The hippocampus: hub of brain network communication for memory
Abstract
A complex brain network, centered on the hippocampus, supports episodic memories throughout their lifetimes. Classically, upon memory encoding during active behavior, hippocampal activity is dominated by theta oscillations (6-10Hz). During inactivity, hippocampal neurons burst synchronously, constituting sharp waves, which can propagate to other structures, theoretically supporting memory consolidation. This 'two-stage' model has been updated by new data from high-density electrophysiological recordings in animals that shed light on how information is encoded and exchanged between hippocampus, neocortex and subcortical structures such as the striatum. Cell assemblies (tightly related groups of cells) discharge together and synchronize across brain structures orchestrated by theta, sharp waves and slow oscillations, to encode information. This evolving dynamical schema is key to extending our understanding of memory processes.
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Theta activity in waking is considered a condition favoring the encoding of new information and associated synaptic plastic processes in hippocampal networks.
“Theta activity in waking is considered a condition favoring the encoding of new information and associated synaptic plastic processes in hippocampal networks (64,371,612,1251).”
From About Sleep's Role in Memory (2013) · cites this paper as [64]
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- Authors
- Battaglia, F. P., Benchenane, K., Sirota, A., Pennartz, C. M. A., & Wiener, S. I.
- Affiliations
- University of Amsterdam (NL)
- Centre National de la Recherche Scientifique (FR)
- University of Tübingen (DE)
- Corresponding author
- Battaglia, Francesco P.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 15
- Issue
- 7
- Pages
- 310-8
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W2141348551
- Cited by
- 351
- References
- 23
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 19 · 2023: 24 · 2022: 21 · 2021: 41 · 2020: 26 · 2019: 26 · 2018: 15 · 2017: 27 · 2016: 27 · 2015: 39 · 2014: 21 · 2013: 22 · 2012: 13
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- HAL (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, episodic memory, memory consolidation, theta oscillations, sharp-wave ripples, slow oscillations, cell assemblies, neuronal synchronization, striatum, memory encoding, brain networks
- MeSH terms
- Animals, Cell Communication, Circadian Rhythm, Hippocampus, Humans, Memory, Neural Pathways, Neurons, Sleep, Neocortex
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