Cited by 116Stress Responses and CortisolChild Abuse and TraumaChild and Adolescent Psychosocial and Emotional Development

Exposure to early adversity: points of cross-species translation that can lead to improved understanding of depression

Open access
Andersen, Susan L.·2015·Development and Psychopathology

Abstract

The relationship between developmental exposure to adversity and affective disorders is reviewed. Adversity discussed herein includes physical and sexual abuse, neglect, or loss of a caregiver in humans. While these stressors can occur at any point during development, the unique temporal relationship to specific depressive symptoms was the focus of discussion. Further influences of stress exposure during sensitive periods can vary by gender and duration of abuse as well. Data from animal studies are presented to provide greater translational and causal understanding of how sensitive periods, different types of psychosocial stressors, and sex interact to produce depressive-like behaviors. Findings from maternal separation, isolation rearing, chronic variable stress, and peer–peer rearing paradigms clarify interpretation about how various depressive behaviors are influenced by age of exposure. Depressive behaviors are broken down into the following categories: mood and affect, anhedonia, energy, working memory, sleep–wake, appetite changes, suicide, and general malaise. Cross-species evidence from humans, nonhuman primates, rats, and mice within each of these categories is discussed. In conclusion, sensitive periods for affective-related behaviors (anxiety, mood, and controllability) occur earlier in life, while other aspects of depression are associated with adversity later during adolescence.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0954579415000103

Cites

220 of 220 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The review's findings support the proposition that exposure to stress early in life has a dose-dependent effect on increasing risk of later psychopathology, particularly internalizing behaviours.

    “Our findings support the proposition from multiple domains of analysis that exposure to stress early in life had a dose-dependent effect on increasing the risk of later psychopathology, particularly in the domain of internalizing behaviours (Andersen 2015).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Wolk S Weissman M 1995 Women and depression: An update American Psychiatric Press review of psychiatry 14227 14259 Washington, DC American Psychiatric Press

Cited by

Sorted by citations

Authors
Andersen, S. L.
Affiliations
Harvard University (US)
Corresponding author
Andersen, Susan L.
Venue
Development and Psychopathology
Published
2015-05
Volume
27
Issue
2
Pages
477-491
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
OpenAlex
W2271686560
Cited by
116
References
217
Citations by year
2026: 2 · 2025: 10 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 17 · 2016: 12 · 2013: 1
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH091114)
  • National Institute on Drug Abuse (R01 DA-026485-04, R01DA026485, R01DA015403, R01 DA-015403-10)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
childhood adversity, developmental stress, depression, sensitive period, cross-species translation, psychosocial stressors, maternal separation, isolation rearing, chronic variable stress, peer rearing, sex differences, anhedonia, appetite changes, suicide, working memory, mood disorders, abuse and neglect, caregiver loss
MeSH terms
Animals, Anxiety, Depression, Depressive Disorder, Disease Models, Animal, Female, Humans, Male, Maternal Deprivation, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review