Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 669

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Genetics of emotional regulation: the role of the serotonin transporter in neural function

Hariri, Ahmad R., Holmes, Andrew·2006·Trends in Cognitive Sciences
DOI 10.1016/j.tics.2006.02.011
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.tics.2006.02.011

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 21 references

Research works printed but not linked: 68

  1. Lucki, 1998, The spectrum of behaviors influenced by serotonin, Biol. Psychiatry, 44, 151, 10.1016/S0006-3223(98)00139-5 · DOI · Paper page
  2. Owens, 1998, The serotonin transporter and depression, Depress. Anxiety, 8, 5, 10.1002/(SICI)1520-6394(1998)8:1+<5::AID-DA2>3.0.CO;2-I · DOI
  3. Ballenger, 1999, Current treatments of the anxiety disorders in adults, Biol. Psychiatry, 46, 1579, 10.1016/S0006-3223(99)00220-6 · DOI
  4. Smith, 1999, Distribution of [3H]citalopram binding sites in the nonhuman primate brain, Ann. N. Y. Acad. Sci., 877, 700, 10.1111/j.1749-6632.1999.tb09305.x · DOI
  5. Griebel, 1995, 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research, Pharmacol. Ther., 65, 319, 10.1016/0163-7258(95)98597-J · DOI · Paper page
  6. Blakely, 1991, Cloning and expression of a functional serotonin transporter from rat brain, Nature, 354, 66, 10.1038/354066a0 · DOI · Paper page
  7. Arango, 2001, Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims, Neuropsychopharmacology, 25, 892, 10.1016/S0893-133X(01)00310-4 · DOI · Paper page
  8. Heinz, 2000, A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity, Biol. Psychiatry, 47, 643, 10.1016/S0006-3223(99)00171-7 · DOI · Paper page
  9. Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 · DOI · Paper page
  10. Cryan, 2005, The ascent of mouse: advances in modelling human depression and anxiety, Nat. Rev. Drug Discov., 4, 775, 10.1038/nrd1825 · DOI · Paper page
  11. Gross, 2004, The developmental origins of anxiety, Nat. Rev. Neurosci., 5, 545, 10.1038/nrn1429 · DOI · Paper page
  12. Bengel, 1998, Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (‘Ecstasy’) in serotonin transporter-deficient mice, Mol. Pharmacol., 53, 649, 10.1124/mol.53.4.649 · DOI · Paper page
  13. Mathews, 2004, Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression, J. Neurosci. Methods, 140, 169, 10.1016/j.jneumeth.2004.05.017 · DOI · Paper page
  14. Montanez, 2003, Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice, J. Neurochem., 86, 210, 10.1046/j.1471-4159.2003.01836.x · DOI
  15. Kim, D.K. et al. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology (in press)
  16. Sen, 2004, Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits, Am. J. Med. Genet B Neuropsychiatr Genet, 127B, 85, 10.1002/ajmg.b.20158 · DOI · Paper page
  17. Munafo, 2005, Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits?, A meta-analysis. Mol. Psychiatry, 10, 415, 10.1038/sj.mp.4001627 · DOI
  18. Willis-Owen, S.A. et al. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol. Psychiatry (in press)
  19. Kendler, 2005, The nature of gene action in psychiatric disorders, Am. J. Psychiatry, 162, 1243, 10.1176/appi.ajp.162.7.1243 · DOI · Paper page
  20. Holmes, 2003, Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background, Genes Brain Behav., 2, 365, 10.1046/j.1601-1848.2003.00050.x · DOI · Paper page
  21. Holmes, 2003, Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior, Neuropsychopharmacology, 28, 2077, 10.1038/sj.npp.1300266 · DOI · Paper page
  22. Holmes, 2001, Targeted gene mutation approaches to the study of anxiety-like behavior in mice, Neurosci. Biobehav. Rev., 25, 261, 10.1016/S0149-7634(01)00012-4 · DOI · Paper page
  23. Zhao, S. et al. Insertion mutation at the C-terminus of the 5-HT transporter disrupts brain 5-HT function and emotional behavior in mice. Neuroscience (in press)
