Perineuronal net formation and structure in aggrecan knockout mice
Open accessAbstract
Perineuronal nets (PNNs) are specialized substructures of the neural extracellular matrix (ECM) which envelop the cell soma and proximal neurites of particular sets of neurons with apertures at sites of synaptic contact. Previous studies have shown that PNNs are enriched with chondroitin sulfate proteoglycans (CSPGs) and hyaluronan, however, a complete understanding of their precise molecular composition has been elusive. In addition, identifying which specific PNN components are critical to the formation of this structure has not been demonstrated. Previous work in our laboratory has demonstrated that the CSPG, aggrecan, is a key activity-dependent component of PNNs in vivo. In order to assess the contribution of aggrecan to PNN formation, we utilized cartilage matrix deficiency (cmd) mice, which lack aggrecan. Herein, we utilized an in vitro model, dissociated cortical culture, and an ex vivo model, organotypic slice culture, to specifically investigate the role aggrecan plays in PNN formation. Our work demonstrates that staining with the lectin, Wisteria floribunda agglutinin (WFA), considered a broad PNN marker, is eliminated in the absence of aggrecan, suggesting the loss of PNNs. However, in contrast, we found that the expression patterns of other PNN markers, including hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R, brevican, and hyaluronan are unaffected by the absence of aggrecan. Lastly, we determined that while all PNN components are bound to the surface in a hyaluronan-dependent manner, only HAPLN1 remains attached to the cell surface when neurons are treated with chondroitinase. These results suggest a different model for the molecular association of PNNs to the cell surface. Together our work has served to assess the contribution of aggrecan to PNN formation while providing key evidence concerning the molecular composition of PNNs in addition to determining how these components ultimately form PNNs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ChABC degrades chondroitin sulfate proteoglycans, which are a major component of perineuronal nets (PNNs).
“ChABC degrades chondroitin sulfate proteoglycans, which are a major component of the PNNs (32).”
From Perineuronal nets protect fast-spiking interneurons against oxidative stress (2013) · cites this paper as [32]
Cortical primary neurons derived from aggrecan-deficient mice are abnormal in that they are not stained by WFA, indicating an essential role of aggrecan in PNN formation.
“cortical primary neurons derived from aggrecan--deficient mice are abnormal in that they are not stained by the lectin Wisteria floribunda agglutinin (WFA), a broad PNN marker, indicating an essential role of aggrecan in PNN formation (Giamanco et al., 2010).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Giamanco et al., 2010
ACAN+/− mice are aggrecan-deficient.
“heterozygote aggrecan-deficient (ACAN+/−) mice”
From Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress (2014) · cites this paper as [36]
Aggrecan is a major component of the brain ECM and of at least a subgroup of PNNs, and contains numerous CS chains with a predominant CS-6 representation.
“Aggrecan is a major component of the brain ECM and of at least a subgroup of PNNs, and contains numerous CS chains with a predominant CS-6 representation.45, 46”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [45]
Reports that aggrecan knockout results in loss of WFA-positive PNNs support the possibility that PNNs may be lost or lack key elements.
“Reports that aggrecan knockout results in loss of WFA-positive PNNs45, 46 support this possibility.”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [45]
WFA may not detect CS-6 sulfation patterns, at least not those recognized by 3B3 and CS56, and may label only some forms of aggrecan.
“Together, these findings indicate that WFA may not detect CS-6 sulfation patterns, at least not those recognized by 3B3 and CS56, and may label only some forms of aggrecan (see below).45”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [45]
Aggrecan is necessary for perineuronal net formation.
