Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions
Open accessAbstract
The stress system effectively restores the internal balance—or homeostasis—of living organisms in the face of random external or internal changes, the stressors. This highly complex system helps organisms to provide a series of neuroendocrine responses to stressors—the stress response—through coordinated activation of the hypothalamic–pituitary–adrenal (HPA) axis and the locus coeruleus/norepinephrine autonomic nervous systems. In addition to stressors, life is influenced by daily light/dark changes due to the 24‐h rotation of Earth. To adjust to these recurrent day/night cycles, the biological clock system employs the heterodimer of transcription factors circadian locomotor output cycle kaput/brain–muscle–arnt–like protein 1 (CLOCK/BMAL1), along with a set of other transcription factors, to regulate the circadian pattern of gene expression. Interestingly, the stress system, through the HPA axis, communicates with the clock system; therefore, any uncoupling or dysregulation could potentially cause several disorders, such as metabolic, autoimmune, and mood disorders. In this review, we discuss the biological function of the two systems, their interactions, and the clinical implications of their dysregulation or uncoupling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clock gene pathways are tightly and bi-directionally linked with HPA axis activity.
“These pathways are tightly and bi-directionally linked with HPA axis activity (Lee et al. 2013;Nicolaides et al. 2014)”
From The HPA axis in bipolar disorder: Systematic review and meta-analysis (2016) · cites this paper as Nicolaides et al. 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149 · see citing works
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works
Self-citationObesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
Bamberger, C. M., Bamberger, A. M., de Castro, M., & Chrousos, G. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117943 · Cited by 642 · see citing works
Self-citationIto, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638 · see citing works
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., & Guarente, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.032 · Cited by 631 · see citing works
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606 · see citing works
Self-citationRipperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 593 · see citing works
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589 · see citing works
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works
Surjit, M., Ganti, K. P., Mukherji, A., Ye, T., Hua, G., Metzger, D., Li, M., & Chambon, P. (2011) · Cell · doi:10.1016/j.cell.2011.03.027 · Cited by 551 · see citing works
Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W., & Eichele, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.002 · Cited by 528 · see citing works
Glucocorticoids and the circadian clock
Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494 · see citing works
SCN Outputs and the Hypothalamic Balance of Life
Kalsbeek, A., Palm, I. F., la Fleur, S., Scheer, F., Perreau‐Lenz, S., Ruiter, M., Kreier, F., Cailotto, C., & Buijs, R. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293854 · Cited by 492 · see citing works
Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators
Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 467 · see citing works
Lu, N. Z., & Cidlowski, J. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.025 · Cited by 455 · see citing works
Interactions of the circadian CLOCK system and the HPA-axis
Nader, N., Chrousos, G. P., & Kino, T. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.12.011 · Cited by 449 · see citing works
Self-citationThe human glucocorticoid receptor: molecular basis of biologic function
Nicolaides, N. C., Galata, Z., Kino, T., Chrousos, G. P., & Charmandari, E. (2010) · Steroids · doi:10.1016/j.steroids.2009.09.002 · Cited by 436 · see citing works
Self-citationGlucocorticoid regulation of the circadian clock modulates glucose homeostasis
So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909733106 · Cited by 431 · see citing works
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426 · see citing works
Buttgereit, F., Doering, G., Schaeffler, A., Witte, S., Sierakowski, S., Gromnica‐Ihle, E., Jeka, S., Krueger, K., Szechiński, J., & Alten, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60132-4 · Cited by 406 · see citing works
Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis
Kalsbeek, A., van der Spek, R., Lei, J., Endert, E., Buijs, R. M., & Fliers, E. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.042 · Cited by 380 · see citing works
The human glucocorticoid receptor: One gene, multiple proteins and diverse responses
Zhou, J., & Cidlowski, J. A. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.006 · Cited by 369 · see citing works
Bornstein, S. R., & Chrousos, G. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5631 · Cited by 354 · see citing works
Self-citationAssociation between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works
Nader, N., Chrousos, G. P., & Kino, T. (2009) · The FASEB Journal · doi:10.1096/fj.08-117697 · Cited by 341 · see citing works
Self-citationEffects of rotating shift work on biomarkers of metabolic syndrome and inflammation
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Alvarez, A., González, C. D., & Pirola, C. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01766.x · Cited by 318 · see citing works
