancer · doi:10.1007/s10120-023-01436-8 · Cited by 30
Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes
Li, S., Sun, X., He, Y., Guo, Y., Zhao, H., Hou, Z.-J., & Xing, M. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-8223-7 · Cited by 30
Balanced role of T3SS and T6SS in contribution to the full virulence of Edwardsiella piscicida
Hu, T., Chen, R., Zhang, L., Wang, Z., Yang, D., Zhang, Y., Liu, X., & Liu, Q. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.08.014 · Cited by 30
Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study
Hedman, A. M., Lundholm, C., Andolf, E. G., Pershagen, G., Fall, T., & Almqvist, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-74722-5 · Cited by 31
TBBPA induces inflammation, apoptosis, and necrosis of skeletal muscle in mice through the ROS/Nrf2/TNF-α signaling pathway
Zhang, Q., Wang, S., Wang, F., Guo, M., & Xu, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120745 · Cited by 30
Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation
Luo, H., Wang, Z., He, Z., Ling, Z., Wang, H., Zhu, J., Nie, J., Chen, D., Feng, Q., & Cao, X. (2023) · Biomaterials Science · doi:10.1039/d3bm00359k · Cited by 30
Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells
Stefanowicz‐Hajduk, J., Sparzak-Stefanowska, B., Krauze‐Baranowska, M., & Ochocka, J. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165372 · Cited by 30
Macrophage polarization by plasma sprayed ceria coatings on titanium-based implants: Cerium valence state matters
Shao, D., Li, K., You, M., Liu, S., Hu, T., Huang, L., Xie, Y., & Zheng, X. (2019) · Applied Surface Science · doi:10.1016/j.apsusc.2019.144070 · Cited by 30
Nothofagin suppresses mast cell-mediated allergic inflammation
Kang, B.-C., Kim, M.-J., Lee, S., Choi, Y., Park, P., Shin, T., Kwon, T. K., Khang, D., & Kim, S. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.10.025 · Cited by 29
Glutathione accelerates osteoclast differentiation and inflammatory bone destruction
Fujita, H., Ochi, M., Ono, M., Aoyama, E., Ogino, T., Kondo, Y., & Ohuchi, H. (2019) · Free Radical Research · doi:10.1080/10715762.2018.1563782 · Cited by 31
Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste
Tenkumo, T., Rojas‐Sánchez, L., Sáenz, J. R. V., Ogawa, T., Miyashita, M., Yoda, N., Prymak, O., Sokolova, V., Sasaki, K., & Epple, M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.01.031 · Cited by 30
H2S counteracts proinflammatory effects of LPS through modulation of multiple pathways in human cells
Yurinskaya, M. M., Krasnov, G. S., Kulikova, D. A., Zatsepina, O. G., Винокуров, М. Г., Chuvakova, L. N., Rezvykh, A. P., Funikov, S. Y., Morozov, A. V., & Evgen’ev, M. B. (2020) · Inflammation Research · doi:10.1007/s00011-020-01329-x · Cited by 29
“It has been shown that the molecular mechanism of TNF-α’s effects include the assembly of NOX2 and a dramatic increase in the production of ROS by phagocytes [33, 34].”
Background
Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis
Guo, F., Hu, Y., Zheng, L., & Wang, Q. (2017) · DNA and Cell Biology · doi:10.1089/dna.2017.3649 · Cited by 31
“ROS are crucial for NF-kB signaling downstream of TNF and may also result in the formation of PYD domain-containing protein 3 inflammasomes, NACHT and LRR, which activate both IL-1 and IL18 (Shi et al., 2015; Blaser et al., 2016).”
Background
Chemotherapy-Mediated Neuronal Aberration
Jaiswara, P. K., & Shukla, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16081165 · Cited by 30
ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing
Li, L., Wang, Y., Xu, Y., Xu, J., Zhao, Y., Cheng, Z., Fang, Y., Miao, Y., & Zhang, X. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.048 · Cited by 28
NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
Maimaiti, Y., Su, T., Zhang, Z., Ma, L., Zhang, Y. E., & Xu, H. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01266-w · Cited by 28
“Previous studies have indicated that TNFα acts as an upstream factor of NOX4, regulating the expression of NOX4 [81–84].”
