Cited by 70Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionLipid metabolism and biosynthesis

Can We Approach Theoretical Lipid Yields in Microalgae?

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Remmers, Ilse M., Wijffels, René H., Barbosa, Maria J., Lamers, Packo P.·2018·Trends in biotechnology

Abstract

Can we approach theoretical lipid yields in microalgae? Yes: we can substantially reduce the gap between current and theoretical maximum yield. A realistic maximum is approximately 0.5g triacylglycerol (TAG) per mol photons, about five times higher than what is currently achieved in outdoor cultivation. Achieving this realistic maximum will require several breakthroughs. First, outdoor operation typically has low yields, mainly caused by fluctuating insolation. Future adaptive control models will help increase these yields. Additionally, the lipid production capacity of currently used strains needs to increase. Powerful strain-specific molecular toolboxes are being developed, shifting the bottleneck towards understanding metabolism and identifying target genes. Finally, strains and processes should be improved concurrently to fully exploit the potential lipid production from microalgae.

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Crossref · 10.1016/j.tibtech.2017.10.020

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Authors
Remmers, I. M., Wijffels, R. H., Barbosa, M. J., & Lamers, P. P.
Affiliations
  • Wageningen University & Research (NL)
  • Nord University (NO)
Venue
Trends in biotechnology
Publisher
Elsevier BV
Published
2018-03
Volume
36
Issue
3
Pages
265-276
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2786958439
Cited by
69
References
81
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 13 · 2018: 4
FWCI
0.50
Type
journal article
Language
en
Open access
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
microalgae, triglycerides, lipid yield, open-field cultivation, adaptive control, strain improvement, metabolic engineering, lipid production
MeSH terms
Genetic Engineering, Light, Nitrogen, Photosynthesis, Selection, Genetic, Triglycerides, Molecular Dynamics Simulation, Biofuels, Microalgae, Metabolic Engineering, Batch Cell Culture Techniques

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