Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease
Open accessAbstract
Abstract Introduction Physical exercise has gained increasing focus as a potential mean to maintain cognitive function in patients with Alzheimer's disease (AD). Alongside the markers of specific AD pathology (amyloid β and tau), other pathologies such as neuronal damage and synaptic loss have been proposed as markers of the disease. Here, we study the effect of physical exercise on biomarkers of neuronal and synaptic integrity. Methods Cerebrospinal fluid (CSF) from 51 AD subjects who participated in the randomized controlled trial Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) was analyzed for the concentration of neurofilament light (NFL), neurogranin (Ng), visinin‐like protein‐1 (VILIP‐1), and chitinase‐3–like protein 1 (YKL‐40). Participants were subjected to either 16 weeks of moderate‐ to high‐intensity exercise ( n = 25) or treatment as usual (control group, n = 26), and CSF was collected before and after intervention. Results No significant differences in CSF concentrations of VILIP‐1, YKL‐40, NFL, and Ng were observed when comparing mean change from baseline between the exercise and control groups. Similarly, when classifying subjects based on their exercise levels, no significant changes were observed for the biomarkers in the control group compared with the high‐exercise group (attending 80% of the exercise sessions with an intensity of 70% of maximum heart rate or above). Discussion These results are not supportive of a modulatory effect of physical exercise on the selected biomarkers of neuronal and synaptic integrity in patients with AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The effect of physical exercise on cerebrospinal fluid biomarkers of AD pathology is still unclear.
“Conversely, the effect of physical exercise on other biological measures of AD pathology, such as cerebrospinal fluid biomarkers is still unclear (64, 65), and further studies are needed on this topic.”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
Rovio, S., Kåreholt, I., Helkala, E.-L., Viitanen, M., Winblad, B., Tuomilehto, J., Soininen, H., Nissinen, A., & Kivipelto, M. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70198-8 · Cited by 1,054 · see citing works
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Groot, C., Hooghiemstra, A. M., Raijmakers, P. G. H. M., van Berckel, B. N. M., Scheltens, P., Scherder, E. J. A., van der Flier, W. M., & Ossenkoppele, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.005 · Cited by 616 · see citing works
YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
Craig-Schapiro, R., Perrin, R. J., Roe, C. M., Xiong, C., Carter, D., Cairns, N. J., Mintun, M. A., Peskind, E. R., Li, G., Galasko, D. R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.025 · Cited by 504 · see citing works
Zetterberg, H., Skillbäck, T., Mattsson, N., Trojanowski, J. Q., Portelius, E., Shaw, L. M., Weiner, M. W., Blennow, K., & Initiative, F. T. A. D. N. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.3037 · Cited by 487 · see citing works
Self-citationHoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150817 · Cited by 356 · see citing works
Self-citationSutphen, C. L., Jasielec, M. S., Shah, A. R., Macy, E. M., Xiong, C., Vlassenko, A. G., Benzinger, T. L. S., Stoops, E., Vanderstichele, H., Brix, B., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1285 · Cited by 294 · see citing works
In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
Bonneh‐Barkay, D., Wang, G., Starkey, A., Hamilton, R. L., & Wiley, C. A. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-34 · Cited by 293 · see citing works
Physical Activity, Brain Plasticity, and Alzheimer's Disease
Erickson, K. I., Weinstein, A. M., & Lopez, O. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.008 · Cited by 288 · see citing works
Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer’s disease
Portelius, E., Zetterberg, H., Skillbäck, T., Törnqvist, U., Andreasson, U., Trojanowski, J. Q., Weiner, M. W., Shaw, L. M., & Mattsson, N. (2015) · Brain · doi:10.1093/brain/awv267 · Cited by 279 · see citing works
Self-citationNeurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease
Kester, M. I., Teunissen, C. E., Crimmins, D. L., Herries, E. M., Ladenson, J. H., Scheltens, P., van der Flier, W. M., Morris, J. C., Holtzman, D. M., & Fagan, A. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1867 · Cited by 246 · see citing works
Cerebrospinal fluid neurogranin and <scp>YKL</scp> ‐40 as biomarkers of Alzheimer's disease
Janelidze, S., Hertze, J., Zetterberg, H., Landqvist Waldö, M., Santillo, A., Blennow, K., & Hansson, O. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.266 · Cited by 179 · see citing works
Self-citationDing, Q., Vaynman, S., Souda, P., Whitelegge, J. P., & Gomez‐Pinilla, F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05026.x · Cited by 174 · see citing works
Vos, A. D., Jacobs, D., Struyfs, H., Fransén, E., Andersson, K., Portelius, E., Andréasson, U., Surgeloose, D. D., Hernalsteen, D., Sleegers, K., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.05.012 · Cited by 156 · see citing works
Self-citationKester, M. I., Teunissen, C. E., Sutphen, C., Herries, E. M., Ladenson, J. H., Xiong, C., Scheltens, P., van der Flier, W. M., Morris, J. C., Holtzman, D. M., et al. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0142-1 · Cited by 146 · see citing works
Wildsmith, K. R., Schauer, S. P., Smith, A. M., Arnott, D. P., Zhu, Y., Haznedar, J., Kaur, S., Mathews, W. R., & Honigberg, L. A. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-22 · Cited by 140 · see citing works
