Cited by 741Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Human apolipoprotein E. The complete amino acid sequence

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Rall, S C, Weisgraber, K H, Mahley, R W·1982·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)34702-1

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Abstract

The amino acid sequence of human apolipoprotein E (apo-E) has been determined.Apo-E2, one of the major isoforms of apolipoprotein E, is a polypeptide of 299 amino acids having a calculated molecular weight of 34,145.The isoform apo-E3 differs from apo-E2 by a single amino acid substitution of arginine for cysteine at residue 158 (italicized).The sequqnce of apo-E2 is:HzN-Lys-Val-Glu-Gln-Ala-Val-Glu-Thr-Glu-Pro-Glu-Pro-Glu-Leu-Arg-Gln-Gln-Thr-Glu-Trp-Gln-Ser-Gly-Gln-Arg-Trp-Glu-Leu-Ala-Leu-Gly-Arg-Phe-Trp-Asp-Tyr-Leu-Arg-Trp-Val-Gln-%-Leu-Ser-Glu-Gln-Val-Gln-Glu-Glu-Leu-Leu-Ser-Ser-Gln-Val-Thr-Gln-Glu-Leu-Arg-Ala-Leu-Met-Asp-Glu-Thr-Met-Lys-Glu-Leu-Lys-Ala-Tyr-Lys-Ser-Glu-Leu-Glu-Glu-Gln-Leu-Thr-Pro-Val-Ala-Glu-Glu-Thr-Arg-Ala-Arg-Leu-Ser-Lys-Glu-Leu-Gln-Ala-Ala-Gln-Ala-Arg-Leu-Gly-Ala-Asp-Met-Glu-Asp-Val-Cys-Gly-Arg-Leu-Val-Gln-Tyr-Arg-Gly-Glu-Val-Gln-Ala-Met-Leu-Gly-Gln-Ser-Thr-Glu-Glu-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-Arg-Asp-Ala-Asp-Asp-Leu-Gln-Lys-Cys-Leu-Ala-Val-Tyr-Gln-Ala-Gly-Ala-Arg-Glu-Gly-Ala-Glu-Arg-Gly-Leu-Ser-Ala-Ile-Arg-Glu-Arg-Leu-Gly-Pro-Leu-Val-Glu-Gln-Gly-Arg-Val-Arg-Ala-Ala-%-Val-Gly-Ser-Leu-Ala-Gly-Gln-Pro-Leu-Gln-Glu-Arg-Ala-Gln-Ala-Trp-Gly-Glu-Arg-Leu-Arg-Ala-Arg

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Authors: Rall, S. C., Weisgraber, K. H., & Mahley, R. W.
ORCID: Mahley, R W
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1982-04
Volume: 257
Issue: 8
Pages: 4171-4178
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)34702-1
OpenAlex: W1736154854
Cited by: 741
References: 38
Citations by year: 2026: 7 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 16 · 2021: 17 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 21 · 2013: 19 · 2012: 10
FWCI: 40.41
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 14090 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: apolipoprotein E, amino acid sequence, apolipoprotein E isoforms, single amino acid substitution, protein sequences
MeSH terms: Amino Acid Sequence, Apolipoproteins, Apolipoproteins E, Carboxypeptidases, Cyanogen Bromide, Humans, Lipoproteins, LDL, Models, Molecular, Molecular Weight, Peptide Fragments, Protein Conformation, Carboxypeptidases A

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Human apolipoprotein E. The complete amino acid sequence

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