Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals
Open accessAbstract
Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75–80% HRmax; maximal heart rate), additional serum was taken at finish-line. Body composition, physical fitness, metabolic rate, cognitive functions, food preference, glucose, insulin and albumin were measured. The spectrum of 174 cytokines was assessed by protein arrays, adiponectin was also determined by ELISA and immunoblotting. CSF adiponectin decreased post-exercise by 21.3% (arrays) and 25.8% (ELISA) (p < 0.009). Immunoblotting revealed reduction in a low-molecular-weight-adiponectin (p < 0.005). CSF adiponectin positively correlated with CSF/serum albumin ratio (p < 0.022), an indicator of blood-brain-barrier permeability. CSF and serum adiponectin were positively associated with memory and running-induced changes in insulinemia and CSF insulin. Additionally, running modulated CSF levels of 16 other cytokines. Acute running reduced CSF adiponectin and modulated insulin and albumin in CSF and serum. Associations of adiponectin with memory and metabolism indicate the potential role of this bioactive molecule in mediating exercise-induced adaptive response in human brain.
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In humans, acute exercise increases plasma adiponectin but decreases cerebrospinal fluid adiponectin.
“For example, in humans, acute exercise increases plasma levels of adiponectin but decreases cerebrospinal fluid levels of adiponectin154.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [154]
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Söderström, H., Blennow, K., Manhem, A., et al. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170037 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
- Authors
- Schön, M., Kovaničová, Z., Košutzká, Z., Nemec, M., Tomková, M., Jacková, L., Máderová, D., Slobodová, L., Valkovič, P., Ukropec, J., & Ukropcová, B.
- Affiliations
- Slovak Academy of Sciences (SK)
- University Hospital Bratislava (SK)
- Corresponding author
- Ukropcová, B.
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-02-13
- Volume
- 9
- Issue
- 1
- Pages
- 1959-1959
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6374465
- OpenAlex
- W2922229371
- Cited by
- 40
- References
- 89
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 3
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Council
- Agentúra na Podporu Výskumu a Vývoja (15-0253, APVV-15-0253, APVV-15)
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (2/0107/18)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- acute exercise, running, adiponectin, insulin, cerebrospinal fluid, cytokines, blood-brain barrier permeability, CSF/serum albumin ratio, memory, low molecular weight adiponectin, insulin levels, healthy young adults, exercise and brain
- MeSH terms
- Adult, Blood Glucose, Body Composition, Female, Humans, Insulin, Insulin Resistance, Male, Obesity, Running, Exercise, Body Mass Index, Cytokines, Adiponectin, Young Adult, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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