Background
Modulation of α‐adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation
Li, T., Yang, S., She, X., Yan, Q., Zhang, P., Zhu, H., Wang, F., Luo, X., & Sun, X. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14565 · Cited by 30
“ROS overproduction is known to interact with various inflammatory mediators, including IL-1β, TNF-α and CCL2, which suggests a principal role for ROS in mediating the stress response (Yang et al., 2007; Blaser et al., 2016).”
Background
Flavonoids from Apios americana Medikus Leaves Protect RAW264.7 Cells against Inflammation via Inhibition of MAPKs, Akt-mTOR Pathways, and Nfr2 Activation
Chu, Q., Yu, X., Jia, R., Wang, Y., Zhang, Y., Zhang, S., Liu, Y., Li, Y., Chen, W., Ye, X., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1563024 · Cited by 28
“Numerous studies have shown that LPS can induce inflammation, leading to oxidative stress and mitochondrial dysfunction, as well as the induction of autophagy [23, 24].”
Background
Insight into anti-oxidative carbohydrate polymers from medicinal plants: Structure-activity relationships, mechanism of actions and interactions with bovine serum albumin
Ghosh, D., & Karmakar, P. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.258 · Cited by 28
Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy
Ito, S., Nakashima, H., Ishikiriyama, T., Nakashima, M., Yamagata, A., Imakiire, T., Kinoshita, M., Seki, S., Kumagai, H., & Oshima, N. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00191.2021 · Cited by 28
Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Thompson, B. S., Davidson, E. A., Chen, Y., Orlicky, D. J., Thompson, D. C., & Vasiliou, V. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109804 · Cited by 28
Coordination between anti-inflammation and antitumor actions for systematic tumor treatments with improved prognosis
Liu, W., Liu, T., Cao, A.-M., Qin, S., Feng, J. X., & Zhang, X. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135711 · Cited by 27
A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
Guan, Z., Peng, X., Zhang, Y., Wang, P., Xie, Z., Li, J., Liu, W., Ye, G., Lin, Y., Li, G., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01906-2 · Cited by 31
“As an inflammatory factor, TNF-α triggers intracellular ROS production, which in turn cooperates with TNF-α to promote the development of inflammation [25, 26].”
Background
Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-α-Induced Apoptosis
Li, S.-M., Yang, X.-H., Feng, Z., Wang, P., Zhu, W.-C., & Cui, S.-L. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493841 · Cited by 31
Reoxygenation Modulates the Adverse Effects of Hypoxia on Wound Repair
Bai, Q., Gao, Q., Hu, F., Zheng, C., Sun, N., Chen, W., Liu, J., Zhang, Y., Wu, X., & Lu, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415832 · Cited by 29
“The result was in agreement with the statement that ROS in excessive inflammation response could aggravate local tissue damage and lead to chronic inflammation [32,50].”
Result
Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice
Wang, C., Song, Y., Wang, X., Mao, R., & Song, L. (2018) · Medical Science Monitor · doi:10.12659/msm.910347 · Cited by 27
“Therefore, NO is thought to be one of the core secondary mediators that acts as an important activator of the inflammatory response and in the cascade of proinflammatory cytokines such as TNF-a, IL-1b, and IL-6 [23].”
BackgroundInfluential
Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics
Liu, D., Qiu, X., Xiong, X., Chen, X., & Pan, F. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02330-w · Cited by 27
ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes
Morimoto, N., Okamura, Y., Maekawa, S., Wang, H., Aoki, T., Kono, T., Sakai, M., & Hikima, J.-I. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.07.027 · Cited by 27
Primary hypercholesterolemia and development of cardiovascular disorders: Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction
Collado, A., Domingo, E., Piqueras, L., & Sanz, M. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106066 · Cited by 32
Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation
Lu, C., Xu, W., Zhang, F., Shao, J., & Zheng, S. (2016) · Toxicology · doi:10.1016/j.tox.2016.07.018 · Cited by 27
“TNF- is critical for mammalian immunity and cellular homeostasis and severs as a regulator of cell survival, apoptosis, and necroptosis in various cell types and tissues (Blaser et al., 2016).”