  24. Kendler, 2004, The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression, Am. J. Psychiatry, 161, 631, 10.1176/appi.ajp.161.4.631 · DOI · Paper page
  25. Kendler, 2005, The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication, Arch. Gen. Psychiatry, 62, 529, 10.1001/archpsyc.62.5.529 · DOI · Paper page
  26. Gillespie, 2005, The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression, Psychol. Med., 35, 101, 10.1017/S0033291704002727 · DOI · Paper page
  27. Grabe, 2005, Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden, Mol. Psychiatry, 10, 220, 10.1038/sj.mp.4001555 · DOI · Paper page
  28. Manuck, 2004, Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region, Psychoneuroendocrinology, 29, 651, 10.1016/S0306-4530(03)00094-5 · DOI
  29. Lotrich, 2004, Meta-analysis of serotonin transporter polymorphisms and affective disorders, Psychiatr. Genet., 14, 121, 10.1097/00041444-200409000-00001 · DOI · Paper page
  30. Murphy, 2004, Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression, Arch. Gen. Psychiatry, 61, 1163, 10.1001/archpsyc.61.11.1163 · DOI · Paper page
  31. Zanardi, 2001, Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression, Biol. Psychiatry, 50, 323, 10.1016/S0006-3223(01)01118-0 · DOI · Paper page
  32. Serretti, 2005, The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments, Prog. Neuropsychopharmacol. Biol. Psychiatry, 29, 1074, 10.1016/j.pnpbp.2005.03.013 · DOI
  33. Barr, 2004, Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques, Proc. Natl. Acad. Sci. U. S. A., 101, 12358, 10.1073/pnas.0403763101 · DOI · Paper page
  34. Champoux, 2002, Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates, Mol. Psychiatry, 7, 1058, 10.1038/sj.mp.4001157 · DOI · Paper page
  35. Li, 2004, Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences, J. Neurosci., 24, 10868, 10.1523/JNEUROSCI.3223-04.2004 · DOI
  36. Tjurmina, 2002, Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene, Endocrinology, 143, 4520, 10.1210/en.2002-220416 · DOI
  37. Adamec, R. et al. Vulnerability to mild predator stress in serotonin transporter knockout mice. Behav. Brain Res. (in press)
  38. Holmes, 2002, Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter, Neuropsychopharmacology, 27, 914, 10.1016/S0893-133X(02)00374-3 · DOI · Paper page
  39. Lira, 2003, Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice, Biol. Psychiatry, 54, 960, 10.1016/S0006-3223(03)00696-6 · DOI · Paper page
  40. Heinz, 2005, Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter, Nat. Neurosci., 8, 20, 10.1038/nn1366 · DOI · Paper page
  41. Bertolino, 2005, Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style, Biol. Psychiatry, 57, 1517, 10.1016/j.biopsych.2005.02.031 · DOI · Paper page
  42. Canli, T. et al. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc. Natl. Acad. Sci. U. S. A. (in press)
  43. Brown, S.R. and Hariri, A.R. Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain and behavior. Cogn. Affect. Behav. Neurosci. (in press)
  44. Domschke, 2005, Association of the functional –1019C/G 5-HT 1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder, Int. J. Neuropsychopharmacol., 9, 1
  45. Furmark, 2004, Serotonin transporter polymorphism linked to amygdala excitability and symptom severity in patients with social phobia, Neurosci. Lett., 362, 189, 10.1016/j.neulet.2004.02.070 · DOI · Paper page
  46. Li, 2003, Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice, J. Neurochem., 84, 1256, 10.1046/j.1471-4159.2003.01607.x · DOI
  47. Gobbi, 2001, Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study, J. Pharmacol. Exp. Ther., 296, 987, 10.1016/S0022-3565(24)38843-3 · DOI
  48. David, 2005, A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans, J. Neurosci., 25, 2586, 10.1523/JNEUROSCI.3769-04.2005 · DOI · Paper page
