Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates
Open accessAbstract
Homeobox transcription factors of the vertebrate CRX/OTX family play critical roles in photoreceptor neurons, the rostral brain and circadian processes. In mouse, the three related proteins, CRX, OTX1, and OTX2, fulfill these functions. In Drosophila, the single founding member of this gene family, called orthodenticle (otd), is required during embryonic brain and photoreceptor neuron development. We have used global gene expression analysis in late pupal heads to better characterize the post-embryonic functions of Otd in Drosophila. We have identified 61 genes that are differentially expressed between wild type and a viable eye-specific otd mutant allele. Among them, about one-third represent potentially direct targets of Otd based on their association with evolutionarily conserved Otd-binding sequences. The spectrum of biological functions associated with these gene targets establishes Otd as a critical regulator of photoreceptor morphology and phototransduction, as well as suggests its involvement in circadian processes. Together with the well-documented role of otd in embryonic patterning, this evidence shows that vertebrate and fly genes contribute to analogous biological processes, notwithstanding the significant divergence of the underlying genetic pathways. Our findings underscore the common evolutionary history of photoperception-based functions in vertebrates and invertebrates and support the view that a complex nervous system was already present in the last common ancestor of all bilateria.
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Ocular photoreceptor cells are a pan-bilaterian cell type in which the Box IV GRN controlling receptor subtypes operates downstream of K50 homeodomain family regulatory genes.
“Ocular photoreceptor cells provide another example of a pan-bilaterian cell type in which the Box IV GRN controlling the various subtypes of receptors (rhabdomeric receptors in insects, and rods and cones in vertebrates) operate downstream of regulatory genes of the K50 homeodomain family (Mishra et al., 2010; Ranade et al., 2008).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Ranade et al., 2008
The Direct and indirect targets of Otd section identifies Otd/OTX/CRX as K50-type homeodomain proteins, and the Conclusions describe their regulation of photoreceptor genes in flies and mice. But the Conclusions say the two lineages use substantially different genetic cascades and present an ancestral regulatory relationship as a hypothesis; the paper does not establish a conserved Box IV network controlling all the receptor subtypes named in the claim. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCertain differentiation gene batteries composed of orthologous effector genes and the regulatory state drivers that activate them are known in all bilaterian animals investigated and even in cnidarians, e.g., in muscle cells, neurons, photoreceptor cells, and neurosecretory cells.
“Certain differentiation gene batteries composed of orthologous effector genes and the regulatory state drivers that activate them are known in all bilaterian animals investigated and even in cnidarians, e.g., in muscle cells (5) neurons (13), photoreceptor cells (14 -17), and neurosecretory cells (17).”
From Transphyletic conservation of developmental regulatory state in animal evolution (2011) · cites this paper as [15]
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- Authors
- Ranade, S. S., Yang-Zhou, D., Kong, S. W., McDonald, E. C., Cook, T. A., & Pignoni, F.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Pignoni, Francesca
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 315
- Issue
- 2
- Pages
- 521-534
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC2329912
- OpenAlex
- W2084953599
- Cited by
- 46
- References
- 89
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2000 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- Prevent Blindness Ohio
- Harvard University
- E. Matilda Ziegler Foundation for the Blind
- National Institutes of Health
- National Eye Institute (P30 EY 14104, R01EY013167, P30EY014104)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD046387, T32HD046387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Drosophila, photoreceptors, phototransduction, photoreceptor morphology, evolutionary conservation, light perception
- MeSH terms
- Animals, Circadian Rhythm, Drosophila, Female, Lac Operon, Male, Mutation, Species Specificity, Vertebrates, Trans-Activators, Genes, Insect, Photoreceptor Cells, Invertebrate, Homeodomain Proteins, Gene Expression Regulation, Developmental, Evolution, Molecular, Oligonucleotide Array Sequence Analysis, Photoreceptor Cells, Vertebrate, Gene Expression Profiling, Drosophila Proteins, Animals, Genetically Modified, Otx Transcription Factors, Light Signal Transduction
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