Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

A Flexible System of Enzymatic Analysis

Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050

Nutrition Needs of Mammalian Cells in Tissue Culture

Eagle, H. (1955) · Science · doi:10.1126/science.122.3168.501 · Cited by 1,619

Measurement of Low Energy Beta-Emitters in Aqueous Solution by Liquid Scintillation Counting of Emulsions.

Patterson, M. S., & Greene, R. C. (1965) · Analytical Chemistry · doi:10.1021/ac60226a017 · Cited by 1,459

Uptake and Metabolism of Plasma Glutamine by the Small Intestine

Windmueller, H. G., & Spaeth, A. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42329-6 · Cited by 791

The Path of Carbon in Photosynthesis. V. Paper Chromatography and Radioautography of the Products1

Benson, A. A., Bassham, J. A., Calvin, M., Goodale, T. C., Haas, V. A., & Stepka, W. (1950) · Journal of the American Chemical Society · doi:10.1021/ja01160a080 · Cited by 479

The Use of Glucose-C14 for the Evaluation of the Pathways of Glucose Metabolism

Katz, J. J., & Wood, H. G. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64593-4 · Cited by 405

Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates

Alp, P. R., Newsholme, E. A., & Zammit, V. A. (1976) · Biochemical Journal · doi:10.1042/bj1540689 · Cited by 404

Uber den Stoffwechsel der Karzinomezellen

Warburg, O. (1924) · Medical Entomology and Zoology · Cited by 401

A new method for the determination of inulin in plasma and urine

Heyrovský, A. (1956) · Clinica Chimica Acta · doi:10.1016/0009-8981(56)90020-1 · Cited by 377

Role of glutamine administration on cellular immunity after total parenteral nutrition enriched with glutamine in patients with systemic inflammatory response syndrome

Cetinbas, F., Yelken, B., & Gülbaş, Z. (2010) · Journal of Critical Care · doi:10.1016/j.jcrc.2010.03.011 · Cited by 58

Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2

Ren, J.-G., Seth, P., Everett, P. C., Clish, C. B., & Sukhatme, V. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012520 · Cited by 58

Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions

Anandhan, A., Lei, S., Levytskyy, R. M., Pappa, A., Panayiotidis, M. I., Cerny, R. L., Khalimonchuk, O., Powers, R., & Franco, R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9906-2 · Cited by 60

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

Barrow, J. J., Balsa, E., Verdeguer, F., Tavares, C. D. J., Soustek, M. S., Hollingsworth, L. R., Jedrychowski, M. P., Vogel, R. O., Paulo, J. A., Smeitink, J. A. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.023 · Cited by 57

Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation

Weatherly, L. M., Nelson, A. J., Shim, J., Riitano, A. M., Gerson, E., Hart, A. J., de Juan‐Sanz, J., Ryan, T. A., Sher, R. B., Hess, S. T., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.04.005 · Cited by 58

Special Lecture: Glutamine Metabolism in the Animal Body

Krebs, H. A. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-506040-0.50023-6 · Cited by 58

A colorimetric assay for the measurement of d-glucose consumption by cultured cells

Blake, D. A., & McLean, N. V. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90031-6 · Cited by 58

Dexamethasone can modulate glucose‐regulated and heat shock protein synthesis

Kasambalides, E. J., & Lanks, K. W. (1983) · Journal of Cellular Physiology · doi:10.1002/jcp.1041140116 · Cited by 58

A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Freund, N., & Croughan, M. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020385 · Cited by 64

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Birts, C. N., Banerjee, A., Darley, M., Dunlop, C. R., Nelson, S., Nijjar, S. K., Parker, R., West, J. J., Tavassoli, A., Rose-Zerilli, M. J. J., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aau9529 · Cited by 56

Acute L ‐glutamine deprivation compromises VEGF‐a upregulation in A549/8 human carcinoma cells

Drogat, B., Bouchecareilh, M., North, S., Petibois, C., Déléris, G., Chevet, É., Bikfalvi, A., & Moenner, M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21044 · Cited by 62

