Human apolipoprotein E. The complete amino acid sequence

Prediction of protein conformation

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Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a001 · Cited by 2,172

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

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A molecular theory of lipid—protein interactions in the plasma lipoproteins

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Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site

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Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 616

Glycoproteins

Marshall, R. (1972) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.41.070172.003325 · Cited by 604

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563

Disturbances in Lipid and Lipoprotein Metabolism

Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433

The helical hydrophobic moments and surface activities of serum apolipoproteins

Krebs, K. E., & Phillips, M. C. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90165-0 · Cited by 33

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Madrid, L., Initiative, A. D. N., Moreno–Grau, S., Ahmad, S., González-Pérez, A., de Rojas, I., Xia, R., Adami, P. V. M., García‐González, P., Kleineidam, L., et al. (2021) · Aging · doi:10.18632/aging.202950 · Cited by 33

Genetic Variation and Atherosclerosis

Biroš, E., Karan, M., & Golledge, J. (2008) · Current Genomics · doi:10.2174/138920208783884856 · Cited by 33

The association of the apolipoprotein E gene promoter polymorphisms and haplotypes with serum lipid and lipoprotein concentrations

Viiri, L. E., Loimaala, A., Nenonen, A., Islam, S., VUORI, I. M., Karhunen, P. J., & Lehtimäki, T. J. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.10.004 · Cited by 32

Untitled work

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Systematic analysis of serum lipoproteins and apolipoproteins by a combined technique of micro two‐dimensional electrophoresis

Manabe, T., Visvikis‐Siest, S., Steinmetz, J., Galteau, M. M., Okuyama, T., & Siest, G. (1987) · Electrophoresis · doi:10.1002/elps.1150080706 · Cited by 31

Functionally inactive apolipoprotein E3 in a type III hyperlipoproteinaemic patient

HAVEKES, L. M., LEUVEN, J. A. G., CORVEN, E. V., WIT, E. D., & EMEIS, J. J. (1984) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1984.tb00696.x · Cited by 31

Olfactory Dysfunction and Alzheimer’s Disease: A Review

McLaren, A., & Kawaja, M. D. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231377 · Cited by 35

Triglyceride-rich lipoproteins, remnants and atherosclerotic cardiovascular disease: What we know and what we need to know

Chapman, M. J., Packard, C. J., Björnson, E., Ginsberg, H. N., & Borén, J. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120529 · Cited by 36

Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages

Siddiqui, R., Suzu, S., Ueno, M., Nasser, H., Koba, R., Bhuyan, F., Noyori, O., Hamidi, S., Sheng, G., Yasuda-Inoue, M., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007372 · Cited by 31

Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories

Lopresti, B. J., Campbell, E. M., Yu, Z., Anderson, S., Cohen, A. D., Minhas, D. S., Snitz, B. E., Royse, S. K., Becker, C. R., Aizenstein, H. J., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.012 · Cited by 32

Nutrigenetics and CVD: what does the future hold?

Lovegrove, J. A., & Gitau, R. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108007040 · Cited by 30

Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice

Yong, S. M., Lim, M., Low, C., & Wong, B. (2014) · Scientific Reports · doi:10.1038/srep06580 · Cited by 33

Apo E: The role of conserved residues in defining function

Frieden, C. (2015) · Protein Science · doi:10.1002/pro.2597 · Cited by 29

Functional diversity of apolipoprotein E: from subcellular localization to mitochondrial function

Rueter, J., Rimbach, G. H., & Huebbe, P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04516-7 · Cited by 32

Alpha, Beta, Gamma, Omega—The Structure of the Plasma Proteins

Putnam, F. W. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-568404-0.50009-0 · Cited by 29

Heterozygosity for apolipoprotein E-4Philadelphia(Glu13—-Lys, Arg145—-Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.

Lohse, P., Rader, D. J., & Brewer, H. B. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42261-2 · Cited by 30

Elevated levels of apolipoprotein E in the high density lipoproteins of human cord blood plasma.

Blum, C. B., Davis, P. A., & Forte, T. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34333-9 · Cited by 29

HDL Heterogeneity and Atherosclerosis

Tailleux, A., Fruchart, J., & Parkes, J. G. (1996) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369609083060 · Cited by 29

Expression of the human apolipoprotein E gene in cultured mammalian cells.

