Identification of a Functional Connectome for Long-Term Fear Memory in Mice
Open accessAbstract
Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Graph theoretical analysis has been applied to Fos datasets to characterize functional relationships in rodent neural circuits.
“Graph theoretical analysis has been applied to Fos datasets to characterize functional relationships in rodent neural circuits66–69.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [66]
A functional connectome study revealed that, whereas absolute hippocampal activity decreases over time, the connectivity of the hippocampus with other brain regions is strengthened, which is associated with remote memory.
“A functional connectome study further revealed that, whereas the absolute hippocampal activity decreases over time, the connectivity of the hippocampus with other brain regions is strengthened, which is associated with remote memory 31 .”
From Role of the hippocampus in systems consolidation of remote fear memory (2026) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Collective dynamics of ‘small-world’ networks
Watts, D. J., & Strogatz, S. H. (1998) · Nature · doi:10.1038/30918 · Cited by 43,060 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Complex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522 · see citing works
Error and attack tolerance of complex networks
Albert, R., Jeong, H., & Barabási, A.-L. (2000) · Nature · doi:10.1038/35019019 · Cited by 7,534 · see citing works
Error and attack tolerance of complex networksPreprint
Albert, R., Jeong, H., & Barabási, A.-Ĺ. (2000) · Cited by 6,554 · see citing works
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256 · see citing works
The Organization of Behavior; A Neuropsychological Theory.
Attneave, F., B., M., & Hebb, D. O. (1950) · The American Journal of Psychology · doi:10.2307/1418888 · Cited by 5,146 · see citing works
Efficient behavior of small-world networks
Latora, V., & Marchiori, M. (2001) · Physical Review Letters · doi:10.1103/physrevlett.87.198701 · Cited by 5,119 · see citing works
Assortative Mixing in Networks
Newman, M. E. J. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.208701 · Cited by 5,034 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
Achard, S., Salvador, R., Whitcher, B., Suckling, J., & Bullmore, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3874-05.2006 · Cited by 2,393 · see citing works
The organization of recent and remote memories
Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138 · see citing works
Self-citationMemory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924 · see citing works
The functional states of the thalamus and the associated neuronal interplay.
Steriade, M., & Llinas, R. R. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.3.649 · Cited by 1,746 · see citing works
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669 · see citing works
Selective suppression of hippocampal ripples impairs spatial memory
Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G., & Zugaro, M. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2384 · Cited by 1,560 · see citing works
Degeneracy and complexity in biological systems
Edelman, G. M., & Gally, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231499798 · Cited by 1,493 · see citing works
Retrograde amnesia and memory consolidation: a neurobiological perspective
Squire, L. R., & Alvarez, P. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80023-9 · Cited by 1,412 · see citing works
Why social networks are different from other types of networks
Newman, M. E. J., & Park, J. M. (2003) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.68.036122 · Cited by 1,362 · see citing works
Neural syntax: cell assemblies, synapsembles, and readers
Buzsáki, G. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.023 · Cited by 1,289 · see citing works
Identification and classification of hubs in brain networks
Sporns, O., Honey, C. J., & Kötter, R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001049 · Cited by 1,165 · see citing works
Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
Sharpe, J. A., Ahlgren, U., Perry, P., Hill, B., Ross, A., Hecksher‐Sørensen, J., Baldock, R., & Davidson, D. R. (2002) · Science · doi:10.1126/science.1068206 · Cited by 1,158 · see citing works
Spatial Pattern Analysis of Functional Brain Images Using Partial Least Squares
McIntosh, A. R., Bookstein, F. L., Haxby, J. V., & Grady, C. L. (1996) · NeuroImage · doi:10.1006/nimg.1996.0016 · Cited by 1,095 · see citing works
Self-citationEntrainment of Neocortical Neurons and Gamma Oscillations by the Hippocampal Theta Rhythm
Sirota, A., Montgomery, S., Fujisawa, S., Isomura, Y., Zugaro, M., & Buzsáki, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.014 · Cited by 1,015 · see citing works
Prefrontal phase locking to hippocampal theta oscillations
Siapas, A. G., Lubenov, E. V., & Wilson, M. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.028 · Cited by 1,014 · see citing works
The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
