The DOI matches its Crossref record; 193 of the 197 references it cites were found in a registry or an index.
The clinical toxicology of caffeine: A review and case study
Open accessAbstract
Caffeine is a widely recognized psychostimulant compound with a long history of consumption by humans. While it has received a significant amount of attention there is still much to be learned with respect to its toxicology in humans, especially in cases of overdose. A review of the history of consumption and the clinical toxicology of caffeine including clinical features, pharmacokinetics, toxicokinetics, a thorough examination of mechanism of action and management/treatment strategies are undertaken. While higher (i.e., several grams) quantities of caffeine are known to cause toxicity and potentially lethality, cases of mainly younger individuals who have experienced severe side effects and death despite consuming doses not otherwise known to cause such harm is troubling and deserves further study. An attempted case reconstruction is performed in an effort to shed light on this issue with a focus on the pharmacokinetics and pharmacodynamics of caffeine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, excessive caffeine consumption (1~1.5 g/day) can cause caffeine poisoning (caffeinism), which includes symptoms such as anxiety, agitation, insomnia, and gastrointestinal disorders.”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 1×
“inhibitor, it is only able to interact with this molecular target at concentrations that greatly exceed those seen with normal caffeine consumption [39,66,67,70].”
BackgroundInternational Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Goldfrank's Toxicologic Emergencies.
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-2-323 · Cited by 1,279
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Heckman, M. A., Weil, J., & de Mejía, E. G. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01561.x · Cited by 1,116
The long QT syndrome. Prospective longitudinal study of 328 families.
Moss, A. J., Schwartz, P. J., Crampton, R. S., Tzivoni, D., Locati, E. H., MacCluer, J. W., Hall, W. J., Weitkamp, L., Vincent, G. M., & Garson, A. (1991) · Circulation · doi:10.1161/01.cir.84.3.1136 · Cited by 966
A Prospective Study of Sudden Cardiac Death among Children and Young Adults
Bagnall, R. D., Weintraub, R. G., Ingles, J., Duflou, J. A., Yeates, L., Lam, L., Davis, A. M., Thompson, T. N., Connell, V., Wallace, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510687 · Cited by 847
Pharmacology of Adenosine Receptors: The State of the Art
Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757
Effects of caffeine on human behavior
Smith, A. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00096-0 · Cited by 741
The Spectrum of Epidemiology Underlying Sudden Cardiac Death
Hayashi, M., Shimizu, W., & Albert, C. M. (2015) · Circulation Research · doi:10.1161/circresaha.116.304521 · Cited by 741
Barone, J. J., & Roberts, H. R. (1996) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00093-3 · Cited by 705
Food sources and intakes of caffeine in the diets of persons in the United States
Frary, C. D., Johnson, R. K., & Wang, M. Q. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.10.027 · Cited by 681
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
G protein coupled receptor structure and activation
Kobilka, B. K. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.10.021 · Cited by 625
Structure and function of adenosine receptors and their genes
Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583
Encyclopedia of Food and Health
(2016) · Choice Reviews Online · doi:10.5860/choice.195123 · Cited by 575
Gennari, F. J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808133390707 · Cited by 565
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501
Coffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490
Metabolic, Catecholamine, and Exercise Performance Responses to Various Doses of Caffeine
Graham, T. E., & Spriet, L. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.867 · Cited by 488
Goldfrank's Toxicologic Emergencies.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-821_6 · Cited by 478
Clinical Experience Over 48 Years With Pheochromocytoma
Goldstein, R. E., O’Neill, J. A., Holcomb, G. W., III, Morgan, W. M., Neblett, W. W., Oates, J. A., Brown, N., Nadeau, J., Smith, B., Page, D. L., et al. (1999) · Annals of Surgery · doi:10.1097/00000658-199906000-00001 · Cited by 463
Barnes, P. J. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0388pp · Cited by 445
Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans
Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1997.tb04356.x · Cited by 400
The absolute bioavailability of caffeine in man
Blanchard, J., & Sawers, S. J. A. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00613933 · Cited by 378
Clinically Significant Pharmacokinetic Interactions Between Dietary Caffeine and Medications
Carrillo, J. A., & Benítez, J. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200039020-00004 · Cited by 370
Caffeine Use in Sports, Pharmacokinetics in Man, and Cellular Mechanisms of Action
Magkos, F., & Kavouras, S. A. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040-830491379245 · Cited by 367
Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults
Fernández, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. (2011) · Pharmaceutics · doi:10.3390/pharmaceutics3010053 · Cited by 364
Caffeine disposition after oral doses
Bonati, M., Latini, R., Galletti, F., Young, J. F., Tognoni, G., & Garattini, S. (1982) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1982.132 · Cited by 353
Coffee, caffeine and blood pressure: a critical review
Nurminen, M.-L., Niittynen, L., Korpela, R., & Vapaatalo, H. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600899 · Cited by 351
Genetics of caffeine consumption and responses to caffeine
Yang, A., Palmer, A. A., & de Wit, H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1900-1 · Cited by 330
Assessment of CYP1A2 Activity in Clinical Practice: Why, How, and When?