“Notably, aggrecan is necessary for PNN formation, as shown in the HEK cell model (Kwok et al., 2010) and in organotypic cultures derived from aggrecan knockout mice (Giamanco et al., 2010).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Giamanco et al., 2010
Cites
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901 · see citing works
Organotypic slice cultures: a technique has come of age
Gähwiler, B. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01122-3 · Cited by 884 · see citing works
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642 · see citing works
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632 · see citing works
Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex
Hendry, S., Schwark, H. D., Jones, E. G., & Yan, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-05-01503.1987 · Cited by 601 · see citing works
Perineuronal nets: past and present
Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497 · see citing works
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495 · see citing works
Extracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465 · see citing works
Perineuronal nets — a specialized form of extracellular matrix in the adult nervous system
Celio, M. R., & Blümcke, I. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90006-x · Cited by 386 · see citing works
Structural and functional recovery from early monocular deprivation in adult rats
Pizzorusso, T., Medini, P., Landi, S., Baldini, S., Berardi, N., & Maffei, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602657103 · Cited by 367 · see citing works
Composition of Perineuronal Net Extracellular Matrix in Rat Brain
Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367 · see citing works
Dityatev, A., Brückner, G., Dityateva, G., Grosche, J., Kleene, R., & Schachner, M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20361 · Cited by 365 · see citing works
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Aggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets
Matthews, R. T., Kelly, G. M., Zerillo, C. A., Gray, G., Tiemeyer, M., & Hockfield, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07536.2002 · Cited by 341 · see citing works
Self-citationCarulli, D., Rhodes, K. E., Brown, D. J., Bonnert, T. P., Pollack, S. J., Oliver, K., Strata, P., & Fawcett, J. W. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20822 · Cited by 341 · see citing works
Härtig, W., Derouiche, A., Welt, K., Brauer, K., Grosche, J., Mäder, M., Reichenbach, A., & Brückner, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01784-9 · Cited by 339 · see citing works
Mjaatvedt, C. H., Yamamura, H., Capehart, A. A., Turner, D., & Markwald, R. R. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9001 · Cited by 321 · see citing works
Maurel, P., Rauch, U., Flad, M., Margolis, R. K., & Margolis, R. U. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2512 · Cited by 305 · see citing works
Aspberg, A., Miura, R., Bourdoulous, S., Shimonaka, M., Heinegård, D., Schachner, M., Ruoslahti, E., & Yamaguchi, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10116 · Cited by 275 · see citing works
Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex
McRae, P. A., Rocco, M. M., Kelly, G., Brumberg, J. C., & Matthews, R. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5425-06.2007 · Cited by 272 · see citing works
Self-citationHockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.049 · Cited by 271 · see citing works
Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7417-7427.2002 · Cited by 264 · see citing works
Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene
Watanabe, H., Kimata, K., Line, S. R. P., Strong, D., Gao, L., Kozak, C. A., & Yamada, Y. (1994) · Nature Genetics · doi:10.1038/ng0694-154 · Cited by 245 · see citing works
Neurocan Is Dispensable for Brain Development
Zhou, X.-H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5970-5978.2001 · Cited by 206 · see citing works
Galtrey, C. M., Kwok, J. C. F., Carulli, D., Rhodes, K. E., & Fawcett, J. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06108.x · Cited by 203 · see citing works
Matthews, R. T., Gary, S. C., Zerillo, C. A., Pratta, M. A., Solomon, K. A., Arner, E. C., & Hockfield, S. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909764199 · Cited by 197 · see citing works
Self-citationGABA immunoreactive neurons in rat visual cortex
Meinecke, D. L., & Peters, A. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902610305 · Cited by 196 · see citing works
Lander, C., Kind, P., Maleski, M., & Hockfield, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-06-01928.1997 · Cited by 195 · see citing works
Mice lacking link protein develop dwarfism and craniofacial abnormalities
Watanabe, H., & Yamada, Y. (1999) · Nature Genetics · doi:10.1038/6016 · Cited by 190 · see citing works
Zaremba, S., Guimaraes, A., Kalb, R. G., & Hockfield, S. J. (1989) · Neuron · doi:10.1016/0896-6273(89)90305-x · Cited by 182 · see citing works
A surface antigen expressed by a subset of neurons in the vertebrate central nervous system.