Frankland, P., Bontempi, B., Talton, L., Kaczmarek, L., & Silva, A. J. (2004) · Science · doi:10.1126/science.1094804 · Cited by 952 · see citing works
Self-citationBenchenane, K., Peyrache, A., Khamassi, M., Tierney, P. L., Gioanni, Y., Battaglia, F. P., & Wiener, S. I. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.013 · Cited by 872 · see citing works
Disruption of ripple‐associated hippocampal activity during rest impairs spatial learning in the rat
Ego‐Stengel, V., & Wilson, M. A. (2010) · Hippocampus · doi:10.1002/hipo.20707 · Cited by 842 · see citing works
Replay of rule-learning related neural patterns in the prefrontal cortex during sleep
Peyrache, A., Khamassi, M., Benchenane, K., Wiener, S. I., & Battaglia, F. P. (2009) · Nature Neuroscience · doi:10.1038/nn.2337 · Cited by 767 · see citing works
Cortical rewiring and information storage
Chklovskii, D. B., Mel, B. W., & Svoboda, K. (2004) · Nature · doi:10.1038/nature03012 · Cited by 717 · see citing works
Serial two-photon tomography for automated ex vivo mouse brain imaging
Ragan, T. M., Kadiri, L. R., Venkataraju, K. U., Bahlmann, K., Sutin, J. D. B., Taranda, J., Arganda‐Carreras, I., Kim, Y., Seung, H. S., & Osten, P. (2012) · Nature Methods · doi:10.1038/nmeth.1854 · Cited by 660 · see citing works
Sites of Neocortical Reorganization Critical for Remote Spatial Memory
Maviel, T., Durkin, T., Menzaghi, F., & Bontempi, B. (2004) · Science · doi:10.1126/science.1098180 · Cited by 659 · see citing works
Can structure predict function in the human brain?
Honey, C. J., Thivierge, J.-P., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.071 · Cited by 629 · see citing works
Schema-dependent gene activation and memory encoding in neocortex
Tse, D., Takeuchi, T., Kakeyama, M., Kajii, Y., Okuno, H., Tohyama, C., Bito, H., & Morris, R. G. M. (2011) · Science · doi:10.1126/science.1205274 · Cited by 618 · see citing works
Dynamics of Retrieval Strategies for Remote Memories
Goshen, I., Brodsky, M., Prakash, R., Wallace, J. L., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.033 · Cited by 546 · see citing works
Hippocampal-Neocortical Interactions in Memory Formation, Consolidation, and Reconsolidation
Wang, S., & Morris, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100523 · Cited by 536 · see citing works
Cortical DNA methylation maintains remote memory
Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., & Sweatt, J. D. (2010) · Nature Neuroscience · doi:10.1038/nn.2560 · Cited by 521 · see citing works
Dendritic spines and long-term plasticity
Segal, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1649 · Cited by 489 · see citing works
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Frankland, P. W., Cestari, V., Filipkowski, R. K., McDonald, R. J., & Silva, A. J. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.4.863 · Cited by 486 · see citing works
Self-citationMultiple models to capture the variability in biological neurons and networks
Marder, E., & Taylor, A. L. (2011) · Nature Neuroscience · doi:10.1038/nn.2735 · Cited by 451 · see citing works
Role of the Basolateral Amygdala in the Storage of Fear Memories across the Adult Lifetime of Rats
Gale, G. D., Anagnostaras, S., Godsil, B. P., Mitchell, S., Nozawa, T., Sage, J. R., Wiltgen, B. J., & Fanselow, M. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4100-03.2004 · Cited by 427 · see citing works
Mapping behaviorally relevant neural circuits with immediate-early gene expression
Guzowski, J. F., Timlin, J. A., Roysam, B., McNaughton, B. L., Worley, P. F., & Barnes, C. A. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.018 · Cited by 404 · see citing works
Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory
Lesburguères, E., Gobbo, O. L., Alaux‐Cantin, S., Hambücken, A., Trifilieff, P., & Bontempi, B. (2011) · Science · doi:10.1126/science.1196164 · Cited by 390 · see citing works
Memory trace reactivation in hippocampal and neocortical neuronal ensembles
Sutherland, G. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00079-9 · Cited by 384 · see citing works
Mapping Cognition to the Brain Through Neural Interactions
McIntosh, A. R. (1999) · Memory · doi:10.1080/096582199387733 · Cited by 374 · see citing works
Self-citationThe hippocampus: hub of brain network communication for memory
Battaglia, F. P., Benchenane, K., Sirota, A., Pennartz, C. M. A., & Wiener, S. I. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.008 · Cited by 351 · see citing works
Context Fear Learning in the Absence of the Hippocampus
Wiltgen, B. J., Sanders, M. J., Anagnostaras, S., Sage, J. R., & Fanselow, M. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2685-05.2006 · Cited by 349 · see citing works
Takehara‐Nishiuchi, K., Kawahara, S., & Kirino, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09897.2003 · Cited by 343 · see citing works
Calcium regulation of gene expression in neuronal cells
Ghosh, A., Ginty, D. D., Bading, H., & Greenberg, M. E. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250309 · Cited by 326 · see citing works
