Human apolipoprotein E. The complete amino acid sequence

Prediction of protein conformation

Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a002 · Cited by 3,309

Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a001 · Cited by 2,172

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777

A molecular theory of lipid—protein interactions in the plasma lipoproteins

Segrest, J. P., Jackson, R. L., Morrisett, J. D., & Gotto, A. M. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80064-5 · Cited by 726

Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site

Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 616

Glycoproteins

Marshall, R. (1972) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.41.070172.003325 · Cited by 604

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563

Disturbances in Lipid and Lipoprotein Metabolism

Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433

Apolipoprotein E and Neurological Disease: Therapeutic Potential and Pharmacogenomic Interactions

Laskowitz, D. T., & Vitek, M. P. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.8.959 · Cited by 58

Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E

Weisgraber, K. H., Pitas, R. E., & Mahley, R. W. (1994) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(94)90212-7 · Cited by 58

Intracellular modifications of human apolipoprotein E.

Zannis, V. I., vanderSpek, J. C., & Silverman, D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67033-4 · Cited by 57

Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases

Minta, K., Brinkmalm, G., Janelidze, S., Sjödin, S., Portelius, E., Stomrud, E., Zetterberg, H., Blennow, K., Hansson, O., & Andréasson, U. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00585-7 · Cited by 57

3 Postprandial lipaemia

Patsch, J. R. (1987) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(87)80023-x · Cited by 56

Immunohistochemical localization of apolipoprotein E in human glial neoplasms.

Murakami, M., Ushio, Y., Morino, Y., Ohta, T., & Matsukado, Y. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113568 · Cited by 55

[49] Genetic polymorphism in human apolipoprotein E

Zannis, V. I. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28109-4 · Cited by 55

Apolipoprotein EBethesda: A New Variant of Apolipoprotein E Associated with Type III Hyperlipoproteinemia

Gregg, R. E., Ghiselli, G., & Brewer, H. B. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-5-969 · Cited by 55

Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study

Leon, A. S., Togashi, K., Rankinen, T., Després, J., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C. (2003) · Metabolism · doi:10.1016/j.metabol.2003.08.013 · Cited by 54

The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis

Zhang, H., Wu, J., & Zhu, J. (2010) · BioMed Research International · doi:10.1155/2010/357412 · Cited by 57

ApoE Induces Serum Paraoxonase PON1 Activity and Stability Similar to ApoA-I

Gaidukov, L., I, V. R., Yacobson, S., Rosenblat, M., Aviram, M., & Tawfik, D. S. (2009) · Biochemistry · doi:10.1021/bi9013227 · Cited by 54

Mercury, APOE, and children's neurodevelopment

Ng, S., Lin, C., Hwang, Y., Hsieh, W., Liao, H., & Chen, P. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.03.012 · Cited by 54

Apolipoprotein E-4Philadelphia (Glu13—-Lys,Arg145—-Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia

Lohse, P., Mann, W. A., Stein, E. A., & Brewer, H. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99249-5 · Cited by 54

Apolipoprotein E Polymorphism and Atherosclerosis

Kolovou, G. D., Daskalova, D. C., & Mikhailidis, D. P. (2003) · Angiology · doi:10.1177/000331970305400108 · Cited by 54

Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors.

Chang, D. J., Paik, Y., Leren, T. P., Walker, D., Howlett, G. J., & Taylor, J. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38877-5 · Cited by 54

Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects.

Ferrières, J., Sing, C. F., Roy, M., Davignon, J., & Lussier‐Cacan, S. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1553 · Cited by 53

Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study.