Reardon, C. A., Lau, Y. C., Paik, Y., Weisgraber, K. H., Mahley, R. W., & Taylor, J. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67595-7 · Cited by 29

Characterization of a Monoclonal Antibody that Binds to Apolipoprotein E and to Lipoprotein of Human Plasma Containing APO E. Applications to ELISA Quantification of Plasma APO E

Leroy, A., Vu‐Dac, N., Koffigan, M., Barthelemy-Clavey, V., & Fruchart, J. (1988) · Journal of Immunoassay · doi:10.1080/01971528808053219 · Cited by 29

Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and & epsilon;1/lsquo;null genotype‡

FEUSSNER, G., FUNKE, H., WENG, W., ASSMANN, G., LACKNER, K. J., & ZIEGLER, R. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01511.x · Cited by 28

Genes and atherosclerosis: at the origin of the predisposition

Puddu, P., Cravero, E., Puddu, G. M., & Muscari, A. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2005.00439.x · Cited by 28

Measurement of apolipoprotein B concentration in plasma lipoproteins by combining selective precipitation and mass spectrometry

Béghin, L., Duhal, N., Poulain, P., Hauw, P., Lacroix, B. D., Lecerf, J., Bonte, J., Fruchart, J., & Luc, G. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32024-1 · Cited by 28

Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.

Wardell, M. R., Rall, S., Brennan, S., Nye, E., George, P., Janus, E., & Weisgraber, K. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43175-x · Cited by 28

Plasma ApoE elevations are associated with NAFLD: The PREVEND Study

van den Berg, E. H., Corsetti, J. P., Bakker, S. J. L., & Dullaart, R. P. F. (2019) · PLOS ONE · doi:10.1371/journal.pone.0220659 · Cited by 27

Bayesian modelling of multivariate quantitative traits using seemingly unrelated regressions

Verzilli, C. J., Stallard, N., & Whittaker, J. C. (2005) · Genetic Epidemiology · doi:10.1002/gepi.20072 · Cited by 27

Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia

Vanschoonbeek, K., Wouters, K., van der Meijden, P. E. J., van Gorp, P. J., Feijge, M. A. H., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P. M., & Heemskerk, J. W. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156992 · Cited by 27

Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosis

Niino, M., Kikuchi, S., Fukazawa, T., Yabe, I., & Tashiro, K. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms934oa · Cited by 27

Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).

Steinmetz, A., Assefbarkhi, N., Eltze, C., Ehlenz, K., Funke, H., Pies, A., Assmann, G., & Kaffarnik, H. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42740-3 · Cited by 27

Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution

Chen, G. C., Guo, L. S. S., Hamilton, R. L., Gordon, V. C., Richards, E. G., & Kane, J. P. (1984) · Biochemistry · doi:10.1021/bi00321a039 · Cited by 27

Molecular Biology of Human Apolipoproteins B and E and Associated Diseases of Lipoprotein Metabolism

Zannis, V. I. (1989) · Advances in lipid research · doi:10.1016/b978-0-12-024923-7.50005-4 · Cited by 26

Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid‐β

Fleeman, R. M., Kuhn, M. K., Chan, D. C., & Proctor, E. A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15781 · Cited by 20

Role of Apolipoprotein E in Alzheimer’s Disease

Zannis, V. I., Zanni, E. E., Makrides, S. C., Kardassis, D., & Aleshkov, S. B. (1998) · Springer eBooks · doi:10.1007/978-1-4899-0133-0_13 · Cited by 26

A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers

Wellnitz, S., Friedlein, A., Bonanni, C., Anquez, V., Goepfert, F., Loetscher, H., Adessi, C., & Czech, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03295.x · Cited by 26

The influence of simvastatin alone or in combination with gemfibrozil on plasma lipids and lipoproteins in patients with type III hyperlipoproteinemia

Feussner, G., Eichinger, M., & Ziegler, R. (1992) · Journal of Molecular Medicine · doi:10.1007/bf00180314 · Cited by 26

Identification of a neuronal endocytic pathway activated by an apolipoprotein E (apoE) receptor binding peptide

Wang, X.-S., Ciraolo, G. M., Morris, R., & Gruenstein, E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00877-9 · Cited by 26

Sialic acid-containing components of lipoproteins influence lipoprotein-proteoglycan interactions

Millar, J. S., Anber, V., Shepherd, J., & Packard, C. J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00071-4 · Cited by 26

