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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
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“glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines10–12”
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Thompson, R. M., Dytfeld, D., Reyes, L., Robinson, R. M., Smith, B. M., Manevich, Y., Jakubowiak, A. J., Komarnicki, M. A., Przybyłowicz-Chalecka, A., Szczepaniak, T., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16262 · Cited by 126
On the Origin of ATP Synthesis in Cancer
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Metadata
- Authors
- Reitzer, L. J., Wice, B. M., & Kennell, D.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-04
- Volume
- 254
- Issue
- 8
- Pages
- 2669-2676
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1483212110
- Cited by
- 1,240
- References
- 39
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 30 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 28 · 2018: 42 · 2017: 42 · 2016: 38 · 2015: 38 · 2014: 48 · 2013: 36 · 2012: 46
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glutamine, glucose, energy metabolism, HeLa cells, cultured cells, energy sources
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Citric Acid Cycle, Fructose, Galactose, Glucose, Glutamine, HeLa Cells, Humans, Kinetics, Lactates, Pentoses
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