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Cited by 549

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

Open access
Feinstein, R, Kanety, H, Papa, M Z, Lunenfeld, B, Karasik, A·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)74276-8
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Abstract

Tumor necrosis factor-alpha (TNF) has recently been shown to induce insulin resistance. We have examined the possible effect of TNF on the early events in insulin transmembrane signaling. Incubation of the insulin-sensitive rat hepatoma Fao cells with 5 nM TNF for 1 h led to a 65% decrease in insulin-induced tyrosine phosphorylation of both the insulin receptor beta-subunit and IRS-1, its major cytosolic substrate. TNF-induced impairment of tyrosine phosphorylation was maximal at 0.5 nM and was not accompanied by any reduction in insulin binding. Sixteen hours of TNF incubation led to further impairment in insulin-induced tyrosine phosphorylation of these proteins. Our findings suggest that TNF may exert its anti-insulin effect by interrupting the early insulin-stimulated tyrosine phosphorylation events, which are crucial to insulin transmembrane signaling.

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Metadata

Authors
Feinstein, R., Kanety, H., Papa, M. Z., Lunenfeld, B., & Karasik, A.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-12
Volume
268
Issue
35
Pages
26055-26058
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)74276-8
OpenAlex
W1521975179
Cited by
549
References
2
FWCI
12.20
Type
journal article
Language
en
Open access
hybrid

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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