Kvartsberg, H., Portelius, E., Andréasson, U., Brinkmalm, G., Hellwig, K., Lelental, N., Kornhuber, J., Hansson, O., Minthon, L., Spitzer, P., et al. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0124-3 · Cited by 139 · see citing works
Self-citationHuang, F. L., Huang, K., Wu, J., & Boucheron, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1182-06.2006 · Cited by 126 · see citing works
Lee, J., Blennow, K., Andreasen, N., Laterza, O., Modur, V., Olander, J. V., Gao, F., Ohlendorf, M. F., & Ladenson, J. H. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.104497 · Cited by 125 · see citing works
Self-citationCSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
Tarawneh, R. M., Lee, J., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2012) · Neurology · doi:10.1212/wnl.0b013e318248e568 · Cited by 107 · see citing works
Ryan, S. M., & Kelly, A. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.03.007 · Cited by 104 · see citing works
Neuronal and Glia-Related Biomarkers in Cerebrospinal Fluid of Patients with Acute Ischemic Stroke
Hjalmarsson, C., Bjerke, M., Andersson, B., Blennow, K., Zetterberg, H., Åberg, N. D., Olsson, B., Eckerström, C., Bokemark, L., & Wallin, A. (2014) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s13821 · Cited by 94 · see citing works
Self-citationJensen, C. S., Hasselbalch, S. G., Waldemar, G., & Simonsen, A. H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00187 · Cited by 74 · see citing works
Self-citationBertens, D., Knol, D. L., Scheltens, P., Visser, P. J., & Initiative, A. D. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.1754 · Cited by 64 · see citing works
Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions
Ossenkoppele, R., van der Flier, W. M., Verfaillie, S. C. J., Vrenken, H., Versteeg, A., van Schijndel, R. A., Sikkes, S. A. M., Twisk, J. W. R., Adriaanse, S. M., Zwan, M. D., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000432 · Cited by 63 · see citing works
Jensen, C. S., Portelius, E., Siersma, V., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Waldemar, G., Hasselbalch, S. G., & Simonsen, A. H. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000449408 · Cited by 57 · see citing works
Self-citationHoffmann, K., Frederiksen, K. S., Sobol, N. A., Beyer, N., Vogel, A., Simonsen, A. H., Johannsen, P., Lolk, A., Terkelsen, O., Cotman, C. W., et al. (2013) · Neuroepidemiology · doi:10.1159/000354632 · Cited by 49 · see citing works
Self-citationSobol, N. A., Hoffmann, K., Vogel, A., Lolk, A., Gottrup, H., Høgh, P., Hasselbalch, S. G., & Beyer, N. (2015) · Aging & Mental Health · doi:10.1080/13607863.2015.1063108 · Cited by 43 · see citing works
Self-citationNovel cerebrospinal fluid biomarkers of axonal degeneration in frontotemporal dementia.
Mattsson, N., Rüetschi, U., Pijnenburg, Y., Blankenstein, M., Podust, V., Li, S., Fagerberg, I., Rosengren, L., Blennow, K., & Zetterberg, H. (2008) · Molecular Medicine Reports · doi:10.3892/mmr_00000025 · Cited by 34 · see citing works
Self-citationZhou, B., Teramukai, S., Yoshimura, K., & Fukushima, M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1124 · Cited by 25 · see citing works
Nanba (2008) · Molecular Medicine Reports · doi:10.3892/mmr_00000010 · Cited by 14 · see citing works
O5‐04‐06: Moderate to high‐intensity physical exercise in patients with Alzheimer's disease
Hoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jacobsen, S., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.07.468 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01058 · Cited by 297 · see citing works
Physical activity, common brain pathologies, and cognition in community-dwelling older adults
Buchman, A. S., Yu, L., Wilson, R. S., Lim, A., Dawe, R. J., Gaiteri, C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2019) · Neurology · doi:10.1212/wnl.0000000000006954 · Cited by 108 · see citing works
da Costa Daniele, T. M., de Bruin, P. F. C., de Matos, R. S., de Bruin, G. S., Maia Chaves, C., & de Bruin, V. M. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112488 · Cited by 59 · see citing works
Late‐life physical activity relates to brain tissue synaptic integrity markers in older adults
Casaletto, K., Ramos‐Miguel, A., VandeBunte, A., Memel, M., Buchman, A., Bennett, D., & Honer, W. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12530 · Cited by 53 · see citing works
Schön, M., Kovaničová, Z., Košutzká, Z., Nemec, M., Tomková, M., Jacková, L., Máderová, D., Slobodová, L., Valkovič, P., Ukropec, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38201-2 · Cited by 40 · see citing works
- Authors
- Jensen, C. S., Portelius, E., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Hasselbalch, S. G., & Simonsen, A. H.
- Affiliations
- University of Copenhagen (DK)
- Sahlgrenska University Hospital (SE)
- Copenhagen University Hospital (DK)
- Odense University Hospital (DK)
- Corresponding author
- Jensen, Camilla Steen
- ORCID
- Venue
- Alzheimer's & Dementia: Translational Research & Clinical Interventions
- Publisher
- Wiley
- Published
- 2017-04-17
- Volume
- 3
- Issue
- 2
- Pages
- 284-290
- ISSN
- 2352-8737 (ISSN-L)
- PMC
- PMC5651430
- OpenAlex
- W2606046023
- Cited by
- 36
- References
- 37
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 2
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Torsten Söderbergs Stiftelse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- physical activity, Alzheimer's disease, cerebrospinal fluid biomarkers, neurofilament light chain, neurogranin, VILIP-1, YKL-40, neuronal integrity, synaptic integrity, exercise intensity, cognitive function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