Faber, M. S., Jetter, A., & Fuhr, U. (2005) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2005.pto_973160.x · Cited by 284
Ghotbi, R., Christensen, M., Roh, H., Ingelman‐Sundberg, M., Aklillu, E., & Bertilsson, L. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0288-2 · Cited by 265
Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities
KALOW, W., & Tang, B.-K. (1991) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1991.176 · Cited by 264
Medicinal chemistry of adenosine, P2Y and P2X receptors
Jacobson, K. A., & Müller, C. E. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.001 · Cited by 262
Pharmacokinetics and metabolism of natural methylxanthines in animal and man
Arnaud, M. J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_3 · Cited by 259
Pharmacokinetics in the newborn.
Alcorn, J., & McNamara, P. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(03)00030-9 · Cited by 252
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action.
Sawynok, J., & Yaksh, T. L. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00450-8 · Cited by 250
Fuhr, U., Klittich, K., & Staib, A. H. (1993) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1993.tb04162.x · Cited by 242
Rasmussen (2002) · Pharmacogenetics · doi:10.1097/00008571-200208000-00008 · Cited by 241
Update on caffeine consumption, disposition and action
Mandel, H. G. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00093-5 · Cited by 240
Fatal caffeine overdose: Two case reports
Kerrigan, S., & Lindsey, T. (2005) · Forensic Science International · doi:10.1016/j.forsciint.2005.04.016 · Cited by 231
CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
Palatini, P., Ceolotto, G., Ragazzo, F., Dorigatti, F., Saladini, F., Papparella, I., Mos, L., Zanata, G., & Santonastaso, M. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832ba850 · Cited by 230
Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders
Ferré, S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4212-2 · Cited by 221
Caffeine and cardiovascular health
Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216
International Society of Sports Nutrition position stand: energy drinks
Campbell, B. I., Wilborn, C., Bounty, P. L., Taylor, L. W., Nelson, M., Greenwood, M., Ziegenfuss, T. N., Lopez, H. L., Hoffman, J. R., Stout, J. R., et al. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-1 · Cited by 207
Plasma and salivary pharmacokinetics of caffeine in man
Newton, R., Broughton, L. J., Lind, M., Morrison, P. J., Rogers, H. J., & Bradbrook, I. D. (1981) · European Journal of Clinical Pharmacology · doi:10.1007/bf00609587 · Cited by 192
Kannankeril, P. J., Mitchell, B. M., Goonasekera, S. A., Chelu, M. G., Zhang, W., Sood, S., Kearney, D. L., Danila, C. I., Biasi, M. D., Wehrens, X. H. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600268103 · Cited by 190
Lampe, J. W., King, I. B., Li, S., Grate, M. T., Barale, K. V., Chen, C., Feng, Z., & Potter, J. D. (2000) · Carcinogenesis · doi:10.1093/carcin/21.6.1157 · Cited by 190
Caffeine intake and its sources: A review of national representative studies
Verster, J. C., & Koenig, J. S. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1247252 · Cited by 189
Energy Drinks: The New Eye-Opener For Adolescents
Babu, K. M., Church, R. J., & Lewander, W. J. (2008) · Clinical Pediatric Emergency Medicine · doi:10.1016/j.cpem.2007.12.002 · Cited by 188
Pharmacology of adenosine receptors in the vasculature
Tabrizchi, R., & Bedi, S. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00152-8 · Cited by 187
Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine
Vistisen, K. K., Poulsen, H. E., & Loft, S. H. (1992) · Carcinogenesis · doi:10.1093/carcin/13.9.1561 · Cited by 174
Structure and activity of tryptophan-rich TSPO proteins
Guo, Y., Kalathur, R. C., Liu, Q., Kloss, B., Bruni, R., Ginter, C., Kloppmann, E., Rost, B., & Hendrickson, W. A. (2015) · Science · doi:10.1126/science.aaa1534 · Cited by 171
Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer
Mellor, H. R., Bell, A. R., Valentin, J., & Roberts, R. R. A. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq378 · Cited by 169
Sympathomimetic effects of paraxanthine and caffeine in humans*
Benowitz, N. L., Jacob, P., Mayan, H., & Denaro, C. P. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90025-x · Cited by 166
Shi, D., Nikodijević, O., Jacobson, K. A., & Daly, J. W. (1993) · Cellular and Molecular Neurobiology · doi:10.1007/bf00733753 · Cited by 163
Comparative pharmacokinetics of caffeine in young and elderly men
Blanchard, J. D., & Sawers, S. (1983) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01061844 · Cited by 159
