Cited by 227Mitochondrial Function and PathologyATP Synthase and ATPases ResearchAdipose Tissue and Metabolism

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

Cadenas, Susana, Buckingham, Julie A., Samec, Sonia, Seydoux, Josiane, Din, Nanni, Dulloo, Abdul G., Brand, Martin D.·1999·FEBS Letters

DOI 10.1016/s0014-5793(99)01540-9

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Abstract

The relationship between UCP2 and UCP3 expression and mitochondrial proton conductance of rat skeletal muscle was examined. Rats were starved for 24 h and the levels of UCP2 and UCP3 mRNA and UCP3 protein were determined by Northern and Western blots. Proton conductance was measured by titrating mitochondrial respiration rate and membrane potential with malonate. Starvation increased UCP2 and UCP3 mRNA levels more than 5‐fold and 4‐fold, respectively, and UCP3 protein levels by 2‐fold. However, proton conductance remained unchanged. These results suggest either that Northern and Western blots do not reflect the levels of active protein or that these UCPs do not catalyse the basal proton conductance in skeletal muscle mitochondria.

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Self-citation

Authors: Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., & Brand, M. D.
Affiliations: University of Cambridge (GB)
University of Geneva (CH)
Novo Nordisk (Denmark) (DK)
University of Fribourg (CH)
Corresponding author: Brand, Martin D.
ORCID: Cadenas, Susana
Dulloo, Abdul G.
Brand, Martin D.
Venue: FEBS Letters
Publisher: Wiley
Published: 1999-11-30
Volume: 462
Issue: 3
Pages: 257-260
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(99)01540-9
OpenAlex: W2072444935
Cited by: 227
References: 25
Citations by year: 2024: 2 · 2023: 1 · 2021: 3 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 12 · 2012: 5
FWCI: 6.90
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: UCP2, UCP3, uncoupling proteins, skeletal muscle, starvation, mRNA expression, protein abundance, mitochondrial respiration, membrane potential
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Animals, Carrier Proteins, Electrophysiology, Female, Food Deprivation, Ion Channels, Kinetics, Mitochondria, Proteins, Protons, RNA, Messenger, Uncoupling Agents, Blotting, Northern, Blotting, Western, Rats, Wistar, Muscle, Skeletal, Mitochondrial Proteins, Membrane Transport Proteins, Rats

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

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