Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

A Flexible System of Enzymatic Analysis

Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050

Nutrition Needs of Mammalian Cells in Tissue Culture

Eagle, H. (1955) · Science · doi:10.1126/science.122.3168.501 · Cited by 1,619

Measurement of Low Energy Beta-Emitters in Aqueous Solution by Liquid Scintillation Counting of Emulsions.

Patterson, M. S., & Greene, R. C. (1965) · Analytical Chemistry · doi:10.1021/ac60226a017 · Cited by 1,459

Uptake and Metabolism of Plasma Glutamine by the Small Intestine

Windmueller, H. G., & Spaeth, A. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42329-6 · Cited by 791

The Path of Carbon in Photosynthesis. V. Paper Chromatography and Radioautography of the Products1

Benson, A. A., Bassham, J. A., Calvin, M., Goodale, T. C., Haas, V. A., & Stepka, W. (1950) · Journal of the American Chemical Society · doi:10.1021/ja01160a080 · Cited by 479

The Use of Glucose-C14 for the Evaluation of the Pathways of Glucose Metabolism

Katz, J. J., & Wood, H. G. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64593-4 · Cited by 405

Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates

Alp, P. R., Newsholme, E. A., & Zammit, V. A. (1976) · Biochemical Journal · doi:10.1042/bj1540689 · Cited by 404

Uber den Stoffwechsel der Karzinomezellen

Warburg, O. (1924) · Medical Entomology and Zoology · Cited by 401

A new method for the determination of inulin in plasma and urine

Heyrovský, A. (1956) · Clinica Chimica Acta · doi:10.1016/0009-8981(56)90020-1 · Cited by 377

Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

Chang, H.-C., Tsai, C., Hsu, C.-L., Tai, T.-S., Cheng, M., Chuang, Y., Tang, H.-Y., Lin, K.-J., Chen, J., Chang, S.-H., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01245-6 · Cited by 41

Systematic analyses of glutamine and glutamate metabolisms across different cancer types

Tian, Y., Du, W., Cao, S., Wu, Y., Dong, N., Wang, Y., & Xu, Y. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0255-y · Cited by 41

Mutations in TIMM50 compromise cell survival in OxPhos‐dependent metabolic conditions

Reyes, A., Melchionda, L., Burlina, A., Robinson, A. J., Ghezzi, D., & Zeviani, M. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708698 · Cited by 44

The effect of tumour bearing on skeletal muscle glutamine metabolism

Parry‐Billings, M., Leighton, B., Dimitriadis, G., Curi, R., & BOND, J. A. (1991) · International Journal of Biochemistry · doi:10.1016/0020-711x(91)90082-x · Cited by 41

Local macromolecule diffusion coefficients in structurally non-uniform bacterial biofilms using fluorescence recovery after photobleaching (FRAP)

Bryers, J. D., & Drummond, F. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19981120)60:4 · Cited by 110

On-line monitoring of monoclonal antibody formation in high density perfusion culture using FIA

Fenge, C., Fraune, E., Freitag, R., Scheper, T. H., & Sch�gerl, K. (1991) · Cytotechnology · doi:10.1007/bf00353703 · Cited by 41

Variation of amino acid concentrations in the medium of HU ?-IFN and HU IL-2 producing cell lines

Wagner, R., Ryll, T., Krafft, H., & Lehmann, J. (1988) · Cytotechnology · doi:10.1007/bf00146815 · Cited by 41

Transcriptional changes in OXPHOS complex I deficiency are related to anti-oxidant pathways and could explain the disturbed calcium homeostasis

Voets, A. M., Huigsloot, M., Lindsey, P. J., Leenders, A. M., Koopman, W. J. H., Willems, P. H. G. M., Rodenburg, R. J., Smeitink, J. A. M., & Smeets, H. J. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.009 · Cited by 40

Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells

Akizuki, R., Maruhashi, R., Eguchi, H., Kitabatake, K., Tsukimoto, M., Furuta, T., Matsunaga, T., Endo, S., & Ikari, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.03.001 · Cited by 40

Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells

Saladini, S., Aventaggiato, M., Barreca, F., Morgante, E., Sansone, L., Russo, M. A., & Tafani, M. (2019) · Cells · doi:10.3390/cells8010049 · Cited by 40