Pheochromocytoma: evaluation, diagnosis, and treatment
Walther, M. M., Keiser, H. R., & Linehan, W. M. (1999) · World Journal of Urology · doi:10.1007/s003450050102 · Cited by 143
Sudden cardiac death with normal heart:
Basso, C., Carturan, E., Pilichou, K., Rizzo, S., Corrado, D., & Thiene, G. (2010) · Cardiovascular Pathology · doi:10.1016/j.carpath.2010.02.003 · Cited by 142
Drewnowski, A., & Rehm, C. (2016) · Nutrients · doi:10.3390/nu8030154 · Cited by 139
Fuhr, U., Anders, E. M., Mahr, G., Sörgel, F., & Staib, A. H. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.5.942 · Cited by 136
MARTINEZ, C., Albet, C., Agúndez, J. A. G., HERRERO, E., Carrillo, J. A., MARQUEZ, M., Benítez, J., & ORTIZ, J. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(99)70129-3 · Cited by 132
Earliest tea as evidence for one branch of the Silk Road across the Tibetan Plateau
Lü, H., Zhang, J., Yang, Y., Yang, X., Xu, B., Yang, W., Tong, T., Jin, S., Shen, C., Rao, H., et al. (2016) · Scientific Reports · doi:10.1038/srep18955 · Cited by 132
Ryanodine Receptor Structure and Function in Health and Disease
Santulli, G., Lewis, D. R., Georges, A. D., Marks, A. R., & Frank, J. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-10-7757-9_11 · Cited by 131
Caffeine attenuates the exercise-induced increase in plasma [K+] in humans
Lindinger, M. I., Graham, T. E., & Spriet, L. L. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.3.1149 · Cited by 130
Estimation of caffeine intake from analysis of caffeine metabolites in wastewater
Gracia‐Lor, E., Rousis, N. I., Zuccato, E., Bade, R., Baz‐Lomba, J. A., Castrignanò, E., Causanilles, A., Hernández, F. J., Kasprzyk‐Hordern, B., Kinyua, J., et al. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.258 · Cited by 126
Adenosine receptors: structure, function and regulation
Stiles, G. L. (1986) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(86)90434-7 · Cited by 123
White, J. R., Padowski, J. M., Zhong, Y., Chen, G., Luo, S., Lazarus, P. J., Layton, M. E., & McPherson, S. (2016) · Clinical Toxicology · doi:10.3109/15563650.2016.1146740 · Cited by 122
Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase
Pohanka, M., & Dobes, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059873 · Cited by 120
Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?
Li, F., Liu, J., Liu, N., Kuhn, L. A., Garavito, R. M., & Ferguson-Miller, S. M. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00142 · Cited by 119
Adolescent Dosing and Labeling Since the Food and Drug Administration Amendments Act of 2007
Momper, J. D., Mulugeta, Y. A., Green, D. J., Karesh, A., Krudys, K. M., Sachs, H. C., Yao, L. P., & Burckart, G. J. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.465 · Cited by 114
Absorption rate of methylxanthines following capsules, cola and chocolate
Mumford, G. K., Benowitz, N. L., Evans, S. M., Kaminski, B. J., Preston, K. L., Sannerud, C. A., Silverman, K., & Griffiths, R. R. (1996) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050205 · Cited by 111
Caffeine and cardiovascular diseases: critical review of current research
Zulli, A., Smith, R. M., Kubatka, P., Novák, J., Uehara, Y., Loftus, H., Qaradakhi, T., Pohanka, M., Kobyliak, N. M., Zagatina, A., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1179-z · Cited by 107
Fletcher, E. A., Lacey, C. S., Aaron, M., Kolasa, M. W., Occiano, A., & Shah, S. A. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004448 · Cited by 107
Low, but not high, dose caffeine is a readily available probe for adenosine actions
Fredholm, B. B., Yang, J., & Wang, Y.-Q. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.011 · Cited by 99
Uncertainty factors for chemical risk assessment
Dorne, J. L. C. M., Walton, K., & RENWICK, A. G. (2001) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00005-9 · Cited by 98
Caffeine: Its Effect on Catecholamines and Metabolism in Lean and Obese Humans
Jung, R. T., Shetty, P. S., James, W. P. T., Barrand, M. A., & Callingham, B. A. (1981) · Clinical Science · doi:10.1042/cs0600527 · Cited by 97
Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence
Kennedy, M. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.202 · Cited by 96
Purinergic transmission in blood vessels
Ralevic, V., & Dunn, W. R. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.007 · Cited by 95
Fatal Caffeine Intoxication: A Series of Eight Cases from 1999 to 2009
Banerjee, P., Ali, Z., Levine, B., & Fowler, D. R. (2014) · Journal of Forensic Sciences · doi:10.1111/1556-4029.12387 · Cited by 93
Measurement of CYP1A2 Activity: A Focus on Caffeine as a Probe