Detection of a new apolipoprotein-E mutation in type III hyperlipidemia using deoxyribonucleic acid restriction isotyping

Walden, C. C., Huff, M. W., Leiter, L. A., Connelly, P. W., & Hegele, R. A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.7907341 · Cited by 26

Carboxyl-Terminal Domain of Human Apolipoprotein E: Expression, Purification, and Crystallization

Forstner, M., Peters-Libeu, C. A., Contreras-Forrest, E., Newhouse, Y. M., Knapp, M. S., Rupp, B., & Weisgraber, K. H. (1999) · Protein Expression and Purification · doi:10.1006/prep.1999.1144 · Cited by 26

Structure and expression of the rat apolipoprotein E gene.

Fung, W. P., Howlett, G. J., & Schreiber, G. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67087-5 · Cited by 26

Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer's disease

Budny, V., Ruminot, I., Wybitul, M., Treyer, V., Barros, L. F., & Tackenberg, C. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03550-w · Cited by 25

Apolipoprotein E4 Is Deficient in Inducing Macrophage ABCA1 Expression and Stimulating the Sp1 Signaling Pathway

Okoro, E. U., Zhao, Y., Guo, Z., Zhou, L., Lin, X., & Yang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044430 · Cited by 25

Genetic variation and intestinal cholesterol absorption in humans: A systematic review and a gene network analysis

Mokhtar, F., Plat, J., & Mensink, R. P. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101164 · Cited by 25

Apolipoprotein E genotypes and their relation to lipid levels in a rural South African population 1

Masemola, M. L., Alberts, M., & Urdal, P. (2007) · Scandinavian Journal of Public Health · doi:10.1080/14034950701355635 · Cited by 24

Different associations of apolipoprotein E polymorphism with metabolic syndrome by sex in an elderly Chinese population

Tao, M. H., Liu, J. W., LaMonte, M. J., Liu, J., Wang, L., He, Y., Li, X. Y., Wang, L. N., & Ye, L. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.004 · Cited by 25

Apolipoprotein E expression by human‐monocyte‐derived macrophages

Rouis, M., Nigon, F., Eggerman, T. L., Brewer, H. B., & Chapman, M. J. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15509.x · Cited by 25

Plasma apolipoprotein secretion by human monocyte-derived macrophages

Wang‐Iverson, P., Gibson, J. C., & Brown, W. V. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90163-8 · Cited by 25

Immunologic approaches to lipoprotein structure.

Schonfeld, G., & Krul, E. S. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38804-0 · Cited by 25

Quantification of human apolipoprotein E in plasma and lipoprotein subfractions by a non-competitive enzyme immunoassay

Koffigan, M., Kora, I., Barthelemy-Clavey, V., Bard, J., Chapman, J., & Fruchart, J. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90243-9 · Cited by 25

The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T＞C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy

Wu, H., Yang, Y., & Hu, Z. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.41996 · Cited by 24

No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controls

Xuan, C., Zhang, B., Li, M., Deng, K., Yang, T., & Zhang, X. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.05.040 · Cited by 24

Isoelectric focusing of apolipoproteins in immobilized pH gradients: Improved determination of apolipoprotein Ephenotypes

Baumstrak, M. W., Berg, A., Halle, M., & Keul, J. (1988) · Electrophoresis · doi:10.1002/elps.1150090918 · Cited by 24

Lack of association of apolipoprotein E polymorphism with plasma Lp(a) levels in the Chinese

Heng, C., Saha, N., & Tay, J. S. H. (1995) · Clinical Genetics · doi:10.1111/j.1399-0004.1995.tb04068.x · Cited by 24

Single radial immunodiffusion of serum apolipoproteins C-II, C-III and E — pretreatment of samples with surfactant

Itakura, K., Matsudate, T., Sakurai, T., Hashimoto, S., Ito, K., Kanno, H., Hirata, M., & Nakamura, K. (1986) · Clinica Chimica Acta · doi:10.1016/0009-8981(86)90011-2 · Cited by 24

Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.

Fazio, S., Horie, Y., Weisgraber, K., Havekes, L., & Rall, S. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40736-9 · Cited by 23

Emerging preclinical pharmacological targets for Parkinson's disease

More, S. V., & Choi, D. (2016) · Oncotarget · doi:10.18632/oncotarget.8104 · Cited by 24

Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.