Hockfield, S. J., & McKay, R. D. G. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5758 · Cited by 175 · see citing works
Kwok, J. C. F., Carulli, D., & Fawcett, J. W. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06878.x · Cited by 170 · see citing works
Brückner, G., Bringmann, A., Härtig, W., Köppe, G., Delpech, B., & Brauer, K. (1998) · Experimental Brain Research · doi:10.1007/s002210050463 · Cited by 162 · see citing works
Carulli, D., Rhodes, K. E., & Fawcett, J. W. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21231 · Cited by 158 · see citing works
Sur, M., Frost, D., & Hockfield, S. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00874.1988 · Cited by 156 · see citing works
Watanabe, H., Nakata, K., Kimata, K., Nakanishi, I., & Yamada, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6943 · Cited by 156 · see citing works
Ha¨rtig, W., Brauer, K., Bigl, V., & Bru¨ckner, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91452-4 · Cited by 147 · see citing works
Maeda, N., Hamanaka, H., Oohira, A., & Noda, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00069-h · Cited by 134 · see citing works
Köppe, G., Brückner, G., Brauer, K., Härtig, W., & Bigl, V. (1997) · Cell and Tissue Research · doi:10.1007/s004410050790 · Cited by 129 · see citing works
Guimaraes, A., Zaremba, S., & Hockfield, S. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03014.1990 · Cited by 128 · see citing works
Organization of neurons in the visual cortex, area 17, of the rat.
Parnavelas, J. G., Lieberman, A. R., & Webster, K. E. (1977) · PubMed · Cited by 127 · see citing works
John, N., Krügel, H., Frischknecht, R., Smalla, K.-H., Schultz, C., Kreutz, M. R., Gundelfinger, E. D., & Seidenbecher, C. I. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.011 · Cited by 122 · see citing works
Kimata, K., Barrach, H.-J., Brown, K. S., & Pennypacker, J. P. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69084-8 · Cited by 118 · see citing works
Bekku, Y., Su, W.-D., Hirakawa, S., Fässler, R., Ohtsuka, A., Kang, J. S., Sanders, J., Murakami, T., Ninomiya, Y., & Oohashi, T. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00133-7 · Cited by 114 · see citing works
Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan
Lander, C., Zhang, H., & Hockfield, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00174.1998 · Cited by 107 · see citing works
Perineuronal nets protect against amyloid β-protein neurotoxicity in cultured cortical neurons
Miyata, S., Nishimura, Y., & Nakashima, T. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.066 · Cited by 101 · see citing works
Jaworski, D. M., Kelly, G. M., & Hockfield, S. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.2.495 · Cited by 98 · see citing works
Morris, N. P., & Henderson, Z. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00970.x · Cited by 98 · see citing works
Köppe, G., Brückner, G., Härtig, W., Delpech, B., & Bigl, V. (1997) · The Histochemical Journal · doi:10.1023/a:1026408716522 · Cited by 95 · see citing works
Extracellular matrix alterations in brains lacking four of its components
Rauch, U., Zhou, X.-H., & Roos, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.026 · Cited by 88 · see citing works
Cartilage matrix deficiency (cmd) : a new autosomal recessive lethal mutation in the mouse
Rittenhouse, E. W., Dunn, L. C., Cookingham, J., Calo, C., Spiegelman, M., Dooher, G. B., & Bennett, D. (1978) · Development · doi:10.1242/dev.43.1.71 · Cited by 84 · see citing works
Kosaka, T., Isogai, K., Barnstable, C. J., & Heizmann, C. W. (1990) · Experimental Brain Research · doi:10.1007/bf00228797 · Cited by 79 · see citing works
Diño, M. R., Harroch, S., Hockfield, S. J., & Matthews, R. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.054 · Cited by 76 · see citing works
Self-citationBrauer, K., Ha¨rtig, W., Bigl, V., & Bru¨ckner, G. (1993) · Brain Research · doi:10.1016/0006-8993(93)91205-7 · Cited by 75 · see citing works
Construction of perineuronal net-like structure by cortical neurons in culture
Miyata, S., Nishimura, Y., Hayashi, N., & Oohira, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.031 · Cited by 75 · see citing works
‘Perineuronal nets’ around cortical interneurons expressing parvalbumin are rich in tenascin
Celio, M. R., & Chiquet‐Ehrismann, R. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90579-a · Cited by 71 · see citing works
