The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
Open accessAbstract
Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.
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“Mitochondrial sirtuins also control mitochondrial physiology51.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [51]
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“Oxidative phosphorylation is pivotal in fueling pre- and post-synaptic processing45, whose alteration impacts mitochondrial function, which in turn affects the sirtuin pathway46.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [46]
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Metadata
- Authors
- Verdin, E., Hirschey, M. D., Finley, L. W. S., & Haigis, M. C.
- Affiliations
- Gladstone Institutes (US)
- Harvard University (US)
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 35
- Issue
- 12
- Pages
- 669-675
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC2992946
- OpenAlex
- W2133727193
- Cited by
- 661
- References
- 66
- Citations by year
- 2026: 23 · 2025: 42 · 2024: 40 · 2023: 40 · 2022: 36 · 2021: 50 · 2020: 62 · 2019: 37 · 2018: 42 · 2017: 35 · 2016: 38 · 2015: 35 · 2014: 47 · 2013: 48 · 2012: 50
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- Ellison Medical Foundation
- Gladstone Institutes
- National Institutes of Health
- National Institute on Aging (R01AG032375, AG032375)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- sirtuins, mitochondrial sirtuins, SIRT3, SIRT4, SIRT5, mitochondrial energy production, apoptosis, intracellular signaling, mitochondrial metabolism, oxidative metabolism, lifespan regulation, stress response
- MeSH terms
- Animals, Energy Metabolism, Humans, Mitochondria, Signal Transduction, Apoptosis, Sirtuins
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