Cited by 323Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyCellular transport and secretion

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Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

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Nguyen, Maria, Wong, Yvette C., Ysselstein, Daniel, Severino, Alex, Krainc, Dimitri·2019·Trends in Neurosciences

DOI 10.1016/j.tins.2018.11.001PMC PMC6452863

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Abstract

The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endophilin A1), have also highlighted disruptions in synaptic vesicle endocytosis (SVE) as a significant contributor to disease pathogenesis. Additionally, the roles of other PD genes such as LRRK2, PRKN, and VPS35 in the regulation of SVE are beginning to emerge. Here we discuss the recent work on the contribution of dysfunctional SVE to midbrain dopaminergic neurons' selective vulnerability and highlight pathways that demonstrate the interplay of synaptic, mitochondrial, and lysosomal dysfunction in the pathogenesis of PD.

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Authors: Nguyen, M., Wong, Y. C., Ysselstein, D., Severino, A., & Krainc, D.
Affiliations: Northwestern University (US)
Corresponding author: Krainc, Dimitri
ORCID: Wong, Yvette C.
Ysselstein, Daniel
Severino, Alex
Krainc, Dimitri
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2019-02
Volume: 42
Issue: 2
Pages: 140-149
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2018.11.001
PMC: PMC6452863
OpenAlex: W2903418495
Cited by: 323
References: 89
Citations by year: 2026: 25 · 2025: 38 · 2024: 53 · 2023: 42 · 2022: 45 · 2021: 57 · 2020: 45 · 2019: 18
FWCI: 4.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (2T32AG020506-16, K99 NS109252, T32 NS041234, R01 NS076054, R37 NS096241)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: Parkinson's disease, synaptic vesicle endocytosis, mitochondrial dysfunction, oxidative stress, DNAJC6, auxilin, SYNJ1, SH3GL2, endophilin A1, LRRK2, Parkin, VPS35, midbrain dopaminergic neurons, selective neuronal vulnerability, risk genes
MeSH terms: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Animals, Autophagy, Dopamine, Endocytosis, Humans, Lysosomes, Mitochondria, Parkinson Disease, Synaptic Vesicles, Oxidative Stress, Genetic Predisposition to Disease, alpha-Synuclein, Dopaminergic Neurons

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Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

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