Cited by 667Sirtuins and Resveratrol in MedicineMitochondrial Function and PathologyAutophagy in Disease and Therapy

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

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Verdin, Eric, Hirschey, Matthew D., Finley, Lydia W.S., Haigis, Marcia C.·2010·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2010.07.003PMC PMC2992946

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Abstract

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.

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Authors: Verdin, E., Hirschey, M. D., Finley, L. W. S., & Haigis, M. C.
Affiliations: Gladstone Institutes (US)
Harvard University (US)
ORCID: Verdin, Eric
Hirschey, Matthew D.
Finley, Lydia W.S.
Haigis, Marcia C.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2010-12
Volume: 35
Issue: 12
Pages: 669-675
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2010.07.003
PMC: PMC2992946
OpenAlex: W2133727193
Cited by: 661
References: 66
Citations by year: 2026: 23 · 2025: 42 · 2024: 40 · 2023: 40 · 2022: 36 · 2021: 50 · 2020: 62 · 2019: 37 · 2018: 42 · 2017: 35 · 2016: 38 · 2015: 35 · 2014: 47 · 2013: 48 · 2012: 50
FWCI: 3.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
Ellison Medical Foundation
Gladstone Institutes
National Institutes of Health
National Institute on Aging (R01AG032375, AG032375)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: sirtuins, mitochondrial sirtuins, SIRT3, SIRT4, SIRT5, mitochondrial energy production, apoptosis, intracellular signaling, mitochondrial metabolism, oxidative metabolism, lifespan regulation, stress response
MeSH terms: Animals, Energy Metabolism, Humans, Mitochondria, Signal Transduction, Apoptosis, Sirtuins

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

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