The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Human apolipoprotein E. The complete amino acid sequence
Open accessAbstract
The amino acid sequence of human apolipoprotein E (apo-E) has been determined.Apo-E2, one of the major isoforms of apolipoprotein E, is a polypeptide of 299 amino acids having a calculated molecular weight of 34,145.The isoform apo-E3 differs from apo-E2 by a single amino acid substitution of arginine for cysteine at residue 158 (italicized).The sequqnce of apo-E2 is:HzN-Lys-Val-Glu-Gln-Ala-Val-Glu-Thr-Glu-Pro-Glu-Pro-Glu-Leu-Arg-Gln-Gln-Thr-Glu-Trp-Gln-Ser-Gly-Gln-Arg-Trp-Glu-Leu-Ala-Leu-Gly-Arg-Phe-Trp-Asp-Tyr-Leu-Arg-Trp-Val-Gln-%-Leu-Ser-Glu-Gln-Val-Gln-Glu-Glu-Leu-Leu-Ser-Ser-Gln-Val-Thr-Gln-Glu-Leu-Arg-Ala-Leu-Met-Asp-Glu-Thr-Met-Lys-Glu-Leu-Lys-Ala-Tyr-Lys-Ser-Glu-Leu-Glu-Glu-Gln-Leu-Thr-Pro-Val-Ala-Glu-Glu-Thr-Arg-Ala-Arg-Leu-Ser-Lys-Glu-Leu-Gln-Ala-Ala-Gln-Ala-Arg-Leu-Gly-Ala-Asp-Met-Glu-Asp-Val-Cys-Gly-Arg-Leu-Val-Gln-Tyr-Arg-Gly-Glu-Val-Gln-Ala-Met-Leu-Gly-Gln-Ser-Thr-Glu-Glu-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-Arg-Asp-Ala-Asp-Asp-Leu-Gln-Lys-Cys-Leu-Ala-Val-Tyr-Gln-Ala-Gly-Ala-Arg-Glu-Gly-Ala-Glu-Arg-Gly-Leu-Ser-Ala-Ile-Arg-Glu-Arg-Leu-Gly-Pro-Leu-Val-Glu-Gln-Gly-Arg-Val-Arg-Ala-Ala-%-Val-Gly-Ser-Leu-Ala-Gly-Gln-Pro-Leu-Gln-Glu-Arg-Ala-Gln-Ala-Trp-Gly-Glu-Arg-Leu-Arg-Ala-Arg
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The most common has a mutation of 158 Arg --Cys (13), but mutations of 145 Arg -* Cys (14) and 146 Lys --Gln (6) have also been reported in individuals with type III hyperlipoproteinemia.”
From Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. (1987) · cites this paper as [13]
In the citing paper
“Three variants ofapo E2 have been described.Each ofthese differs from apo E3 by a single amino acid substitution (6, 12- 14).”
From Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. (1987) · cites this paper as [13]
In the citing paper
“Secondary structure predictions (54,55) suggest that position 136 is part of an a-helix that extends between residues 130 and 150 (13,24), encompassing the receptor-binding domain from 140 to 150 (22).”
From Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. (1987) · cites this paper as [13]
In the citing paper
“The mature apoE protein consists of 299 amino acids and an 18amino acid signal peptide is removed post-translationally [17,28].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [17]
In the citing paper
“The low density lipoprotein (LDL) receptor binding region is situated in helix four between amino acids 136 and 150 [17,28].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [17]
In the citing paper
“Both codons 112 and 158 showed the amino acid cysteine (Cys) (shown in Fig. 3), which indicated that the isoform of apoE was apoE2/E2 [8, 9].”
In the citing paper
“In normal apoE3, peptide T15 is a 15-residue peptide encompassing residues 120-134 (23).”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [23]
In the citing paper
“This profile is similar to that for normal apoE3 (17, 23) except for the presence of a new peak (CBX) eluting at the column volume.”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [23]
Citations
Cites
Prediction of protein conformation
Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a002 · Cited by 3,309
Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a001 · Cited by 2,172
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citationA molecular theory of lipid—protein interactions in the plasma lipoproteins
Segrest, J. P., Jackson, R. L., Morrisett, J. D., & Gotto, A. M. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80064-5 · Cited by 726
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Self-citationWeisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 616
Self-citationMarshall, R. (1972) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.41.070172.003325 · Cited by 604
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Disturbances in Lipid and Lipoprotein Metabolism
Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495
Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433
Self-citation
Research works printed but not linked: 2
- Mahley, 1977, Am. J. Pathol., 87, 205
- Utermann, 1980, Am. J. Hum. Genet., 32, 339
Cited by
Sorted by citations
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Self-citationApolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Self-citationPlasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155
Self-citationApolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Self-citationApolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review
Eichner, J. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.6.487 · Cited by 796
Lipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Self-citationApolipoprotein E in animal models of CNS injury and in alzheimer's disease
Poirier, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90156-2 · Cited by 637
ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
Kanekiyo, T., Xu, H., & Bu, G. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.045 · Cited by 608
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580
Self-citationSullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575
A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.056 · Cited by 570
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
Brown, M. S., & Goldstein, J. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111044 · Cited by 545
Hallman, D. M., Boerwinkle, E., Saha, N., Sandholzer, C., Menzel, H., Csazar, A., & Utermann, G. (1991) · PubMed · Cited by 511
Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis.