High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study

Papandreou, C., Hernández‐Alonso, P., Bulló, M., Ruiz‐Canela, M., Li, J., Guasch‐Ferré, M., Toledo, E., Clish, C. B., Corella, D., Estruch, R., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa273 · Cited by 40

Mutations in Subunit Interface and B-cell Epitopes Improve Antileukemic Activities of Escherichia coli Asparaginase-II

Mehta, R. K., Verma, S., Pati, R., Sengupta, M., Khatua, B., Jena, R. K., Sethy, S., Kar, S. K., Mandal, C., Roehm, K. H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.486530 · Cited by 40

Malnutrition impairs alveolar fluid clearance in rat lungs

Sakuma, T., Zhao, Y., Sugita, M., Sagawa, M., Toga, H., Ishibashi, T., Nishio, M., & Matthay, M. A. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00229.2003 · Cited by 40

Lactate stimulates CA IX expression in normoxic cancer cells

Pánisová, E., Kery, M., Sedlakova, O., Brisson, L., Debreova, M., Sboarina, M., Sonveaux, P., Pastoreková, S., & Švastová, E. (2017) · Oncotarget · doi:10.18632/oncotarget.20836 · Cited by 41

Glucose metabolism in insulin-producing tumoral cells

Giroix, M.-H., Sener, A., Dufrane, S. P., MALAISSE-LAGAE, F., & Malaisse, W. J. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90581-8 · Cited by 40

Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma

Nakahara, Y., Yamasaki, M., Sawada, G., Miyazaki, Y., Makino, T., Takahashi, T., Kurokawa, Y., Nakajima, K., Takiguchi, S., Mimori, K., et al. (2016) · Oncology · doi:10.1159/000445323 · Cited by 39

Energy sources identify metabolic phenotypes in pancreatic cancer

Liang, C., Qin, Y., Zhang, B., Ji, S., Shi, S., Xu, W., Liu, J., Xiang, J., Liang, D., Hu, Q., et al. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw097 · Cited by 37

Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg’s Discovery

de Souza, A. C. S., Justo, G. Z., de Araújo, D. R., & Cavagis, A. D. M. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000335792 · Cited by 39

Cell–cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype

Rubin, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800747105 · Cited by 39

Current concepts in the immunohistochemical evaluation of liver tumors

de Gonzalez, A. K. K. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i10.1403 · Cited by 39

Hamster cell mutants unable to grow on galactose and exhibiting an overlapping complementation pattern are defective in the electron transport chain.

Whitfield, C. D., Bostedor, R., Goodrum, D. D., Haak, M., & Chu, E. H. Y. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69040-x · Cited by 39

A Nuclear Magnetic Resonance Technique for Determining Hybridoma Cell Concentration in Hollow Fiber Bioreactors

Mancuso, A., Fernández, E., Blanch, H. W., & Clark, D. S. (1990) · Nature Biotechnology · doi:10.1038/nbt1290-1282 · Cited by 39

Effect of different cell culture conditions on the polypeptide integrity and N‐glycosylation of a recombinant model glycoprotein

Gawlitzek, M., Conradt, H. S., & Wagner, R. (1995) · Biotechnology and Bioengineering · doi:10.1002/bit.260460606 · Cited by 39

Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.

Rübsamen, H., Saltenberger, K., Friis, R. R., & EIGENBRODT, E. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.228 · Cited by 39

Influence of amino acids on hybridoma cell viability and antibody secretion

Geaugey, V., Duval, D., Geahel, I., Marc, A., & Engasser, J. (1989) · Cytotechnology · doi:10.1007/bf00386144 · Cited by 39

Studies on monoclonal antibody production by a hybridoma cell line (C1E3) immobilised in a fixed bed, porosphere culture system

Racher, A. J., Looby, D., & Griffiths, J. B. (1990) · Journal of Biotechnology · doi:10.1016/0168-1656(90)90056-h · Cited by 39

Erratum: A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors

Mancuso, A., Fernández, E., Blanch, H. W., & Clark, D. S. (2010) · Nature Biotechnology · doi:10.1038/nbt0210-178e · Cited by 39

p32 (C1QBP) and Cancer Cell Metabolism: Is the Warburg Effect a Lot of Hot Air?

