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Cited by 249

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies

Open access
Geevarghese, Anita, Herman, Ira M.·2014·Translational Research
DOI 10.1016/j.trsl.2014.01.011
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Abstract

Pericytes are mural cells of the microcirculation, which have been shown to play key roles in regulating microvascular morphogenesis and stability, throughout each tissue bed and organ system assessed. Importantly, recent work has revealed that pericytes share several characteristics with mesenchymally- and adipose-derived stem cells suggesting that there may be lineage-related connections amongst bonafide pericytes and these vascular ‘progenitors,’ which can assume a perivascular position in association with endothelial cells. Hence, pericyte identity as a mediator of vascular remodeling may be confounded by its close relationships with its progenitors or pluripotent cell counterparts and yet demonstrates their potential utility as cell-based therapies for unmet clinical needs. Crucial to the development of such therapies will be a comprehensive understanding of the origin and fate regulating these related cell types as well as the unveiling of the molecular mechanisms by which pericytes and endothelial cells communicate. Such mechanistic inputs, which disrupt normal cellular ‘cross-talk’ during disease inception and progression, offer opportunities for intervention and will be discussed in the context of the vasculopathies accompanying tumor growth, diabetes, and fibrosis.

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Metadata

Authors
Geevarghese, A., & Herman, I. M.
Venue
Translational Research
Publisher
Elsevier BV
Published
2014-04
Volume
163
Issue
4
Pages
296-306
ISSN
  • 1878-1810 (ISSN-L)
  • 1931-5244
DOI
10.1016/j.trsl.2014.01.011
OpenAlex
W2050497029
Cited by
249
References
9
FWCI
6.81
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies. https://app.cochat.ai/papers/10.1016/j.trsl.2014.01.011
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Geevarghese, A., & Herman, I. M. (2014). Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies. Translational Research. https://doi.org/10.1016/j.trsl.2014.01.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.