Cited by 1,240Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismMetabolism, Diabetes, and Cancer

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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

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Reitzer, L.J., Wice, B.M., Kennell, D.·1979·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(17)30124-2

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Authors: Reitzer, L. J., Wice, B. M., & Kennell, D.
Affiliations: Washington University in St. Louis (US)
ORCID: Reitzer, L.J.
Wice, B.M.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1979-04
Volume: 254
Issue: 8
Pages: 2669-2676
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)30124-2
OpenAlex: W1483212110
Cited by: 1,240
References: 39
Citations by year: 2026: 14 · 2025: 19 · 2024: 30 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 28 · 2018: 42 · 2017: 42 · 2016: 38 · 2015: 38 · 2014: 48 · 2013: 36 · 2012: 46
FWCI: 12.54
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 15189 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: American Cancer Society
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: glutamine, glucose, energy metabolism, HeLa cells, cultured cells, energy sources
MeSH terms: Adenosine Diphosphate, Adenosine Triphosphate, Citric Acid Cycle, Fructose, Galactose, Glucose, Glutamine, HeLa Cells, Humans, Kinetics, Lactates, Pentoses

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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

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