Dang, C. V. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01661-09 · Cited by 38

Brucella Genital Tropism: What's on the Menu

Letesson, J., Barbier, T., Zúñiga-Ripa, A., Godfroid, J., Bolle, X. D., & Moriyón, I. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00506 · Cited by 38

Blood–Brain Barrier, Cell Junctions, and Tumor Microenvironment in Brain Metastases, the Biological Prospects and Dilemma in Therapies

Guan, Z., Lan, H., Cai, X., Zhang, Y., Liang, A., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.722917 · Cited by 39

Characterization of glutamine metabolism in two related murine hybridomas

JENKINS, H. A., Butler, M., & Dickson, A. J. (1992) · Journal of Biotechnology · doi:10.1016/0168-1656(92)90090-v · Cited by 38

Origin, cellular expression, and cybrid transmission of mitochondrial CAP-R, PYR-IND, and OLI-R mutant phenotypes

Howell, N. (1983) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01544045 · Cited by 38

Production of human immune interferon by recombinant mammalian cells cultivated on microcarriers

Smiley, A. L., Hu, W., & Wang, D. I. C. (1989) · Biotechnology and Bioengineering · doi:10.1002/bit.260330914 · Cited by 38

Glutaminase inhibition in multiple myeloma induces apoptosisviaMYC degradation

Effenberger, M., Bommert, K. S., Kunz, V., Kruk, J., Leich, E., Rudelius, M., Bargou, R. C., & Bommert, K. (2017) · Oncotarget · doi:10.18632/oncotarget.20691 · Cited by 38

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Khan, A. U. H., Allende-Vega, N., Gitenay, D., Gerbal‐Chaloin, S., Gondeau, C., Vo, D.-N., Belkahla, S., Orecchioni, S., Talarico, G., Bertolini, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10339-5 · Cited by 40

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression

Catanzaro, D., Gabbia, D., Cocetta, V., Biagi, M., Ragazzi, E., Montopoli, M., & Carrara, M. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.10.007 · Cited by 38

Non-coding RNAs rewire cancer metabolism networks

Lin, X., Wu, Z., Hu, H., Luo, M., & Song, E. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.019 · Cited by 37

Balancing of energy‐consuming processes of K 562 cells

Siems, W. G., Schmidt, H., Gruner, S., & Jakstadt, M. (1992) · Cell Biochemistry and Function · doi:10.1002/cbf.290100110 · Cited by 37

Metabolic Profiling Comparison of Human Pancreatic Ductal Epithelial Cells and Three Pancreatic Cancer Cell Lines using NMR Based Metabonomics

Watanabe, M. (2012) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.s3-002 · Cited by 37

Role of acetoin on the regulation of intermediate metabolism of ehrlich ascites tumor mitochondria: Its contribution to membrane cholesterol enrichment modifying passive proton permeability

Baggetto, L. G., & Testa-Parussini, R. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90638-f · Cited by 37

Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis

Oursler, M. J., Bradley, E. W., Elfering, S. L., & Giulivi, C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2004 · Cited by 37

Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts

Mojena, M., Boscá, L., & Hue, L. (1985) · Biochemical Journal · doi:10.1042/bj2320521 · Cited by 36

High density mammalian cell growth in leibovitz bicarbonate-free medium: Effects of fructose and galactose on culture biochemistry

Barngrover, D. A., Thomas, J., & Thilly, W. G. (1985) · Journal of Cell Science · doi:10.1242/jcs.78.1.173 · Cited by 37

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

Krycer, J. R., Elkington, S. D., Díaz‐Vegas, A., Cooke, K. C., Burchfield, J. G., Fisher‐Wellman, K. H., Cooney, G. J., Fazakerley, D. J., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011695 · Cited by 33

The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

Fernández-García, E., Paudel, U., Noji, M., Bowman, C. E., Pitarresi, J. R., Rustgi, A. K., Wellen, K. E., Arany, Z. P., Weissenrieder, J., & Foskett, J. K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1082213 · Cited by 35

Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia

Sanchez-Aranguren, L. C., Espinosa-Gonzalez, C. T., González-Ortiz, L. M., Sanabria‐Barrera, S. M., Riaño-Medina, C. E., Nuñez, A. F., Ahmed, A., Vasquez-Vivar, J. M., & López, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00083 · Cited by 39