Son, G. H., Chung, S., Choe, H. K., Kim, H.-D., Baik, S. M., Lee, H., Lee, H., Choi, S., Sun, W., Kim, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806962106 · Cited by 316 · see citing works
Yamamoto, T., Nakahata, Y., Tanaka, M., Yoshida, M., Soma, H., Shinohara, K., Yasuda, A., Mamine, T., & Takumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509600200 · Cited by 302 · see citing works
Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification
Duma, D., Jewell, C. M., & Cidlowski, J. A. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.009 · Cited by 267 · see citing works
Straub, R. H., & Cutolo, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22368 · Cited by 262 · see citing works
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works
Ulrich‐Lai, Y. M., Arnhold, M. M., & Engeland, W. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00042.2003 · Cited by 247 · see citing works
Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 243 · see citing works
Crofford, L. J. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1279 · Cited by 242 · see citing works
Self-citationIntracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic
Chrousos, G. P., & Kino, T. (2005) · Science s STKE · doi:10.1126/stke.3042005pe48 · Cited by 241 · see citing works
Self-citationMultilevel regulation of the circadian clock
Cermakian, N., & Sassone‐Corsi, P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036078 · Cited by 226 · see citing works
A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers
Fujino, Y., Iso, H., Tamakoshi, A., Inaba, Y., Koizumi, A., Kubo, T., & Yoshimura, T. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj185 · Cited by 225 · see citing works
Kino, T., Su, Y. A., & Chrousos, G. P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0098-z · Cited by 179 · see citing works
Self-citationPinchera, A., & BERTAGNA, X. Y. (2001) · Medical Entomology and Zoology · Cited by 178 · see citing works
Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta
Yudt, M. R., Jewell, C. M., Bienstock, R. J., & Cidlowski, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4319-4330.2003 · Cited by 174 · see citing works
Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex
Padmanabhan, K., Robles, M. S., Westerling, T., & Weitz, C. J. (2012) · Science · doi:10.1126/science.1221592 · Cited by 173 · see citing works
Circadian and Glucocorticoid Regulation of Rev-erbα Expression in Liver 1
Pineda‐Torra, I., Tsibulsky, V. P., Delaunay, F., Saladin, R., Laudet, V., Fruchart, J., Kosykh, V., & Staels, B. (2000) · Endocrinology · doi:10.1210/endo.141.10.7708 · Cited by 169 · see citing works
The timing of glucocorticoid administration in rheumatoid arthritis
Arvidson, N. G., Guðbjörnsson, B., Larsson, A. O., & Hällgren, R. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.1.27 · Cited by 163 · see citing works
Shift work at young age is associated with increased risk for multiple sclerosis
Hedström, A. K., Åkerstedt, T., Hillert, J. A., Olsson, T. P., & Alfredsson, L. S. (2011) · Annals of Neurology · doi:10.1002/ana.22597 · Cited by 156 · see citing works
Charmandari, E., Chrousos, G. P., Lambrou, G. I., Pavlaki, A., Koide, H., Ng, S. S. M., & Kino, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025612 · Cited by 139 · see citing works
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Son, G. H., Chung, S., & Kim, K. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.003 · Cited by 136 · see citing works
Charmandari, E., Chrousos, G. P., Ichijo, T., Bhattacharyya, N., Vottero, A., Souvatzoglou, E., & Kino, T. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0112 · Cited by 131 · see citing works
Self-citationThe BMAL1 C terminus regulates the circadian transcription feedback loop
Kiyohara, Y. B., Tagao, S., Tamanini, F., Morita, A., Sugisawa, Y., Yasuda, M., Yamanaka, I., Ueda, H. R., van der Horst, G. T. J., Kondo, T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601416103 · Cited by 114 · see citing works
Prevalence of Common Infections Among Employees in Different Work Schedules
Mohren, D. C. L., Jansen, N., Kant, I., Galama, J. M. D., van den Brandt, P. A., & Swaen, G. M. H. (2002) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-200211000-00005 · Cited by 105 · see citing works
Glucocorticoid Action Networks—An Introduction to Systems Biology
Chrousos, G. P., Charmandari, E., & Kino, T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032026 · Cited by 90 · see citing works
Self-citationKondratov, R. V., Kondratova, A. A., Lee, C., Gorbacheva, V., Chernov, M. V., & Antoch, M. P. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2684 · Cited by 88 · see citing works
Interaction of central and peripheral clocks in physiological regulation
Barclay, J. L., Tsang, A. H. K., & Oster, H. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00030-7 · Cited by 86 · see citing works
SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
Amat, R., Solanes, G., Giralt, M., & Villarroya, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707114200 · Cited by 85 · see citing works
Kino, T., & Chrousos, G. P. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.001 · Cited by 74 · see citing works
Self-citationGlucocorticoid and mineralocorticoid receptors and associated diseases
Kino, T., & Chrousos, G. P. (2004) · Essays in Biochemistry · doi:10.1042/bse0400137 · Cited by 67 · see citing works
Self-citationShift work and autoimmune thyroid disorders.