Pelvic Ewing sarcoma

Hoffmann, C., Ahrens, S., Dunst, J., Hillmann, A., Winkelmann, W., Craft, A. W., G�bel, U., R�be, C., te, P. A. V., Harms, D., et al. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990215)85:4 · Cited by 101

Inducing single-cell suspension of BTI-TN5B1-4 insect cells: I. The use of sulfated polyanions to prevent cell aggregation and enhance recombinant protein production

Dee, K. U., Shuler, M. L., & Wood, H. A. (1997) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19970505)54:3 · Cited by 63

The enhancement of specific antibody production rate in glucose- and glutamine-controlled fed-batch culture

Ōmasa, T., Ishimoto, M., Higashiyama, K., Shioya, S., & Suga, K. (1992) · Cytotechnology · doi:10.1007/bf02540032 · Cited by 57

Fructose as a carbohydrate source yields stable pH and redox parameters in microcarrier cell culture

Imamura, T., Crespi, C. L., Thilly, W. G., & Brunengraber, H. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90051-3 · Cited by 57

Influence of cumene hydroperoxide and 4-hydroxynonenal on the glutathione metabolism during in vitro ageing of human skin fibroblasts

Poot, M., Verkerk, A., Koster, J. F., Esterbauer, H., & Jongkind, J. F. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb10598.x · Cited by 57

XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species

Rezvani, H. R., Rossignol, R., Ali, N., Bénard, G., Tang, X., Yang, H. S., Jouary, T., de Verneuil, H., Taı̈eb, A., Kim, A. L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.12.006 · Cited by 59

Insight into metabolism of CHO cells at low glucose concentration on the basis of the determination of intracellular metabolites

Lu, S., Sun, X., & Zhang, Y. (2004) · Process Biochemistry · doi:10.1016/j.procbio.2004.07.004 · Cited by 56

Targeting Metabolic Changes in Cancer: Novel Therapeutic Approaches

Bobrovnikova-Marjon, E. V., & Hurov, J. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-092012-112344 · Cited by 56

Energetic and Morphological Plasticity of C6 Glioma Cells Grown on 3-D Support; Effect of Transient Glutamine Deprivation

Martin, M., Beauvoit, B. P., Voisin, P. J., Canioni, P., Guérin, B., & Rigoulet, M. (1998) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1020584517588 · Cited by 56

Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma

Osada, T., Nagashima, I., Tsuno, N. H., Kitayama, J., & Nagawa, H. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80365-7 · Cited by 55

Carbohydrate metabolism in cultured animal cells

Morgan, M. J., & Faik, P. (1981) · Bioscience Reports · doi:10.1007/bf01116465 · Cited by 55

Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues.

Nagel, W. O., Dauchy, R. T., & Sauer, L. A. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85602-8 · Cited by 55

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

Marignac, V. L. M., Smith, S. E., Toban, N., Bazile, M., & Aloyz, R. S. (2013) · Oncotarget · doi:10.18632/oncotarget.1508 · Cited by 54

Metabolic responses to different glucose and glutamine levels in baby hamster kidney cell culture

Cruz, H. J., Ferreira, A. S., Freitas, C., Moreira, J. L., & Carrondo, M. J. T. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051435 · Cited by 54

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling

Zhdanov, A. V., Waters, A. H. C., Golubeva, A. V., Dmitriev, R. I., & Papkovsky, D. B. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.07.008 · Cited by 52

End products of glucose and glutamine metabolism by L929 cells.

