Neocortical neurogenesis in humans is restricted to development
Open accessAbstract
Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of 14 C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.
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Most neurons in the human brain are generated before birth.
“The bulk of neurons in the human brain are generated prenatally204.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [204]
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- Authors
- Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F. H., Druid, H., Eriksson, P. S., & Frisén, J.
- Affiliations
- Karolinska Institutet (SE)
- Salk Institute for Biological Studies (US)
- *Department of Cell and Molecular Biology, Medical Nobel Institute, and
- Lawrence Livermore National Laboratory (US)
- Australian Nuclear Science and Technology Organisation (AU)
- Oncology and
- Sahlgrenska University Hospital (SE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-08-15
- Volume
- 103
- Issue
- 33
- Pages
- 12564-12568
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1567918
- OpenAlex
- W1966295032
- Cited by
- 448
- References
- 52
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 13 · 2021: 17 · 2020: 52 · 2019: 22 · 2018: 24 · 2017: 14 · 2016: 21 · 2015: 20 · 2014: 25 · 2013: 27 · 2012: 25
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Australian Nuclear Science and Technology Organisation Institutional Repository (The Australian Nuclear Science and Technology Organisation) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- U.S. Department of Energy (W-7405, -7405-ENG-48)
- Australian Nuclear Science and Technology Organisation
- Parkinson Society Canada
- Neurological Foundation of New Zealand
- Cancerfonden
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- National Institutes of Health
- National Institute of General Medical Sciences (P41GM103483)
- National Center for Research Resources (RR13461, P41RR013461)
- Lawrence Livermore National Laboratory (W-7405-ENG 48, -7405-Eng-48)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, neocortical neurogenesis, human cerebral cortex, postnatal brain development, BrdU labeling, cell turnover
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Antimetabolites, Atmosphere, Autopsy, Bromodeoxyuridine, Carbon Radioisotopes, Humans, Middle Aged, Nuclear Warfare, Stem Cells, Time Factors, Neocortex
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