Eichner, J. E., Kuller, L. H., Ferrell, R. E., Meilahn, E. N., & Kamboh, M. I. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.3.379 · Cited by 54

Detection of DNA hybridization on chemically modified graphene platforms

Giovanni, M., Bonanni, A., & Pumera, M. (2011) · The Analyst · doi:10.1039/c1an15910k · Cited by 53

Chromosomal localization of the human apoprotein ci gene and of a polymorphic apoprotein AII gene

Knott, T. J., Eddy, R. L., Robertson, M. E., Priestley, L. M., Scott, J., & Shows, T. B. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80368-x · Cited by 53

MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism

Vuu, Y. M., Roberts, C.-T., & Rastegar, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044218 · Cited by 55

O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain

Flowers, S. A., Grant, O. C., Woods, R. J., & Rebeck, G. W. (2020) · Glycobiology · doi:10.1093/glycob/cwz084 · Cited by 52

Desialylation of human apolipoprotein E decreases its binding to human high-density lipoprotein and its ability to deliver esterified cholesterol to the liver

Marmillot, P., Rao, M. N., Liu, Q., & Lakshman, M. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90136-1 · Cited by 50

Apolipoprotein-E degradation in human very low density lipoproteins by plasma protease(s): Chemical and biological consequences

Bradley, W. A., Gilliam, E. B., Gotto, A. M., & Gianturco, S. H. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91927-1 · Cited by 52

Comparison of Lipid-Binding and Lecithin:Cholesterol Acyltransferase Activation of the Amino- and Carboxyl-Terminal Domains of Human Apolipoprotein E3

Pauw, M. D., Vanloo, B., Weisgraber, K. H., & Rosseneu, M. (1995) · Biochemistry · doi:10.1021/bi00034a030 · Cited by 50

Anion-exchange fast protein liquid chromatographic characterization and purification of apolipoproteins A-I, A-II, C-I, C-II, C-III0, C-III1, C-III2 and E from human plasma

Mezdour, H., Barthelemy-Clavey, V., Kora, I., Koffigan, M., Barkia, A., & Fruchart, J. (1987) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(87)80022-1 · Cited by 51

Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment‐associated cytotoxicity

Maezawa, I., Jin, L., Woltjer, R. L., Maeda, N., Martin, G. M., Montine, T. J., & Montine, K. S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02818.x · Cited by 51

Apolipoprotein E2/E3/E4 genotyping with agarose gels

Dallinga‐Thie, G. M., Trip, M. V. L.-S., Kock, L. A., & de Bruin, T. W. A. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.1.73 · Cited by 49

Complex adaptive systems and human health: the influence of common genotypes of the apolipoprotein E ( ApoE ) gene polymorphism and age on the relational order within a field of lipid metabolism traits

Zerba, K. E., Ferrell, R. E., & Sing, C. F. (2000) · Human Genetics · doi:10.1007/s004390000394 · Cited by 49

Conformational flexibility in the apolipoprotein E amino‐terminal domain structure determined from three new crystal forms: Implications for lipid binding

Segelke, B. W., Forstner, M., Knapp, M., Trakhanov, S. D., Parkin, S., Newhouse, Y. M., Bellamy, H. D., Weisgraber, K. H., & Rupp, B. (2000) · Protein Science · doi:10.1110/ps.9.5.886 · Cited by 47

ApoE Production in Human Monocytes and Its Regulation by Inflammatory Cytokines

Braesch‐Andersen, S., Paulie, S., Smedman, C., Mia, S., & Kumagai‐Braesch, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079908 · Cited by 49

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

Huang, Y. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390924 · Cited by 53

Association of theAPOE-ε4allele with outcome of traumatic brain injury in children and youth: a meta-analysis and meta-regression

Kassam, I., Gagnon, F., & Cusimano, M. D. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310500 · Cited by 48

Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study

Hubacek, J. A., Pitha, J. V., Škodová, Z., Poledne, R., Lánská, V., Waterworth, D. M., Humphries, S. E., & Talmud, P. J. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00025-0 · Cited by 46

Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide primers.