Lanks, K. W. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61081-6 · Cited by 54

Purification and characterization of the cytosolic NADP+‐dependent malic enzyme from human breast cancer cell line

Chang, G., Wang, J. K., Huang, T.-M., Lee, H. J., Chou, W., & Meng, C. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16423.x · Cited by 54

Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase

Christie, A., & Butler, M. (1994) · Journal of Biotechnology · doi:10.1016/0168-1656(94)90134-1 · Cited by 54

Bioenergetics of tumor cells: Glutamine metabolism in tumor cell mitochondria

Matsuno, T. (1987) · International Journal of Biochemistry · doi:10.1016/0020-711x(87)90002-4 · Cited by 54

Effect of heat shock treatment on the production of variant testosterone-repressed prostate message-2 (TRPM-2) mRNA in culture cells

Kimura, K., Asami, K., & Yamamoto, M. (1997) · Cell Biochemistry and Function · doi:10.1002/(sici)1099-0844(199712)15:4 · Cited by 26

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Delp, J., Funke, M., Rudolf, F., Cediel-Ulloa, A., Bennekou, S. H., van der Stel, W., Carta, G., Jennings, P., Toma, C., Gardner, I. B., et al. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02473-y · Cited by 53

Glutamine is a potentially limiting amino acid for milk production in dairy cows: A hypothesis

Meijer, G. A. L., van der Meulen, J., & van Vuuren, A. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90087-5 · Cited by 53

Polarized Micro-Raman and FT-IR Spectra of L-Glutamine

Dhamelincourt, P., & Ramírez, F. J. (1993) · Applied Spectroscopy · doi:10.1366/0003702934335083 · Cited by 53

Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture

Zanghi, J. A., Fussenegger, M., & Bailey, J. E. (1999) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19990705)64:1 · Cited by 80

Multicomponent Investigations of the Hydrogen Peroxide- and Hydroxyl Radical-Scavenging Antioxidant Capacities of Biofluids: The Roles of Endogenous Pyruvate and Lactate Relevance to Inflammatory Joint Diseases

Herz, H., Blake, D. R., & Grootveld, M. C. (1997) · Free Radical Research · doi:10.3109/10715769709097781 · Cited by 53

l-glutamine: a major substrate for tumor cells in vivo?

Kallinowski, F., Runkel, S., Fortmeyer, H. P., F�rster, H., & Vaupel, P. W. (1987) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00396375 · Cited by 52

Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts

Sumbilla, C. M., Zielke, C. L., Reed, W. D., Ozand, P. T., & Zielke, H. R. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90242-7 · Cited by 52

Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines.

Rho, M.-S., Kim, J., Jee, C. D., Lee, Y. M., Lee, H. E., Kim, M. A., Lee, H. S., & Kim, W. H. (2007) · PubMed · Cited by 51

Expression of cytosolic malic enzyme ( ME 1) is associated with disease progression in human oral squamous cell carcinoma

Nakashima, C., Yamamoto, K., Fujiwara‐Tani, R., Luo, Y., Matsushima, S., Fujii, K., Ohmori, H., Sasahira, T., Sasaki, T., Kitadai, Y., et al. (2018) · Cancer Science · doi:10.1111/cas.13594 · Cited by 51

The concentrations of glutamine and ammonia in commercially available cell culture media

Heeneman, S., Deutz, N. E. P., & Buurman, W. A. (1993) · Journal of Immunological Methods · doi:10.1016/0022-1759(93)90331-z · Cited by 51

Scanning electrochemical microscopy of HeLa cells – Effects of ferrocene methanol and silver ion

Li, X., & Bard, A. J. (2009) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2009.01.002 · Cited by 50

Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells

Naderi, S., Meshram, M., Wei, C., McConkey, B. J., Ingalls, B., Budman, H. M., & Scharer, J. M. (2011) · Biotechnology Progress · doi:10.1002/btpr.647 · Cited by 51

Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory?

Seyfried, T. N., & Chinopoulos, C. (2021) · Metabolites · doi:10.3390/metabo11090572 · Cited by 54

Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism.