  49. Lee, 2005, Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women, Mol. Psychiatry, 10, 715, 10.1038/sj.mp.4001680 · DOI
  50. Phillips, 2003, Neurobiology of emotion perception: II. Implications for major psychiatric disorders, Biol. Psychiatry, 54, 515, 10.1016/S0006-3223(03)00171-9 · DOI · Paper page
  51. Mayberg, 2003, Positron emission tomography imaging in depression: a neural systems perspective, Neuroimaging Clin. N. Am., 13, 805, 10.1016/S1052-5149(03)00104-7 · DOI · Paper page
  52. Uylings, 2003, Do rats have a prefrontal cortex?, Behav. Brain Res., 146, 3, 10.1016/j.bbr.2003.09.028 · DOI · Paper page
  53. Gelernter, 1997, Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects, Hum. Genet., 101, 243, 10.1007/s004390050624 · DOI · Paper page
  54. Greenberg, 1999, Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets, Am. J. Med. Genet., 88, 83, 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 · DOI · Paper page
  55. Little, 1998, Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels, Am. J. Psychiatry, 155, 207, 10.1176/ajp.155.2.207 · DOI · Paper page
  56. Parsey, 2006, Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain, Am. J. Psychiatry, 163, 48, 10.1176/appi.ajp.163.1.48 · DOI · Paper page
  57. Hu, 2005, An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk, Alcohol. Clin. Exp. Res., 29, 8, 10.1097/01.ALC.0000150008.68473.62 · DOI · Paper page
  58. Kilic, 2003, A human serotonin transporter mutation causes constitutive activation of transport activity, Mol. Pharmacol., 64, 440, 10.1124/mol.64.2.440 · DOI
  59. Prasad, 2005, Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase, Proc. Natl. Acad. Sci. U. S. A., 102, 11545, 10.1073/pnas.0501432102 · DOI
  60. Caspi, 2002, Role of genotype in the cycle of violence in maltreated children, Science, 297, 851, 10.1126/science.1072290 · DOI · Paper page
  61. Manuck, 1999, Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene, Biol. Psychiatry, 45, 603, 10.1016/S0006-3223(98)00375-8 · DOI · Paper page
  62. Walther, 2003, Synthesis of serotonin by a second tryptophan hydroxylase isoform, Science, 299, 76, 10.1126/science.1078197 · DOI · Paper page
  63. Kugaya, 2003, Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration, Neuropsychopharmacology, 28, 413, 10.1038/sj.npp.1300036 · DOI · Paper page
  64. Duman, 1998, Novel therapeutic approaches beyond the serotonin receptor, Biol. Psychiatry, 44, 324, 10.1016/S0006-3223(98)00031-6 · DOI · Paper page
  65. Holmes, 2003, Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression, Biol. Psychiatry, 54, 953, 10.1016/j.biopsych.2003.09.003 · DOI · Paper page
  66. Esaki, 2005, Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice, Proc. Natl. Acad. Sci. U. S. A., 102, 5582, 10.1073/pnas.0501509102 · DOI
  67. Gaspar, 2003, The developmental role of serotonin: news from mouse molecular genetics, Nat. Rev. Neurosci., 4, 1002, 10.1038/nrn1256 · DOI · Paper page
  68. Holmes, 2005, Early life genetic, epigenetic and environmental factors shaping emotionality in rodents, Neurosci. Biobehav. Rev., 29, 1335, 10.1016/j.neubiorev.2005.04.012 · DOI · Paper page

Cited by

See all 669

Metadata

Authors
Hariri, A. R., & Holmes, A.
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2006-04
Volume
10
Issue
4
Pages
182-191
ISSN
1364-6613 (ISSN-L)
DOI
10.1016/j.tics.2006.02.011
OpenAlex
W2149823098
Cited by
669
References
21
FWCI
4.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Genetics of emotional regulation: the role of the serotonin transporter in neural function. https://app.cochat.ai/papers/10.1016/j.tics.2006.02.011
The paper
Hariri, A. R., & Holmes, A. (2006). Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends in Cognitive Sciences. https://doi.org/10.1016/j.tics.2006.02.011

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.