Perera, V., Gross, A. S., & McLachlan, A. J. (2012) · Current Drug Metabolism · doi:10.2174/1389200211209050667 · Cited by 92
Methylxanthines, Seizures, and Excitotoxicity
Boison, D. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_9 · Cited by 90
Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans
Orrù, M., Guitart, X., Karcz‐Kubicha, M., Solinas, M., Justinová, Z., Barodia, S. K., Zanoveli, J. M., Cortés, A., Lluı́s, C., Casadó, V., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.029 · Cited by 89
The Bronchodilator Effects and Pharmacokinetics of Caffeine in Asthma
Becker, A. B., Simons, K. J., Gillespie, C., & Simons, F. E. R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403223101202 · Cited by 88
Adenosine Receptors and Reperfusion Injury of the Heart
Headrick, J. P., & Lasley, R. D. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_7 · Cited by 87
Witmer, C. M. (1991) · Plenum Press eBooks · Cited by 86
Age and prior caffeine use alter the cardiovascular and adrenomedullary responses to oral caffeine
Izzo, J. L., Ghosal, A., Kwong, T., Freeman, R. B., & Jaenike, J. R. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90413-7 · Cited by 85
Caffeine reduces myocardial blood flow during exercise
Higgins, J. P., & Babu, K. M. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.12.023 · Cited by 85
Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure
Campana, C., Griffin, P. L., & Simon, E. L. (2013) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2013.08.042 · Cited by 85
Specific and Dose–Dependent Enzyme Induction by Omeprazole in Human Beings
Rost, K. L., Brösicke, H., Heinemeyer, G., & Roots, I. (1994) · Hepatology · doi:10.1002/hep.1840200516 · Cited by 85
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
Cornelis, M. C., El‐Sohemy, A., & Campos, H. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.022012 · Cited by 84
Vistisen, K. K., Loft, S. H., & Poulsen, H. E. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5877-0_55 · Cited by 83
Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths
Wang, D., Shah, K., Um, S. Y., Eng, L. S., Zhou, B., Lin, Y. L., Mitchell, A. A., Nicaj, L., Prinz, M., McDonald, T. V., et al. (2014) · Forensic Science International · doi:10.1016/j.forsciint.2014.01.014 · Cited by 83
Fatal Caffeine Overdose: A Case Report and Review of Literature
Jabbar, S. B., & Hanly, M. G. (2013) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000058 · Cited by 82
Rhabdomyolysis induced by a caffeine overdose
Wrenn, K. D., & Oschner, I. (1989) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(89)80323-3 · Cited by 80
A case of fatal caffeine poisoning
RUDOLPH, T., & Knudsen, K. (2010) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02201.x · Cited by 79
Interaction between oral ciprofloxacin and caffeine in normal volunteers
Healy, D. P., Polk, R. E., Kanawati, L., Rock, D. T., & Mooney, M. L. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.4.474 · Cited by 78
Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness
Kamimori, G. H., Penetar, D. M., Headley, D. B., Thorne, D. R., Otterstetter, R., & Belenky, G. L. (2000) · European Journal of Clinical Pharmacology · doi:10.1007/s002280000186 · Cited by 77
Sanchis‐Gomar, F., Pareja-Galeano, H., Cervellin, G., Lippi, G., & Earnest, C. P. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.12.019 · Cited by 76
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test
Nardi, A. E., Lopes, F. L., Freire, R. C. R., Veras, A. B., Nascimento, I., Valença, A. M., Neto, V. L. D. M., Soares‐Filho, G. L., King, A. L. S., Araújo, D. M. R., et al. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.023 · Cited by 75
Pharmacological research in pediatrics: From neonates to adolescents☆
Rakhmanina, N. Y., & VANDENANKER, J. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.12.001 · Cited by 74
Evaluation of the central effects of alcohol and caffeine interaction.
Azcona, O., Barbanoj, M. J., Torrent, J., & Jané, F. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb04562.x · Cited by 74
Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca2+ Sparks
Porta, M., Zima, A. V., Nani, A., Díaz‐Sylvester, P., Copello, J. A., Ramos‐Franco, J., Blatter, L. A., & Fill, M. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.01.017 · Cited by 74
Caffeine fatalities – Do sales restrictions prevent intentional intoxications?
Thelander, G., Jönsson, A. K., Personne, M., Sjölin‐Forsberg, G., Lundqvist, K. M., & Ahlner, J. (2010) · Clinical Toxicology · doi:10.3109/15563650903586752 · Cited by 72
The role of adenosine receptors in the central action of caffeine.