Hirakawa, S., Oohashi, T., Su, W.-D., Yoshioka, H., MURAKAMI, T., Arata, J., & Ninomiya, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3583 · Cited by 70 · see citing works
Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
Haunsø, A., Ibrahim, M., Bartsch, U., Letiembre, M., Celio, M. R., & Menoud, P.-A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02173-9 · Cited by 61 · see citing works
Haunsø, A., Celio, M. R., Margolis, R. K., & Menoud, P.-A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01596-6 · Cited by 52 · see citing works
Grosche, J., & Br�ckner, G. (2001) · Experimental Brain Research · doi:10.1007/s002210000617 · Cited by 50 · see citing works
Schüppel, K., Brauer, K., Härtig, W., Grosche, J., Earley, B., Leonard, B. E., & Brückner, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03569-2 · Cited by 47 · see citing works
Wintergerst, E. S., Faissner, A., & Celio, M. R. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00011-1 · Cited by 46 · see citing works
Wintergerst, E. S., Weisenhorn, D. M. V., Rathjen, F. G., Riederer, B. M., Lambert, S., & Celio, M. R. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12643-4 · Cited by 44 · see citing works
Reimers, S., Hartlage‐Rübsamen, M., Brückner, G., & Roßner, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05514.x · Cited by 38 · see citing works
Brückner, G., Kacza, J., & Grosche, J. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000023374.22298.50 · Cited by 33 · see citing works
Kind, P. C., Beaver, C. J., & Mitchell, D. E. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903590402 · Cited by 32 · see citing works
Jojović, M., Delpech, B., Prehm, P., & Schumacher, U. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00037-x · Cited by 31 · see citing works
Kosaka, T., Heizmann, C. W., & Barnstable, C. J. (1989) · Experimental Brain Research · doi:10.1007/bf00230685 · Cited by 30 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Künzle, H., & Arendt, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.018 · Cited by 28 · see citing works
Self-citationPreuss, T. M., Gray, D., & Cusick, C. G. (1998) · Somatosensory & Motor Research · doi:10.1080/08990229870772 · Cited by 22 · see citing works
MURAKAMI, T., Ohtsuka, A., Su, W., TAGUCHI, T., Oohashi, T., Murakami, T., Abe, K., & Ninomiya, Y. (1999) · Archivum histologicum japonicum · doi:10.1679/aohc.62.273 · Cited by 21 · see citing works
Perineuronal Nets of Proteoglycans in the Adult Mouse Brain are Digested by Collagenase.
MURAKAMI, T., Murakami, T., SU, W. D., Ohtsuka, A., Abe, K., & Ninomiya, Y. (1999) · Archivum histologicum japonicum · doi:10.1679/aohc.62.199 · Cited by 18 · see citing works
Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
Br�ckner, G., Grosche, J., Schmidt, S., H�rtig, W., Margolis, R. U., Delpech, B., Seidenbecher, C. I., Czaniera, R., & Schachner, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001225)428:4
Hagihara (1999) · doi:10.1002/(sici)1096-9861(19990726)410:2
Flagged first, then by citations
1 of the 77 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works
Perineuronal nets protect fast-spiking interneurons against oxidative stress
Cabungcal, J.-H., Steullet, P., Morishita, H., Kraftsik, R., Cuenod, M., Hensch, T. K., & Do, K. Q. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300454110 · Cited by 512 · see citing works
Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
Sorg, B. A., Berretta, S., Blacktop, J. M., Fawcett, J. W., Kitagawa, H., Kwok, J. C. F., & Miquel, M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2351-16.2016 · Cited by 454 · see citing works
Extracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395 · see citing works
The perineuronal net and the control of CNS plasticity
Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Crosstalk between glia, extracellular matrix and neurons
Song, I., & Dityatev, A. E. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.003 · Cited by 263 · see citing works
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
Muñoz-Manchado, A. B., Bengtsson Gonzales, C., Zeisel, A., Munguba, H., Bekkouche, B., Skene, N. G., Lönnerberg, P., Ryge, J., Harris, K. D., Linnarsson, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.053 · Cited by 229 · see citing works
Extracellular matrix regulation of inflammation in the healthy and injured spinal cord
Gaudet, A. D., & Popovich, P. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.11.020 · Cited by 223 · see citing works
Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Rowlands, D., Lensjø, K. K., Dinh, T., Yang, S., Andrews, M. R., Hafting, T., Fyhn, M., Fawcett, J. W., & Dick, G. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1122-18.2018 · Cited by 204 · see citing works
Proteoglycans and their roles in brain cancer
Wade, A., Robinson, A. E., Engler, J. R., Petritsch, C. K., James, C. D., & Phillips, J. J. (2013) · FEBS Journal · doi:10.1111/febs.12109 · Cited by 193 · see citing works
Cognitive-Affective Functions of the Cerebellum
Rudolph, S., Badura, A., Lutzu, S., Pathak, S. S., Thieme, A. G., Verpeut, J. L., Wagner, M. J., Yang, Y., & Fioravante, D. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1451-23.2023 · Cited by 196 · see citing works
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works
Suttkus, A., Rohn, S., Weigel, S., Glöckner, P., Arendt, T., & Morawski, M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.25 · Cited by 168 · see citing works
Self-citationMiyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works
The Brain’s Extracellular Matrix and Its Role in Synaptic Plasticity
Frischknecht, R., & Gundelfinger, E. D. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_7 · Cited by 156 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., & Arendt, T. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00557.x · Cited by 157 · see citing works
Self-citationPantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works
Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works
Chondroitin sulfates and their binding molecules in the central nervous system
Djerbal, L., Lortat-Jacob, H., & Kwok, J. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9761-z · Cited by 144 · see citing works
The perineuronal net component of the extracellular matrix in plasticity and epilepsy
McRae, P. A., & Porter, B. E. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.007 · Cited by 143 · see citing works
Giamanco, K. A., & Matthews, R. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.055 · Cited by 138 · see citing works
Self-citationVo, T., Carulli, D., Ehlert, E., Kwok, J. C. F., Dick, G., Mecollari, V., Moloney, E. B., Neufeld, G., de Winter, F., Fawcett, J. W., et al. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.04.009 · Cited by 138 · see citing works
Chondroitin sulfate: A key molecule in the brain matrix
Kwok, J. C. F., Warren, P. M., & Fawcett, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.004 · Cited by 134 · see citing works
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works
Aggrecan: Beyond cartilage and into the brain
Morawski, M., Brückner, G., Arendt, T., & Matthews, R. T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.010 · Cited by 136 · see citing works
Self-citationExtracellular matrix protein expression is brain region dependent
Dauth, S., Grevesse, T., Pantazopoulos, H., Campbell, P. H., Maoz, B. M., Berretta, S., & Parker, K. K. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23965 · Cited by 134 · see citing works
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131 · see citing works
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 118 · see citing works
“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system
Smith, P. D., Coulson‐Thomas, V. J., Foscarin, S., Kwok, J. C. F., & Fawcett, J. W. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.004 · Cited by 112 · see citing works
Seizure-like activity in hyaluronidase-treated dissociated hippocampal cultures
Vedunova, M., Sakharnova, T., Mitroshina, E., Perminova, M., Pimashkin, A., Zakharov, Y., Dityatev, A., & Mukhina, I. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00149 · Cited by 107 · see citing works
Morawski, M., Dityatev, A., Hartlage-Rübsamen, M., Blosa, M., Holzer, M., Flach, K., Pavlica, S., Dityateva, G., Grosche, J., Brückner, G., et al. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0046 · Cited by 100 · see citing works
Self-citationProtective Properties of Neural Extracellular Matrix
Suttkus, A., Morawski, M., & Arendt, T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8990-4 · Cited by 108 · see citing works
Self-citationTewari, B. P., Chaunsali, L., Prim, C. E., & Sontheimer, H. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022754 · Cited by 107 · see citing works
Andrews, E. M., Richards, R. J., Yin, F. Q., Viapiano, M. S., & Jakeman, L. B. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.008 · Cited by 102 · see citing works