Pennartz, C. M. A., Lee, E., Verheul, J., Lipa, P., Barnes, C. A., & McNaughton, B. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-04.2004 · Cited by 282 · see citing works
Shift from hippocampal to neocortical centered retrieval network with consolidation
Takashima, A., Nieuwenhuis, I. L. C., Jensen, O., Talamini, L. M., Rijpkema, M., & Fernández, G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0799-09.2009 · Cited by 276 · see citing works
Lesting, J., Narayanan, R. T., Kluge, C., Sangha, S., Seidenbecher, T., & Pape, H.-C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021714 · Cited by 275 · see citing works
Role of Secondary Sensory Cortices in Emotional Memory Storage and Retrieval in Rats
Sacco, T., & Sacchetti, B. (2010) · Science · doi:10.1126/science.1183165 · Cited by 272 · see citing works
Ribeiro, S., Gervasoni, D., Soares, E. S., Zhou, Y., Lin, S.-C., Pantoja, J., Lavine, M., & Nicolelis, M. A. L. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020024 · Cited by 272 · see citing works
Winocur, G., Moscovitch, M., & Sekeres, M. J. (2007) · Nature Neuroscience · doi:10.1038/nn1880 · Cited by 270 · see citing works
Spontaneous Changes of Neocortical Code for Associative Memory During Consolidation
Takehara‐Nishiuchi, K., & McNaughton, B. L. (2008) · Science · doi:10.1126/science.1161299 · Cited by 248 · see citing works
An embedded subnetwork of highly active neurons in the neocortex
Yassin, L., Benedetti, B. L., Jouhanneau, J.-S., Wen, J. A., Poulet, J. F. A., & Barth, A. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.029 · Cited by 227 · see citing works
Markov clustering versus affinity propagation for the partitioning of protein interaction graphs
Vlasblom, J., & Wodak, S. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-99 · Cited by 223 · see citing works
Retinotopic organization of early visual spatial attention effects as revealed by PET and ERPs
Woldorff, M. G., Fox, P. T., Matzke, M., Lancaster, J. L., Veeraswamy, S., Zamarripa, F., Seabolt, M., Glass, T. G., Gao, J., Martin, C. C., et al. (1997) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1997)5:4 · Cited by 195 · see citing works
Self-citationVetere, G., Restivo, L., Cole, C. J., Ross, P. J., Ammassari‐Teule, M., Josselyn, S. A., & Frankland, P. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016275108 · Cited by 183 · see citing works
Self-citationCorcoran, K. A., Donnan, M. D., Tronson, N. C., Guzmán, Y. F., Gao, C., Jovasevic, V., Guedea, A. L., & Radulović, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-11.2011 · Cited by 182 · see citing works
Stone, S. S. D., Teixeira, C. M., Zaslavsky, K., Wheeler, A. L., Martínez-Canabal, A., Wang, A. H., Sakaguchi, M., Lozano, A. M., & Frankland, P. W. (2010) · Hippocampus · doi:10.1002/hipo.20845 · Cited by 167 · see citing works
Self-citationQuinn, J. J., Ma, Q. D., Tinsley, M. R., Christof Koch, A., & Fanselow, M. S. (2008) · Learning & Memory · doi:10.1101/lm.813608 · Cited by 154 · see citing works
Loureiro, M., Cholvin, T., Lopez, J., Mérienne, N., Latreche, A., Cosquer, B., Geiger, K., Kelche, C. R., Cassel, J., & de Vasconcelos, A. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0410-12.2012 · Cited by 145 · see citing works
Sutherland, R. J., O'Brien, J., & Lehmann, H. (2008) · Hippocampus · doi:10.1002/hipo.20431 · Cited by 137 · see citing works
Sutherland, R., Sparks, F. T., & Lehmann, H. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.015 · Cited by 99 · see citing works
Network analysis of brain cognitive function using metabolic and blood flow data
Horwitz, B., McIntosh, A. R., Haxby, J. V., & Grady, C. L. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00139-7 · Cited by 81 · see citing works
Self-citationContextual Fear Memories Formed in the Absence of the Dorsal Hippocampus Decay Across Time
Zelikowsky, M., Bissière, S., & Fanselow, M. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4339-11.2012 · Cited by 77 · see citing works
Spontaneous changes of neocortical code for associative memory during consolidation
Takahara-Nishiuchi, K., & McNaughton, B. L. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.09.1498 · Cited by 65 · see citing works
Nair, H. P., & Gonzalez-Lima, F. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08646.1999 · Cited by 61 · see citing works
The Intralaminar Thalamic Nuclei Contribute to Remote Spatial Memory
Lopez, J., Wolff, M., Lecourtier, L., Cosquer, B., Bontempi, B., Dalrymple‐Alford, J. C., & Cassel, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5576-08.2009 · Cited by 57 · see citing works
Three-dimensional reconstruction of serial histological mouse brain sections
Chakravarty, M. M., Bedell, B. J., Zehntner, S. P., Evans, A. C., & Collins, D. L. (2008) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2008.4541164 · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 76 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [7]Lashley KS (1950) In search of the engram. In: Society of Experimental Biology Symposium 4. Oxford, England: Academic Press. pp 454–482.