Daly, J. W., Shi, D., Nikodijević, O., & Jacobson, K. A. (1994) · PubMed · Cited by 71
Coffee, CYP1A2 genotype and risk of myocardial infarction
El‐Sohemy, A., Cornelis, M. C., Kabagambe, E. K., & Campos, H. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0043-4 · Cited by 70
Membrane Protein Complexes: Structure and Function
Harris, J. R., & Boekema, E. J. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-10-7757-9 · Cited by 70
Samah, N. H. A., & Heard, C. M. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.05.042 · Cited by 69
Massive Caffeine Overdose Requiring Vasopressin Infusion and Hemodialysis
Holstege, C. P., Hunter, Y., Baer, A. B., Savory, J., Bruns, D. E., & Boyd, J. C. (2003) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-120026526 · Cited by 69
Effects of cimetidine on caffeine disposition in smokers and nonsmokers
May, D. C., Jarboe, C. H., VanBakel, A. B., & Williams, W. M. (1982) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1982.91 · Cited by 68
Ammar, R., Song, J. C., Kluger, J., & White, C. M. (2001) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.5.437.34502 · Cited by 68
Teekachunhatean, S., Tosri, N., Rojanasthien, N., Srichairatanakool, S., & Sangdee, C. (2013) · ISRN Pharmacology · doi:10.1155/2013/147238 · Cited by 67
Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death
Aiba, I., Wehrens, X. H. T., & Noebels, J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605216113 · Cited by 64
Doxofylline is not just another theophylline!
Matera, M. G., Page, C. P., & Cazzola, M. (2017) · International Journal of COPD · doi:10.2147/copd.s150887 · Cited by 64
Notes on the History of Caffeine Use
Fredholm, B. B. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_1 · Cited by 63
A Case of Caffeine-Induced Coronary Artery Vasospasm of a 17-Year-Old Male
Wilson, R. E., Kado, H. S., Samson, R., & Miller, A. B. (2012) · Cardiovascular Toxicology · doi:10.1007/s12012-011-9152-9 · Cited by 63
Human metabolism of [1-methyl-14C]- and [2-14C]caffeine after oral administration.
Callahan, M. M., Robertson, R., Arnaud, M. J., Branfman, A. R., McComish, M. F., & Yesair, D. W. (1982) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07906-1 · Cited by 62
Caffeine Overdose in a Premature Infant: Clinical Course and Pharmacokinetics
Anderson, B. J., Gunn, T. R., Holford, N. H. G., & Johnson, R. (1999) · Anaesthesia and Intensive Care · doi:10.1177/0310057x9902700316 · Cited by 61
Caffeine Content of Prepackaged National‐Brand and Private‐Label Carbonated Beverages
Chou, K.-H., & Bell, L. N. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00414.x · Cited by 61
β-Blockers, Cocaine, and the Unopposed α-Stimulation Phenomenon
Richards, J. R., Hollander, J. E., Ramoska, E. A., Fareed, F. N., Sand, I. C., Gómez, M. M. I., & Lange, R. A. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248416681644 · Cited by 61
Yu, L., Coelho, J. E., Zhang, X., Fu, Y., Tillman, A., Karaöz, U., Fredholm, B. B., Weng, Z., & Chen, J. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.90353.2008 · Cited by 58
Trudo, S. P., Schwarz, Y., Li, S. S., Li, L., King, I. B., Chen, C., Eaton, D. L., Potter, J. D., & Lampe, J. W. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0589 · Cited by 55
Effects of caffeine on baroreflex activity in humans
Mosqueda-Garcia, R., Tseng, C.-J., Biaggioni, I., Robertson, R. M., & Robertson, D. (1990) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1990.193 · Cited by 54
Jones, A. W. (2017) · Journal of Analytical Toxicology · doi:10.1093/jat/bkx011 · Cited by 54
Arrhythmogenic effects of energy drinks
Enriquez, A. A., & Frankel, D. S. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13210 · Cited by 52
Treatment of caffeine toxicity with esmolol
Price, K. R., & Fligner, D. J. (1990) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)82139-0 · Cited by 50
Caffeine toxicity in forensic practice: possible effects and under-appreciated sources
Musgrave, I., Farrington, R., Hoban, C. L., & Byard, R. W. (2016) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-016-9786-9 · Cited by 48
Congenital type 1 long QT syndrome unmasked by a highly caffeinated energy drink
Dufendach, K., Horner, J. M., Cannon, B. C., & Ackerman, M. J. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.10.011 · Cited by 47
Qi, X., Xu, J., Wang, F., & Xiao, J. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/162934 · Cited by 46
Myocardial Infarction Resulting From Caffeine Overdose in an Anorectic Woman
Forman, J. P., Aizer, A., & Young, C. R. (1997) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(97)70326-3 · Cited by 45