Main, B. F., Jones, P. J. H., MacGillivray, R., & Banfield, D. K. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42257-6 · Cited by 48

Improved phenotyping of apolipoprotein E: application to population frequency distribution

Hill, J. S., & Pritchard, P. H. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.11.1871 · Cited by 48

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Raulin, A.-C., Kraft, L., Al-Hilaly, Y. K., Xue, W.-F., McGeehan, J. E., Atack, J. R., & Serpell, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.019 · Cited by 47

From beta amyloid to altered proteostasis in Alzheimer’s disease

Bruni, A. C., Bernardi, L., & Gabelli, C. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101126 · Cited by 47

The Underlying Molecular Mechanism of Apolipoprotein E Polymorphism: Relationships to Lipid Disorders, Cardiovascular Disease, and Alzheimer’s Disease

Contois, J. H., Anamani, D. E., & Tsongalis, G. J. (1996) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30290-7 · Cited by 45

The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra‐hepatic tissues.

Wallis, S. C., Rogne, S., Gill, L., Markham, A. F., Edge, M., Woods, D. E., Williamson, R., & Humphries, S. E. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01748.x · Cited by 46

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease

Giannisis, A., Al-Grety, A., Carlsson, H., Patra, K., Twohig, D., Sando, S. B., Lauridsen, C., Berge, G., Grøntvedt, G. R., Bråthen, G., et al. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01058-9 · Cited by 46

Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-α and IL-6 in macrophages

Tsoi, L.-M., Wong, K., Liu, Y.-M., & Ho, Y.-Y. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.01.019 · Cited by 46

APOE polymorphism affects episodic memory among non demented elderly subjects

Blasi, S. D., Montesanto, A., Martino, C., Dato, S., Rango, F. D., Bruni, A. C., Mari, V., Feraco, E., & Passarino, G. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.11.005 · Cited by 45

Personalized nutrition for the prevention of cardiovascular disease: a future perspective

Lovegrove, J. A., & Gitau, R. (2008) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00889.x · Cited by 46

Explorative and targeted neuroproteomics in Alzheimer's disease

Brinkmalm, A., Portelius, E., Öhrfelt, A., Brinkmalm, G., Andréasson, U., Gobom, J., Blennow, K., & Zetterberg, H. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.01.009 · Cited by 45

Expression of ApoE Gene in Chinese Hamster Cells with a Reversible Defect in O-Glycosylation

Zanni, E. E., Kouvatsi, A., Hadzopoulou‐Cladaras, M., Krieger, M., & Zannis, V. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60504-6 · Cited by 45

Anthropology of the apolipoprotein E (apo E) gene: low frequency of apo E4 allele in Basques and in tribal (Baiga) populations of India

Mastana, S. S., Calderón, R., Peña, J. A., Reddy, P. H., & Papiha, S. S. (1998) · Annals of Human Biology · doi:10.1080/03014469800005512 · Cited by 45

Apolipoprotein E: A pharmacogenetic target for the treatment of Alzheimer's disease*

Poirier, J. (1999) · Molecular Diagnosis · doi:10.1016/s1084-8592(99)80010-1 · Cited by 44

Genetic Epidemiology of Alzheimer Disease

Slooter, A. J. C., & van Duijn, C. M. (1997) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017933 · Cited by 44

Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice

Ong, Q.-R., Chan, E. S., Lim, M.-L., Cole, G. M., & Wong, B.-S. (2014) · Scientific Reports · doi:10.1038/srep03754 · Cited by 44

Increased frequency of the apolipoprotein E‐4 isoform in male subjects with multifactorial hypercholesterolemia

Leren, T. P., Bbøresen, A., Berg, K., Hjermann, I., & Luren, P. (1985) · Clinical Genetics · doi:10.1111/j.1399-0004.1985.tb00231.x · Cited by 43

Untitled work

(1993) · PubMed · Cited by 43

Apolipoprotein E and atherosclerosis in Alaska Natives

Scheer, W. D., Boudreau, D. A., Malcom, G. T., & Middaugh, J. P. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05483-y · Cited by 43

Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII

Houlston, R. S., Snowden, C. P., Green, F. R., Alberti, K. G. M. M., & Humphries, S. E. (1989) · Human Genetics · doi:10.1007/bf00291382 · Cited by 43

Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer

Mrkonjic, M., Chappell, E., Pethe, V. V., Manno, M., Daftary, D., Greenwood, C. M. T., Gallinger, S., Zanke, B. W., Knight, J. A., & Bapat, B. V. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605097 · Cited by 43

Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers

Sauer, I., Nikolenko, H., Keller, S., Ajaj, K. A., Bienert, M., & Dathe, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.017 · Cited by 42

Circulating apolipoprotein E concentration and cardiovascular disease risk: meta-analysis of results from three studies

Sofat, R., Cooper, J. A., Kumari, M., Casas, J. P., Mitchell, J. P., Acharya, J., Thom, S., Hughes, A. D., Humphries, S. E., & Hingorani, A. D. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002146 · Cited by 42

Apolipoprotein E Modifies Neurological Outcome by Affecting Cerebral Edema but not Hematoma Size after Intracerebral Hemorrhage in Humans

James, M. L., Blessing, R., Bennett, E. R., & Laskowitz, D. T. (2009) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2008.09.012 · Cited by 41

Only multimers of a synthetic peptide of human apolipoprotein E are biologically active

Dyer, C. A., Smith, R. S., & Curtiss, L. K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98578-9 · Cited by 41

The Role of Apolipoprotein E Isoforms in Alzheimer’s Disease

Roda, A. R., Montoliu‐Gaya, L., & Villegas, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180740 · Cited by 41

Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene

Salero, E., Giménez, C., & Zafra, F. (2003) · Biochemical Journal · doi:10.1042/bj20021142 · Cited by 39

The Apolipoprotein E Genotype Predicts Postprandial Hypertriglyceridemia in Patients with the Metabolic Syndrome

Cardona, F., Morcillo, S., Gonzalo‐Marín, M., & Tinahones, F. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1912 · Cited by 40

Apolipoprotein measurements in clinical biochemistry and their utility vis-a-vis conventional assays

Bachorik, P. S., & Kwiterovich, P. O. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90265-3 · Cited by 40

Adsorption of proteins onto glass surfaces and its effect on the intensity of circular dichroism spectra

Wu, C. C., & Chen, G. C. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90036-5 · Cited by 40

Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity

Wardell, M., Rall, S., Schaefer, E., Kane, J., & Weisgraber, K. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42076-0 · Cited by 40

COVID-19 as a Risk Factor for Alzheimer’s Disease

Golzari-Sorkheh, M., Weaver, D. F., & Reed, M. A. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220800 · Cited by 39

Multi-functional role of apolipoprotein E in neurodegenerative diseases

Islam, S., Noorani, A. A., Sun, Y., Michikawa, M., & Zou, K. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1535280 · Cited by 43

Type III Hyperlipoproteinemia: Still Worth Considering?

Blum, C. B. (2016) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2016.07.007 · Cited by 39

Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes

Weisgraber, K. H., Newhouse, Y. M., & Mahley, R. W. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81003-9 · Cited by 39

Human Low Density Lipoprotein Receptor Fragment

Simmons, T., Newhouse, Y. M., Arnold, K. S., Innerarity, T. L., & Weisgraber, K. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25531 · Cited by 37

Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

Utermann, G., Weisgraber, K. H., Weber, W., & Mahley, R. W. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37811-1 · Cited by 39

The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s Disease

Chernick, D., Zhong, R., & Li, L. (2020) · Biomolecules · doi:10.3390/biom10091276 · Cited by 39

Frequency of phenotype-genotype discrepancies at the apolipoprotein E locus in a large population study

Lahoz, C., Osgood, D. P., Wilson, P. W., Schaefer, E. J., & Ordovás, J. M. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.11.1817 · Cited by 37

Concerning the structure of apoE

Frieden, C., & Garai, K. (2013) · Protein Science · doi:10.1002/pro.2379 · Cited by 39

