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ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease
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“CSF from participants with cognitive impairment has a lower capacity to induce cholesterol efflux via ABCA1 ex vivo (Yassine et al., 2016;Marchi et al., 2019).”
From ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes (2019) · cites this paper as Marchi et al., 2019
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“A growing body of evidence supports the concept of an altered brain cholesterol metabolism and trafficking in AD [11,12,13] and its critical role in AD pathogenesis [14].”
From PCSK9 affects astrocyte cholesterol metabolism and reduces neuron cholesterol supplying in vitro: potential implications in Alzheimer’s disease (2022) · cites this paper as [13]
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Citations
Cites
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citationCriteria for the diagnosis of corticobasal degeneration
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Poirier, S., Mayer, G., Benjannet, S., Bergeron, E., Marcinkiewicz, J., Nassoury, N., Mayer, H., Nimpf, J., Prat, A., & Seidah, N. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708098200 · Cited by 477
Central nervous system: cholesterol turnover, brain development and neurodegeneration
Dietschy, J. M. (2009) · bchm · doi:10.1515/bc.2009.035 · Cited by 394
Beecham, G. W., Hamilton, K., Naj, A. C., Martin, E. R., Huentelman, M., Myers, A. J., Corneveaux, J. J., Hardy, J., Vonsattel, J.-P., Younkin, S. G., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004606 · Cited by 343
HDL and cholesterol handling in the brain
Vitali, C., Wellington, C. L., & Calabresi, L. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu148 · Cited by 254
What are lipoproteins doing in the brain?
Wang, H., & Eckel, R. H. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.003 · Cited by 234
Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease
Liao, F., Yoon, H., & Kim, J. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000383 · Cited by 191 · cited 4×
“In the present work, we confirmed and extended the observation of Yassine et al. by evaluating the capacity of the CSF of AD patients and controls to promote cholesterol efflux; namely, cholesterol efflux capacity (CEC), by all major cholesterol efflux pathways of ABCA1 and ABCG1, two transporters largely expressed in…”
BackgroundInfluentialCholesterol homeostasis failure as a unifying cause of synaptic degeneration
Koudinov, A. R., & Koudinova, N. V. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.036 · Cited by 139
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ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes
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Self-citationPapotti, B., Adorni, M. P., Marchi, C., Zimetti, F., Ronda, N., Panighel, G., Lupo, M. G., Vilella, A., Giuliani, D., Ferri, N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012192 · Cited by 41
Self-citationHigh-density lipoprotein-related cholesterol metabolism in Alzheimer's disease
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Metadata
- Authors
- Marchi, C., Adorni, M. P., Caffarra, P., Ronda, N., Spallazzi, M., Barocco, F., Galimberti, D., Bernini, F., & Zimetti, F.
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 60
- Issue
- 8
- Pages
- 1449-1456
- ISSN
- 0022-2275
- Cited by
- 64
- References
- 14
- Language
- en
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