Kapur, R., & Smith, M. D. (2009) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2008.06.028 · Cited by 45
Neurobehavioral hazard identification and characterization for caffeine
Turnbull, D., Rodricks, J. V., & Mariano, G. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.12.002 · Cited by 45
Caffeine—A Drug with a Surprise
Waldvogel, S. R. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390173 · Cited by 44
GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens
Lymperopoulos, A., Brill, A. R., & McCrink, K. A. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.02.003 · Cited by 44
Caffeine Intoxication Successfully Treated by Hemoperfusion and Hemodialysis
Ishigaki, S., Fukasawa, H., Kinoshita‐Katahashi, N., Yasuda, H., Kumagai, H., & Furuya, R. (2014) · Internal Medicine · doi:10.2169/internalmedicine.53.2882 · Cited by 43
Risk of caffeine toxicity associated with the use of ‘legal highs’ (novel psychoactive substances)
Davies, S., Lee, T., Ramsey, J., Dargan, P. I., & Wood, D. M. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1144-y · Cited by 42
Energy Drinks and Myocardial Ischemia: A Review of Case Reports
Lippi, G., Cervellin, G., & Sanchis‐Gomar, F. (2015) · Cardiovascular Toxicology · doi:10.1007/s12012-015-9339-6 · Cited by 41
A case of suicide by ingestion of caffeine
Bonsignore, A., Sblano, S., Pozzi, F., Ventura, F., Dell'Erba, A. S., & Palmière, C. (2014) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-014-9571-6 · Cited by 41
Khondker, A., Dhaliwal, A. K., Alsop, R. J., Tang, J., Backholm, M., Shi, A., & Rheinstadter, M. C. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c6cp08104e · Cited by 41
Matthaei, J., Tzvetkov, M. V., Strube, J., Sehrt, D. B., Sachse-Seeboth, C., Hjelmborg, J., Möller, S., Halekoh, U., Hofmann, U., Schwab, M. G., et al. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.444 · Cited by 38
Regulation of Atherosclerosis and Associated Risk Factors by Adenosine and Adenosine Receptors
Koupenova, M., Johnston‐Cox, H., & Ravid, K. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0263-y · Cited by 37
Debrah, K., Haigh, R. A., Sherwin, R., Murphy, J., & Kerr, D. E. (1995) · Clinical Science · doi:10.1042/cs0890475 · Cited by 36
Turner, J. E., & Cravey, R. H. (1977) · Clinical Toxicology · doi:10.3109/15563657708992428 · Cited by 36
Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men
Jűrgens, G., Lange, K. H. W., Reuther, L. Ø., Rasmussen, B. B., Brøsen, K., & Christensen, H. R. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.121373 · Cited by 36
Fatal cardiac arrhythmia following voluntary caffeine overdose in an amateur body-builder athlete
Poussel, M., Kimmoun, A., Lévy, B., Gambier, N., Dudek, F., Puskarczyk, E., Poussel, J. F., & Chenuel, B. J. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.238 · Cited by 35
Passmore, A. P., Kondowe, G. B., & Johnston, G. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-3-468_1 · Cited by 34
Influence of Grapefruit Juice on Caffeine Pharmacokinetics and Pharmacodynamics
Maish, W. A., Hampton, E. M., Whitsett, T. L., Shepard, J. D., & Lovallo, W. R. (1996) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1996.tb03031.x · Cited by 33
The influence of rifampin treatment on caffeine clearance in healthy man
Wietholtz, H., Zysset, T., Marschall, H., Generet, K., & Matern, S. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80263-0 · Cited by 33
Mitchell, D. C., Hockenberry, J., Teplansky, R., & Hartman, T. J. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.03.024 · Cited by 33
Basu, S., Barawkar, D. A., Vidya, R., Patel, M. A., Waman, Y., Panmand, A., Kumar, S., Thorat, S., Naykodi, M., Goswami, A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.04.014 · Cited by 33
Short-Term Fasting Alters Cytochrome P450–Mediated Drug Metabolism in Humans
Lammers, L. A., Achterbergh, R., de Vries, E. M., van Nierop, F. S., Klümpen, H., Soeters, M. R., Boelen, A., Romijn, J. A., & Mathôt, R. A. A. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.062299 · Cited by 32
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans
Ryu, S.-D., & Chung, W.-G. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(03)00037-1 · Cited by 31
Caffeine poisoning and lactate rise: an overlooked toxic effect?
SCHMIDT, A., & Karlson-Stiber, C. (2008) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2008.01680.x · Cited by 30
Caffeine Poisoning Treated by Hemoperfusion
Nagesh, R. V., & Murphy, K. A. (1988) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(88)80226-9 · Cited by 30
Cocaine, Myocardial Infarction, and β-Blockers: Time to Rethink the Equation?