Use of Glucose, Glutamine, and Fatty Acids for Trophoblast Respiration in Lean Women, Women With Obesity, and Women With Gestational Diabetes

Wang, Y., Bucher, M., & Myatt, L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00166 · Cited by 36

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells

Hayes, P., Fergus, C., Ghanim, M., Cirzi, C., Burtnyak, L., McGrenaghan, C. J., Tuorto, F., Nolan, D. P., & Kelly, V. P. (2020) · Nutrients · doi:10.3390/nu12030871 · Cited by 36

Interactions among mitochondrial aspartate aminotransferase, malate dehydrogenase, and the inner mitochondrial membrane from heart, hepatoma, and liver.

Teller, J. K., Fahien, L. A., & Valdiviá, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45399-3 · Cited by 36

1H NMR Spectroscopy: An Approach to Evaluation of Diseased Skin In Vivo

Kim, Y. H., Orenberg, E. K., Faull, K. F., Wade-Jardetzky, N., & Jardetzky, O. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12276738 · Cited by 36

Genetic engineering of hybridoma glutamine metabolism

Bell, S. L., Bebbington, C. R., Scott, M. F., Wardell, J. N., Spier, R. E., Bushell, M. E., & Sanders, P. G. (1995) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(94)00056-w · Cited by 36

Enzymology of Glutamine

Meister, A. (1984) · Springer eBooks · doi:10.1007/978-3-642-69754-8_1 · Cited by 36

The Nutrient Requirements of Cultured Mammalian Cells

Bettger, W. J., & Ham, R. G. (1982) · Springer eBooks · doi:10.1007/978-1-4613-9934-6_9 · Cited by 36

Targeting redox regulation and autophagy systems in cancer stem cells

Khan, S. U., Rayees, S., Sharma, P., & Malik, F. A. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00955-5 · Cited by 36

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinoma

Ziki, R. A., & Colnot, S. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101077 · Cited by 36

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

Belkahla, S., Khan, A. U. H., Gitenay, D., Alexia, C., Gondeau, C., Vo, D.-N., Orecchioni, S., Talarico, G., Bertolini, F., Cartron, G., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23305 · Cited by 35

Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

Zhang, Z., Marrachelli, V. G., Yang, W., Trenson, S., Huang, Q., Wei, F., Thijs, L., Keer, J. M. V., Monleón, D., Verhamme, P. B., et al. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318797395 · Cited by 35

Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

FIUME, L., Manerba, M., Vettraino, M., & Stefano, G. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.038 · Cited by 35

Growth limitations in microcarrier cultures

Butler, M. (2005) · Springer eBooks · doi:10.1007/bfb0000673 · Cited by 35

MDCK microcarrier cultures: Seeding density effects and amino acid utilization

Butler, M., & Thilly, W. G. (1982) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02618573 · Cited by 35

The role of vitamin E in cellular energy metabolism in cultured adrenocortical cells

Hornsby, P. J. (1982) · Journal of Cellular Physiology · doi:10.1002/jcp.1041120208 · Cited by 35

Rationale for mitochondria-targeting strategies in cancer bioenergetic therapies

José, C., & Rossignol, R. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.005 · Cited by 35

Advanced model‐based control strategies for the intensification of upstream and downstream processing in mAb production

Papathanasiou, M. M., Quiroga-Campano, A. L., Steinebach, F., Elviro, M., Mantalaris, A., & Pistikopoulos, E. N. (2017) · Biotechnology Progress · doi:10.1002/btpr.2483 · Cited by 34

A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines

Gowda, G. A. N., Barding, G. A., Dai, J., Gu, H., Margineantu, D. H., Hockenbery, D. M., & Raftery, D. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00049 · Cited by 34

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

Moreno‐Sánchez, R., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Pacheco-Velázquez, S. C., Robledo‐Cadena, D. X., Padilla-Flores, J. A., Saavedra, E., & Rodríguez‐Enríquez, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00429 · Cited by 34

Enhanced erythropoietin heterogeneity in a CHO culture is caused by proteolytic degradation and can be eliminated by a high glutamine level

