Cited by 51Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyNeuroscience and Neuropharmacology Research

Newborn cortical neurons: only for neonates?

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Feliciano, David M., Bordey, Angélique·2013·Trends in Neurosciences

Abstract

Despite a century of debate over the existence of adult cortical neurogenesis, a consensus has not yet been reached. Here, we review evidence of the existence, origin, migration, and integration of neurons into the adult and neonatal cerebral cortex. We find that the lack of consensus likely stems from the low rate of postnatal cortical neurogenesis that has been observed, the fact that neurogenesis may be limited to subtypes of interneurons, and variability in other conditions, both physiological and environmental. We emphasize that neurogenesis occurs in the neonatal cortex and that neural stem cells are present into adulthood; it is possible that these progenitors are dormant, but they may be reactivated, for example, following injury.

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Crossref · 10.1016/j.tins.2012.09.004

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  • Combining goal-based with aerobic training may improve automatic and cognitive motor control and reduce the attentional demands of consciously processing behaviors such as walking.

    “More importantly, studies suggest that combining goal based with aerobic training the possibility for improving automatic with cognitive motor control may be possible and thus reduce the attentional demands of consciously processing behaviors such as walking.126”
  • The adult mammalian brain, including humans, displays a high degree of neurogenesis.

    “It is well established that the adult mammalian brain including humans displays a high degree of neurogenesis, the birth of newborn cells.”
  • Neurogenesis is limited by age and to a very limited number of anatomical sites including regions adjacent to the lateral ventricle and hippocampus.

    “However, neurogenesis is limited by both age and to a very limited number of anatomical sites including the regions adjacent to the lateral ventricle and hippocampus {Feliciano, 2013 #43937}.”

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Authors
Feliciano, D. M., & Bordey, A.
Affiliations
Yale University (US)
Corresponding author
Bordey, Angélique
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2013-01
Volume
36
Issue
1
Pages
51-61
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1977950675
Cited by
51
References
100
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 8
FWCI
1.03
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Defense (W81XWH-10-1-0041)
  • National Institutes of Health (R01 DC007681, NRSA 10668225)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, neural stem cells, interneurons, neuronal migration, neural integration, cerebral cortex
MeSH terms
Animals, Animals, Newborn, Cell Differentiation, Cerebral Cortex, Humans, Infant, Newborn, Adult Stem Cells, Neurogenesis, Neural Stem Cells

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