Magrini, A., Pietroiusti, A., Coppeta, L., Babbucci, A., Barnaba, E., Papadia, C., Iannaccone, U., BOSCOLO, P., Bergamaschi, E., & Bergamaschi, A. (2006) · PubMed · Cited by 64 · see citing works
Kino, T., & Chrousos, G. P. (2010) · Endocrine development · doi:10.1159/000321232 · Cited by 55 · see citing works
Self-citationThe glucocorticoid receptor gene, longevity, and the complex disorders of Western societies
Chrousos, G. P. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.05.006 · Cited by 48 · see citing works
Self-citationDickmeis, T., & Foulkes, N. S. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.09.001 · Cited by 47 · see citing works
Circadian clock signals in the adrenal cortex
Ota, T., Fustin, J., Yamada, H., Doi, M., & Okamura, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.010 · Cited by 44 · see citing works
Ekstrand, K., Boström, P. A., Arborelius, M., Nilsson, J., & Lindell, S. (1996) · Angiology · doi:10.1177/000331979604701109 · Cited by 42 · see citing works
Calogero, A. E., Bernardini, R., Gold, P. W., & Chrousos, G. P. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_13 · Cited by 42 · see citing works
Self-citationCorticotropin-Releasing Hormone: From Endocrinology to Psychobiology
Smith, M. A., Kling, M. A., Whitfield, H. J., Brandt, H. A., Demitrack, M. A., Geracioti, T. D., Chrousos, G. P., & Gold, P. W. (2008) · Hormone Research · doi:10.1159/000181089 · Cited by 36 · see citing works
Self-citationModulation of glucocorticoid receptor induction properties by core circadian clock proteins
Han, D., Lee, Y., Kim, K., Kim, C., & Cho, S. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.12.013 · Cited by 36 · see citing works
More Night Than Day — Circadian Rhythms in Polymyalgia Rheumatica and Ankylosing Spondylitis
Spies, C. M., Cutolo, M., Straub, R. H., Burmester, G. R., & Buttgereit, F. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.091283 · Cited by 33 · see citing works
Glucocorticoid receptor: implications for rheumatic diseases.
