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Cited by 230

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Stem cell niches in mammals

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Mitsiadis, Thimios A., Barrandon, Ornella, Rochat, Ariane, Barrandon, Yann, De Bari, Cosimo·2007·Experimental Cell Research
DOI 10.1016/j.yexcr.2007.07.027
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Abstract

Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between symmetric and asymmetric division of stem cells. Here we highlight recent progress made on the anatomical and molecular characterization of mammalian stem cell niches, focusing particularly on bone marrow, tooth and hair follicle. The knowledge of the regulation of stem cells within their niches in health and disease will be instrumental to develop novel therapies that target stem cell niches to achieve tissue repair and re-establish tissue homeostasis.

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Cited by

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Metadata

Authors
Mitsiadis, T. A., Barrandon, O., Rochat, A., Barrandon, Y., & De Bari, C.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2007-10
Volume
313
Issue
16
Pages
3377-3385
ISSN
0014-4827 (ISSN-L)
DOI
10.1016/j.yexcr.2007.07.027
OpenAlex
W2148883451
Cited by
230
References
4
FWCI
11.16
Type
journal article
Language
en
Open access
green
Licence
Funders
Universität Zürich

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CoChat. (2026). Citation check: Stem cell niches in mammals. https://app.cochat.ai/papers/10.1016/j.yexcr.2007.07.027
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Mitsiadis, T. A., Barrandon, O., Rochat, A., Barrandon, Y., & De Bari, C. (2007). Stem cell niches in mammals. Experimental Cell Research. https://doi.org/10.1016/j.yexcr.2007.07.027

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