Perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats
Abstract
The destruction of the extracellular matrix by inflammatory processes may induce neuronal dysfunction and accelerate neurodegeneration. We describe that chondroitin sulphate proteoglycan-immunoreactive perineuronal nets and the enwrapped interneurons persisted 2 weeks after trimethyltin intoxication of rats (TMT, 8 mg/kg, i.p.) in all regions of the severely affected hippocampus and dentate gyrus, whereas the diffuse immunoreactivity around the CA2 pyramidal cells was reduced. Fluoro-Jade staining of degenerating neurons and staining of microglia by Griffonia simplicifolia agglutinin showed that net-associated neurons survived in the vicinity of damaged pyramidal cells and that perineuronal nets were not removed by activated microglia. We conclude that the extracellular matrix of perineuronal nets resists destruction after TMT treatment in the inflamed neural tissue. A permanent reconstitution of matrix components may be one of the factors that may support the viability of distinct types of neurons during neurodegenerative diseases.
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PNNs are found primarily around fast-spiking, parvalbumin (PV)-containing GABAergic interneurons in many brain regions, but not all regions.
“PNNs are found primarily around fast--spiking, parvalbumin (PV)--containing GABAergic interneurons in many brain regions (Hartig et al., 1992;Schuppel et al., 2002;Dityatev et al., 2007), but not all regions (e.g., cerebellum; see below).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Schuppel et al., 2002
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- Authors
- Schüppel, K., Brauer, K., Härtig, W., Grosche, J., Earley, B., Leonard, B. E., & Brückner, G.
- Affiliations
- Leipzig University (DE)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Brückner, Gert
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 958
- Issue
- 2
- Pages
- 448-453
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2023003530
- Cited by
- 47
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- perineuronal nets, extracellular matrix, hippocampal interneurons, microglia, trimethyltin, neuroinflammation, chondroitin sulfate proteoglycans, neurodegeneration, dentate gyrus, neuronal survival
- MeSH terms
- Animals, Extracellular Matrix, Hippocampus, Interneurons, Male, Oligodendroglia, Trimethyltin Compounds, Rats, Sprague-Dawley, Microglia, Rats
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