Kino, T., Charmandari, E., & Chrousos, G. P. (2011) · PubMed · Cited by 27 · see citing works
Self-citationCircadian and Glucocorticoid Regulation of Rev-erb Expression in Liver
Torra, I. P. (2000) · Endocrinology · doi:10.1210/en.141.10.3799 · Cited by 27 · see citing works
Corticotropin releasing factor: Basic studies and clinical applications
Chrousos, G. P., Calabrese, J. R., Avgerinos, P. C., Kling, M. A., Rubinow, D. R., Oldfield, E. H., Schuermeyer, T., Kellner, C. H., Cutler, G. B., Loriaux, D. L., et al. (1985) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(85)90187-3 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [59]Kino T Chrousos GP Steckler T 2005 Glucocorticoid effect on gene expression Handbook on Stress and the Brain 295 312 Elsevier BV
Cited by
Sorted by citations
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works
The HPA axis in bipolar disorder: Systematic review and meta-analysis
Belvederi Murri, M., Prestia, D., Mondelli, V., Pariante, C., Patti, S., Olivieri, B., Arzani, C., Masotti, M., Respino, M., Antonioli, M., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.014 · Cited by 391 · see citing works
Cortisol and DHEA in development and psychopathology
Kamin, H. S., & Kertes, D. A. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.018 · Cited by 311 · see citing works
Daily eating patterns and their impact on health and disease
Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263 · see citing works
Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition
Menon, R., Bonney, E. A., Condon, J. C., Mesiano, S. A., & Taylor, R. N. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw022 · Cited by 262 · see citing works
Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System
Azmi, N. A. S. M., Juliana, N., Azmani, S., Effendy, N. M., Abu, I. F., Teng, N. I. M. F., & Das, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020676 · Cited by 235 · see citing works
Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds
Sundahl, N., Bridelance, J., Libert, C., Bosscher, K. D., & Beck, I. M. E. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.001 · Cited by 218 · see citing works
de Melo, Nunes, S. O. V., Anderson, G., Vargas, H. O., Barbosa, D. S., Gałecki, P., Carvalho, A. F., & Maes, M. H. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.027 · Cited by 189 · see citing works
Nicolaides, N. C., Charmandari, E., Kino, T., & Chrousos, G. P. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00070 · Cited by 149 · see citing works
Self-citationExercise, inflammation, and fatigue in cancer survivors
LaVoy, E. C. P., Fagundes, C. P., & Dantzer, R. (2026) · PubMed · doi:10.22029/eir.2016.1710 · Cited by 138 · see citing works
Entrainment of the mouse circadian clock by sub-acute physical and psychological stress
Tahara, Y., Shiraishi, T., Kikuchi, Y., Haraguchi, A., Kuriki, D., Sasaki, H., Motohashi, H., Sakai, T., & Shibata, S. (2015) · Scientific Reports · doi:10.1038/srep11417 · Cited by 128 · see citing works
Stavreva, D. A., Garcia, D. A., Fettweis, G., Gudla, P. R., Zaki, G., Soni, V., McGowan, A., Williams, G. L., Huynh, A., Palangat, M., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.042 · Cited by 120 · see citing works
Kino, T. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00230 · Cited by 111 · see citing works
Self-citationMazurek, B., Szczepek, A. J., & Hébert, S. (2015) · HNO · doi:10.1007/s00106-014-2973-7 · Cited by 101 · see citing works
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology
Emens, J. S., & Burgess, H. J. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.001 · Cited by 102 · see citing works
Interplay between the endocrine and circadian systems in fishes
Isorna, E., de Pedro, N., Valenciano, A. I., Alonso-Gómez, A. L., & Delgado, M. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0330 · Cited by 93 · see citing works
Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones
Kim, B. H., Joo, Y., Kim, M., Choe, H. K., Tong, Q., & Kwon, O. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.405 · Cited by 98 · see citing works
Chronic psychosocial stressors in adulthood: Studies in mice, rats and tree shrews
Pryce, C. R., & Fuchs, E. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.10.001 · Cited by 91 · see citing works
Circadian control of pain and neuroinflammation