Background
Photoprotective effects of 2S,3R-6-methoxycarbonylgallocatechin isolated from Anhua dark tea on UVB-induced inflammatory responses in human keratinocytes
Kim, D., Hu, R., Fan, Y., Xu, Y., Park, H. J., & Lee, S. K. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111704 · Cited by 28
Natural products for gastric carcinoma prevention and treatment: Focus on their antioxidant stress actions in the Correa's cascade
Guo, C., Wan, L., Li, C., Wen, Y., Pan, H., Zhao, M., Wang, J., Ma, X., Nian, Q., Tang, J., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155253 · Cited by 27
Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-κB and MAPK Activation
Liu, M., Fang, G., Yin, S., Zhao, X. S., Zhang, C., Li, J., & Liu, Z. (2019) · Mediators of Inflammation · doi:10.1155/2019/1897820 · Cited by 26
Immunomodulatory and antineoplastic efficacy of common spices and their connection with phenolic antioxidants
Xu, B., Ganesan, K., Mickymaray, S., Alfaiz, F. A., Thatchinamoorthi, R., & Aboody, M. S. A. (2020) · Bioactive Compounds in Health and Disease · doi:10.31989/bchd.v3i2.687 · Cited by 28
“The results of excess production of NO may lead to the initiation and progression of cancer formation [44-46].”
Background
Network pharmacology-based predictions of active components and pharmacological mechanisms of Artemisia annua L. for the treatment of the novel Corona virus disease 2019 (COVID-19)
Tang, Y., Li, X., Yuan, Y., Zhang, H., Zou, Y., Xu, Z., Xu, Q., Song, J., Deng, C., & Wang, Q. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03523-2 · Cited by 27
“TNF is an intensely studied proinflammatory cytokine, which can trigger either cell survival or cell death by regulating a complex inflammatory network [69, 70], and its hyperproduction is related to the pathogenesis of COVID19 as well.”
Background
The protective effect of DNA aptamer on osteonecrosis of the femoral head by alleviating TNF-α-mediated necroptosis via RIP1/RIP3/MLKL pathway
Fan, X., Xu, X., Wu, X., Xia, R., Gao, F., Zhang, Q., & Sun, W. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.07.001 · Cited by 26
Managing Cancer Drug Resistance from the Perspective of Inflammation
Lu, S., Li, Y., Zhu, C., Wang, W., & Zhou, Y. (2022) · Journal of Oncology · doi:10.1155/2022/3426407 · Cited by 28
“Furthermore, ROS production also creates a positive feedback loop through autocrine TNF-α-mediated inflammatory cytokine/chemokine expression, which contributes to tumor progression [106, 107].”
Background
Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice
Zhou, Z., Wang, M., Huang, C., Li, Y., Gao, L., Zhu, Y., Ying, C., & Zhou, X. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.09.018 · Cited by 26
Comparative toxicogenomics of benzotriazole ultraviolet stabilizers at environmental concentrations in Asian clam (Corbicula fluminea): Insight into molecular networks and behavior
Zhang, J., Chen, H., Tong, T., Liu, R., Yan, S., Liang, X., Martyniuk, C. J., & Zha, J. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.130811 · Cited by 26
Reactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases
Zhang, Y., Liu, L., Wang, T., Mao, C., Shan, P., Lau, C. S., Li, Z., Guo, W., & Wang, W. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301394 · Cited by 26
[Ru(bpy)2(NO)SO3](PF6), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice
Rossaneis, A. C., Longhi-Balbinot, D. T., Bertozzi, M. M., Fattori, V., Vendrameto, C. Z. S., Badaro‐Garcia, S., Zaninelli, T. H., Staurengo‐Ferrari, L., Borghi, S. M., de Carvalho, T. T., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00229 · Cited by 26
“TNF-α and IL-6 contribute to the recruitment of inflammatory cells and their activation with the production of ROS and RNS (Lin et al., 2010, 2015; Blaser et al., 2016; Lee et al., 2017).”
Background
Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline
Paciello, F., Ripoli, C., Fetoni, A. R., & Grassi, C. (2023) · Antioxidants · doi:10.3390/antiox12020332 · Cited by 27
“NFκB-dependent genes have been shown to modulate ROS levels and, in turn, NF-κB activity is also affected by the free radical amount [12,161,162].”
