A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial

Pittas, Anastassios G.; Das, Sai Krupa; Hajduk, Cheryl L.; Golden, Julie; Saltzman, Edward; Stark, Paul C.; Greenberg, Andrew S.; Roberts, Susan B.

doi:10.2337/diacare.28.12.2939

Cited by 163Diet and metabolism studiesDiabetes, Cardiovascular Risks, and LipoproteinsDietary Effects on Health

A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial

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Pittas, Anastassios G., Das, Sai Krupa, Hajduk, Cheryl L., Golden, Julie, Saltzman, Edward, Stark, Paul C., Greenberg, Andrew S., Roberts, Susan B.·2005·Diabetes Care

DOI 10.2337/diacare.28.12.2939

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Abstract

HOMA-IR, homeostasis model assessment of insulin resistance; INS-30, insulin value at 30 min.A table elsewhere in this issue shows conventional and Syste `me International (SI) units and conversion factors for many substances.

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Some variability in weight loss may be due to interactions between diet type and patient genetics or baseline physiology such as insulin sensitivity.
“Some of this variability may be due to interactions between diet type and patient genetics62,63 or baseline physiology such as insulin sensitivity64–67.”
From Maintenance of Lost Weight and Long-Term Management of Obesity (2018) · cites this paper as [67]
The Results (page not provided) report that baseline insulin secretion interacted with diet type in predicting weight loss. But the same section reports no interaction between diet and HOMA-R, the study’s measure of insulin resistance; it therefore does not support insulin sensitivity as the specific example. The genetics portion is attributed to other citations. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Individuals with high insulin secretion or other abnormalities of glucose homeostasis appear especially susceptible to adverse metabolic responses and weight gain when consuming a high-GL diet.
“Furthermore, studies suggest a unique diet–phenotype interaction, in that individuals with high insulin secretion or other abnormalities of glucose homeostasis appear especially susceptible to adverse metabolic responses and weight gain when consuming a high-GL diet (96, 105–110).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [109]

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Authors: Pittas, A. G., Das, S. K., Hajduk, C. L., Golden, J., Saltzman, E., Stark, P. C., Greenberg, A. S., & Roberts, S. B.
Affiliations: Tufts Medical Center (US)
Tufts University (US)
ORCID: Pittas, Anastassios G.
Das, Sai Krupa
Saltzman, Edward
Greenberg, Andrew S.
Roberts, Susan B.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2005-12-01
Volume: 28
Issue: 12
Pages: 2939-2941
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.28.12.2939
OpenAlex: W2156813200
Semantic Scholar: 85f6e81b0ad0c8e4ea20e51277c36c2fa78b2dd7
Cited by: 163
References: 37
Citations by year: 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 14 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 12 · 2012: 7
FWCI: 7.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture (58‐1950‐4‐401)
National Institutes of Health
National Institute on Aging (U01AG020480)
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK061506)
Topics: Health Sciences › Medicine › Physiology › Diet and metabolism studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords: low glycemic load diet, weight loss, insulin secretion, insulin resistance, HOMA-IR, overweight adults, dietary intervention
MeSH terms: Insulin Secretion, Adult, Body Weight, Diet, Reducing, Dietary Carbohydrates, Female, Humans, Insulin, Male, Reference Values, Weight Loss, Glycemic Index, Overweight

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A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial

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