Segal, J. P., Tresidder, K. A., Bhatt, C., Gilron, I., & Ghasemlou, N. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24150 · Cited by 89 · see citing works
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress
Agorastos, A., Nicolaides, N. C., Bozikas, V. P., Chrousos, G. P., & Pervanidou, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01003 · Cited by 89 · see citing works
Self-citationCircadian Disruption in Psychiatric Disorders
Jones, S. G., & Benca, R. M. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.004 · Cited by 86 · see citing works
Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-71 · Cited by 83 · see citing works
Self-citationLight and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease
Hsu, C., & Tain, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062232 · Cited by 82 · see citing works
Picard, K., St‐Pierre, M., Vecchiarelli, H. A., Bordeleau, M., & Tremblay, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104987 · Cited by 77 · see citing works
Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake
Hong, C., & Efferth, T. (2015) · Trauma Violence & Abuse · doi:10.1177/1524838015585313 · Cited by 79 · see citing works
Circadian rhythms and attention deficit hyperactivity disorder: The what, the when and the why
Coogan, A. N., Baird, A. L., Popa‐Wagner, A., & Thome, J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.006 · Cited by 73 · see citing works
Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders
Barandas, R., Landgraf, D., McCarthy, M. J., & Welsh, D. K. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0637-2 · Cited by 68 · see citing works
Chronic variable stress alters hypothalamic–pituitary–adrenal axis function in the female mouse
Borrow, A. P., Heck, A. L., Miller, A. M., Sheng, J. A., Stover, S. A., Daniels, R. M., Bales, N. J., Fleury, T. K., & Handa, R. J. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112613 · Cited by 68 · see citing works
Chrousos syndrome: from molecular pathogenesis to therapeutic management
Nicolaides, N. C., & Charmandari, E. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12426 · Cited by 61 · see citing works
Self-citationSex differences in circadian endocrine rhythms: Clinical implications
Nicolaides, N. C., & Chrousos, G. P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14692 · Cited by 59 · see citing works
Self-citationBasic Concepts and Hormonal Regulators of the Stress System
Kazakou, P., Nicolaides, N. C., & Chrousos, G. P. (2022) · Hormone Research in Paediatrics · doi:10.1159/000523975 · Cited by 63 · see citing works
Self-citationNovel insights into glucocorticoid replacement therapy for pediatric and adult adrenal insufficiency
Oprea, A., Bonnet, N., Pollé, O. G., & Lysy, P. A. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818821294 · Cited by 54 · see citing works
Nicolaides, N. C., & Charmandari, E. (2017) · Hormones · doi:10.14310/horm.2002.1728 · Cited by 52 · see citing works
Self-citationPark, H. J., Lee, S., Jung, J. W., Kim, B. C., Ryu, J. H., & Kim, D. H. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0548-0 · Cited by 53 · see citing works
Angeli, E., Korpa, T., Johnson, E. O., Apostolakou, F., Papassotiriou, I., Chrousos, G. P., & Pervanidou, P. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.026 · Cited by 52 · see citing works
Self-citationCircadian rhythms and the <scp>HPA</scp> axis: A systems view
Androulakis, I. P. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1518 · Cited by 55 · see citing works
Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms
Torres‐Fuentes, C., Suárez, M., Aragonès, G., Mulero, M., Ávila‐Román, J., Arola‐Arnal, A., Salvadó, M. J., Arola, L., Bravo, F. I., & Muguerza, B. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100990 · Cited by 49 · see citing works
The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
Astiz, M., Heyde, I., Fortmann, M. I., Boßung, V., Roll, C., Stein, A., Grüttner, B., Göpel, W., Härtel, C., Obleser, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17429-5 · Cited by 44 · see citing works
Mallappa, A., Nella, A. A., Sinaii, N., Rao, H., Gounden, V., Perritt, A. F., Kumar, P., Ling, A., Liu, C., Soldin, S. J., et al. (2018) · Clinical Endocrinology · doi:10.1111/cen.13813 · Cited by 45 · see citing works
Depressive disorders: Processes leading to neurogeneration and potential novel treatments