Zannis, V. I., Nicolosi, R. J., Jensen, E., Breslow, J. L., & Hayes, K. C. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34247-4 · Cited by 23

Genetic Epidemiology of Alzheimer Disease

Mayeux, R. P. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200607001-00008 · Cited by 25

Enhanced binding activity of an apolipoprotein E mutant, apo E5, to LDL receptors on human fibroblasts

Dong, L.-M., Yamamura, T., & Yamamoto, A. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)92336-x · Cited by 23

Apolipoprotein E Phenotypes, Lipoprotein Composition, and Xanthelasmas

Gómez, J. A. (1988) · Archives of Dermatology · doi:10.1001/archderm.1988.01670080042015 · Cited by 23

Identification of a new apolipoprotein E variant (E2 Arg142 → Leu) in type III hyperlipidemia

Richard, P. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05393-w · Cited by 23

Tissue-specific posttranslational modification of rat apoE. Synthesis of sialated apoE forms by neonatal rat aortic smooth muscle cells

Hussain, M. M., Bucher, N. L. R., Faris, B., Franzblau, C., & Zannis, V. I. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38484-4 · Cited by 23

Polymorphism of apolipoprotein E influences levels of serum apolipoproteins E and B in the human neonate

Steinmetz, A., Thiemann, E., Czekelius, P., & Kaffarnik, H. (1989) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1989.tb00247.x · Cited by 23

Monoclonal antibodies and the characterization of apolipoprotein structure and function

Marcel, Y. L., WEECH, P. K., Milthorp, P., Tercé, F., Vézina, C., & Milne, R. W. (1984) · Progress in Lipid Research · doi:10.1016/0163-7827(84)90010-9 · Cited by 23

Clinical features of type III hyperlipoproteinemia: analysis of 64 patients

Feussner, G., Wagner, A., Kohl, B., & Ziegler, R. (1993) · The Clinical Investigator · doi:10.1007/bf00186624 · Cited by 27

Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

Gharibyan, A. L., Islam, T., Pettersson, N., Surano, S., Lundgren, J., Johansson, G., Genot, M., Schultz, N., Wennström, M., & Olofsson, A. (2020) · Biomolecules · doi:10.3390/biom10010134 · Cited by 22

Protein structures in Alzheimer's disease: The basis for rationale therapeutic design

Montoliu‐Gaya, L., & Villegas, S. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.10.005 · Cited by 24

Remodeling of apolipoprotein E-containing spherical reconstituted high density lipoproteins by phospholipid transfer protein

Settasatian, N., Barter, P. J., & Rye, K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700220-jlr200 · Cited by 23

Apolipoprotein E phenotypes and hyperlipidemia in patients under maintenance hemodialysis

Feussner, G., Wey, S., Bommer, J., Deppermann, D., Gr�itzmacher, P., & Ziegler, R. (1992) · Human Genetics · doi:10.1007/bf00197265 · Cited by 23

Lipoproteins in pinnipeds: analysis of a high molecular weight form of apolipoprotein E.

Davis, R. A., Pierotti, V., Lauer, S., Hubl, S., McLean, J., Witztum, J., & Young, S. G. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41998-4 · Cited by 22

Identification and characterization of apolipoprotein(AII-E2-AII) complex in human plasma lipoprotein

Tozuka, M., Hidaka, H., Miyachi, M., Furihata, K., Katsuyama, T., & Kanai, M. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90076-8 · Cited by 22

Apolipoprotein E: phospholipid binding studies with synthetic peptides containing the putative receptor binding region

Sparrow, J. T., Culwell, A. R., Gotto, A. M., & Sparrow, D. A. (1985) · Biochemistry · doi:10.1021/bi00345a035 · Cited by 22

Characterization of very low density lipoproteins and intermediate density lipoproteins of normo- and hyperlipidemic apolipoprotein E-2 homozygotes.

Schmitz, G., Assmann, G., Augustin, J., Dirkes-Kersting, A., Brennhausen, B., & Karoff, C. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34374-1 · Cited by 22

Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs.