Freeman, K., & Feldman, J. A. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.08.020 · Cited by 30
Beach, C. A., Bianchine, J. R., & GERBER, N. (1984) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1984.tb02774.x · Cited by 30
Intralipid in acute caffeine intoxication: a case report
Muraro, L., Longo, L., Geraldini, F., Bortot, A., Paoli, A., & Boscolo, A. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2198-x · Cited by 30
The effects of quinolones on xanthine pharmacokinetics
Robson, R. A. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90303-s · Cited by 28
Tang, Z., Diamond, M. A., Chen, J.-M., Holly, T. A., Bonow, R. O., Dasgupta, A., Hyslop, T., Purzycki, A., Wagner, J. L., McNamara, D. M., et al. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100331 · Cited by 27
Bott‐Flügel, L., Bernshausen, A., Schneider, H., Luppa, P. B., Zimmermann, K. C., Albrecht-Küpper, B. E., Kast, R., Laugwitz, K., Ehmke, H., Knorr, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018048 · Cited by 27
Rießelmann, B., Rosenbaum, F., Roscher, S., & Schneider, V. (1999) · Forensic Science International · doi:10.1016/s0379-0738(99)00073-0 · Cited by 27
Survival of a highly toxic dose of caffeine
Bioh, G., Gallagher, M. M., & Prasad, U. (2013) · BMJ Case Reports · doi:10.1136/bcr-2012-007454 · Cited by 27
Lammers, L. A., Achterbergh, R., van Schaik, R. H. N., Romijn, J. A., & Mathôt, R. A. A. (2017) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0515-7 · Cited by 23
Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension
King, A. M., Dimovska, M., & Bisoski, L. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0807-9 · Cited by 23
Rhabdomyolysis induced by excessive coffee drinking
Chiang, W., Liao, M.-T., Cheng, C.-J., & Lin, S.-H. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113510536 · Cited by 22
Schmidt, M., Farna, H., Kurcová, I., Zakharov, S., Fric, M., Waldauf, P., Ilgova, Z., Pažout, J., Pachl, J., & Duška, F. (2014) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2014.11.002 · Cited by 21
Caffeine: Characterization and Properties
Oestreich-Janzen, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-384947-2.00098-2 · Cited by 20
Laskowski, L. K., Henesch, J. A., Nelson, L. S., Hoffman, R. S., & Smith, S. W. (2015) · Clinical Toxicology · doi:10.3109/15563650.2015.1075247 · Cited by 20
Direct Block of Human Ether-a-go-go-Related Gene Potassium Channels by Caffeine
Cockerill, S., & Mitcheson, J. S. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.094755 · Cited by 18
Modulation of Catecholamine Release by Endogenous Adenosine in the Rat Adrenal Medulla
Tseng, C., Chan, J. Y. H., Lo, W.-C., & Jan, C. (2001) · Journal of Biomedical Science · doi:10.1007/bf02255947 · Cited by 17
Electrocardiogram Abnormalities of Caffeine Overdose
Fabrizio, C. A., Desiderio, M. C., & Coyne, R. F. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003088 · Cited by 17
Multiple cardiac arrests following an overdose of caffeine complicated by penetrating trauma
Emohare, O., & Ratnam, V. (2005) · Anaesthesia · doi:10.1111/j.1365-2044.2005.04430.x · Cited by 16
Schurr, J. W., Gitman, B., & Belchikov, Y. G. (2014) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1486 · Cited by 16
Dual cocaine and methamphetamine cardiovascular toxicity: rapid resolution with labetalol
Richards, J. R., Lange, R. A., Arnold, T., & Horowitz, B. Z. (2016) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2016.09.040 · Cited by 16
Safety issues of compounds acting on adenosinergic signalling
Schmidt, J., & Ferk, P. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12720 · Cited by 15
“One” Cup of Coffee and Nuclear SPECT to Go
Bangalore, S., Parkar, S., & Messerli, F. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.044 · Cited by 14
Pediatric Development: Physiology. Enzymes, Drug Metabolism, Pharmacokinetics and Pharmacodynamics
Jong, G. W. ‘. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4899-8011-3_2 · Cited by 12
Intoxication sévère à la caféine traitée par hémodialyse et hémodiafiltration
Colin-Benoit, E., Friolet, R., Rusca, M., Teta, D., & Gobin, N. (2017) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2016.10.005 · Cited by 12
Sinués, E. M., Fanlo, A., Sinués, B., Mayayo, E., Labarta, J. I., de Jalón, Á. G., & Longás, Á. F. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0082-y · Cited by 11
Lee, J.-W., Kim, Y., Perera, V., McLachlan, A. J., & Bae, K. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-015-2581-x · Cited by 10
Kochańska-Dziurowicz, A. A., Janikowska, G., Bijak, A., Stanjek-Cichoracka, A., & Mazurek, U. M. (2015) · PubMed · Cited by 9
Perera, V., Gross, A. S., Forrest, A., Landersdorfer, C. B., Xu, H., Ait‐Oudhia, S., & McLachlan, A. J. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.053074 · Cited by 8
