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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
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“glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines10–12”
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Metadata
- Authors
- Reitzer, L. J., Wice, B. M., & Kennell, D.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-04
- Volume
- 254
- Issue
- 8
- Pages
- 2669-2676
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1483212110
- Cited by
- 1,240
- References
- 39
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 30 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 28 · 2018: 42 · 2017: 42 · 2016: 38 · 2015: 38 · 2014: 48 · 2013: 36 · 2012: 46
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glutamine, glucose, energy metabolism, HeLa cells, cultured cells, energy sources
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Citric Acid Cycle, Fructose, Galactose, Glucose, Glutamine, HeLa Cells, Humans, Kinetics, Lactates, Pentoses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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