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus

Sparrow, J. T., Sparrow, D. A., Fernando, G. J. P., Culwell, A. R., Kovar, M., & Gotto, A. M. (1992) · Biochemistry · doi:10.1021/bi00119a015 · Cited by 38

Untitled work

Lalazar (1989) · doi:10.1016/s0021-9258(18)81806-3 · Cited by 238

LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR 5 repeat

Martínez-Oliván, J., Arias‐Moreno, X., Velázquez‐Campoy, A., Millet, Ó., & Sancho, J. (2014) · FEBS Journal · doi:10.1111/febs.12721 · Cited by 37

Apolipoprotein E Gene Polymorphism and the Risk of Cervical Myelopathy in Patients With Chronic Spinal Cord Compression

Setzer, M., Hermann, E. J., Seifert, V., & Marquardt, G. (2008) · Spine · doi:10.1097/brs.0b013e3181657cf7 · Cited by 37

Effect of apolipoprotein E genotype on the outcome after anterior cervical decompression and fusion in patients with cervical spondylotic myelopathy

Setzer, M., Vrionis, F. D., Hermann, E. J., Seifert, V., & Marquardt, G. (2009) · Journal of Neurosurgery Spine · doi:10.3171/2009.7.spine08667 · Cited by 37

Regulation of reconstituted high density lipoprotein structure and remodeling by apolipoprotein E

Rye, K.-A., Bright, R., Psaltis, M., & Barter, P. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500525-jlr200 · Cited by 33

Abnormalities of Apolipoprotein E in the Acquired Immunodeficiency Syndrome

Grünfeld, C., Doerrler, W. T., Pang, M., Jensen, P., Weisgraber, K. H., & Feingold, K. R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4366 · Cited by 37

Rapid determination of apolipoprotein E phenotypes from whole plasma by automated isoelectric focusing using PhastSystem and immunofixation.

Hackler, R., Schäfer, J., Motzny, S., Brand, S., Kleine, T. O., Kaffarnik, H., & Steinmetz, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40122-1 · Cited by 37

Disorders of lipid transport—Update 1983

Schonfeld, G. (1983) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(83)90025-7 · Cited by 37

Apolipoprotein E Phenotyping: A Word of Caution

Wenham, P. R., Sedky, A., & Spooner, R. J. (1991) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329102800610 · Cited by 36

A monoclonal antibody recognizing apolipoprotein E peptides in systemic amyloid deposits.

Yamada, T., Kakihara, T., Gejyo, F., & Okada, M. (1994) · PubMed · Cited by 37

Major apolipoprotein B-100 mutations in lipoprotein metabolism and atherosclerosis.

Vrablı́k, M., Češka, R., & Hořínek, A. (2001) · PubMed · Cited by 36

ApoE Genotype Does Not Predict Lipid Response to Changes in Dietary Saturated Fatty Acids in a Heterogeneous Normolipidemic Population

Lefevre, M., Ginsberg, H. N., Kris‐Etherton, P. M., Elmer, P. J., Stewart, P. W., Ershow, A. G., Pearson, T. A., Roheim, P. S., Ramakrishnan, R., Derr, J., et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2914 · Cited by 36

The contribution of α‐helices to the surface activities of proteins

Krebs, K. E., & Phillips, M. C. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80748-6 · Cited by 36

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

Passarella, D., Ciampi, S., Liberto, V. D., Zuccarini, M., Ronci, M., Medoro, A., Foderà, E., Frinchi, M., Mignogna, D., Russo, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168921 · Cited by 38

Differences in the binding capacity of human apolipoprotein E3 and E4 to size‐fractionated lipid emulsions

Perugini, M. A., Schuck, P., & Howlett, G. J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03319.x · Cited by 35

The neurobiology of APOE in schizophrenia and mood disorders

Gibbons, A. S. (2010) · Frontiers in bioscience · doi:10.2741/3729 · Cited by 35

Pharmacogenetics of Target Genes Across the Warfarin Pharmacological Pathway

Lal, S., Jada, S. R., Xiang, X., Lim, W., Lee, E. J. D., & Chowbay, B. (2006) · Clinical Pharmacokinetics · doi:10.2165/00003088-200645120-00004 · Cited by 35