Yang, M., & Butler, M. (2000) · Cytotechnology · doi:10.1023/a:1008137712611 · Cited by 35

Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

Karra, S. R., Sager, B., & Karim, M. N. (2010) · Industrial & Engineering Chemistry Research · doi:10.1021/ie100125a · Cited by 34

Extra- and intracellular amino acid concentrations in continuous Chinese hamster ovary cell culture

Hansen, H. A., & Emborg, C. (1994) · Applied Microbiology and Biotechnology · doi:10.1007/bf00178489 · Cited by 34

Studies with GIP/Ins cells indicate secretion by gut K cells is KATPchannel independent

Wang, S. Y., Chi, M. M.-Y., Li, C., Moley, K. H., & Wice, B. M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00398.2002 · Cited by 34

Formation and utilization of acetoin, an unusual product of pyruvate metabolism by Ehrlich and AS30-D tumor mitochondria.

Baggetto, L. G., & Lehninger, A. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47966-5 · Cited by 34

Energy substrate utilization in freshly isolated Morris Hepatoma 7777 cells.

Mares‐Perlman, J. A., & Shrago, E. S. (1988) · PubMed · Cited by 34

Carbohydrate Metabolism and Neoplasia: New Perspectives for Diagnosis and Therapy

EIGENBRODT, E., Gerbracht, U., Mazurek, S., Presek, P., & Friis, R. R. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-564499-0.50014-6 · Cited by 34

Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer

Yaman, İ., Çobanoğlu, D. A., Xie, T., Ye, Y., & Amit, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108199 · Cited by 35

Hypothesis: solid tumours behave as systemic metabolic dictators

Lee, Y., Chang, W., & Ma, W. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12794 · Cited by 35

A critical review of the role of M2PYK in the Warburg effect

Harris, R. A., & Fenton, A. W. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.004 · Cited by 32

Optical ammonia sensors based on fluorescent aza-BODIPY dyes— a flexible toolbox

Maierhofer, M., Rieger, V., & Mayr, T. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02891-3 · Cited by 33

2-deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione

Fico, A., Manganelli, G., Cigliano, L., Bergamo, P., Abrescia, P., Franceschi, C., Martini, G., & Filosa, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.017 · Cited by 33

Measurement of key metabolic enzyme activities in mammalian cells using rapid and sensitive microplate‐based assays

Janke, R., Genzel, Y., Wahl, A., & Reichl, U. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22817 · Cited by 33

Suppression of transformation by and growth adaptation to low concentrations of glutamine in NIH-3T3 cells.

Rubin, A. L. (1990) · PubMed · Cited by 33

Comparison of Glucose, Fructose, Ascorbic Acid and Glucosephosphate lsomerase Enzymatic Activity in Uterine Flushings from Nonpregnant and Pregnant Guts and Pony Mares12

Zavy, M. T., Clark, W., Sharp, D. C., Roberts, R. M., & Bazer, F. W. (1982) · Biology of Reproduction · doi:10.1095/biolreprod27.5.1147 · Cited by 33

Death of mouse embryos that lack a functional gene for glucose phosphate isomerase

West, J. D., Flockhart, J. H., Peters, J., & Ball, S. T. (1990) · Genetics Research · doi:10.1017/s0016672300035321 · Cited by 33

Optimization of culture conditions for high cell density proliferation of hl-60 human promyelocytic leukemia cells

Schumpp, B., & Schlaeger, E. (1990) · Journal of Cell Science · doi:10.1242/jcs.97.4.639 · Cited by 33

Ribose-1-P is the essential precursor for nucleic acid synthesis in animal cells growing on uridine in the absence of sugar.