Dzyubenko, E., Rozenberg, A., Hermann, D. M., & Faissner, A. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.09.001 · Cited by 98 · see citing works
Yi, J., Katagiri, Y., Susarla, B., Figge, D., Symes, A. J., & Geller, H. M. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23156 · Cited by 93 · see citing works
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
Krishnaswamy, V. R., Benbenishty, A., Blinder, P., & Sagi, I. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03182-6 · Cited by 92 · see citing works
Lendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93 · see citing works
Self-citationArreola, M. A., Soni, N., Crapser, J. D., Hohsfield, L. A., Elmore, M. R. P., Matheos, D. P., Wood, M. A., Swarup, V., Mortazavi, A., & Green, K. N. (2021) · Science Advances · doi:10.1126/sciadv.abg1601 · Cited by 89 · see citing works
(2012) · Europe PMC (PubMed Central) · Cited by 88 · see citing works
Self-citationPersistent decrease in multiple components of the perineuronal net following status epilepticus
McRae, P. A., Baranov, E., Rogers, S. L., & Porter, B. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08268.x · Cited by 85 · see citing works
Murase, S., Lantz, C. L., & Quinlan, E. M. (2017) · eLife · doi:10.7554/elife.27345 · Cited by 87 · see citing works
Molecular signature of extracellular matrix pathology in schizophrenia
Pantazopoulos, H., Katsel, P., Haroutunian, V. H., Chelini, G., Klengel, T., & Berretta, S. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15009 · Cited by 79 · see citing works
Madinier, A., Quattromani, M. J., Sjölund, C., Ruscher, K., & Wieloch, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093121 · Cited by 82 · see citing works
Repeated Binge Drinking Increases Perineuronal Nets in the Insular Cortex
Chen, H., He, D., & Lasek, A. W. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12847 · Cited by 77 · see citing works
Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation
Yim, E. K. F., Jain, D., Mattiassi, S., & Goh, E. K. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266907 · Cited by 76 · see citing works
Morikawa, S., Ikegaya, Y., Narita, M., & Tamura, H. (2017) · Scientific Reports · doi:10.1038/srep46024 · Cited by 74 · see citing works
Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
Hou, X., Yoshioka, N., Tsukano, H., Sakai, A., Miyata, S., Watanabe, Y., Yanagawa, Y., Sakimura, K., Takeuchi, K., Kitagawa, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04007-x · Cited by 75 · see citing works
Miyata, S., & Kitagawa, H. (2016) · Neural Plasticity · doi:10.1155/2016/1305801 · Cited by 70 · see citing works
Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate
Miyata, S., & Kitagawa, H. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu067 · Cited by 70 · see citing works
Releasing Addiction Memories Trapped in Perineuronal Nets
Lasek, A. W., Chen, H., & Chen, W.-Y. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.004 · Cited by 71 · see citing works
Inflammation modulates expression of laminin in the central nervous system following ischemic injury
Ji, K., & Tsirka, S. E. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-159 · Cited by 69 · see citing works
Miyata, S., Nadanaka, S., Igarashi, M., & Kitagawa, H. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00003 · Cited by 68 · see citing works
Bekku, Y., Saito, M., Moser, M., Fuchigami, M., Maehara, A., Nakayama, M., Kusachi, S., Ninomiya, Y., & Oohashi, T. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23009 · Cited by 65 · see citing works
Drzewiecki, C. M., Willing, J., & Juraska, J. M. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02137-z · Cited by 67 · see citing works
The Role of Extracellular Matrix in Human Neurodegenerative Diseases
Pintér, P., & Alpár, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911085 · Cited by 66 · see citing works
Horii‐Hayashi, N., Sasagawa, T., Matsunaga, W., & Nishi, M. (2015) · Neural Plasticity · doi:10.1155/2015/256389 · Cited by 66 · see citing works
Yang, S., Hilton, S., Alves, J. N., Saksida, L. M., Bussey, T., Matthews, R. T., Kitagawa, H., Spillantini, M. G., Kwok, J. C. F., & Fawcett, J. W. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.002 · Cited by 61 · see citing works
Self-citationHyaluronic acid and neural stem cells: implications for biomaterial design