Dallongeville, J., Lussier‐Cacan, S., & Davignon, J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41611-6 · Cited by 444
Fullerton, S. M., Clark, A. G., Weiss, K. M., Nickerson, D. A., Taylor, S. L., Stengård, J., Salomaa, V. V., Vartiainen, E. A., Perola, M., Boerwinkle, E., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/303070 · Cited by 429
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
Weintraub, M. S., Eisenberg, S., & Breslow, J. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113243 · Cited by 418
Ehnholm, C., Lukka, M., Kuusi, T., Nikkilä, E. A., & Utermann, G. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38833-7 · Cited by 403
Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype.
Kesäniemi, Y. A., Ehnholm, C., & Miettinen, T. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113107 · Cited by 402
Apolipoprotein E polymorphism in health and disease
Utermann, G. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90610-7 · Cited by 389
Martins, I. J., Hone, E., Foster, J. K., Sünram-Lea, S. I., Gnjec, A., Fuller, S. J., Nolan, D., Gandy, S. E., & Martins, R. N. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001854 · Cited by 388
Apolipoprotein E: from atherosclerosis to Alzheimerʼs disease and beyond
Mahley, R. W., & Huang, Y. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00003 · Cited by 308
Self-citationSTRUCTURE AND PHYSIOLOGIC FUNCTION OF THE LOW-DENSITY LIPOPROTEIN RECEPTOR
Jeon, H., & Blacklow, S. C. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133354 · Cited by 310
Nelson, M. R., Kardia, S. L. R., Ferrell, R. E., & Sing, C. F. (2001) · Genome Research · doi:10.1101/gr.172901 · Cited by 377
Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss‐Coray, T., Mucke, L., & Mahley, R. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04867.1999 · Cited by 363
Self-citationIsolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.
Das, H. K., McPherson, J. D., Bruns, G. A. P., Karathanasis, S. K., & Breslow, J. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88963-3 · Cited by 354
Regulation of coagulation by a multivalent Kunitz-type inhibitor
Broze, G., Girard, T., & Novotny, W. F. (1990) · Biochemistry · doi:10.1021/bi00485a001 · Cited by 354
Abnormal in vivo metabolism of apolipoprotein E4 in humans.
Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., & Brewer, H. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112645 · Cited by 345
Rall, S. C., Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.15.4696 · Cited by 345
Self-citationDong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., & Agard, D. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31797-0 · Cited by 320
Self-citationApolipoprotein E: From lipid transport to neurobiology
Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320
Impact of apoE genotype on oxidative stress, inflammation and disease risk
Jofre‐Monseny, L., Minihane, A. M., & Rimbach, G. H. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700322 · Cited by 326
Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
Lahoz, C., Schaefer, E. J., Cupples, L. A., Wilson, P. W. F., Levy, D. A., Osgood, D. P., Parpos, S., Pedro‐Botet, J., Daly, J. A., & Ordovás, J. M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00570-0 · Cited by 319
Li, W., Tanimura, M., Luo, C. C., Datta, S., & Chan, L. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38532-1 · Cited by 316
Familial apolipoprotein E deficiency.
Schaefer, E. J., Gregg, R. E., Ghiselli, G., Forte, T. M., Ordovas, J. M., Zech, L. A., & Brewer, H. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112704 · Cited by 313
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease
Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00413-4 · Cited by 306
Weisgraber, K. H. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42621-5 · Cited by 304
Self-citationGenotyping and sequence analysis of apolipoprotein E isoforms*1
EMI, M. (1988) · Genomics · doi:10.1016/0888-7543(88)90130-9 · Cited by 301
Graphene Platform for Hairpin-DNA-Based Impedimetric Genosensing
Bonanni, A., & Pumera, M. (2011) · ACS Nano · doi:10.1021/nn200091p · Cited by 298
Basu, S. K., Ho, Y. K., Brown, M. S., Bilheimer, D. W., Anderson, R. G., & Goldstein, J. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34141-3 · Cited by 232
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.
Wetterau, J. R., Aggerbeck, L. P., Rall, S. C., & Weisgraber, K. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68778-2 · Cited by 293
Self-citationAmino acid distributions around O-linked glycosylation sites
Wilson, I. B. H., Gavel, Y., & von HEIJNE, G. (1991) · Biochemical Journal · doi:10.1042/bj2750529 · Cited by 281
Nucleotide sequence and structure of the human apolipoprotein E gene.