Background
Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes‐associated cognitive decline: An in vivo study in a rat model
Ghaderi, S., Gholipour, P., Komaki‬, A., Shahidi, ‬., Seif, F., Bahrami‐Tapehebur, M., Salehi, I., Zarei, M., Sarihi, A., & Rashno, M. (2024) · Phytotherapy Research · doi:10.1002/ptr.8111 · Cited by 26
“As a major pro-inflammatory cytokine, TNF-α can also induce the production of ROS from mitochondria and trigger inflammatory cell death and tissue damage through binding to the membrane-bound or soluble receptors (Blaser et al., 2016), thus accelerating the ROS-cytokine vicious cycle.”
Background
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
Zhao, T., Ma, J., Li, L., Teng, W., Tian, Y., Ma, Y., Wang, W., Yan, W., & Jiao, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197161 · Cited by 26
“The resultant chronic inflammatory response is associated with extensive free radical production by immune cells, thereby causing substantial oxidative stress [51].”
Background
Toll-like receptor-7/8 agonist kill Leishmania amazonensis by acting as pro-oxidant and pro-inflammatory agent
Kaushik, D., Granato, J., Macedo, G. C., Dib, P. R. B., Piplani, S., Fung, J., da Silva, A. D., Coimbra, E. S., Petrovsky, N., & Salunke, D. B. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab063 · Cited by 25
A chicken and egg scenario in psychoneuroimmunology: Bidirectional mechanisms linking cytokines and depression
Rengasamy, M. L., Marsland, A. L., Spada, M. L., Hsiung, K. S., Kovats, T., & Price, R. B. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100177 · Cited by 29
“Additionally, TNF α binds to TNF α R1, which activates the enzyme NAPDH Oxidase (NOX) through protein-protein interactions, resulting in direct production of ROS (Blaser et al., 2016).”
Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes
Du, X., Liu, M., Tai, W., Yu, H., Hao, X., Loor, J. J., Jiang, Q., Fang, Z., Gao, X., Fan, M., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22009 · Cited by 27
Exosomes in pathogenesis, diagnosis, and treatment of pulmonary fibrosis
Yang, Y., Liu, Y., Chai, Y., Liu, K., Hu, W., Zhao, K., Zhu, Y., Gao, P., Huang, Q., & Zhang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927653 · Cited by 25
“ROS can be involved in inflammation by affecting NF-κB signaling, TNF signaling, and so on (Blaser et al., 2016).”
Background
Apigenin suppresses mycoplasma-induced alveolar macrophages necroptosis via enhancing the methylation of TNF-α promoter by PPARγ-Uhrf1 axis
Mei, X., Wang, J., Zhang, C., Zhu, J., Liu, B., Xie, Q., Yuan, T., Wu, Y., Chen, R., Xie, X., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154504 · Cited by 25
Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress
Elizalde-Velázquez, G. A., Gómez‐Oliván, L. M., Herrera-Vázquez, S. E., Rosales-Pérez, K. E., SanJuan‐Reyes, N., García-Medina, S., & Galar‐Martínez, M. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106610 · Cited by 25
Carbon Dots from Camelina Decorating hFGF2-Linked Camelina Lipid Droplets Cooperate to Accelerate Wound Healing
Zhang, Y., Wang, R., Fan, H., Wang, M., Liu, H., Wang, Y., Cui, X., Wang, E., Zhang, B., Gao, H., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c04523 · Cited by 25
Activation of aryl hydrocarbon receptor by 6‐formylindolo[3,2‐b]carbazole alleviated acute kidney injury by repressing inflammation and apoptosis
Tao, S., Guo, F., Ren, Q., Liu, J., Wei, T., Li, L., Ma, L., & Fu, P. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16168 · Cited by 25
Wild Artichoke (Cynara cardunculus subsp. sylvestris, Asteraceae) Leaf Extract: Phenolic Profile and Oxidative Stress Inhibitory Effects on HepG2 Cells
Acquaviva, R., Malfa, G. A., Santangelo, R., Bianchi, S., Pappalardo, F., Taviano, M. F., Miceli, N., Giacomo, C. D., & Tomasello, B. (2023) · Molecules · doi:10.3390/molecules28062475 · Cited by 24
“High levels of ROS such as H2O2 in hepatocytes that have been exposed to FFAs are directly correlated with a promotion of an inflammatory response mediated by pro-inflammatory mediators such as TNF-α, IL-1β, and IL-6, particularly TNF-α and ROS, which are positively promoted by each other [41] and are capable of induc…”
Background
Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression
Hsu, P.-S., Lin, C., Chang, J., Wu, C., Sia, K., Lee, I., Huang, K., & Lin, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051078 · Cited by 24
“Unbalanced ROS contribute to inflammatory gene expression [30].”