Severe Hypokalemia in 2 Young Bicycle Riders Due to Massive Caffeine Intake
Rigato, I., Blarasin, L., & Kette, F. (2010) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181ceca64 · Cited by 7
Kennedy, M. J., Davis, D. A., Smith, N. B., Gaedigk, A., Pearce, R. E., & Kearns, G. L. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.09.012 · Cited by 7
Caffeine Content in Beverages Commonly Consumed in Jordan
Hammad, S. S., Tayyem, R., & Musaiger, A. O. (2015) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2015.447.452 · Cited by 7
Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose
Zheng, J., Zhao, W., Xu, K. Y., Chen, Q., Chen, Y., Shen, Y., Xiao, L., Jiang, L., & Chen, Y. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.018 · Cited by 7
Bayramoğlu, A., Sarıtemur, M., Citirik, F., Emet, M., & Çakır, Z. G. (2014) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2014.10.040 · Cited by 6
Richards, J. R., Gould, J. B., Laurin, E. G., & Albertson, T. E. (2018) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.17.247 · Cited by 5
Authors’ response to: “Beta-blocker treatment of caffeine-induced tachydysrhythmias”
Laskowski, L. K., Nelson, L. S., Smith, S. W., & Hoffman, R. S. (2016) · Clinical Toxicology · doi:10.3109/15563650.2016.1159313 · Cited by 2
Beta-blocker treatment of caffeine-induced tachydysrhythmias
Richards, J. R., Ramoska, E. A., & Sand, I. C. (2016) · Clinical Toxicology · doi:10.3109/15563650.2016.1159311 · Cited by 2
Ye, J. J., Nagy, E., & Millard, J. T. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.lb738 · Cited by 1
Flagged first, then by citations
4 of the 197 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- N.a.A, 2015, EFSA NDA panel (EFSA panel on dietetic products, scientific opinion on the safety of caffeine, EFSA J., 13, 4102
- Colin-Benoit, 2017, Combination of hemodialysis and hemofiltration in severe caffeine intoxication, Néphrol, Thér., 13, 183
- G. Watts, Press Release, http://rccosc.com/news-2015-archive/. (Accessed 28 August 2017).
- Santos, 2015, Does CYP1A2 genotype influence coffee consumption?, Austin J. Pharmacol. Ther., 3, 1065
Cited by
Sorted by citations
Barrea, L., Pugliese, G., Frías-Toral, E., Ghoch, M. E., Castellucci, B., Chapela, S. P., Carignano, M. D. L. A., Laudisio, D., Savastano, S., Colao, A., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1963207 · Cited by 170
“After ingestion, caffeine is completely absorbed in the gastrointestinal tract within 45minutes and rapidly distributed to all tissues, with an average volume of distribution of 0.7 l/kg, including the brain, due to its lipophilic nature (Higdon and Frei 2006; Willson 2018).”
BackgroundInfluentialJee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y.-S. (2020) · Nutrients · doi:10.3390/nu12103080 · Cited by 111
“5 g/day) can cause caffeine poisoning (caffeinism), which includes symptoms such as anxiety, agitation, insomnia, gastrointestinal disorders, tremors, and mental disorders [12].”
BackgroundRisk or benefit? Side effects of caffeine supplementation in sport: a systematic review
de Souza, J. G., Coso, J. D., Fonseca, F. D. S., da Silva, B. V. C., de Souza, D. B., Gianoni, R. L. D. S., Filip-Stachnik, A., Serrão, J. C., & Claudino, J. G. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02874-3 · Cited by 124
“However, little attention has been paid to the undesirable side effects of caffeine consumption, especially among athletes and in the doses administered to obtain performance benefits [23, 24].”
BackgroundChieng, D., Cánovas, R., Segan, L. A., Sugumar, H., Voskoboinik, A., Prabhu, S., Ling, L., Lee, G., Morton, J. B., Kaye, D. M., et al. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac189 · Cited by 89
Jahrami, H., Al-Mutarid, M., Penson, P. E., Faris, M. E., Saif, Z., & Hammad, L. (2020) · Foods · doi:10.3390/foods9040473 · Cited by 86
“Based upon laboratory observations, it is often claimed that caffeine is a phosphodiesterase inhibitor, however, this action is unlikely to occur, at any but the very highest concentrations in vivo, and the relevance to anxiety is unclear [37].”
Background
Metadata
- Authors
- Willson, C.
- Corresponding author
- Willson, Cyril
- Venue
- Toxicology Reports
- Publisher
- Elsevier BV
- Published
- 2018
- Volume
- 5
- Pages
- 1140-1152
- ISSN
- 2214-7500 (ISSN-L)
- PMC
- PMC6247400
- OpenAlex
- W2899447541
- Cited by
- 289
- References
- 197
- Citations by year
- 2026: 21 · 2025: 50 · 2024: 61 · 2023: 35 · 2022: 39 · 2021: 47 · 2020: 27 · 2019: 8
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Toxicology Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- caffeine, caffeine toxicity, psychostimulants, pharmacokinetics, toxicokinetics, mechanism of action, case reconstruction, young adults
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