Herscovitz, H., Gantz, D., Tercyak, A. M., Zannis, V. I., & SMALL, D. M. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41505-6 · Cited by 22

Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis

Badimón, J. J., Kottke, B. A., Chen, T. C., Chan, L., & Mao, S. J. T. (1986) · Atherosclerosis · doi:10.1016/0021-9150(86)90113-9 · Cited by 22

Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia

van Dam, M., Zwart, M., de Beer, F., Smelt, A. H. M., Prins, M. H., Trip, M. D., Havekes, L. M., Lansberg, P. J., & Kastelein, J. J. P. (2002) · Heart · doi:10.1136/heart.88.3.234 · Cited by 21

Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders

Kelley, C. M., Ginsberg, S. D., Liang, W. S., Counts, S., & Mufson, E. J. (2022) · Brain Communications · doi:10.1093/braincomms/fcac162 · Cited by 23

Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing

Stoppini, M. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.025 · Cited by 21

Apolipoprotein e genotyping methods for the clinical laboratory

Maekawa, B., Cole, T. G., Seip, R. L., & Bylund, D. (1995) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860090112 · Cited by 21

Characterization of the gene for apolipoprotein E5‐Frankfurt (Gln81 ‐> Lys, Cys112 ‐> Arg) by polymerase chain reaction, restriction isotyping, and temperature gradient gel electrophoresis

Ruzicka, V., Mäz, W., Russ, A., Fisher, E., Mondorf, W., & Groß, W. (1993) · ELECTROPHORESIS · doi:10.1002/elps.11501401164 · Cited by 21

Rapid determination of apolipoprotein E genotype using a heteroduplex generator

Bolla, M. K., Wood, N., & Humphries, S. E. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32109-x · Cited by 21

Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.

Raffai, R., Maurice, R., Weisgraber, K., Innerarity, T., Wang, X., MacKenzie, R., Hirama, T., Watson, D., Rassart, E., & Milne, R. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41109-5 · Cited by 21

mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency.

Zannis, V. I., Ordovas, J. M., Cladaras, C., Cole, F. S., Forbes, G., & Schaefer, E. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38808-7 · Cited by 21

Frequencies of apolipoproteins E5 and E7 in apparently healthy Japanese

Tsuchiya, S., Yamanouchi, Y., Onuki, M., Yamakawa, K., Miyazaki, R., Taya, T., Kondo, I., Ohnuki, M., & Hamaguchi, H. (1985) · The Japanese Journal of Human Genetics · doi:10.1007/bf01907964 · Cited by 21

Apolipoprotein ε4 allele is associated with Psoriasis severity: reply

Coto‐Segura, P., Coto, E., Álvarez, V., & Santos‐Juanes, J. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-010-1031-x · Cited by 21

Lessons from genome‐wide association studies findings in Alzheimer's disease

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Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population

Das, S., Kaul, S., Jyothy, A., & Munshi, A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.032 · Cited by 20

Apolipoprotein ε4 allele is associated with psoriasis severity

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Binding and Repressive Activities of Apolipoprotein E3 and E4 Isoforms on the Human ApoD Promoter

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Apolipoprotein-E2 and Hyperlipoproteinemia in Noninsulin-Dependent Diabetes Mellitus*

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Cloning and sequencing of bovine apolipoprotein E complementary DNA and molecular evolution of apolipoproteins E, C-I, and C-II

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Role of apolipoproteins E and C in type V hyperlipoproteinemia.

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The Oligosaccharides of Plasma Glycoproteins: Synthesis, Structure, and Function

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Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins

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Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio

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Epigenetic considerations of the APOE gene

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Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before

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APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome.

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Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers.

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Amino acid sequence of rabbit apolipoprotein E.

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Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.

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Identification of Human Apolipoprotein E Variant Gene: Apolipoprotein E7 (Glu244,245↑Lys244,245)1

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Identification of a New Structural Variant of Human Apolipoprotein E, E2(Lys,46, Gln), in a Type III Hyperlipoproteinemic Subject

Phenotype, T. E., Rall, S. C., Weisgraber, K. H., Innerarity, T. L., Bersot, T. P., Mahley, R. W., Gladstone Foundation, Blum, C. B., Department Of Medicine, & Arteriosclerosis, T. (1983)

Identification of an Italian Kindred with a Variant Apolipoprotein E (E1) Associated with Type III Hyperlipoproteinemia

Gabelli, C., Baggio, G., Pagnan, A., Zanetti, G., Barbato, G. M., Martini, S., Bilato, C., Corti, C., & Crepaldi, G. (1989) · Springer eBooks · doi:10.1007/978-1-4615-9549-6_23 · Cited by 1