Background
Cell‐specific immune‐modulation of cadmium on murine macrophages and mast cell lines in vitro
García‐Mendoza, D., Han, B., van den Berg, H. H. J., & van den Brink, N. W. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3788 · Cited by 24
The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection
Hausmann, A., & Hardt, W. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.bai-0004-2019 · Cited by 24
Glycomacropeptide Prevents Iron/Ascorbate-Induced Oxidative Stress, Inflammation and Insulin Sensitivity with an Impact on Lipoprotein Production in Intestinal Caco-2/15 Cells
Sauvé, M. F., Ahmarani, L., DELVIN, E. E., Sané, A. T., Spahis, S., & Levy, E. H. (2020) · Nutrients · doi:10.3390/nu12041175 · Cited by 25
“It is equally important to mention the crosstalk between OxS and inflammation processes [67,68].”
Background
Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy
Singh, N., Pay, S. L., Bhandare, S. B., Arimpur, U., & Motea, E. A. (2020) · Cancers · doi:10.3390/cancers12040972 · Cited by 24
“This process forces NAD + replenishment through the salvage pathway, which decreases cellular ATP levels and results in bioenergetic crisis, eventually leading to necrotic cell death that is typically associated with inﬂammation [3,135].”
Metabolic response of blood vessels to TNFα
Junaid, A., Schoeman, J. C., Yang, W., Stam, W., Mashaghi, A., van Zonneveld, A. J., & Hankemeier, T. (2020) · eLife · doi:10.7554/elife.54754 · Cited by 24
“Mechanistically, TNFa signaling in endothelial cells involves the activation of NFkB and results in the increased synthesis of reactive oxygen species (ROS) from a number of sources such as mitochondria, NADPH oxidase, uncoupled eNOS, xanthine oxidase, and peroxidases (Cai and Harrison, 2000; Blaser et al., 2016).”
Background
Zika virus NS1 suppresses the innate immune responses via miR-146a in human microglial cells
Shukla, A., Rastogi, M., & Singh, S. K. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.11.061 · Cited by 24
The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway
Wang, K., Sun, M., Juan, Z., Zhang, J., Sun, Y., Wang, G., Wang, C., Li, Y., Kong, W., Fan, L., et al. (2022) · Behavioural Neurology · doi:10.1155/2022/3777351 · Cited by 24
“At present, many studies have found that the continuous production of ROS is closely associated with neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease [15], as well as cell necrosis and apoptosis related to inflammation [16].”
Background
The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species
Cai, W., Shen, K., Ji, P., Jia, Y., Han, S., Zhang, W., Hu, X., Yang, X., Han, J., & Hu, D. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac008 · Cited by 24
“Furthermore, the accumulation of ROS results in cell apoptosis by inducing the production of inflammatory cytokines [53].”
Edible bird’s nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades
Lai, Q. W. S., Fan, Q., Zheng, B. Z.-Y., Chen, Y., Dong, T. T.-X., & Tsim, K. W. K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.941413 · Cited by 28
“Since the ROS signaling induced by TNF-α could activate Nrf2-and HO-1-mediated pathways (Blaser et al., 2016).”