Murphy, C., & Newsholme, P. (1999) · PubMed · Cited by 50

Manganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars

Surve, T., & Gadgil, M. (2014) · Biotechnology Progress · doi:10.1002/btpr.2029 · Cited by 49

Novel Therapeutic Targets of Tumor Metabolism

Kishton, R. J., & Rathmell, J. C. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000099 · Cited by 48

Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium

McDermott, R. H., & Butler, M. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.1.51 · Cited by 49

Hybridoma growth and antibody production as a function of cell density and specific growth rate in perfusion culture

Banik, G. G., & Heath, C. A. (1995) · Biotechnology and Bioengineering · doi:10.1002/bit.260480315 · Cited by 49

Effects of cell density and glucose and glutamine levels on the respiration rates of hybridoma cells

Wohlpart, D., Kirwan, D. J., & Gainer, J. L. (1990) · Biotechnology and Bioengineering · doi:10.1002/bit.260360611 · Cited by 49

Local glutamine metabolism in wounds and inflammation

Caldwell, M. D. (1989) · Metabolism · doi:10.1016/0026-0495(89)90137-6 · Cited by 49

Glutamine at focus: versatile roles in cancer

Vitto, H. D., Pérez-Valencia, J. A., & Radosevich, J. A. (2015) · Tumor Biology · doi:10.1007/s13277-015-4671-9 · Cited by 54

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

Qi, J., Zhou, N., Li, L., Mo, S., Zhou, Y., Deng, Y. J., Chen, T., Shan, C., Chen, Q., & Lü, B. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02779-1 · Cited by 50

Influence of two glutamine-containing dipeptides on growth of mammalian cells

Roth, E., Ollenschläger, G., Hamilton, G., Simmel, A., Langer, K., Fekl, W. L., & Jakesz, R. (1988) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623607 · Cited by 48

Heat flux and the calorimetric-respirometric ratio as measures of catabolic flux in mammalian cells

Kemp, R. B., & Guan, Y. H. (1997) · Thermochimica Acta · doi:10.1016/s0040-6031(96)03125-5 · Cited by 48

Amino Acids in Cancer and Cachexia: An Integrated View

Ragni, M., Fornelli, C., Nisoli, E., & Penna, F. (2022) · Cancers · doi:10.3390/cancers14225691 · Cited by 48

Versatility in the acquisition of energy and carbon sources by the Apicomplexa

Polonais, V., & Soldati‐Favre, D. (2010) · Biology of the Cell · doi:10.1042/bc20100005 · Cited by 47

Metabolic and Functional Characterization of Human Adipose-Derived Stem Cells in Tissue Engineering

Mischen, B. T., Follmar, K. E., Moyer, K. E., Buehrer, B. M., Olbrich, K. C., Levin, L. S., Klitzman, B. M., & Erdmann, D. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e318180ec9f · Cited by 47

Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin

Javeshghani, S., Zakikhani, M., Austin, S., Bazile, M., Blouin, M., Topisirović, I., St‐Pierre, J., & Pollak, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2907 · Cited by 49

Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy

Sun, N.-Y., & Yang, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00792 · Cited by 48

Glycolysis–respiration relationships in a neuroblastoma cell line

Swerdlow, R. H., Lezi, E., Aires, D., & Lu, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.002 · Cited by 47

Factors affecting the stability of L-glutamine in solution

Khan, K., & Elia, M. (1991) · Clinical Nutrition · doi:10.1016/0261-5614(91)90037-d · Cited by 47

Is pyruvate an endogenous anti-inflammatory molecule?

Das, U. N. (2006) · Nutrition · doi:10.1016/j.nut.2006.05.009 · Cited by 47

Metabolic regulation during early frog development: Glycogenic flux in Xenopus oocytes, eggs, and embryos

Dworkin, M. B., & Dworkin‐Rastl, E. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90246-7 · Cited by 47

A fluorescence-microscopic and flow-cytometric study of HeLa cells with an experimentally induced respiratory deficiency

Skowronek, P., Haferkamp, O., & Rödel, G. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91295-2 · Cited by 47

Environmental factors affecting pregnancy: Endocrine disrupters, nutrients and metabolic pathways

Bazer, F. W., Wu, G., Johnson, G. A., & Wang, X. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.007 · Cited by 47

Mitoplasticity: Adaptation Biology of the Mitochondrion to the Cellular Redox State in Physiology and Carcinogenesis

José, C., Melser, S., Bénard, G., & Rossignol, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4357 · Cited by 51