Khaing, Z. Z., & Seidlits, S. K. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00974j · Cited by 63 · see citing works
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy
Chaunsali, L., Tewari, B. P., & Sontheimer, H. W. (2021) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597211018688 · Cited by 60 · see citing works
Yamada, J., & Jinno, S. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24132 · Cited by 59 · see citing works
Blosa, M., Sonntag, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., Rübsamen, R., Arendt, T., & Morawski, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.003 · Cited by 59 · see citing works
Self-citationEffects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder
Lasek, A. W. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13200 · Cited by 57 · see citing works
Rupert, D. D., & Shea, S. D. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.886629 · Cited by 58 · see citing works
Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex
Harkness, J. H., Gonzalez, A. E., Bushana, P. N., Jorgensen, E. T., Hegarty, D. M., Nardo, A. A. D., Prochiantz, A., Wisor, J. P., Aicher, S. A., Brown, T. E., et al. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02229-4 · Cited by 51 · see citing works
Umemori, J., Winkel, F., Ċastrén, E., & Karpova, N. N. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.05.006 · Cited by 52 · see citing works
Perineuronal Nets: Subtle Structures with Large Implications
Carceller, H., Gramuntell, Y., Klimczak, P., & Nácher, J. (2022) · The Neuroscientist · doi:10.1177/10738584221106346 · Cited by 48 · see citing works
Suttkus, A., Holzer, M., Morawski, M., & Arendt, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.040 · Cited by 50 · see citing works
Self-citationCaught in the Net: Perineuronal Nets and Addiction
Slaker, M. L., Blacktop, J. M., & Sorg, B. A. (2016) · Neural Plasticity · doi:10.1155/2016/7538208 · Cited by 50 · see citing works
Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity
Valenzuela, J. C., Heise, C., Franken, G., Singh, J. B., Schweitzer, B., Seidenbecher, C. I., & Frischknecht, R. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0606 · Cited by 46 · see citing works
Irvine, S., & Kwok, J. C. F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041172 · Cited by 49 · see citing works
Review of Design Considerations for Brain-on-a-Chip Models
Cameron, T., Bennet, T. J., Rowe, E. M., Anwer, M., Wellington, C. L., & Cheung, K. C. (2021) · Micromachines · doi:10.3390/mi12040441 · Cited by 48 · see citing works
Perineuronal nets in the auditory system
Sonntag, M., Blosa, M., Schmidt, S., Rübsamen, R., & Morawski, M. (2015) · Hearing Research · doi:10.1016/j.heares.2014.12.012 · Cited by 47 · see citing works
Self-citationPerineuronal and perisynaptic extracellular matrix in the human spinal cord
Jäger, C., Lendvai, D., Seeger, G., Brückner, G., Matthews, R. T., Arendt, T., Alpár, A., & Morawski, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.014 · Cited by 48 · see citing works
Self-citationExpression of aggrecan components in perineuronal nets in the mouse cerebral cortex
Ueno, H., Fujii, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Aoki, S., Okamoto, M., Ishihara, T., & Takao, K. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.002 · Cited by 47 · see citing works
Karetko-Sysa, M., Skangiel-Kramska, J., & Nowicka, D. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.05.022 · Cited by 45 · see citing works
Ueno, H., Suemitsu, S., Okamoto, M., Matsumoto, Y., & Ishihara, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.041 · Cited by 46 · see citing works
Xiao, M., Li, X., Song, Q., Zhang, Q., Lazzarino, M., Cheng, G., Severino, F. P. U., & Torre, V. (2018) · Advanced Materials · doi:10.1002/adma.201806132 · Cited by 45 · see citing works
Nadanaka, S., Miyata, S., Yaqiang, B., Tamura, J.-I., Habuchi, O., & Kitagawa, H. (2020) · Biomolecules · doi:10.3390/biom10111499 · Cited by 43 · see citing works
Extracellular matrixes and neuroinflammation
Jang, D. G., Sim, H. J., Song, E. K., Kwon, T., & Park, T. J. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.10.156 · Cited by 42 · see citing works
New Insights into ADAMTS Metalloproteases in the Central Nervous System
Mohamedi, Y., Fontanil, T., Cobo, T., Cal, S., & Obaya, Á. J. (2020) · Biomolecules · doi:10.3390/biom10030403 · Cited by 39 · see citing works
Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology
Luca, C. D., & Papa, M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.04.002 · Cited by 39 · see citing works
Cortical diurnal rhythms remain intact with microglial depletion
Barahona, R. A., Morabito, S., Swarup, V., & Green, K. N. (2022) · Scientific Reports · doi:10.1038/s41598-021-04079-w · Cited by 38 · see citing works
Bitanihirwe, B. K. Y., Mauney, S. A., & Woo, T.-U. W. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1047 · Cited by 37 · see citing works
Neural ECM in regeneration and rehabilitation
Yang, S., Kwok, J. C. F., & Fawcett, J. W. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00008-6 · Cited by 37 · see citing works
Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., Seeger, G., Hecker, D., Schick, B., Arendt, T., et al. (2018) · BMC Biology · doi:10.1186/s12915-018-0566-8 · Cited by 37 · see citing works
Self-citationNeurocan Contributes to Perineuronal Net Development
Schmidt, S., Arendt, T., Morawski, M., & Sonntag, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.040 · Cited by 37 · see citing works
Self-citationEnzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation
Willis, A., Pratt, J. A., & MORRIS, B. J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02772-z · Cited by 35 · see citing works
Bartolini, B., Thelin, M. A., Rauch, U., Feinstein, R. E., Oldberg, Å., Malmström, A., & Maccarana, M. (2012) · Glycobiology · doi:10.1093/glycob/cws065 · Cited by 37 · see citing works
Mueller-Buehl, C., Reinhard, J., Roll, L., Bader, V., Winklhofer, K. F., & Faissner, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886527 · Cited by 35 · see citing works
From molecules to behavior: Implications for perineuronal net remodeling in learning and memory
Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 37 · see citing works
Dwyer, C. A., Katoh, T., Tiemeyer, M., & Matthews, R. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.614099 · Cited by 35 · see citing works
Self-citationWegrzyn, D., Freund, N., Faissner, A., & Juckel, G. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.637549 · Cited by 33 · see citing works
Myers, A. K., Ray, J., & Kulesza, R. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.024 · Cited by 34 · see citing works
The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure
Eill, G. J., Sinha, A., Morawski, M., Viapiano, M. S., & Matthews, R. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010830 · Cited by 32 · see citing works
Self-citationThe protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure
Eill, G. J., Sinha, A., Morawski, M., Viapiano, M. S., & Matthews, R. T. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49907-8 · Cited by 32 · see citing works
Self-citationDistinct roles for hyaluronan in neural stem cell niches and perineuronal nets
Su, W., Matsumoto, S. G., Sorg, B. A., & Sherman, L. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.022 · Cited by 32 · see citing works
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies
Auer, S., Schicht, M., Hoffmann, L., Budday, S., Frischknecht, R., Blümcke, I., & Paulsen, F. P. (2025) · Cells · doi:10.3390/cells14050321 · Cited by 30 · see citing works
Warford, J. R., Lamport, A.-C., Clements, D. R., Malone, A., Kennedy, B. E., Kim, Y., Gujar, S. A., Hoskin, D. W., & Easton, A. S. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0506-9 · Cited by 30 · see citing works
- Authors
- Giamanco, K. A., Morawski, M., & Matthews, R. T.
- Affiliations
- SUNY Upstate Medical University (US)
- Leipzig University (DE)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 170
- Issue
- 4
- Pages
- 1314-1327
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2033004840
- Cited by
- 207
- References
- 77
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 9 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 11 · 2012: 17
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- perineuronal nets, aggrecan, chondroitin sulfate proteoglycans, hyaluronic acid, HAPLN1, tenascin-R, brevican, Wisteria floribunda agglutinin, chondroitinase, organotypic slice cultures
- MeSH terms
- Proteoglycan Link Protein, Animals, Cells, Cultured, Chondroitin Sulfates, Extracellular Matrix, gamma-Aminobutyric Acid, Hyaluronic Acid, Interneurons, Neurons, Parvalbumins, Proteoglycans, Extracellular Matrix Proteins, Mice, Knockout, Tenascin, Mice, Aggrecans, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