Paik, Y. K., Chang, D. J., Reardon, C. A., Davies, G. E., Mahley, R. W., & Taylor, J. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3445 · Cited by 281
Self-citationThe receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
Innerarity, T. L., Friedlander, E. J., Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44180-9 · Cited by 276
Self-citationYe, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., & Mahley, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508693102 · Cited by 275
Self-citationFless, G. M., ZumMallen, M. E., & Scanu, A. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84439-3 · Cited by 273
A rapid micromethod for apolipoprotein E phenotyping directly in serum
Havekes, L. M., de Knijff, P., Beisiegel†, U., HAVINGA, J. R., de Smit, M. H., & Klasen, E. C. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38697-1 · Cited by 262
Eichner, J. E., Kuller, L. H., Orchard, T. J., Grandits, G. A., McCallum, L. M., Ferrell, R. E., & Neaton, J. D. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90732-r · Cited by 247
Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242
Self-citationRamassamy, C., Averill‐Bates, D. A., Beffert, U., Bastianetto, S., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Davignon, J., Quirion, R., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00102-1 · Cited by 244
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.
Weisgraber, K. H., Rall, S. C., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35898-2 · Cited by 240
Self-citationApolipoprotein E phenotypes and hyperlipidemia
Utermann, G., Kindermann, I., Kaffarnik, H., & Steinmetz, A. (1984) · Human Genetics · doi:10.1007/bf00286508 · Cited by 238
Ordovas, J. M., Litwack-Klein, L., Wilson, P. W., Schaefer, M. M., & Schaefer, E. J. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38690-9 · Cited by 238
Apolipoprotein E and Alzheimer’s disease: Findings, hypotheses, and potential mechanisms
Koutsodendris, N., Nelson, M. R., Rao, A., & Huang, Y. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-030421-112756 · Cited by 231
Cladaras, C., Hadzopoulou‐Cladaras, M., Nolte, R. T., Atkinson, D., & Zannis, V. I. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04675.x · Cited by 229
Aggerbeck, L. P., Wetterau, J. R., Weisgraber, K. H., Wu, C. S., & Lindgren, F. T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68779-4 · Cited by 229
Self-citationLaws, S. M., Hone, E., Gandy, S., & Martins, R. N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01615.x · Cited by 223
Genetic factors affecting blood lipoproteins: the candidate gene approach.
Lusis, A. J. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38516-3 · Cited by 219
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220
Simonet, W. S., Bucay, N., Lauer, S., & Taylor, J. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53085-4 · Cited by 213
Structure and evolution of the apolipoprotein multigene family
Luo, C.-C., Li, W.-H., Moore, M. N., & Chan, L. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90436-5 · Cited by 173
Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study.
Lehtimäki, T. J., Moilanen, T. P. S., Viikari, J. S. A., Akerblom, H., Ehnholm, C., Rönnemaa, T., Marniemi, J., Dahlén, G., & Nikkari, T. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43170-0 · Cited by 205
Apolipoprotein E4 Forms a Molten Globule
Morrow, J. A., Hatters, D. M., Lu, B., Höchtl, P., Oberg, K. A., Rupp, B., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204898200 · Cited by 204
Self-citationSethi, S. M., Gamez, J. D., Vrana, J. A., Theis, J. D., Bergen, H. R., Zipfel, P. F., Doǧan, A., & Smith, R. J. (2009) · Kidney International · doi:10.1038/ki.2008.657 · Cited by 198
Human apolipoprotein B-100 heparin-binding sites.
Weisgraber, K. H., & Rall, S. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60931-7 · Cited by 194
Self-citationSynthesis, intracellular processing, and signal peptide of human apolipoprotein E.
Zannis, V. I., McPherson, J. D., Goldberger, G., Karathanasis, S. K., & Breslow, J. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91039-2 · Cited by 189
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
Beffert, U. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00008-3 · Cited by 190
Genomic variants, genes, and pathways of Alzheimer's disease: An overview
Naj, A. C., & Schellenberg, G. D. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32499 · Cited by 186
Innerarity, T. L., Weisgraber, K. H., Arnold, K. S., Rall, S. C., & Mahley, R. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39866-6 · Cited by 179
Self-citationApolipoprotein E phenotyping from serum by Western blotting
Menzel, H., & Utermann, G. (1986) · Electrophoresis · doi:10.1002/elps.1150071103 · Cited by 174
Role of apolipoprotein E in neurodegenerative diseases
Giau, V. V., Bagyinszky, E., An, S. S. A., & Kim, S. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s84266 · Cited by 177
Koch, W., Ehrenhaft, A., Grießer, K., Pfeufer, A., Mueller, J. C., Schömig, A., & Kastrati, A. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.197 · Cited by 169
Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
Pedro‐Botet, J., Schaefer, E. J., Bakker-Arkema, R. G., Black, D. M., Stein, E., Corella, D., & Ordovás, J. M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00410-5 · Cited by 173
Parameters modulating the maximum insertion pressure of proteins and peptides in lipid monolayers
Calvez, P., Bussières, S., Demers, É., & Salesse, C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.03.018 · Cited by 166
Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164
Crean, S., Ward, A., Mercaldi, C. J., Collins, J. M., Cook, M. N., Baker, N. L., & Arrighi, H. M. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321984 · Cited by 163
The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.