Mitochondrial respiration without ubiquinone biosynthesis

Wang, Y., & Hekimi, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt330 · Cited by 47

Optimization and purification of anticancer enzyme L-glutaminase from Alcaligenes faecalis KLU102

Pandian, S. R. K., Deepak, V., Sivasubramaniam, S. D., Hariharan, N., & Sundar, K. (2014) · Biologia · doi:10.2478/s11756-014-0486-1 · Cited by 46

Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes

Scoonen, W. G. E. J., Wanamarta, A. H., Moorsel, J. M. V. D. K., Jakobs, C., & Joejne, H. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90023-k · Cited by 46

Differential Sensitivity to 2-Deoxy-D-glucose Between Two Pancreatic Cell Lines Correlates With GLUT-1 Expression

Maher, J. C., Savaraj, N., Priebe, W., Liu, H., & Lampidis, T. J. (2005) · Pancreas · doi:10.1097/01.mpa.0000153327.46945.26 · Cited by 46

The effect of specific growth rate and death rate on monoclonal antibody production in hybridoma chemostat cultures

Linardos, T. I., Kalogerakis, N. E., Behie, L. A., & Lamontagne, L. R. (1991) · The Canadian Journal of Chemical Engineering · doi:10.1002/cjce.5450690205 · Cited by 46

Glutamine and glutamate nitrogen exchangeable pools in cultured fibroblasts: A stable isotope study

Darmaun, D., Matthews, D. E., Desjeux, J. F., & Bier, D. M. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041340118 · Cited by 46

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

Kumar, M. A., Baba, S. K., Khan, I. R., Khan, M. S., Husain, F. M., Ahmad, S., Haris, M., Singh, M., Akil, A. A., Macha, M. A., et al. (2025) · MedComm · doi:10.1002/mco2.70120 · Cited by 52

Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia

Fernandes, T. G., Diogo, M. M., Fernandes‐Platzgummer, A., da Silva, C. L., & Cabral, J. M. S. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.04.003 · Cited by 45

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α

Distelmaier, F., Valsecchi, F., Liemburg-Apers, D. C., Lebiedzińska, M., Rodenburg, R. J., Heil, S. G., Keijer, J., Fransen, J. A. M., Imamura, H., Danhauser, K., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.012 · Cited by 46

Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation

Kumar, A. A., Giri, S., & Shaha, C. (2018) · FEBS Journal · doi:10.1111/febs.14406 · Cited by 47

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+

Iannetti, E. F., Smeitink, J. A. M., Willems, P. H. G. M., Beyrath, J., & Koopman, W. J. H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1179-4 · Cited by 46

Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr -cells decreases accumulation of ammonium ion in culture media

Park, H.-S., Kim, I. H., Kim, K., Kim, K., & Kim, H.-J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00282-0 · Cited by 45

Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells

Zeng, A., & Deckwer, W. ‐. (1995) · Biotechnology and Bioengineering · doi:10.1002/bit.260470308 · Cited by 45

Mitochondrial Complex I activity signals antioxidant response through ERK5

Khan, A. U. H., Allende-Vega, N., Gitenay, D., Garaude, J., Vo, D.-N., Belkhala, S., Gerbal‐Chaloin, S., Gondeau, C., Daujat‐Chavanieu, M., Delettre, C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23884-4 · Cited by 46

Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis

Ohashi, Y., Takahashi, N., Terabe, K., Tsuchiya, S., Kojima, T., Knudson, C. B., Knudson, W., & Imagama, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-94611-9 · Cited by 46

Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts

Beck, G. R., Sullivan, E. C., Morán, E., & Zerler, B. R. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980201)68:2 · Cited by 224

Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme.

Teller, J. K., Fahien, L. A., & Davis, J. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50036-9 · Cited by 44

Mitochondrial DNA of two independent oligomycin-resistant Chinese hamster ovary cell lines contains a single nucleotide change in the ATPase 6 gene.