Brown, G. M., McIntyre, R. S., Rosenblat, J. D., & Hardeland, R. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.023 · Cited by 44 · see citing works
Labad, J., Salvat‐Pujol, N., Armario, A., Cabezas, Á., de Arriba‐Arnau, A., Nadal, R. A., Martorell, L., Urretavizcaya, M., Monreal, J. A., Crespo, J. M., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207600 · Cited by 42 · see citing works
Spinal Cord Injury in Rats Disrupts the Circadian System
Gaudet, A. D., Fonken, L. K., Ayala, M. T., Bateman, E. M., Schleicher, W. E., Smith, E. J., D’Angelo, H. M., Maier, S. F., & Watkins, L. R. (2018) · eNeuro · doi:10.1523/eneuro.0328-18.2018 · Cited by 40 · see citing works
Wang, D., Opperhuizen, A., Reznick, J., Turner, N. A., Su, Y., Cooney, G. J., & Kalsbeek, A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.07.006 · Cited by 39 · see citing works
Manousopoulou, A., Koutmani, Y., Karaliota, S., Woelk, C. H., Manolakos, E. S., Karalis, K. P., & Garbis, S. D. (2016) · Nutrition and Diabetes · doi:10.1038/nutd.2016.10 · Cited by 38 · see citing works
Albrecht, A., & Stork, O. (2017) · Neural Plasticity · doi:10.1155/2017/3750307 · Cited by 37 · see citing works
Stanton, L. M., Price, A. J., & Manning, E. E. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13268 · Cited by 35 · see citing works
Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance
Nicolaides, N. C., Lamprokostopoulou, A., Sertedaki, A., & Charmandari, E. (2016) · HORMONES · doi:10.14310/horm.2002.1660 · Cited by 33 · see citing works
Self-citationSoltani, A., Chugaeva, U. Y., Ramadan, M. F., Saleh, E. A. M., Al-Hasnawi, S. S., Romero‐Parra, R. M., Alsaalamy, A. H., Mustafa, Y. F., Zamanian, M. Y., & Golmohammadi, M. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01361-3 · Cited by 30 · see citing works
Redondo-Flórez, L., Tornero-Aguilera, J. F., & Clemente‐Suárez, V. J. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113017 · Cited by 30 · see citing works
Strahler, J., Skoluda, N., Rohleder, N., & Nater, U. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.008 · Cited by 29 · see citing works
Paediatric stress: from neuroendocrinology to contemporary disorders
Stavrou, S., Nicolaides, N. C., Critselis, E., Darviri, C., Charmandari, E., & Chrousos, G. P. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12724 · Cited by 28 · see citing works
Self-citationLee, H., Kang, S., Kim, M.-A., Lee, E., Cho, H., Moon, E., & Kim, I. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00267.2017 · Cited by 29 · see citing works
Salivary Studies of the Social Neuroscience of Human–Animal Interaction
Pendry, P., & Vandagriff, J. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-35784-9_23 · Cited by 30 · see citing works
Song, D., Zhou, J., Ma, J., Chang, J. K., Qiu, Y., Zhuang, Z., Xiao, H., & Zeng, L. (2021) · Geriatric Nursing · doi:10.1016/j.gerinurse.2021.06.004 · Cited by 32 · see citing works
Ferrari, D., Bonaventura, I., Simeoli, C., Tomaselli, A., Vincenzi, L., De Alcubierre, D., Sciarra, F., Rizzo, F., Cerroni, L., Di Paola, N., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf206 · Cited by 28 · see citing works
Perinatal Programming of Circadian Clock-Stress Crosstalk
Astiz, M., & Oster, H. (2018) · Neural Plasticity · doi:10.1155/2018/5689165 · Cited by 28 · see citing works
The GH-IGF-1 Axis in Circadian Rhythm
Wang, W., Duan, X., Huang, Z., Pan, Q., Chen, C., & Guo, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.742294 · Cited by 27 · see citing works
Beltrametti, S. P., Ianniello, A., & Ricci, C. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s112685 · Cited by 26 · see citing works
Yamakawa, G. R., Brady, R. D., Sun, M., McDonald, S. J., Shultz, S. R., & Mychasiuk, R. (2020) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2020.100058 · Cited by 25 · see citing works
Moustafa, A. (2020) · International Journal of Endocrinology · doi:10.1155/2020/1426846 · Cited by 28 · see citing works
Roles of peripheral clocks: lessons from the fly
Yildirim, E., Curtis, R., & Hwangbo, D. (2021) · FEBS Letters · doi:10.1002/1873-3468.14251 · Cited by 25 · see citing works
Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders
Marco, E. M., Velarde, E., Llorente, R., & Laviola, G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_419 · Cited by 25 · see citing works