Cited by
Sorted by citations
Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087 · see citing works
The Consolidation and Transformation of Memory
Dudai, Y., Karni, A., & Born, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.004 · Cited by 741 · see citing works
Squire, L. R., Genzel, L., Wixted, J. T., & Morris, R. G. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021766 · Cited by 700 · see citing works
Josselyn, S. A., Köhler, S., & Frankland, P. W. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4000 · Cited by 687 · see citing works
Self-citationTemporal evolution of cortical ensembles promoting remote memory retrieval
DeNardo, L. A., Liu, C. D., Allen, W. E., Adams, E. L., Friedmann, D., Dadgar‐Kiani, E., Fu, L., Guenthner, C. J., Lee, J. H., Tessier‐Lavigne, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0318-7 · Cited by 615 · see citing works
Bidirectional switch of the valence associated with a hippocampal contextual memory engram
Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature · doi:10.1038/nature13725 · Cited by 512 · see citing works
The role of engram cells in the systems consolidation of memory
Tonegawa, S., Morrissey, M. D., & 北村, 貴. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0031-2 · Cited by 454 · see citing works
Memory engram storage and retrieval
Tonegawa, S., Pignatelli, M., Roy, D. S., & Ryan, T. J. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.07.009 · Cited by 389 · see citing works
The hippocampus and related neocortical structures in memory transformation
Sekeres, M. J., Winocur, G., & Moscovitch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.006 · Cited by 370 · see citing works
Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice
Vetere, G., Kenney, J. W., Tran, L. M., Xia, F., Steadman, P. E., Parkinson, J., Josselyn, S. A., & Frankland, P. W. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.037 · Cited by 293 · see citing works
Self-citationKol, A., Adamsky, A., Groysman, M., Kreisel, T., London, M., & Goshen, I. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0679-6 · Cited by 289 · see citing works
Insular cortex mediates approach and avoidance responses to social affective stimuli
Rogers-Carter, M. M., Varela, J. A., Gribbons, K. B., Pierce, A. F., McGoey, M. T., Ritchey, M., & Christianson, J. P. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0071-y · Cited by 277 · see citing works
The neurobiological foundation of memory retrieval
Frankland, P. W., Josselyn, S. A., & Köhler, S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0493-1 · Cited by 228 · see citing works
Self-citationTanimizu, T., Kenney, J. W., Okano, E., Kadoma, K., Frankland, P. W., & Kida, S. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3451-16.2017 · Cited by 214 · see citing works
Self-citationRecovery of “Lost” Infant Memories in Mice
Guskjolen, A. J., Kenney, J. W., de la Parra, J., Yeung, B.-R. A., Josselyn, S. A., & Frankland, P. W. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.059 · Cited by 160 · see citing works
Self-citationJosselyn, S. A., Köhler, S., & Frankland, P. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0056-17.2017 · Cited by 122 · see citing works
Self-citationA cFos activation map of remote fear memory attenuation
Silva, B. A., Burns, A. M., & Gräff, J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5000-y · Cited by 118 · see citing works
Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
Matos, M. R., Visser, E., Kramvis, I., van der Loo, R. J., Gebuis, T., Zalm, R., Rao‐Ruiz, P., Mansvelder, H. D., Smit, A. B., & van den Oever, M. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10266-1 · Cited by 119 · see citing works
Restivo, L., Niibori, Y., Mercaldo, V., Josselyn, S. A., & Frankland, P. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3238-14.2015 · Cited by 112 · see citing works
Self-citationZhou, M., Liu, Z., Melin, M. D., Ng, Y. H., Xu, W., & Südhof, T. C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0248-4 · Cited by 112 · see citing works
Entorhinal cortex and consolidated memory