Breen, G. A. M., Miller, D. L., Holmans, P. L., & Welch, G. R. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67297-7 · Cited by 44

Role of ATP and Pi in the mechanism of insulin secretion in the mouse insulinoma βTC3 cell line

Papas, K. K., Long, R. C., Constantinidis, I., & Sambanis, A. (1997) · Biochemical Journal · doi:10.1042/bj3260807 · Cited by 44

Molecular Diagnosis of Multistage Hepatocarcinogenesis

Sakamoto, M., Effendi, K., & Masugi, Y. (2010) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyq099 · Cited by 42

Metabolic PET Imaging in Oncology

Sai, K. K. S., Zachar, Z., Bingham, P. M., & Mintz, A. (2017) · American Journal of Roentgenology · doi:10.2214/ajr.17.18112 · Cited by 43

Nucleocytoplasmic shuttling of hexokinase II in a cancer cell

Neary, C. L., & Pastorino, J. G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.129 · Cited by 43

The metabolic interaction of cancer cells and fibroblasts – coupling between NAD(P)H and FAD, intracellular pH and hydrogen peroxide

Николаевна, Д. И., Shirmanova, M. V., Lukina, M. M., Dudenkova, V. V., Mishina, N. M., & Вадимовна, З. Е. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1160974 · Cited by 43

Synthesis of sugar fatty acid esters by modified lipase

Tsuzuki, W., Kitamura, Y., Suzuki, T., & Kobayashi, S. (1999) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19990805)64:3 · Cited by 46

Potential and problems of animal cells in suspension culture

Leist, C., Meyer, H., & Fiechter, A. (1990) · Journal of Biotechnology · doi:10.1016/0168-1656(90)90049-h · Cited by 43

Role of glutamine in hybridoma cell culture: Effects on cell growth, antibody production, and cell metabolism

Jeong, Y.-H., & Wang, S. S. (1995) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(94)00041-o · Cited by 43

Metabolite regulation of heat shock protein levels.

Lanks, K. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.17.5325 · Cited by 43

Regulation of glutamine and pyruvate oxidation in cultured adrenocortical cells by cortisol, antioxidants, and oxygen: Effects on cell proliferation

Hornsby, P. J., & Gill, G. N. (1981) · Journal of Cellular Physiology · doi:10.1002/jcp.1041090113 · Cited by 43

Comparison of Parenteral Nutrition Supplemented With L‐Glutamine or Glutamine Dipeptides

Jiang, Z., Wang, L., Qi, Y., Liu, T., Qiu, M., Yang, N., & Wilmore, D. W. (1993) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607193017002134 · Cited by 43

The crisscross between p53 and metabolism in cancer

Mao, Y., & Jiang, P. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023109 · Cited by 45

Determination of Phosphate-activated Glutaminase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)

Botman, D., Tigchelaar, W., & Noorden, C. J. F. V. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414551177 · Cited by 41

Glutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: Relationship to mitochondrial membrane potential

Friday, E., Oliver, R., Welbourne, T., & Turturro, F. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22360 · Cited by 42

Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

FIUME, L., Vettraino, M., Manerba, M., & Stefano, G. D. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.12.005 · Cited by 42

Glutamine: a major energy source for cultured mammalian cells.

Zielke, H. R., Zielke, C. L., & Pt, O. (1984) · PubMed · Cited by 240

Metabolic basis for differential glutamine requirements of human leukemia cell lines

鬼頭, 敏. (1990)

Bioenergetics of tumor cells: Glutamine metabolism in tumor cell mitochondria

Matsuno, T. (1987) · International Journal of Biochemistry · doi:10.1016/0020-711x(87)90002-4 · Cited by 54

Growth of human diploid fibroblasts in the absence of glucose utilization.

Zielke, H. R., Ozand, P. T., Tildón, J. T., Sevdalian, D. A., & Cornblath, M. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4110 · Cited by 106

An examination of the efficiency of glucose and glutamine as energy sources for cultured chick pigment epithelial cells

Barbehenn, E. K., Masterson, E., Koh, S. M., Passonneau, J. V., & Chader, G. J. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041180308 · Cited by 6