Relocation and Hair Cortisol Concentrations in New Zealand White Rabbits
Peric, T., Comin, A., Corazzin, M., Montillo, M., Canavese, F., Stebel, M., & Prandi, A. (2016) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2016.1183489 · Cited by 25 · see citing works
Functional characterization of the hGRαT556I causing Chrousos syndrome
Nicolaides, N. C., Skyrla, E., Vlachakis, D., Psarra, A. G., Moutsatsou, P., Sertedaki, A., Κοσσίδα, Σ., & Charmandari, E. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12563 · Cited by 25 · see citing works
Self-citationRedondo-Flórez, L., Fernández‐Lucas, J., & Clemente‐Suárez, V. J. (2020) · Nutrients · doi:10.3390/nu12123644 · Cited by 25 · see citing works
Chakoma, S. M., Pei, X. M., Qin, H., Ghandehari, A., Najafikhoshnoo, S., Rajendran, J., & Esfandyarpour, R. (2024) · Nano Research · doi:10.1007/s12274-024-6738-7 · Cited by 24 · see citing works
Dietary fat and corticosterone levels are contributing factors to meal anticipation
Namvar, S., Gyte, A., Denn, M., Leighton, B., & Piggins, H. D. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00308.2015 · Cited by 23 · see citing works
Kim, Y.-I., Kim, E., Lee, Y., & Park, J. (2025) · Physical Activity and Nutrition · doi:10.20463/pan.2025.0003 · Cited by 27 · see citing works
Konakchieva, R., Mladenov, M. I., Konaktchieva, M. N., Sazdova, I., Gagov, H., & Nikolaev, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136267 · Cited by 28 · see citing works
Nicolaides, N. C., Vgontzas, A. N., Kritikou, I., & Chrousos, G. P. (2016) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Self-citationColeman, G., Gigg, J., & Canal, M. M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13388 · Cited by 22 · see citing works
Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Lee, D. Y., Jung, I., Park, S. Y., Yu, J. H., Seo, J. A., Kim, K. J., Kim, N. H., Yoo, H. J., Kim, S. G., Choi, K. M., et al. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0193 · Cited by 21 · see citing works
Rapson, A., Collman, E., Faustini, S. E., Yonel, Z., Chapple, I., Drayson, M. T., Richter, A. G., Campbell, J. P., & Heaney, J. L. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.018 · Cited by 21 · see citing works
Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep
Campbell, E., & Figueiro, M. G. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1390216 · Cited by 20 · see citing works
Rowe, R. K., & Griesbach, G. S. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.017 · Cited by 20 · see citing works
Peris-Ramos, H. C., Carreira-Míguez, M., Rodríguez-Besteiro, S., David-Fernandez, S., & Clemente‐Suárez, V. J. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21040385 · Cited by 23 · see citing works
Roa, S. L. R., Martínez, E. Z., Martins, C. S., Antonini, S. R. R., de Castro, M., & Moreira, A. C. (2017) · Endocrinology · doi:10.1210/en.2016-1782 · Cited by 20 · see citing works
Mihailidou, C., Panagiotou, C., Kiaris, H., Kassi, E. N., & Moutsatsou, P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.001 · Cited by 19 · see citing works
RetractedFennell, K. A., Busby, R. G. G., Li, S., Bodden, C., Stanger, S. J., Nixon, B., Short, A. K., Hannan, A. J., & Pang, T. Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-72560-z · Cited by 19 · see citing works
Rapid volumetric brain changes after acute psychosocial stress
Uhlig, M., Reinelt, J. D., Lauckner, M. E., Kumral, D., Schaare, H. L., Mildner, T., Babayan, A., Möller, H. E., Engert, V., Villringer, A., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119760 · Cited by 18 · see citing works
Biological Rhythms Advance in Depressive Disorder
Hong, W., & Zhang, Q. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_6 · Cited by 18 · see citing works
Erythropoietin negatively regulates pituitary ACTH secretion
Dey, S., Scullen, T. A., & Noguchi, C. T. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.052 · Cited by 17 · see citing works
Transcriptome Profile in Unilateral Adrenalectomy-Induced Compensatory Adrenal Growth in the Rat
Jopek, K., Tyczewska, M., Celichowski, P., Malendowicz, L. K., & Ruciński, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041111 · Cited by 17 · see citing works
The impact of night-shift work on platelet function in healthy medical staff