Association between apolipoprotein E polymorphism and macroalbuminuria in patients with non-insulin dependent diabetes mellitus

Ha, S.-K., Park, H. S., Kim, K. W., Kim, S. J., Kim, D.-H., Kim, J. H., Lee, H. Y., & Han, D. S. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.9.2144 · Cited by 34

Proteomic analysis of the human colon carcinoma cell line (LIM 1215): Development of a membrane protein database

Simpson, R. J., Connolly, L. M., Eddes, J. S., Pereira, J. J., Moritz, R. L., & Reid, G. E. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000501)21:9 · Cited by 205

Low-density lipoprotein cholesterol responsiveness to diet in normolipidemic subjects

Cobb, M. M., & RISCH, N. J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90164-j · Cited by 35

Synthesis of Apolipoprotein E by Peripheral Tissues

Williams, D. L., Dawson, P. A., Newman, T. C., & Rudel, L. L. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb11861.x · Cited by 34

Apolipoprotein E Deficiency Leads to Cutaneous Foam Cell Formation in Mice

Feingold, K. R., Elias, P. M., Mao-Qiang, M. A. N., Fartasch, M., Zhang, S. H., & Maeda, N. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12612790 · Cited by 34

Metabolism of human intermediate and very low density lipoprotein subfractions from normal and dysbetalipoproteinemic plasma. In vivo studies in rat.

Musliner, T. A., McVicker, K. M., Iosefa, J. F., & Krauss, R. M. (1987) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.7.4.408 · Cited by 34

Type III Hyperlipoproteinemia: A Focus on Lipoprotein Receptor-Apolipoprotein E2 Interactions

Innerarity, T. L., Hui, D. Y., Bersot, T. P., & Mahley, R. W. (1986) · Springer eBooks · doi:10.1007/978-1-4684-1262-8_24 · Cited by 34

Apolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis

Zende, P. D. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/6195.3455 · Cited by 34

Cerebral lipid deposition in aged apolipoprotein-E-deficient mice.

Walker, L. C., Parker, C. A., Lipinski, W. J., Callahan, M. J., Carroll, R. T., Gandy, S., Smith, J. D., Jucker, M., & Bisgaier, C. L. (1997) · Europe PMC (PubMed Central) · Cited by 33

Amino acid sequence of rabbit apolipoprotein E.

Lee, B., Miller, J., Yang, C. Y., Ramdas, L., Yang, M., Morrisett, J. D., & Mims, M. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42255-2 · Cited by 13

Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.

McLean, J. W., Elshourbagy, N. A., Chang, D. J., Mahley, R. W., & Taylor, J. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82169-3 · Cited by 150

Identification of Human Apolipoprotein E Variant Gene: Apolipoprotein E7 (Glu244,245↑Lys244,245)1

Maeda, H., Nakamura, H., Kobori, S., Okada, M., Mori, H., Niki, H., Ogura, T., & Hiraga, S. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122618 · Cited by 29

Identification of a New Structural Variant of Human Apolipoprotein E, E2(Lys,46, Gln), in a Type III Hyperlipoproteinemic Subject

Phenotype, T. E., Rall, S. C., Weisgraber, K. H., Innerarity, T. L., Bersot, T. P., Mahley, R. W., Gladstone Foundation, Blum, C. B., Department Of Medicine, & Arteriosclerosis, T. (1983)

Identification of an Italian Kindred with a Variant Apolipoprotein E (E1) Associated with Type III Hyperlipoproteinemia

Gabelli, C., Baggio, G., Pagnan, A., Zanetti, G., Barbato, G. M., Martini, S., Bilato, C., Corti, C., & Crepaldi, G. (1989) · Springer eBooks · doi:10.1007/978-1-4615-9549-6_23 · Cited by 1