Cited by 227Mitochondrial Function and PathologyATP Synthase and ATPases ResearchAdipose Tissue and Metabolism

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

Cadenas, Susana, Buckingham, Julie A., Samec, Sonia, Seydoux, Josiane, Din, Nanni, Dulloo, Abdul G., Brand, Martin D.·1999·FEBS Letters

DOI 10.1016/s0014-5793(99)01540-9

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Abstract

The relationship between UCP2 and UCP3 expression and mitochondrial proton conductance of rat skeletal muscle was examined. Rats were starved for 24 h and the levels of UCP2 and UCP3 mRNA and UCP3 protein were determined by Northern and Western blots. Proton conductance was measured by titrating mitochondrial respiration rate and membrane potential with malonate. Starvation increased UCP2 and UCP3 mRNA levels more than 5‐fold and 4‐fold, respectively, and UCP3 protein levels by 2‐fold. However, proton conductance remained unchanged. These results suggest either that Northern and Western blots do not reflect the levels of active protein or that these UCPs do not catalyse the basal proton conductance in skeletal muscle mitochondria.

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Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602
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Self-citation
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Gimeno, R. E., Dembski, M., Weng, X., Deng, N., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Woolf, E. A., & Tartaglia, L. A. (1997) · Diabetes · doi:10.2337/diab.46.5.900 · Cited by 496
The causes and functions of mitochondrial proton leak
Brand, M. D., Chien, L.-F., Ainscow, E. K., Rolfe, D. F. S., & Porter, R. K. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90099-x · Cited by 466
Self-citation
UCP4, a novel brain‐specific mitochondrial protein that reduces membrane potential in mammalian cells
Mao, W., Yu, X. X., Zhong, A. W., Li, W., Brush, J., Sherwood, S. W., Adams, S. H., & Pan, G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01713-x · Cited by 381
BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast
Sanchı́s, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Gregoire, F. M., Easlick, J. L., Raimbault, S., Lévi-Meyrueis, C., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34611 · Cited by 310
Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?
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Self-citation

Show all 25 references

Research works printed but not linked: 4

Stuart J.A. Brindle K.M. Harper J.A. and Brand M.D. (1999) J. Bioenerg. Biomemb. (in press).
Monemdjou S. Kozak L.P. and Harper M.-E. (1997) in: Proceedings of the Annual Meeting of the North American Association for the Study of Obesity Cancun.
Cannon B., 1999, Prog. Obes. Res., 8, 13
Stuart J.A. Brindle K.M. Harper J.A. and Brand M.D. (1999) Biochim. Biophys. Acta (in press).

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Authors: Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., & Brand, M. D.
Affiliations: University of Cambridge (GB)
University of Geneva (CH)
Novo Nordisk (Denmark) (DK)
University of Fribourg (CH)
Corresponding author: Brand, Martin D.
ORCID: Cadenas, Susana
Dulloo, Abdul G.
Brand, Martin D.
Venue: FEBS Letters
Publisher: Wiley
Published: 1999-11-30
Volume: 462
Issue: 3
Pages: 257-260
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(99)01540-9
OpenAlex: W2072444935
Cited by: 227
References: 25
Citations by year: 2024: 2 · 2023: 1 · 2021: 3 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 12 · 2012: 5
FWCI: 6.90
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: UCP2, UCP3, uncoupling proteins, skeletal muscle, starvation, mRNA expression, protein abundance, mitochondrial respiration, membrane potential
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Animals, Carrier Proteins, Electrophysiology, Female, Food Deprivation, Ion Channels, Kinetics, Mitochondria, Proteins, Protons, RNA, Messenger, Uncoupling Agents, Blotting, Northern, Blotting, Western, Rats, Wistar, Muscle, Skeletal, Mitochondrial Proteins, Membrane Transport Proteins, Rats

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

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