Nakao, T., Yasumoto, A., Tokuoka, S. M., Kita, Y., Kawahara, T., Daimon, M., & Yatomi, Y. (2018) · Journal of Occupational Health · doi:10.1539/joh.2018-0027-fs · Cited by 17 · see citing works
Murray, A., Tharmalingam, S., Khurana, S., Lalonde, C., Nguyen, P., & Tai, T. C. (2022) · Cells · doi:10.3390/cells11101613 · Cited by 16 · see citing works
Circadian Biology and the Neurovascular Unit
Li, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S., & Lo, E. H. (2024) · Circulation Research · doi:10.1161/circresaha.124.323514 · Cited by 16 · see citing works
Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
Lee, N. R., Kim, B. J., Lee, C. H., Lee, Y. B., Lee, S., Hwang, H. J., Kim, E., Kim, S. H., Lee, M., Lee, S. E., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77281-x · Cited by 16 · see citing works
Das, M., Minocha, T., Kumar, D., Yadav, S. K., & Haldar, C. (2022) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-022-00210-6 · Cited by 15 · see citing works
Lin, Y., Jen, H., Lin, Y., Seo, J., & Chang, W. (2022) · BioMed Research International · doi:10.1155/2022/9506583 · Cited by 14 · see citing works
Panagiotou, K., Stefanou, G., Kourlaba, G., Athanasopoulos, D., Kassari, P., & Charmandari, E. (2024) · Nutrients · doi:10.3390/nu16213700 · Cited by 16 · see citing works
Self-citationBehavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission
Isingrini, E., Guinaudie, C., Perret, L. C., Guma, E., Gorgievski, V., Blum, I. D., Colby-Milley, J., Bairachnaya, M., Mella, S., Adamantidis, A., et al. (2023) · Biomolecules · doi:10.3390/biom13030511 · Cited by 15 · see citing works
From circadian clocks to non-alcoholic fatty liver disease
Ji, Y., Elkin, K. B., Yip, J., Guan, L., Han, W., & Ding, Y. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1684899 · Cited by 14 · see citing works
Bao, C., Jin, D., Sun, S., Xu, L., Wang, C., Tang, W., Zhang, W., Bao, Y., Xu, D., Zhou, S., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.762719 · Cited by 14 · see citing works
Sallam, A. E.-D., Hassan, S. A., Hassaneen, E., & Ali, E. M. (2016) · Biological Rhythm Research · doi:10.1080/09291016.2016.1173361 · Cited by 14 · see citing works
Gewehr, M. C. F., Silvério, R., Neto, J. C. R., Lira, F. S., Reckziegel, P., & Ferro, E. S. (2020) · Molecules · doi:10.3390/molecules25051093 · Cited by 14 · see citing works
Mezhibovsky, E., Tveter, K. M., Villa-Rodríguez, J. A., Bacalia, K. M. A., Kshatriya, D., Desai, N., Cabales, A., Wu, Y., Sui, K., Duran, R. M., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad095 · Cited by 12 · see citing works
Miller, L. A., Careaga, M. B. L., Handa, R. J., & Wu, T. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.011 · Cited by 13 · see citing works
Deer, L. K., Chen, S., Thwaites, N. A., Davis, E. P., & Doom, J. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1111474 · Cited by 13 · see citing works
The Role of Circulating β-endorphin in Different Stress Models in Equines: A Review
Ferlazzo, A., Fazio, E., Cravana, C., & Medica, P. (2018) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2018.10.012 · Cited by 12 · see citing works
Cardiovascular disease and depression: a bidirectional relationship and its clinical implications
Wu, J., Tian, Z., Qi, Z., Liu, X., & Yu, P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1675680 · Cited by 13 · see citing works
- Authors
- Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- King Abdulaziz University (SA)
- National Institutes of Health (US)
- Corresponding author
- Nicolaides, Nicolas C.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2014-05
- Volume
- 1318
- Issue
- 1
- Pages
- 71-80
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC4104011
- OpenAlex
- W1598021542
- Cited by
- 183
- References
- 78
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 15 · 2023: 16 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 20 · 2015: 17 · 2014: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD008732)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- circadian rhythm, hypothalamic-pituitary-adrenal axis, stress response, biological clock, Clock/BMAL1, circadian gene expression, circadian dysfunction, metabolic disorders, autoimmune disease, mood disorders
- MeSH terms
- Animals, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid, CLOCK Proteins, ARNTL Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