Takehara‐Nishiuchi, K. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.02.012 · Cited by 105 · see citing works
Early remodeling of the neocortex upon episodic memory encoding
Bero, A. W., Meng, J., Cho, S., Shen, A. H., Canter, R. G., Ericsson, M., & Tsai, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408378111 · Cited by 106 · see citing works
Wirt, R. A., & Hyman, J. M. (2017) · Brain Sciences · doi:10.3390/brainsci7040043 · Cited by 103 · see citing works
Brain-wide functional architecture remodeling by alcohol dependence and abstinence
Kimbrough, A., Lurie, D. J., Collazo, A., Kreifeldt, M., Sidhu, H., Macedo, G. C., D’Esposito, M., Contet, C., & George, O. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909915117 · Cited by 97 · see citing works
Morena, M., Berardi, A., Colucci, P., Palmery, M., Trezza, V., Hill, M. N., & Campolongo, P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.305 · Cited by 94 · see citing works
Besnard, A., Gao, Y., Kim, M. T., Twarkowski, H., Reed, A. K., Langberg, T., Feng, W., Xu, X., Saur, D., Zweifel, L. S., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0330-y · Cited by 94 · see citing works
Sekeres, M. J., Winocur, G., Moscovitch, M., Anderson, J. A. E., Pishdadian, S., Wojtowicz, J. M., St‐Laurent, M., McAndrews, M. P., & Grady, C. L. (2018) · Hippocampus · doi:10.1002/hipo.23009 · Cited by 95 · see citing works
The neurocircuitry of remote cued fear memory
Bergstrom, H. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.028 · Cited by 92 · see citing works
Ferraris, M., Ghestem, A., Vicente, A. F., Nallet-Khosrofian, L., Bernard, C., & Quilichini, P. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3058-17.2018 · Cited by 91 · see citing works
A thalamo-amygdalar circuit underlying the extinction of remote fear memories
Silva, B. A., Astori, S., Burns, A. M., Heiser, H., van den Heuvel, L., Santoni, G., Martínez-Reza, M. F., Sandi, C., & Gräff, J. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00856-y · Cited by 88 · see citing works
Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., Drexler, S. M., Lange, M. D., Jüngling, K., Nees, F., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.020 · Cited by 89 · see citing works
Ferraris, M., Cassel, J., de Vasconcelos, A. P., Stéphan, A., & Quilichini, P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.025 · Cited by 85 · see citing works
Brain networks activated to form object recognition memory
Tanimizu, T., Kono, K., & Kida, S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.017 · Cited by 81 · see citing works
Structural and functional organization of the midline and intralaminar nuclei of the thalamus
Vertes, R. P., Linley, S. B., & Rojas, A. K. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.964644 · Cited by 82 · see citing works
Brain activation induced by chronic psychosocial stress in mice
Laine, M. A., Sokolowska, E., Dudek, M., Callan, S., Hyytiä, P., & Hovatta, I. (2017) · Scientific Reports · doi:10.1038/s41598-017-15422-5 · Cited by 76 · see citing works
Čulig, L., Surget, A., Bourdey, M., Khemissi, W., Guisquet, A. L., Vogel, E., Sahay, A., Hen, R., & Belzung, C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.009 · Cited by 75 · see citing works
Neuronal competition: microcircuit mechanisms define the sparsity of the engram
Rao‐Ruiz, P., Yu, J., Kushner, S. A., & Josselyn, S. A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.10.013 · Cited by 74 · see citing works
A 3D adult zebrafish brain atlas (AZBA) for the digital age
Kenney, J. W., Steadman, P. E., Young, O., Shi, M. T., Polanco, M., Dubaishi, S., Covert, K., Mueller, T., & Frankland, P. W. (2021) · eLife · doi:10.7554/elife.69988 · Cited by 72 · see citing works
Self-citationShrestha, P., Ayata, P., Herrero-Vidal, P., Longo, F., Guilabert, A. G., LeDoux, J. E., Heintz, N., & Klann, E. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0568-z · Cited by 71 · see citing works
Systems consolidation and the content of memory
Wiltgen, B. J., & Tanaka, K. Z. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.001 · Cited by 71 · see citing works
The nonspecific thalamus: A place in a wedding bed for making memories last?
de Vasconcelos, A. P., & Cassel, J. (2015) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.021 · Cited by 54 · see citing works
A hippocampo-cerebellar centred network for the learning and execution of sequence-based navigation
Babayan, B. M., Watilliaux, A., Viejo, G., Paradis, A.-L., Girard, B., & Rondi-Reig, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-18004-7 · Cited by 70 · see citing works
Whole-brain mapping of behaviourally induced neural activation in mice
Vousden, D. A., Epp, J. R., Okuno, H., Nieman, B. J., van Eede, M., Dazai, J., Ragan, T. M., Bito, H., Frankland, P. W., Lerch, J. P., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0774-0 · Cited by 69 · see citing works
Self-citationHamani, C., Amorim, B. O., Wheeler, A. L., Diwan, M., Driesslein, K., Covolan, L., Butson, C. R., & Nóbrega, J. N. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.007 · Cited by 68 · see citing works
Self-citationNeural correlates of ingroup bias for prosociality in rats
Bartal, I. B.-A., Breton, J., Sheng, H., Long, K. L. P., Chen, S., Halliday, A., Kenney, J. W., Wheeler, A. L., Frankland, P. W., Shilyansky, C., et al. (2021) · eLife · doi:10.7554/elife.65582 · Cited by 68 · see citing works
Self-citationMechanisms of Memory Consolidation and Transformation
Sekeres, M. J., Moscovitch, M., & Winocur, G. (2017) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-319-45066-7_2 · Cited by 69 · see citing works
Chiaruttini, N., Castoldi, C., Requie, L. M., Camarena-Delgado, C., Bianco, B. D., Gräff, J., Seitz, A., & Silva, B. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115876 · Cited by 66 · see citing works
A Synaptic Framework for the Persistence of Memory Engrams
Rao‐Ruiz, P., Visser, E., Mitrić, M. M., Smit, A. B., & van den Oever, M. C. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.661476 · Cited by 65 · see citing works
Roland, A. V., Coelho, C. A. O., Haun, H. L., Gianessi, C. A., Lopez, M. F., D’Ambrosio, S. R., Machinski, S. N., Kroenke, C. D., Frankland, P. W., Becker, H. C., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.01.018 · Cited by 64 · see citing works
Self-citationDisrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex
Scott, G. A., Terstege, D. J., Vu, A. P., Law, S., Evans, A., & Epp, J. R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00407 · Cited by 64 · see citing works
Neurobiology of systems memory consolidation
Takehara‐Nishiuchi, K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14694 · Cited by 65 · see citing works
Contrast flow selectivity during transforaminal lumbosacral epidural steroid injections.
Furman, M. B., Lee, T. S., Mehta, A. R., Simon, J. I., & Cano, W. G. (2008) · PubMed · Cited by 58 · see citing works
Dudai, Y., & Morris, R. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.039 · Cited by 59 · see citing works
Prefrontal engrams of long-term fear memory perpetuate pain perception
Stegemann, A., Liu, S., Romero, O. A. R., Oswald, M. J., Han, Y., Beretta, C. A., Gan, Z., Tan, L. L., Wisden, W., Gräff, J., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01291-x · Cited by 57 · see citing works
Emerging imaging methods to study whole-brain function in rodent models
Markicevic, M., Savvateev, I., Grimm, C., & Zerbi, V. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01575-5 · Cited by 54 · see citing works
Gongwer, M. W., Klune, C. B., Couto, J., Jin, B., Enos, A. S., Chen, R., Friedmann, D., & DeNardo, L. A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0697-23.2023 · Cited by 51 · see citing works
The mysteries of remote memory
Albo, Z., & Gräff, J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0029 · Cited by 53 · see citing works
An inhibitory hippocampal–thalamic pathway modulates remote memory retrieval
Vetere, G., Xia, F., Ramsaran, A. I., Tran, L. M., Josselyn, S. A., & Frankland, P. W. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00819-3 · Cited by 51 · see citing works
Self-citationWhole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta
Yang, Y., Jiang, T., Jia, X., Yuan, J., Li, X., & Gong, H. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00930-w · Cited by 51 · see citing works
Broadbent, N., & Clark, R. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.008 · Cited by 51 · see citing works
Fee, C., Prévot, T. D., Misquitta, K. A., Banasr, M., & Sibille, E. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.034 · Cited by 48 · see citing works
The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
Dixsaut, L., & Gräff, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212113 · Cited by 50 · see citing works
der Weel, M. J. D.-V., Lopes, F. H. D. S., & Witter, M. P. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1350-6 · Cited by 46 · see citing works
maLPA1-null mice as an endophenotype of anxious depression
Moreno‐Fernández, R. D., Pérez‐Martín, M., Castilla‐Ortega, E., Rosell‐Valle, C., Garcia‐Fernandez, M. I., Chun, J. J. M., Estivill‐Torrús, G., de Fonseca, F. R., Santín, L. J., & Pedraza, C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.24 · Cited by 48 · see citing works
Dixsaut, L., & Gräff, J. (2022) · eLife · doi:10.7554/elife.78542 · Cited by 46 · see citing works
The optogenetic revolution in memory research
Goshen, I. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.06.002 · Cited by 49 · see citing works
Activation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior
Ferri, S. L., Kreibich, A. S., Torre, M., Piccoli, C. T., Dow, H. C., Pallathra, A. A., Li, H., Bilker, W. B., Gur, R. C., Abel, T. G., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.006 · Cited by 48 · see citing works
Lee, M.-J., Ryu, J.-S., Won, S.-K., Namgung, U., Jung, J., Lee, S., & Park, J.-Y. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01353 · Cited by 47 · see citing works
Rinaldi, A., Leonibus, E. D., Cifra, A., Torromino, G., Minicocci, E., Sanctis, E. D., López‐Pedrajas, R., Oliverio, A., & Mele, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68025-y · Cited by 47 · see citing works
Propranolol Decreases Fear Expression by Modulating Fear Memory Traces
Santos, S. L., Stackmann, M., Zamora, A., Mastrodonato, A., Landri, A. V. D., Vaughan, N. D., Chen, B. K., Lanio, M., & Denny, C. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.005 · Cited by 47 · see citing works
The claustrum: Considerations regarding its anatomy, functions and a programme for research
Dillingham, C. M., Jankowski, M. M., Chandra, R., Frost, B. E., & O’Mara, S. M. (2017) · Brain and Neuroscience Advances · doi:10.1177/2398212817718962 · Cited by 45 · see citing works
McReynolds, J. R., Christianson, J. P., Blacktop, J. M., & Mantsch, J. R. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.05.004 · Cited by 42 · see citing works
Engram stability and maturation during systems consolidation
Refaeli, R., Kreisel, T., Groysman, M., Adamsky, A., & Goshen, I. (2023) · Current Biology · doi:10.1016/j.cub.2023.07.042 · Cited by 42 · see citing works
The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical
Genzel, L., Rossato, J. I., Jacobse, J., Grieves, R. M., Spooner, P. A., Battaglia, F. P., Fernández, G., & Morris, R. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2000531 · Cited by 43 · see citing works
Neural reinstatement reveals divided organization of fear and extinction memories in the human brain
Hennings, A. C., McClay, M., Drew, M. R., Lewis‐Peacock, J. A., & Dunsmoor, J. E. (2021) · Current Biology · doi:10.1016/j.cub.2021.11.004 · Cited by 45 · see citing works
System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment
Bonaccorsi, J., Cintoli, S., Mastrogiacomo, R., Baldanzi, S., Braschi, C., Pizzorusso, T., Cenni, M. C., & Berardi, N. (2013) · Neural Plasticity · doi:10.1155/2013/956312 · Cited by 43 · see citing works
Wotjak, C. T. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5111-5 · Cited by 42 · see citing works
Tyebji, S., Seizova, S., Garnham, A. L., Hannan, A. J., & Tonkin, C. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.028 · Cited by 41 · see citing works
Brain-wide maps of Fos expression during fear learning and recallPreprint
Cho, J.-H., Rendall, S., & Gray, J. M. (2017) · Learning & Memory · doi:10.1101/lm.044446.116 · Cited by 42 · see citing works
Cavalcante, L. E. S., Zinn, C. G., Schmidt, S. D., Saenger, B. F., Ferreira, F. F., Furini, C. R. G., Myskiw, J. D. C., & Izquierdo, I. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.044 · Cited by 41 · see citing works
Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics
Kveim, V. A., Salm, L., Ulmer, T., Lahr, M., Kandler, S., Imhof, F., & Donato, F. (2024) · Science · doi:10.1126/science.adk0997 · Cited by 37 · see citing works
Engram cell connectivity: an evolving substrate for information storage
Ryan, T. J., Luis, C. O. S., Pezzoli, M., & Sen, S. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.01.006 · Cited by 38 · see citing works
Lux, V., Atucha, E., Kitsukawa, T., & Sauvage, M. M. (2016) · eLife · doi:10.7554/elife.11862 · Cited by 35 · see citing works
What does engram encode?: Heterogeneous memory engrams for different aspects of experience
Nambu, M. F., Lin, Y.-J., Reuschenbach, J., & Tanaka, K. Z. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102568 · Cited by 34 · see citing works
Ali, M., Cholvin, T., Muller, M., Cosquer, B., Kelche, C. R., Cassel, J., & de Vasconcelos, A. P. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.03.021 · Cited by 34 · see citing works
Wadhera, T., & Kakkar, D. (2021) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2021.102556 · Cited by 34 · see citing works
Kimbrough, A., Smith, L. C., Kallupi, M., Simpson, S., Collazo, A., & George, O. (2021) · eNeuro · doi:10.1523/eneuro.0208-19.2021 · Cited by 33 · see citing works
The reuniens and rhomboid nuclei are necessary for contextual fear memory persistence in rats
Quet, É., Majchrzak, M. J., Cosquer, B., Morvan, T., Wolff, M., Cassel, J., de Vasconcelos, A. P., & Stéphan, A. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02048-z · Cited by 33 · see citing works
Engram cell connectivity as a mechanism for information encoding and memory function
Luis, C. O. S., Pezzoli, M., Urrieta, E., & Ryan, T. J. (2023) · Current Biology · doi:10.1016/j.cub.2023.10.074 · Cited by 33 · see citing works
Thalamo-cortical coupling during encoding and consolidation is linked to durable memory formation
Wagner, I. C., van Buuren, M., & Fernández, G. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.055 · Cited by 32 · see citing works
Single-cell memory trace imaging with immediate-early genes
Sauvage, M. M., Kitsukawa, T., & Atucha, E. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108368 · Cited by 32 · see citing works
Moretti, J., Terstege, D. J., Poh, E. Z., Epp, J. R., & Rodger, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-24934-8 · Cited by 32 · see citing works
Han, J.-K., Kwon, S., Kim, Y. G., Choi, J., Kim, J., Lee, Y., Ye, S.-K., & Kim, S. J. (2021) · eLife · doi:10.7554/elife.63291 · Cited by 31 · see citing works
Hu, Y., Du, W., Qi, J., Luo, H., Zhang, Z., Luo, M., & Wang, Y. (2023) · eLife · doi:10.7554/elife.88420 · Cited by 30 · see citing works
Méndez‐Couz, M., Conejo, N. M., González‐Pardo, H., & Arias, J. L. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.005 · Cited by 30 · see citing works
Pilarzyk, K., Klett, J., Peña, E. A., Porcher, L., Smith, A. J., & Kelly, M. P. (2019) · Current Biology · doi:10.1016/j.cub.2019.06.018 · Cited by 28 · see citing works
Torromino, G., Autore, L., Khalil, V., Mastrorilli, V., Griguoli, M., Pignataro, A., Centofante, E., Biasini, G. M., de Turris, V., Ammassari‐Teule, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13703-3 · Cited by 27 · see citing works
Focus on females: a less biased approach for studying strategies and mechanisms of memory
Tronson, N. C. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.04.005 · Cited by 26 · see citing works
Neural activation associated with outgroup helping in adolescent rats
Breton, J., Eisner, J. S., Gandhi, V. S., Musick, N., Zhang, A., Long, K. L. P., Perloff, O. S., Hu, K. Y., Pham, C. M., Lalchandani, P., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104412 · Cited by 26 · see citing works
Roles for the Dorsal Striatum in Aversive Behavior
Stanley, A. T., Lippiello, P., Sulzer, D. L., & Miniaci, M. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.634493 · Cited by 26 · see citing works
- Authors
- Wheeler, A. L., Teixeira, C. M., Wang, A. H., Xiong, X., Kovacevic, N., Lerch, J. P., McIntosh, A. R., Parkinson, J., & Frankland, P. W.
- Affiliations
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Baycrest Hospital (CA)
- Corresponding author
- Frankland, Paul W.
- ORCID
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-03
- Volume
- 9
- Issue
- 1
- Pages
- e1002853
- ISSN
- 1553-734X (ISSN-L)
- 1553-7358
- PMC
- PMC3536620
- OpenAlex
- W1995227930
- Cited by
- 315
- References
- 76
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 31 · 2023: 42 · 2022: 33 · 2021: 36 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 24 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 5
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Computational Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Hospital for Sick Children
- Canadian Institutes of Health Research (82940_1, MOP77561, 82940)
- Fundação para a Ciência e a Tecnologia
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- memory retrieval, functional connectome, Fos expression, memory age, thalamus, hippocampus, prefrontal cortex, small-world networks, hub regions, memory traces, mice
- MeSH terms
- Animals, Brain, Fear, Immunohistochemistry, Memory, Mice, Mutant Strains, Nerve Net, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