Weisgraber, K. H., Innerarity, T. L., Harder, K. J., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44181-0 · Cited by 220
Self-citationGianturco, S. H., Gotto, A. M., Hwang, S. L., Karlin, J. B., Lin, A., Prasad, S. C., & Bradley, W. A. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32655-3 · Cited by 161
Nolte, R. T., & Atkinson, D. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81698-3 · Cited by 161
Kuusi, T., Nieminen, M. S., Ehnholm, C., Yki‐Järvinen, H., Valle, M., Nikkilä, E. A., & Taskinen, M. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.2.237 · Cited by 159
Wardell, M. R., Brennan, S. O., Janus, E. D., Fraser, R., & Carrell, R. W. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113096 · Cited by 159
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
McLean, J. W., Elshourbagy, N. A., Chang, D. J., Mahley, R. W., & Taylor, J. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82169-3 · Cited by 150
Self-citation[13] Isolation and characterization of apolipoprotein E
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28073-8 · Cited by 150
Self-citationThe role of apolipoprotein E genetic variants in lipoprotein disorders.
RALL, S. C., & MAHLEY, R. W. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb01254.x · Cited by 150
Self-citationFlowers, S. A., & Rebeck, G. W. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104724 · Cited by 149
Glycosylation of Human Apolipoprotein E
Wernette-Hammond, M. E., Lauer, S. J., Corsini, A., Walker, D., Taylor, J. M., & Rall, S. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81907-x · Cited by 149
Self-citationThe pathogenesis and clinical significance of xanthelasma palpebrarum
Bergman, R. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(94)70023-0 · Cited by 145
Beffert, U., Cohn, J. S., Petit-Turcotte, C., Tremblay, M., Aumont, N., Ramassamy, C., Davignon, J., & Poirier, J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01894-6 · Cited by 142
Genetic and epigenetic regulation of human aging and longevity
Morris, B. J., Willcox, B. J., & Donlon, T. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.039 · Cited by 140
Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
Remaley, A. T., Rifai, N., & Warnick, G. R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6164-9.00027-5 · Cited by 139
Grehan, S., Tse, E., & Taylor, J. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00812.2001 · Cited by 138
Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
de Knijff, P., van den Maagdenberg, A. M. J. M., Frants, R. R., & Havekes, L. M. (1994) · Human Mutation · doi:10.1002/humu.1380040303 · Cited by 137
Ehnholm, C., Mahley, R. W., Chappell, D. A., Weisgraber, K. H., Ludwig, E. H., & Witztum, J. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5566 · Cited by 137
Self-citationRat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA.
McLean, J. W., Fukazawa, C., & Taylor, J. M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32155-0 · Cited by 136
A Mechanism for the Neuroprotective Effect of Apolipoprotein E
Pedersen, W. A., Chan, S. L., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741426.x · Cited by 130
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2
Breslow, J. L., Zannis, V. I., SanGiacomo, T. R., Third, J. L., Tracy, T., & Glueck, C. J. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38060-3 · Cited by 174
Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43536-8 · Cited by 128
Self-citationHermier, D., Forgez, P., & Chapman, M. J. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90226-7 · Cited by 128
Bielicki, J. K., Zhang, H., Cortez, Y., Zheng, Y. Y., Narayanaswami, V., Patel, A., Johansson, J., & Azhar, S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003665 · Cited by 126
Rasmussen, K. L. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.10.037 · Cited by 125
Metadata
- Authors
- Rall, S. C., Weisgraber, K. H., & Mahley, R. W.
- ORCID
- Mahley, R W
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-04
- Volume
- 257
- Issue
- 8
- Pages
- 4171-4178
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1736154854
- Cited by
- 741
- References
- 38
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 16 · 2021: 17 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 21 · 2013: 19 · 2012: 10
- FWCI
- 40.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, amino acid sequence, apolipoprotein E isoforms, single amino acid substitution, protein sequences
- MeSH terms
- Amino Acid Sequence, Apolipoproteins, Apolipoproteins E, Carboxypeptidases, Cyanogen Bromide, Humans, Lipoproteins, LDL, Models, Molecular, Molecular Weight, Peptide Fragments, Protein Conformation, Carboxypeptidases A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