Background
Ezetimibe alleviates acetic acid-induced ulcerative colitis in rats: targeting the Akt/NF-κB/STAT3/CXCL10 signaling axis
Mostafa, R. E., & Abdel-Rahman, R. F. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad013 · Cited by 24
Small Ceria Nanoclusters with High ROS Scavenging Activity and Favorable Pharmacokinetic Parameters for the Amelioration of Chronic Kidney Disease
Wu, Q., Lü, Y., Zou, L., Wang, Y., Liu, Q., Zhang, A., Cao, J., Shi, G., He, J., & Yang, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300632 · Cited by 24
Protein Disulfide Isomerase Silence Inhibits Inflammatory Functions of Macrophages by Suppressing Reactive Oxygen Species and NF-κB Pathway
Xiao, Y., Li, C., Gu, M., Wang, H., Chen, W., Luo, G., Yang, G., Zhang, Z., Zhang, Y., Xian, G., et al. (2018) · Inflammation · doi:10.1007/s10753-017-0717-z · Cited by 24
Flazin as a Promising Nrf2 Pathway Activator
Fuda, H., Miyanaga, S., Furukawa, T., Umetsu, S., Joko, S., Roan, Y., Hirotaka, S., Hui, S., Watanabe, M., & Chiba, H. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04600 · Cited by 24
Styrene targets sensory and neural cochlear function through the crossroad between oxidative stress and inflammation
Fetoni, A. R., Paciello, F., Rolesi, R., Pisani, A., Moleti, A., Sisto, R., Troiani, D., Paludetti, G., & Grassi, C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.001 · Cited by 24
Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications
Shen, T., Wang, Y., Cheng, L., Bode, A. M., Gao, Y., Zhang, S., Chen, X., & Luo, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118241 · Cited by 24
Functions of transcription factors NF-κB and Nrf2 in the inhibition of LPS-stimulated cytokine release by the resin monomer HEMA
Schweikl, H., Gallorini, M., Pöschl, G., Urmann, V., Petzel, C., Bolay, C., Hiller, K., Cataldi, A., & Buchalla, W. (2018) · Dental Materials · doi:10.1016/j.dental.2018.08.292 · Cited by 23
Effects of dexmedetomidine on lipopolysaccharide-induced acute kidney injury in rats and mitochondrial function in cell culture
Kiyonaga, N., Moriyama, T., & Kanmura, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109912 · Cited by 23
In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis
Kwon, H.-C., Sohn, H., Kim, D. H., Shin, D., Jeong, C. H., Chang, Y. H., Yune, J. H., Kim, Y., Kim, D.-W., Kim, S.-H., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01086 · Cited by 23
Molecular mechanisms of Huanglian jiedu decoction on ulcerative colitis based on network pharmacology and molecular docking
Yang, J. H., Tang, C., Jin, R., Liu, B., Wang, P., Chen, Y., & Zeng, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-09559-1 · Cited by 23
Cell responses to cariogenic microorganisms and dental resin materials—Crosstalk at the dentin-pulp interface?
Schweikl, H., Buchalla, W., & Krifka, S. (2017) · Dental Materials · doi:10.1016/j.dental.2017.02.006 · Cited by 23
TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon
Cheng, Z., Chu, H., Wang, S., Huang, Y., Hou, X., Zhang, Q., Zhou, W., Jia, L., Meng, Q., Shang, L., et al. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.06.096 · Cited by 24

Authors: Blaser, H., Dostert, C., Mak, T. W., & Brenner, D.
Affiliations: University Health Network (CA)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Brenner, Dirk
ORCID: Mak, Tak W.
Brenner, Dirk
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2016-04
Volume: 26
Issue: 4
Pages: 249-261
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.12.002
OpenAlex: W2236270374
Cited by: 1,008
References: 131
Citations by year: 2026: 75 · 2025: 89 · 2024: 114 · 2023: 134 · 2022: 147 · 2021: 143 · 2020: 110 · 2019: 73 · 2018: 53 · 2017: 51 · 2016: 19
FWCI: 6.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Fonds National de la Recherche Luxembourg (C15/BM/10355103)
Canadian Institutes of Health Research (S2B141816)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: TNF-α, reactive oxygen species, reactive nitrogen species, inflammation, innate immunity, NF-κB signaling, JNK signaling, apoptosis, necroptosis, cell survival, innate immune cells
MeSH terms: Animals, Cell Survival, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Inflammation, Lymphocytes, Necrosis, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species, MAP Kinase Kinase 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TNF and ROS Crosstalk in Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks