Newborn cortical neurons: only for neonates?
Open accessAbstract
Despite a century of debate over the existence of adult cortical neurogenesis, a consensus has not yet been reached. Here, we review evidence of the existence, origin, migration, and integration of neurons into the adult and neonatal cerebral cortex. We find that the lack of consensus likely stems from the low rate of postnatal cortical neurogenesis that has been observed, the fact that neurogenesis may be limited to subtypes of interneurons, and variability in other conditions, both physiological and environmental. We emphasize that neurogenesis occurs in the neonatal cortex and that neural stem cells are present into adulthood; it is possible that these progenitors are dormant, but they may be reactivated, for example, following injury.
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Combining goal-based with aerobic training may improve automatic and cognitive motor control and reduce the attentional demands of consciously processing behaviors such as walking.
“More importantly, studies suggest that combining goal based with aerobic training the possibility for improving automatic with cognitive motor control may be possible and thus reduce the attentional demands of consciously processing behaviors such as walking.126”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [126]
The adult mammalian brain, including humans, displays a high degree of neurogenesis.
“It is well established that the adult mammalian brain including humans displays a high degree of neurogenesis, the birth of newborn cells.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as Feliciano, 2013 #43937
Neurogenesis is limited by age and to a very limited number of anatomical sites including regions adjacent to the lateral ventricle and hippocampus.
“However, neurogenesis is limited by both age and to a very limited number of anatomical sites including the regions adjacent to the lateral ventricle and hippocampus {Feliciano, 2013 #43937}.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as Feliciano, 2013 #43937
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“Neurogenesis in the hippocampal dentate gyrus also persists in the neonatal period (and throughout adulthood), and recent evidence indicates lingering neurogenesis in different cortical regions, including the prefrontal cortex in human infants (Sanai et al., 2011; Feliciano and Bordey, 2012).”
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- Authors
- Feliciano, D. M., & Bordey, A.
- Affiliations
- Yale University (US)
- Corresponding author
- Bordey, Angélique
- ORCID
- Bordey, Angélique
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 36
- Issue
- 1
- Pages
- 51-61
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3534801
- OpenAlex
- W1977950675
- Cited by
- 51
- References
- 100
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 8
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (W81XWH-10-1-0041)
- National Institutes of Health (R01 DC007681, NRSA 10668225)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, neural stem cells, interneurons, neuronal migration, neural integration, cerebral cortex
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Cerebral Cortex, Humans, Infant, Newborn, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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