Wice, B. M., & Kennell, D. E. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34963-9 · Cited by 33

Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers

Villalba, M., López-Royuela, N., Krzywińska, E., Rathore, M. G., Hipskind, R. A., Haouas, H., & Allende-Vega, N. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113136660374 · Cited by 32

Effects of glucose and glycerol on γ-poly(glutamic acid) formation byBacillus licheniformis ATCC 9945a

Ko, Y. H., & Gross, R. A. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19980220)57:4 · Cited by 108

Effect of glutamine deprivation and glutamate or ammonium chloride addition on growth rate, metabolism and differentiation of human colon cancer cell-line HT29

Viallard, V., Denis, C., Trocheris, V., & Murat, J. C. (1986) · International Journal of Biochemistry · doi:10.1016/0020-711x(86)90116-3 · Cited by 32

Enhanced monoclonal antibody production by gradual increase of osmotic pressure

Lin, J., Takagi, M., Qu, Y., Gao, P., & Yoshida, T. (1999) · Cytotechnology · doi:10.1023/a:1008016806599 · Cited by 32

Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level

Schmid, G., & Keller, T. (1992) · Cytotechnology · doi:10.1007/bf02521749 · Cited by 32

POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity

Young, M. J., Humble, M. M., DeBalsi, K. L., Sun, K. Y., & Copeland, W. C. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv240 · Cited by 32

Nucleosides are overlooked fuels in central carbon metabolism

Strefeler, A., Blanco-Fernández, J., & Jourdain, A. A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.01.013 · Cited by 31

Glutamine, Glucose and other Fuels for Cancer

Ruiz-Pérez, M. V., Sánchez‐Jiménez, F., Alonso, F. J., Segura, J., Márquez, J., & Medina, M. Á. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990482 · Cited by 31

The Creation of Cybrids Harboring Mitochondrial Haplogroups in the Taiwanese Population of Ethnic Chinese Background: An ExtensiveIn VitroTool for the Study of Mitochondrial Genomic Variations

Lin, T., Lin, H., Chen, S., Chuang, Y., Chuang, J., Wang, P., Huang, S., Tiao, M., Chen, J., & Liou, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/824275 · Cited by 33

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

Alvero, A. B., Montagna, M. K., Sumi, N. J., Joo, W. D., Graham, E., & Mor, G. (2014) · Oncotarget · doi:10.18632/oncotarget.2367 · Cited by 31

p53 and regulation of tumor metabolism

Yang, X., Jiang, P., & Du, W. (2013) · Journal of Carcinogenesis · doi:10.4103/1477-3163.122760 · Cited by 32

Global changes to HepG2 cell metabolism in response to galactose treatment

Skolik, R., Solocinski, J., Konkle, M. E., Chakraborty, N., & Menze, M. A. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00460.2020 · Cited by 31

Lactic acid in alternative polarization and function of macrophages in tumor microenvironment

Goswami, K. K., Banerjee, S., Bose, A., & Baral, R. (2022) · Human Immunology · doi:10.1016/j.humimm.2022.02.007 · Cited by 31

Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor

Cheng, L., Wu, C., Zhu, L., Li, H., & Chen, L.-X. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.01.057 · Cited by 31

A novel process for the production of a veterinary rabies vaccine in BHK-21 cells grown on microcarriers in a 20-l bioreactor

Kallel-Mhiri, H., Rourou, S., Majoul, S., & Loukil, H. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1245-3 · Cited by 31

Altered G-protein glycosylation in vesicular stomatitis virus-infected glucose-deprived baby hamster kidney cells.

Turco, S. J., & Pickard, J. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34181-4 · Cited by 31

Growth of fish cell lines in glutamine-free media

Bols, N. C., GANASSIN, R. C., Tom, D. J., & Lee, L. E. J. (1994) · Cytotechnology · doi:10.1007/bf00749903 · Cited by 31

Glutamine: a major energy source for cultured mammalian cells.

Zielke, H. R., Zielke, C. L., & Pt, O. (1984) · PubMed · Cited by 240

Metabolic basis for differential glutamine requirements of human leukemia cell lines

鬼頭, 敏. (1990)

Bioenergetics of tumor cells: Glutamine metabolism in tumor cell mitochondria

Matsuno, T. (1987) · International Journal of Biochemistry · doi:10.1016/0020-711x(87)90002-4 · Cited by 54

Growth of human diploid fibroblasts in the absence of glucose utilization.

Zielke, H. R., Ozand, P. T., Tildón, J. T., Sevdalian, D. A., & Cornblath, M. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4110 · Cited by 106

An examination of the efficiency of glucose and glutamine as energy sources for cultured chick pigment epithelial cells

Barbehenn, E. K., Masterson, E., Koh, S. M., Passonneau, J. V., & Chader, G. J. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041180308 · Cited by 6